GUİLLAİN-BARRÉ SENDROMUNDA AĞIR ÖZÜRLÜLÜĞÜN ERKEN BELİRTEÇLERİ

Year 2022, Volume: 29 Issue: 4, 643 - 649, 27.12.2022

Ümit Görgülü Burak Geçer Şule Bilen Giray Kolcu

https://doi.org/10.17343/sdutfd.1188650

Abstract

Amaç
Guillain-Barré sendromu (GBS), ihmal edilemez morbidite
ve mortaliteye sahip otoimmün nörolojik bir hastalıktır.
Bu çalışma, GBS hastalarında ağır engelliliğin
erken belirteçleri olarak farklı hasta özelliklerini ve laboratuvar
bulgularını değerlendirmeyi amaçladı.
Gereç ve Yöntem
1 Ocak 2018 ile 31 Aralık 2021 tarihleri arasında GBS
tanısı alan 121 hastanın tıbbi kayıtlarını retrospektif
olarak inceledik. Demografik özellikler, başvuru şikayetleri,
ek hastalıklar, geçirilmiş enfeksiyon öyküsü,
nörolojik muayene bulguları, 1. gün ve 1. ay sonu
GBS Disabilite Skorları (GDS), serolojik ve beyin
omurilik sıvısı (BOS) incelemesi laboratuvar parametreleri,
elektromiyonörografi sonuçları, GBS alt tipleri,
tedaviler, tedaviye bağlı komplikasyonlar ve prognozlar
kaydedildi.
Bulgular
121 hastanın ortanca yaşı 58’di (20-87) (n = 73 erkek,
%60). Ortalama GDS başvuruda 3 ve birinci ayın sonunda
2 idi. Serum C-reaktif protein (CRP) ve BOS
protein seviyeleri yüksek, D vitamini seviyeleri düşüktü.
İleri yaş, kraniyal sinir tutulumu, enfeksiyon öyküsü,
yoğun bakım ünitesine (YBÜ) yatış, mekanik ventilasyon
(MV) ihtiyacı, komplikasyon varlığı, yüksek
plazma CRP düzeyleri, nötrofil-lenfosit oranı (NLR)
ve trombosit-lenfosit oranı (PLO) GBS hastalarında
1. gün ve 1. ayın sonunda ciddi engellilik ile anlamlı
şekilde ilişkiliydi.
Sonuç
GBS hastalarında ciddi engelliliği tahmin edebilecek
çok sayıda özellik belirledik.

Keywords

Biyobelirteçler, Guillain-Barré disabilite skoru, Guillain-Barré sendromu, Hughes skoru, Özürlülük belirteçleri, Biomarkers, Guillain–Barré disability score, Guillain–Barré syndrome, Hughes score, Predictors of disability

Supporting Institution

YOK

Project Number

YOK

EARLY PREDICTORS OF SEVERE DISABILITY IN GUILLAIN–BARRÉ SYNDROME

Abstract

Objective
Guillain-Barré syndrome (GBS) is an autoimmune
neurological disorder with non-negligible morbidity
and mortality. This study aimed to evaluate different
patient characteristics and laboratory findings as early
predictors of severe disability in GBS patients.
Material and Method
We retrospectively reviewed the medical records of
121 patients diagnosed with GBS between January
1, 2018, and December 31, 2021. Data regarding
demographic characteristics, presenting complaints,
co-morbidities, previous infection history, neurological
examination findings, GBS Disability Scores (GDS)
on the 1st day and by the end of the first month,
laboratory parameters of serological and cerebrospinal
fluid (CSF) examination, electromyoneurography
results, GBS subtypes, treatments, treatment-related
complications, and prognoses were recorded.
Results
The median age of the 121 patients was 58 (20–87)
years (n = 73 males, 60%). The average GDS was
3 on admission and 2 at the end of the first month.
The serum C-reactive protein (CRP) and CSF protein
levels were raised, while vitamin D levels were
reduced. Advanced age, cranial nerve involvement,
history of infection, admission to the intensive care
unit (ICU), need for mechanical ventilation (MV),
presence of complications, high plasma CRP levels,
neutrophil-lymphocyte ratio (NLR), and plateletlymphocyte
ratio (PLO) were significantly associated
with severe disability in GBS patients at day 1 and at
the end of the first month.
Conclusion
We identified multiple characteristics that can predict
severe disability in GBS patients.

Keywords

Biomarkers, Guillain–Barré disability score, Guillain–Barré syndrome, Hughes score, Predictors of disability

Project Number

YOK

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