Research Article
BibTex RIS Cite

Mitral anülüs kalsifikasyonunun elektrokardiyogram parametreleri üzerinde etkileri

Year 2019, Volume: 26 Issue: 3, 274 - 279, 01.09.2019
https://doi.org/10.17343/sdutfd.447971

Abstract

Amaç: Mitral anüler kalsifikasyon (MAK) mortalite
indikatörü olan azalmış kalp hızı değişkenliği, bozulmuş P dalgası dispersiyonu
ve atriyal elektromekanik gecikme ile ilişkili olduğu saptanmıştır. MAK’ın
potansiyel aritmojenik etkileri olabileceğini göz önüne alarak çalışmamızda
MAK’ın kalbin elektrofizyolojisi üzerine etkilerini klasik EKG parametrelerine
ek olarak f(QRS‐T) açısı ve Tp-e/QT gibi yeni aritmojenik idikatörleri
kullanarak araştırmayı amaçladık.



Hastalar ve Yöntemler: Toplam 200 ardışık hasta [n=100
MAK (+) ve n=100 MAK (-)] çalışmaya dahil edildi.
Toplanılan tüm veriler ve elektrokardiyogram parametreleri
gruplar arasında karşılaştırıldı.



Bulgular: P Dalgası MAK (+) grubunda, kontrol
grubuna göre anlamlı şekilde uzun izlenmiştir (p<0.001). Düzeltilmiş QT intervali MAK (+) grubunda,
kontrol grubuna göre anlamlı olarak uzun izlenmiştir (p<0.001). Tp-e intervali MAK (+) grubunda,
kontrol grubuna göre anlamlı olarak uzun izlenmiştir (p<0.001). Tp-e/ QT intervali ve Tp-e/ düzeltilmiş QT intervali
oranı MAK (+) grubunda, kontrol grubuna göre anlamlı olarak uzun izlenmiştir (p<0.001). Frontal QRS-T açısı
MAK (+) grubunda anlamlı olarak fazla izlenmiştir (p<0.001).



Sonuç: Çalışmamızda MAK’ın EKG üzerindeki
etkileri değerlendirilmiştir ve literatürde ilk kez MAK’ın kalbin
repolarizasyon parametreleri üzerinde negatif etkileri olduğu saptanmıştır.

