Research Article
BibTex RIS Cite

EFFECT OF THE INFLAMMATORY BOWEL DISEASES ON CHOROIDAL AND MACULAR THICKNESS

Year 2018, Volume: 25 Issue: 3, 317 - 321, 01.09.2018
https://doi.org/10.17343/sdutfd.434235

Abstract

Abstract

Objective: Crohn’s disease (CD)
and ulcerative colitis (UC) are a group of inflammatory bowel disease (IBD).
Ophthalmic disorders might occur in IBD. The most common findings are
episcleritis and uveitis.Then purpose of the study was to evaulate the
choroidal and macular thickness (MT and CT) in the  IBD and to check it with the disease
activity.

Methods:
IBD group was including 50 patients and the control group consisted of 50
healty volunteers.  All participants were
tested with spectral domain optical coherence tomography (SD-OCT). The CT
values were obtained at seven different points.

Results:
Mean duration of the IBD was
3.9
±1.5 years. Foveal macular thickness was 258.1 ± 14.2 µm in study group and
262.7 ± 20.9 µm in the control group. There was not significant difference
between groups(P=0,19).
Subfoveal, temporal 500 µm, 1000 µm, and 1500 µm CT
measurements were respectively statistically significant in the study group
(p<0.001). Mean CT  was
289.8 ± 25.6 µm in study group and 273.9 ± 33.2 µm in
the control group. There was a significant difference between groups (P=0.008).
There
was no correlation  between mean CT and
erythrocyte sedimentation rate, C-reactive protein level and other  clinical parameters (P˃ 0,05).









Conclusion:
Inflammation of the bowels might affect the choroidal vascular structure.

İNFLAMATUAR
BAĞIRSAK HASTALIKLARININ KOROİDAL VE MAKULAR KALINLIK ÜZERİNE ETKİSİ

ÖZET

Amaç:
Crohn hastalığı (CD) ve ülseratif kolit (ÜK) bir grup inflamatuar barsak
hastalığıdır (IBD) .IBD'de oftalmik bozukluklar ortaya çıkabilir. En sık
görülen bulgular episklerit ve üveittir. Çalışmanın amacı IBD'deki koroidal ve
maküla kalınlığını (MT ve CT) değerlendirmek ve bunu hastalık aktivitesi ile
kontrol etmektir.

Yöntem:
IBD grubu 50 hastanın 50 sağ gözünü içeriyorken, kontrol grubu ise 50 sağlıklı
gönüllünün herhangi bir gözünden oluşmuştu. Tüm katılımcılar spectral domain
optical coherence tomography (SD-OCT) ile test edildi. CT değerleri yedi farklı
noktada elde edildi.

Bulgular:
IBD'nin ortalama süresi 3.9 ± 1.5 yıl idi. Foveal maküler kalınlık; çalışma
grubunda 258.1 ± 14.2 µm, kontrol grubunda 262.7 ± 20.9 µm idi. Gruplar
arasında anlamlı fark yoktu (P = 0,19). Subfoveal, temporal 500 µm, 1000 µm ve
1500 µm CT ölçümleri, çalışma grubunda sırasıyla istatistiksel olarak anlamlıydı
(p <0.001). Çalışma grubunda ortalama BT 289.8 ± 25.6 µm, kontrol grubunda
273.9 ± 33.2 µm idi. Gruplar arasında anlamlı fark vardı (P = 0.008). Ortalama
BT ve eritrosit sedimentasyon hızı, C-reaktif protein düzeyi ve diğer klinik
parametreler arasında korelasyon yoktu (P = 0,05).

Sonuç:
Bağırsak iltihabı, koroidal vasküler yapıyı etkileyebilir.













Anahtar
kelimeler:
koroidal kalınlık, inflamatuar bağırsak
hastalıkları, makuler kalınlık

