Primary testicular lymphoma: report of five cases and review of the literature

Year 2013, Volume: 20 Issue: 4, 149 - 154, 30.12.2013

Şirin Başpınar , Sema Bircan , Emine Alanoğlu Kemal Bozkurt , Raşit Akdeniz , Alim Koşar

Abstract

Primary testicular lymphoma: report of five cases and review of the literaturePrimary testicular lymphoma (PTL) comprises around 3- 9% of testicular cancers and 1-2% of all non-Hodgkinlymphomas. It is the most common testicular malignancy in men aged over 60 years. The most commonhistological subtype is diffuse large B-cell lymphoma. It usually presents as a painless unilateral testicularmass and swelling. Scrotal pain or lymphocele may also occur. Lymphoma may locally invade the epididymis,spermatic cord, and scrotal skin. At the time of diagnosis or during the course of the disease, spread mayoccur to the extranodal sites, including the contralateral testis, central nervous system, skin, lung,pleura,Waldeyer's ring and soft tissues. Although PTL is rare, testicular involvement of nodal lymphomas is morecommon. In this study we aimed to discuss the clinicopathological features of the cases diagnosed as PTLwith the review of the literature

Keywords

Primary testicular lymphoma, diffuse large B cell lymphoma, treatment

PRİMER TESTİS LENFOMALARI: BEŞ OLGU SUNUMU VE LİTERATÜRÜN GÖZDEN GEÇİRİLMESİ

Abstract

Primer testis lenfomaları testis tümörlerinin yaklaşık %3-9'unu ve tüm non-Hodgkin lenfomaların yaklaşık %1-2'sini oluştururlar. 60 yaşın üstünde en sık görülen testis malignitesidir. En sık görülen histolojik subtip diffüz büyük B hücreli tip lenfomadır. Genellikle tek taraflı ağrısız testiküler kitle ve şişlik izlenir. Skrotal ağrı ve lenfosel oluşabilir. Lenfoma, lokal olarak epididim, spermatik kord ve skrotum derisini invaze edebilir. Tanı anında veya hastalığın seyri sırasında karşı testis, santral sinir sistemi, deri, akciğer, plevra, Waldeyer halkası ve yumuşak dokular gibi ekstranodal bölgelere yayılım görülebilir. Primer testis lenfoması (PTL) nadir olmasına karşın, nodal lenfomaların testis tutulumuna daha sık rastlanır. Bu çalışmada PTL tanısı alan olguların klinikopatolojik bulgularının literatür bilgileri eşliğinde tartışılması amaçlanmıştır.

