POPÜLER BİR TAMAMLAYICI TIP TEDAVİSİ: PROLOTERAPİ

Aydan Örsçelik; İlker Solmaz

doi:10.17343/sdutfd.1162009

Review

A POPULAR COMPLEMENTARY MEDICINE TREATMENT: PROLOTHERAPY

Year 2023, Volume: 30 Issue: 1, 135 - 142, 14.03.2023

Aydan Örsçelik İlker Solmaz

https://doi.org/10.17343/sdutfd.1162009

Cited By: 1

Abstract

Prolotherapy, which is a complementary medicine
treatment method used for almost centuries in the
treatment of chronic musculoskeletal diseases, has
become popular both in Turkey and in the world in the
last ten years. Prolotherapy practitioners is saying that
"prolotherapy method provides improvement in pain
and functions, increases the quality of life by treating
the disease". With its widespread usage recently,
more studies are being conducted and it is becoming
more evidence-based therapy method. In this review,
information supported by the current literature about
prolotherapy treatment has been conveyed.

Keywords

Musculoskeletal System, Pain, Prolotherapy

References

1. Solmaz I. Kas İskelet Sistemi Ağrılarında Proloterapi Enjeksiyonları. J Biotechnol Strateg Heal Res 2019;3:91–114.
2. Hackett G, Hemwall G, Montgomery G. Ligament and Tendon Relaxation Treated by Prolotherapy. 5th ed. Oak Park;2008.
3. Solmaz I, Orscelik A. Features and Clinical Effectiveness of the Regenerative Injection Treatments: Prolotherapy and Platelet- Rich Plasma for Musculoskeletal Pain Management. In: Cascella M. From Conventional to Innovative Approaches for Pain Treatment (1st Ed) IntechOpen, 2019;73–86. Doi:10.5772/ intechopen.77716
4. Solmaz I. Kas iskelet sistemi ağrılarında proloterapi uygulamaları. In: Ozlü A. Kas iskelet sistemi hastalıklarında geleneksel ve tamamlayıcı tıp uygulamaları (1st Ed) Ankara, Akademisyen kitabevi, 2020; 153–70.
5. Orscelik A, Akpancar S, Seven MM, Erdem Y, Koca K. The Efficacy of Platelet Rich Plasma and Prolotherapy in Chondromalacia Patella Treatment. Turkish J Sport Med 2020;55(1):28–37.
6. Yıldız Y, Apaydın AH, Seven MM, Orscelik A. The Effects of Prolotherapy (Hypertonic Dextrose) in Recreational Athletes with Patellofemoral Pain Syndrome. J Exp Integr Med 2016;6(2):53.
7. Dagenais S, Yelland MJ, Del Mar C, Schoene ML. Prolotherapy injections for chronic low-back pain. Cochrane Database Syst Rev 2007;2007(2):CD004059.
8. Waldman S. Pain Management. 2nd ed. Philadelphia: Saunders (Elsevier); 2011.
9. Rabago D, Lee KS, Ryan M, Chourasia AO, Sesto ME, Zgierska A, et al. Hypertonic dextrose and morrhuate sodium injections (prolotherapy) for lateral epicondylosis (tennis elbow): Results of a single-blind, pilot-level, randomized controlled trial. Am J Phys Med Rehabil 2013;92(7):587–96.
10. Rabago D, Patterson JJ, Mundt M, Zgierska A, Fortney L, Grettie J, et al. Dextrose and Morrhuate Sodium Injections (Prolotherapy) for Knee Osteoarthritis: A Prospective Open-Label Trial. J Altern Complement Med 2014;20(5):383–91.
11. Topol GA, Podesta LA, Reeves KD, Giraldo MM, Johnson LL, Grasso R, et al. Chondrogenic Effect of Intra-articular Hypertonic- Dextrose (Prolotherapy) in Severe Knee Osteoarthritis. PM&R 2016;8(11):1072–82.
12. Seven MM, Ersen O, Akpancar S, Ozkan H, Turkkan S, Yıldız Y, et al. Effectiveness of prolotherapy in the treatment of chronic rotator cuff lesions. Orthop Traumatol Surg Res 2017;103(3):427–33.
13. Solmaz I, Orscelik A, Koroglu O. Modified prolotherapy by 5% dextrose: Two years experiences of a traditional and complementary medicine practice center in Turkey. J Back Musculoskelet Rehabil 2022;35(4):763–70.
14. Solmaz I, Orscelik A, Karasimav Ö, Akpancar S. Is Prolotherapy Effective in the Treatment of Avascular Necrosis of the Femoral Head? Altern Ther Health Med 2019;25(5):57–9.
15. Erdem Y, Gul D, Akpancar S. Comparison of Intraarticular Injections of Hyaluronic Acid versus Dextrose Applied with Periarticular Prolotherapy in the Treatment of Recreational Athletes with Knee Osteoarthritis. Turkish J Sport Med 2020;55(1):6–13.
16. Gül D, Orsçelik A, Akpancar S. Treatment of Osteoarthritis Secondary to Developmental Dysplasia of the Hip with Prolotherapy Injection versus a Supervised Progressive Exercise Control. Med Sci Monit 2020;26:e919166.
17. Jensen KT, Rabago DP, Best TM, Patterson JJ, Vanderby R. Early inflammatory response of knee ligaments to prolotherapy in a rat model. J Orthop Res 2008;26(6):816–23.
18. Güran Ş, Dilşad çoban Z, Karasimav Ö, Demirhan S, Karaağaç N, Orscelik A, et al. Dextrose solution used for prolotherapy decreases cell viability and increases gene expressions of angiogenic and apopitotic factors. Gulhane Med J 2018;60(2):42–6.