References

  • 1. Adler Y, Herz I, Vaturi M et al. Mitral annular calcium detected by transthoracic echocardiography is a marker for high prevalence and severity of coronary artery disease in patients undergoing coronary angiography. Am J Cardiol 82(10), 1183-1186 (1998).
  • 2. Adler Y, Koren A, Fink N et al. Association between mitral annulus calcification and carotid atherosclerotic disease. Stroke 29(9), 1833-1837 (1998).
  • 3. Fox CS, Vasan RS, Parise H et al. Mitral Annular Calcification Predicts Cardiovascular Morbidity and Mortality. Circulation 107(11), 1492 (2003).
  • 4. Allison MA, Cheung P, Criqui MH, Langer RD, Wright CM. Mitral and aortic annular calcification are highly associated with systemic calcified atherosclerosis. Circulation 113(6), 861-866 (2006).
  • 5. Aronow WS, Schwartz KS, Koenigsberg M. Correlation of serum lipids, calcium and phosphorus, diabetes mellitus, aortic valve stenosis and history of systemic hypertension with presence or absence of mitral anular calcium in persons older than 62 years in a long-term health care facility. Am J Cardiol 59(4), 381-382 (1987).
  • 6. Afshar M, Luk K, Do R et al. Association of Triglyceride-Related Genetic Variants With Mitral Annular Calcification. J Am Coll Cardiol 69(24), 2941-2948 (2017).
  • 7. Algra A, Tijssen JG, Roelandt JR, Pool J, Lubsen J. QTc prolongation measured by standard 12-lead electrocardiography is an independent risk factor for sudden death due to cardiac arrest. Circulation 83(6), 1888-1894 (1991).
  • 8. Kors JA, Ritsema Van Eck HJ, Van Herpen G. The meaning of the Tp-Te interval and its diagnostic value. Journal of electrocardiology 41(6), 575-580 (2008).
  • 9. Antzelevitch C, Sicouri S, Di Diego JM et al. Does Tpeak-Tend provide an index of transmural dispersion of repolarization? Heart rhythm 4(8), 1114-1116; author reply 1116-1119 (2007).
  • 10. Erikssen G, Liestol K, Gullestad L, Haugaa KH, Bendz B, Amlie JP. The terminal part of the QT interval (T peak to T end): a predictor of mortality after acute myocardial infarction. Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc 17(2), 85-94 (2012).
  • 11. Gupta P, Patel C, Patel H et al. T(p-e)/QT ratio as an index of arrhythmogenesis. Journal of electrocardiology 41(6), 567-574 (2008).
  • 12. Macfarlane PW. The frontal plane QRS-T angle. EP Europace 14(6), 773-775 (2012).
  • 13. Andrew O, Trevor F, A. HC, G. TL. QRS‐T Angle: A Review. Annals of Noninvasive Electrocardiology 19(6), 534-542 (2014).
  • 14. Aro AL, Huikuri HV, Tikkanen JT et al. QRS-T angle as a predictor of sudden cardiac death in a middle-aged general population. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 14(6), 872-876 (2012).
  • 15. Raposeiras-Roubin S, Virgos-Lamela A, Bouzas-Cruz N et al. Usefulness of the QRS-T angle to improve long-term risk stratification of patients with acute myocardial infarction and depressed left ventricular ejection fraction. Am J Cardiol 113(8), 1312-1319 (2014).
  • 16. Kurtoðlu E, Aktürk E, Korkmaz H, Ataþ H, Pekdemir H. Impaired heart rate variability in patients with mitral annular calcification: an observational study. The Anatolian Journal of Cardiology 13(7), 668-674 (2013).
  • 17. Eweda I, Abul-Saud M, Fouad H, Hanna RN, Nammas W. P wave dispersion and atrial electromechanical delay: do they vary with the extent of mitral annular calcification? Acta cardiologica 71(4), 449-455 (2016).
  • 18. Potpara TS, Vasiljevic ZM, Vujisic-Tesic BD et al. Mitral annular calcification predicts cardiovascular morbidity and mortality in middle-aged patients with atrial fibrillation: the Belgrade Atrial Fibrillation Study. Chest 140(4), 902-910 (2011).
  • 19. Hevia JC, Antzelevitch C, Bárzaga FT et al. Tpeak-Tend and Tpeak-Tend Dispersion as Risk Factors for Ventricular Tachycardia/ Ventricular Fibrillation in Patients With the Brugada Syndrome. Journal of the American College of Cardiology 47(9), 1828-1834 (2006).
  • 20. Zhang Z-M, Rautaharju PM, Prineas RJ, Tereshchenko L, Soliman EZ. Electrocardiographic QRS-T angle and the risk of incident silent myocardial infarction in the Atherosclerosis Risk in Communities study. Journal of electrocardiology 50(5), 661-666 (2017).
  • 21. Kanjanauthai S, Nasir K, Katz R et al. Relationships of mitral annular calcification to cardiovascular risk factors: the Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis 213(2), 558-562 (2010).
  • 22. Fox CS, Larson MG, Vasan RS et al. Cross-sectional association of kidney function with valvular and annular calcification: the Framingham heart study. J Am Soc Nephrol 17(2), 521-527 (2006).
  • 23. Thubrikar MJ, Deck JD, Aouad J, Chen JM. Intramural stress as a causative factor in atherosclerotic lesions of the aortic valve. Atherosclerosis 55(3), 299-311 (1985).
  • 24. Plotnick GD, Fisher ML, Becker LC. Ventricular arrhythmias in patients with rest angina: correlation with ST segment changes and extent of coronary atherosclerosis. American heart journal 105(1), 32-36 (1983).
  • 25. Agarwal SK, Heiss G, Rautaharju PM, Shahar E, Massing MW, Simpson RJ, Jr. Premature ventricular complexes and the risk of incident stroke: the Atherosclerosis Risk In Communities (ARIC) Study. Stroke 41(4), 588-593 (2010).
  • 26. Chen LY, Sotoodehnia N, Buzkova P et al. Atrial fibrillation and the risk of sudden cardiac death: the atherosclerosis risk in communities study and cardiovascular health study. JAMA internal medicine 173(1), 29-35 (2013).
  • 27. Fulkerson PK, Beaver BM, Auseon JC, Graber HL. Calcification of the mitral annulus: etiology, clinical associations, complications and therapy. The American journal of medicine 66(6), 967-977 (1979).
  • 28. Fox CS, Parise H, Vasan RS et al. Mitral annular calcification is a predictor for incident atrial fibrillation. Atherosclerosis 173(2), 291-294 (2004).
  • 29. Wang AY, Ho SS, Wang M et al. Cardiac valvular calcification as a marker of atherosclerosis and arterial calcification in end-stage renal disease. Archives of internal medicine 165(3), 327-332 (2005).
  • 30. Kurtoglu E, Akturk E, Korkmaz H, Atas H, Cuglan B, Pekdemir H. Impaired heart rate variability in patients with mitral annular calcification: an observational study. Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 13(7), 668-674 (2013).
  • 31. Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation 93(5), 1043-1065 (1996).
  • 32. Dilaveris P, Antoniou CK, Gatzoulis K, Tousoulis D. T wave axis deviation and QRS-T angle - Controversial indicators of incident coronary heart events. Journal of electrocardiology 50(4), 466-475 (2017).
  • 33. Gungor M, Celik M, Yalcinkaya E et al. The Value of Frontal Planar QRS-T Angle in Patients without Angiographically Apparent Atherosclerosis. Medical principles and practice : international journal of the Kuwait University, Health Science Centre 26(2), 125-131 (2017).
Year 2019, Volume: 26 Issue: 3, 274 - 279, 01.09.2019
https://doi.org/10.17343/sdutfd.447971