Keywords

Primer testis lenfomasý, diffüz büyük B hücreli lenfoma, tedavi

References

• Shahab N, Doll DC. Testicular Lymphoma. Semin Oncol 1999;26(3):259-269
• Moller MB, d’Amore F, Christensen BE. Testicular lymphoma: a population-based study of incidence, clinicopathological correlations and prognosis. The Danish Lymphoma Study Group, LYFO. Eur J Cancer 1994;30A(12):1760-1764
• Eble JN, Sauter G, Epstein JI, Sesterhenn IA. Tumours of the Testis and Paratesticular Tissue . In: World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs Lyon, IARC Press, 2004; 217-279.
• Ferry JA, Harris NL, Young RH, Coen J, Zietman A, Scully RE. Malignant lymphoma of the testis, epididymis, and spermatic cord. A clinicopathologic study of 69 cases with immunophenotypic analysis. Am J Surg Pathol 1994;18(4):376-390
• Vural F, Cagirgan S, Saydam G, Hekimgil M, Soyer NA, Tombuloglu M. Primary testicular lymphoma. J N a t l M e d A s s o c 2 0 0 7 ; 9 9 ( 11 ) : 1 2 7 7 - 1 2 8 2
• Fonseca R, Habermann TM, Colgan JP, O'Neill BP, White WL, Witzig TE, et al. Testicular lymphoma is associated with a high incidence of extranodal recurrence. Cancer 2000;88(1):154-161
• Sampat MB, Sirsat MV, Kamat MR. Malignant lymphoma of the testis in Indians. Br J Urol 1974;46(5):569-575
• Zicherman JM, Weissman D, Gribbin C, Epstein R. Best cases from the AFIP: primary diffuse large B-cell lymphoma of the epididymis and testis. Radiographics 2005;25(1):243-248
• Mazloom A, Fowler N, Medeiros LJ, Iyengar P, Horace P, Dabaja BS. Outcome of patients with diffuse large B-cell lymphoma of the testis by era of treatment: the M. D. Anderson Cancer Center experience. Leuk Lymphoma 2010;51(7):1217-1224
• Mlika M, Chelly I, Benrhouma M, Haouet S, Horchani A, Zitouna MM, et al. A Primary Testicular Diffuse
• Large B-cell Lymphoma Belonging to the Germinal Center B-cell-like Group. J Clin Med Res. 2010;2(1):47-49
• Curling TB. Practical Treatise on the diseases of the testis and of the spermatic cord and scrotum. London, Churchill 1866;605
• Zucca E, Conconi A, Mughal TI, Sarris AH, Seymour JF, Vitolo U, et al. Patterns of outcome and prognostic factors in primary large-cell lymphoma
• of the testis in a survey by the International Extranodal Lymphoma Study Group. J Clin Oncol 2003;21(1):20- 27
• Gundrum JD, Mathiason MA, Moore DB, Go RS. Primary testicular diffuse large B-cell lymphoma: a population-based study on the incidence, natural history, and survival comparison with primary nodal counterpart before and after the introduction of rituximab. J Clin Oncol 2009;27(31):5227-5232
• Doll DC, Weiss RB. Malignant lymphoma of the testis. Am J Med 1986;81(3):515–524
• Li D, Xie P, Mi C. Primary testicular diffuse large B- cell lymphoma shows an activated B-cell-like phenotype. Pathol Res Pract 2010;206(9):611-615
• Kemmerling R, Stintzing S, Muhlmann J, Dietze O, Neureiter D. Primary testicular lymphoma: a strictly homogeneous hematological disease? Oncol Rep 2010;23(5):1261-1267
• Booman M, Douwes J, Glas AM, de Jong D, Schuuring E, Kluin PM. Primary testicular diffuse large B-cell lymphomas have activated B-cell-like subtype characteristics. J Pathol 2006;210(2):163-171
• Wang Y, Li ZM, Huang JJ, Xia Y, Li H, Li YJ, et al. Three prognostic factors influence clinical outcomes of primary testicular lymphoma. 2013;34(1):55-63
• Licci S, Morelli L, Covello R. Primary mantle cell lymphoma of the testis. Ann Hematol 2011;90(4):483- 484
• Sugimoto K, Koike H, Esa A. Plasmablastic lymphoma of the right testis. Int J Urol 2011;18(1):85-86
• Moertel CL, Watterson J, McCormick SR, Simonton SC. Follicular large cell lymphoma of the testis in a child. Cancer 1995;75(5):1182-1186
• Horne MJ, Adeniran AJ. Arch Pathol Lab Med. 2011;135(10):1363-1367
• Ulbright TM. The most common, clinically significant misdiagnoses in testicular tumor pathology, and how to avoid them. Adv Anat Pathol 2008;15(1):18–27
• Sussman EB, Hajdu SI, Lieberman PH, Whitmore WF. Malignant lymphoma of the testis: a clinicopathologic study of 37 cases. J Urol 1977;118(6):1004–1007
• Moller MB, d’Amore F, Christensen BE. Testicular lymphoma: a population based study of incidence, clinicopathological correlations and prognosis. The Danish Lymphoma Study Group, LYFO. Eur J Cancer
• 1994;30A(12):1760–1764
• Bhatia K, Vaid AK, Gupta S, Doval DC, Talwar
• V. Primary testicular non-Hodgkin’s lymphoma-a review article. Sao Paulo Med J 2007;125(5):286-288
• Darby S, Hancock BW. Localised non-Hodgkin lymphoma of the testis: the Sheffield Lymphoma Group experience. Int J Oncol 2005;26(4):1093-1099
• Miller TP, Dahlberg S, Cassady JR, Adelstein DJ, Spier CM, Grogan TM, et al. Chemotherapy alone compared with chemotherapy plus radiotherapy for localized intermediate- and high-grade non-Hodgkin’s lymphoma. N Engl J Med 1998;339(1):21-26
• Reyes F, Lepage E, Ganem G, Molina TJ, Brice P, Coiffier B, et al. ACVBP versus CHOP plus radiotherapy for localized aggressive lymphoma. N Engl J Med. 2005;352:1197–1205
• Ergun O, Kosar A, Bas E, Bircan S, Alanoglu EG. Primer testis lenfomasý: bir olgu sunumu ve rituximab ile kombine kemoterapinin etkinliði. Turkiye Klinikleri J Med Sci 2011;31(3):748-751