References

  • 1. Bernstein CN. Extraintestinal manifestations of inflammatory bowel disease. Current gastroenterology reports. 2001;3(6):477-83.
  • 2. Goudet P, Dozois RR, Kelly KA, Ilstrup DM, Phillips SF. Characteristics and evolution of extraintestinal manifestations associated with ulcerative colitis after proctocolectomy. Digestive surgery. 2001;18(1):51-5.
  • 3. Mady R, Grover W, Butrus S. Ocular Complications of Inflammatory Bowel Disease. The Scientific World Journal. 2015;2015:1-5.
  • 4. Troncoso LL, Biancardi AL, de Moraes HV, Jr., Zaltman C. Ophthalmic manifestations in patients with inflammatory bowel disease: A review. World J Gastroenterol. 2017;23(32):5836-48.
  • 5. Felekis T, Katsanos K, Kitsanou M, Trakos N, Theopistos V, Christodoulou D, et al. Spectrum and frequency of ophthalmologic manifestations in patients with inflammatory bowel disease: a prospective single-center study. Inflamm Bowel Dis. 2009;15(1):29-34.
  • 6. Ishikawa S, Taguchi M, Muraoka T, Sakurai Y, Kanda T, Takeuchi M. Changes in subfoveal choroidal thickness associated with uveitis activity in patients with Behcet's disease. The British journal of ophthalmology. 2014;98(11):1508-13.
  • 7. Fong AH, Li KK, Wong D. Choroidal evaluation using enhanced depth imaging spectral-domain optical coherence tomography in Vogt-Koyanagi-Harada disease. Retina (Philadelphia, Pa). 2011;31(3):502-9.
  • 8. Onal IK, Yuksel E, Bayrakceken K, Demir MM, Karaca EE, Ibis M, et al. Measurement and clinical implications of choroidal thickness in patients with inflammatory bowel disease. Arquivos brasileiros de oftalmologia. 2015;78(5):278-82.
  • 9. Nickla DL, Wallman J. The multifunctional choroid. Progress in Retinal and Eye Research. 2010;29(2):144-68.
  • 10. Baltmr A, Lightman S, Tomkins-Netzer O. Examining the choroid in ocular inflammation: a focus on enhanced depth imaging. Journal of ophthalmology. 2014;2014:459136.
  • 11. Gundogan FC, Akay F, Uzun S, Ozge G, Toyran S, Genç H. Choroidal thickness changes in the acute attack period in patients with familial Mediterranean fever. Ophthalmologica Journal international d'ophtalmologie International journal of ophthalmology Zeitschrift fur Augenheilkunde. 2015;235(2):72-7.
  • 12. Kim M, Kim H, Kwon HJ, Kim SS, Koh HJ, Lee SC. Choroidal thickness in Behcet's uveitis: an enhanced depth imaging-optical coherence tomography and its association with angiographic changes. Investigative ophthalmology & visual science. 2013;54(9):6033-9.
  • 13. Banares A, Jover JA, Fernandez-Gutierrez B, Benitez del Castillo JM, Garcia J, Vargas E, et al. Patterns of uveitis as a guide in making rheumatologic and immunologic diagnoses. Arthritis and rheumatism. 1997;40(2):358-70.
  • 14. Cloche V, Buisson A, Trechot F, Batta B, Locatelli A, Favel C, et al. Ocular symptoms are not predictive of ophthalmologic inflammation in inflammatory bowel disease. Dig Liver Dis. 2013;45(3):195-9.

İNFLAMATUAR BAĞIRSAK HASTALIKLARININ KOROİDAL VE MAKULAR KALINLIK ÜZERİNE ETKİSİ

Year 2018, Volume: 25 Issue: 3, 317 - 321, 01.09.2018
https://doi.org/10.17343/sdutfd.434235

Abstract

Amaç:
Crohn hastalığı (CD) ve ülseratif kolit (ÜK) bir grup inflamatuar barsak
hastalığıdır (IBD) .IBD'de oftalmik bozukluklar ortaya çıkabilir. En sık
görülen bulgular episklerit ve üveittir. Çalışmanın amacı IBD'deki koroidal ve
maküla kalınlığını (MT ve CT) değerlendirmek ve bunu hastalık aktivitesi ile
kontrol etmektir.

Yöntem:
IBD grubu 50 hastanın 50 sağ gözünü içeriyorken, kontrol grubu ise 50 sağlıklı
gönüllünün herhangi bir gözünden oluşmuştu. Tüm katılımcılar spectral domain
optical coherence tomography (SD-OCT) ile test edildi. CT değerleri yedi farklı
noktada elde edildi.

Bulgular:
IBD'nin ortalama süresi 3.9 ± 1.5 yıl idi. Foveal maküler kalınlık; çalışma
grubunda 258.1 ± 14.2 µm, kontrol grubunda 262.7 ± 20.9 µm idi. Gruplar
arasında anlamlı fark yoktu (P = 0,19). Subfoveal, temporal 500 µm, 1000 µm ve
1500 µm CT ölçümleri, çalışma grubunda sırasıyla istatistiksel olarak anlamlıydı
(p <0.001). Çalışma grubunda ortalama BT 289.8 ± 25.6 µm, kontrol grubunda
273.9 ± 33.2 µm idi. Gruplar arasında anlamlı fark vardı (P = 0.008). Ortalama
BT ve eritrosit sedimentasyon hızı, C-reaktif protein düzeyi ve diğer klinik
parametreler arasında korelasyon yoktu (P = 0,05).