Abstract

References

  • 1. Adler Y, Herz I, Vaturi M et al. Mitral annular calcium detected by transthoracic echocardiography is a marker for high prevalence and severity of coronary artery disease in patients undergoing coronary angiography. Am J Cardiol 82(10), 1183-1186 (1998).
  • 2. Adler Y, Koren A, Fink N et al. Association between mitral annulus calcification and carotid atherosclerotic disease. Stroke 29(9), 1833-1837 (1998).
  • 3. Fox CS, Vasan RS, Parise H et al. Mitral Annular Calcification Predicts Cardiovascular Morbidity and Mortality. Circulation 107(11), 1492 (2003).
  • 4. Allison MA, Cheung P, Criqui MH, Langer RD, Wright CM. Mitral and aortic annular calcification are highly associated with systemic calcified atherosclerosis. Circulation 113(6), 861-866 (2006).
  • 5. Aronow WS, Schwartz KS, Koenigsberg M. Correlation of serum lipids, calcium and phosphorus, diabetes mellitus, aortic valve stenosis and history of systemic hypertension with presence or absence of mitral anular calcium in persons older than 62 years in a long-term health care facility. Am J Cardiol 59(4), 381-382 (1987).
  • 6. Afshar M, Luk K, Do R et al. Association of Triglyceride-Related Genetic Variants With Mitral Annular Calcification. J Am Coll Cardiol 69(24), 2941-2948 (2017).
  • 7. Algra A, Tijssen JG, Roelandt JR, Pool J, Lubsen J. QTc prolongation measured by standard 12-lead electrocardiography is an independent risk factor for sudden death due to cardiac arrest. Circulation 83(6), 1888-1894 (1991).
  • 8. Kors JA, Ritsema Van Eck HJ, Van Herpen G. The meaning of the Tp-Te interval and its diagnostic value. Journal of electrocardiology 41(6), 575-580 (2008).
  • 9. Antzelevitch C, Sicouri S, Di Diego JM et al. Does Tpeak-Tend provide an index of transmural dispersion of repolarization? Heart rhythm 4(8), 1114-1116; author reply 1116-1119 (2007).
  • 10. Erikssen G, Liestol K, Gullestad L, Haugaa KH, Bendz B, Amlie JP. The terminal part of the QT interval (T peak to T end): a predictor of mortality after acute myocardial infarction. Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc 17(2), 85-94 (2012).
  • 11. Gupta P, Patel C, Patel H et al. T(p-e)/QT ratio as an index of arrhythmogenesis. Journal of electrocardiology 41(6), 567-574 (2008).
  • 12. Macfarlane PW. The frontal plane QRS-T angle. EP Europace 14(6), 773-775 (2012).
  • 13. Andrew O, Trevor F, A. HC, G. TL. QRS‐T Angle: A Review. Annals of Noninvasive Electrocardiology 19(6), 534-542 (2014).
  • 14. Aro AL, Huikuri HV, Tikkanen JT et al. QRS-T angle as a predictor of sudden cardiac death in a middle-aged general population. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 14(6), 872-876 (2012).
  • 15. Raposeiras-Roubin S, Virgos-Lamela A, Bouzas-Cruz N et al. Usefulness of the QRS-T angle to improve long-term risk stratification of patients with acute myocardial infarction and depressed left ventricular ejection fraction. Am J Cardiol 113(8), 1312-1319 (2014).
  • 16. Kurtoðlu E, Aktürk E, Korkmaz H, Ataþ H, Pekdemir H. Impaired heart rate variability in patients with mitral annular calcification: an observational study. The Anatolian Journal of Cardiology 13(7), 668-674 (2013).
  • 17. Eweda I, Abul-Saud M, Fouad H, Hanna RN, Nammas W. P wave dispersion and atrial electromechanical delay: do they vary with the extent of mitral annular calcification? Acta cardiologica 71(4), 449-455 (2016).
  • 18. Potpara TS, Vasiljevic ZM, Vujisic-Tesic BD et al. Mitral annular calcification predicts cardiovascular morbidity and mortality in middle-aged patients with atrial fibrillation: the Belgrade Atrial Fibrillation Study. Chest 140(4), 902-910 (2011).