Sonuç:
Bağırsak iltihabı, koroidal vasküler yapıyı etkileyebilir.

References

  • 1. Bernstein CN. Extraintestinal manifestations of inflammatory bowel disease. Current gastroenterology reports. 2001;3(6):477-83.
  • 2. Goudet P, Dozois RR, Kelly KA, Ilstrup DM, Phillips SF. Characteristics and evolution of extraintestinal manifestations associated with ulcerative colitis after proctocolectomy. Digestive surgery. 2001;18(1):51-5.
  • 3. Mady R, Grover W, Butrus S. Ocular Complications of Inflammatory Bowel Disease. The Scientific World Journal. 2015;2015:1-5.
  • 4. Troncoso LL, Biancardi AL, de Moraes HV, Jr., Zaltman C. Ophthalmic manifestations in patients with inflammatory bowel disease: A review. World J Gastroenterol. 2017;23(32):5836-48.
  • 5. Felekis T, Katsanos K, Kitsanou M, Trakos N, Theopistos V, Christodoulou D, et al. Spectrum and frequency of ophthalmologic manifestations in patients with inflammatory bowel disease: a prospective single-center study. Inflamm Bowel Dis. 2009;15(1):29-34.
  • 6. Ishikawa S, Taguchi M, Muraoka T, Sakurai Y, Kanda T, Takeuchi M. Changes in subfoveal choroidal thickness associated with uveitis activity in patients with Behcet's disease. The British journal of ophthalmology. 2014;98(11):1508-13.
  • 7. Fong AH, Li KK, Wong D. Choroidal evaluation using enhanced depth imaging spectral-domain optical coherence tomography in Vogt-Koyanagi-Harada disease. Retina (Philadelphia, Pa). 2011;31(3):502-9.
  • 8. Onal IK, Yuksel E, Bayrakceken K, Demir MM, Karaca EE, Ibis M, et al. Measurement and clinical implications of choroidal thickness in patients with inflammatory bowel disease. Arquivos brasileiros de oftalmologia. 2015;78(5):278-82.
  • 9. Nickla DL, Wallman J. The multifunctional choroid. Progress in Retinal and Eye Research. 2010;29(2):144-68.
  • 10. Baltmr A, Lightman S, Tomkins-Netzer O. Examining the choroid in ocular inflammation: a focus on enhanced depth imaging. Journal of ophthalmology. 2014;2014:459136.
  • 11. Gundogan FC, Akay F, Uzun S, Ozge G, Toyran S, Genç H. Choroidal thickness changes in the acute attack period in patients with familial Mediterranean fever. Ophthalmologica Journal international d'ophtalmologie International journal of ophthalmology Zeitschrift fur Augenheilkunde. 2015;235(2):72-7.
  • 12. Kim M, Kim H, Kwon HJ, Kim SS, Koh HJ, Lee SC. Choroidal thickness in Behcet's uveitis: an enhanced depth imaging-optical coherence tomography and its association with angiographic changes. Investigative ophthalmology & visual science. 2013;54(9):6033-9.
  • 13. Banares A, Jover JA, Fernandez-Gutierrez B, Benitez del Castillo JM, Garcia J, Vargas E, et al. Patterns of uveitis as a guide in making rheumatologic and immunologic diagnoses. Arthritis and rheumatism. 1997;40(2):358-70.
  • 14. Cloche V, Buisson A, Trechot F, Batta B, Locatelli A, Favel C, et al. Ocular symptoms are not predictive of ophthalmologic inflammation in inflammatory bowel disease. Dig Liver Dis. 2013;45(3):195-9.
There are 14 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Research Articles
Authors

Fahrettin Akay 0000-0001-9679-9379

Halil Genç

Yusuf Çağdaş Kumbul 0000-0002-0713-2933

Publication Date September 1, 2018
Submission Date June 16, 2018
Acceptance Date June 26, 2018
Published in Issue Year 2018 Volume: 25 Issue: 3

Cite

Vancouver Akay F, Genç H, Kumbul YÇ. EFFECT OF THE INFLAMMATORY BOWEL DISEASES ON CHOROIDAL AND MACULAR THICKNESS. Med J SDU. 2018;25(3):317-21.

                                                                                               14791 


Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi/Medical Journal of Süleyman Demirel University is licensed under Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International.