  • 19. Hevia JC, Antzelevitch C, Bárzaga FT et al. Tpeak-Tend and Tpeak-Tend Dispersion as Risk Factors for Ventricular Tachycardia/ Ventricular Fibrillation in Patients With the Brugada Syndrome. Journal of the American College of Cardiology 47(9), 1828-1834 (2006).
  • 20. Zhang Z-M, Rautaharju PM, Prineas RJ, Tereshchenko L, Soliman EZ. Electrocardiographic QRS-T angle and the risk of incident silent myocardial infarction in the Atherosclerosis Risk in Communities study. Journal of electrocardiology 50(5), 661-666 (2017).
  • 21. Kanjanauthai S, Nasir K, Katz R et al. Relationships of mitral annular calcification to cardiovascular risk factors: the Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis 213(2), 558-562 (2010).
  • 22. Fox CS, Larson MG, Vasan RS et al. Cross-sectional association of kidney function with valvular and annular calcification: the Framingham heart study. J Am Soc Nephrol 17(2), 521-527 (2006).
  • 23. Thubrikar MJ, Deck JD, Aouad J, Chen JM. Intramural stress as a causative factor in atherosclerotic lesions of the aortic valve. Atherosclerosis 55(3), 299-311 (1985).
  • 24. Plotnick GD, Fisher ML, Becker LC. Ventricular arrhythmias in patients with rest angina: correlation with ST segment changes and extent of coronary atherosclerosis. American heart journal 105(1), 32-36 (1983).
  • 25. Agarwal SK, Heiss G, Rautaharju PM, Shahar E, Massing MW, Simpson RJ, Jr. Premature ventricular complexes and the risk of incident stroke: the Atherosclerosis Risk In Communities (ARIC) Study. Stroke 41(4), 588-593 (2010).
  • 26. Chen LY, Sotoodehnia N, Buzkova P et al. Atrial fibrillation and the risk of sudden cardiac death: the atherosclerosis risk in communities study and cardiovascular health study. JAMA internal medicine 173(1), 29-35 (2013).
  • 27. Fulkerson PK, Beaver BM, Auseon JC, Graber HL. Calcification of the mitral annulus: etiology, clinical associations, complications and therapy. The American journal of medicine 66(6), 967-977 (1979).
  • 28. Fox CS, Parise H, Vasan RS et al. Mitral annular calcification is a predictor for incident atrial fibrillation. Atherosclerosis 173(2), 291-294 (2004).
  • 29. Wang AY, Ho SS, Wang M et al. Cardiac valvular calcification as a marker of atherosclerosis and arterial calcification in end-stage renal disease. Archives of internal medicine 165(3), 327-332 (2005).
  • 30. Kurtoglu E, Akturk E, Korkmaz H, Atas H, Cuglan B, Pekdemir H. Impaired heart rate variability in patients with mitral annular calcification: an observational study. Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 13(7), 668-674 (2013).
  • 31. Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation 93(5), 1043-1065 (1996).
  • 32. Dilaveris P, Antoniou CK, Gatzoulis K, Tousoulis D. T wave axis deviation and QRS-T angle - Controversial indicators of incident coronary heart events. Journal of electrocardiology 50(4), 466-475 (2017).
  • 33. Gungor M, Celik M, Yalcinkaya E et al. The Value of Frontal Planar QRS-T Angle in Patients without Angiographically Apparent Atherosclerosis. Medical principles and practice : international journal of the Kuwait University, Health Science Centre 26(2), 125-131 (2017).
There are 33 citations in total.

Details

Primary Language Turkish
Subjects Clinical Sciences
Journal Section Research Articles
Authors

Mevlüt Kuyumcu

Publication Date September 1, 2019
Submission Date July 26, 2018
Acceptance Date September 11, 2018
Published in Issue Year 2019 Volume: 26 Issue: 3

Cite

Vancouver Kuyumcu M. Mitral anülüs kalsifikasyonunun elektrokardiyogram parametreleri üzerinde etkileri. Med J SDU. 2019;26(3):274-9.

                                                                                               14791 


Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi/Medical Journal of Süleyman Demirel University is licensed under Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International.