19. Solmaz I, Akpancar S, Orscelik A, Yener-Karasimav O, Gül D. Dextrose injections for failed back surgery syndrome: a consecutive case series. Eur Spine J 2019:21;28(7):1610–7.
20. Maniquis-Smigel L, Dean Reeves K, Jeffrey Rosen H, Lyftogt J, Graham-Coleman C, Cheng A-L, et al. Short Term Analgesic Effects of 5% Dextrose Epidural Injections for Chronic Low Back Pain: A Randomized Controlled Trial. Anesthesiol Pain Med 2016;7(1):e42550.
21. Köroğlu O, Orscelik A, Karasimav Ö, Demir Y, Solmaz I. Is 5% dextrose prolotherapy effective for radicular low back pain? Gulhane Med J 2019;61(3):123.
22. Inceöz H, Akçalı DT, Solmaz I. Proloterapi ve Enjeksiyonlardaki Yeri. In: Babacan A. Ağrı ve Enjeksiyonlar (1st Ed) Ankara, Türkiye Klinikleri, 2019; 104–9.
23. Dagenais S, Jaime C, Scott H. A systematic review of low back pain cost of illness studies in the United States and internationally. Spine J 2008;8(1):8–20.
24. Yelland MJ, Glasziou PP, Bogduk N, Schluter PJ, McKernon M. Prolotherapy Injections, Saline Injections, and Exercises for Chronic Low-Back Pain: A Randomized Trial. Spine (Phila Pa 1976) 2004;29(1):9–16.
25. Kim WM, Lee HG, Won Jeong C, Kim CM, Yoon MH. A Randomized Controlled Trial of Intra-Articular Prolotherapy Versus Steroid Injection for Sacroiliac Joint Pain. J Altern Complement Med 2010;16(12):1285–90.
26. Dechow E, Davies RK, Carr AJ, Thompson PW. A randomized, double-blind, placebo-controlled trial of sclerosing injections in patients with chronic low back pain. Rheumatology 1999;38(12):1255–9.
27. Dagenais S, Haldeman S, Wooley JR. Intraligamentous injection of sclerosing solutions (prolotherapy) for spinal pain: a critical review of the literature. Spine J 2005;5(3):310–28.
28. Reeves KD, Klein RG, DeLong WB. Letters. Spine (Phila Pa 1976) 2004;29(16):1839–40.
29. Miller, Matthew R, Matthews, Robert S RKD. Treatment of painful advanced internal lumbar disc derangement with intradiscal injection of hypertonic dextrose. Pain Physician 2006;9(2):115–21.
30. Solmaz İ, Orscelik A. Approximately Three Years of Prolotherapy Experience of a Traditional and Complementary Medicine Center: An Epidemiologic Study. Int J Tradit Complement Med Res 2022;3(2):64–70.
31. Orscelik A. The Importance of the Core Region in Sports Injuries and Sports Performance. Turkiye Klin J Sport Med-Special Top 2017;3(3):191–5.
32. Tauchi R, Imagama S, Muramoto A, Tsuboi M, Ishiguro N, Hasegawa Y. Influence of spinal imbalance on knee osteoarthritis in community-living elderly adults. Nagoya J Med Sci 2015;77(3):329–37.
33. Tsuji T, Matsuyama Y, Goto M, Yimin Y, Sato K, Hasegawa YIN. Knee – spine syndrome: correlation between sacral inclination and patellofemoral joint pain. J Orthop Sci 2002;7(5):519–23.
34. Centeno CJ, Elliott J, Elkins WL, Freeman M. Fluoroscopically guided cervical prolotherapy for instability with blinded pre and post radiographic reading. Pain Physician 2005;8(1):67–72.
35. Hooper RA, Frizzell JB, Faris P. Case series on chronic whiplash related neck pain treated with intraarticular zygapophysial joint regeneration injection therapy. Pain Physician 2007;10(2):313–8.
36. DeChellis DM, Cortazzo MH. Regenerative medicine in the field of pain medicine: Prolotherapy, platelet-rich plasma therapy, and stem cell therapy—Theory and evidence. Tech Reg Anesth Pain Manag 2011;15(2):74–80.
37. Hung C-Y, Hsiao M-Y, Chang K-V, Han D-S, Wang T-G. Comparative effectiveness of dextrose prolotherapy versus control injections and exercise in the management of osteoarthritis pain: a systematic review and meta-analysis. J Pain Res 2016;9:847–57.
38. Rabago D, Patterson JJ, Mundt M, Kijowski R, Grettie J, Segal NA, et al. Dextrose Prolotherapy for Knee Osteoarthritis: A Randomized Controlled Trial. Ann Fam Med 20131;11(3):229–37.
39. Reeves KD, Hassanein KM. Long-term effects of dextrose prolotherapy for anterior cruciate ligament laxity. Altern Ther Health Med 2003;9(3):58–62.
40. Rabago D, Zgierska A, Fortney L, Kijowski R, Mundt M, Ryan M, et al. Hypertonic Dextrose Injections (Prolotherapy) for Knee Osteoarthritis: Results of a Single-Arm Uncontrolled Study with 1-Year Follow-Up. J Altern Complement Med 2012;18(4):408–14.
41. Rezasoltani Z, Taheri M, Kazempour Mofrad M, Mohajerani S. Periarticular dextrose prolotherapy instead of intra-articular injection for pain and functional improvement in knee osteoarthritis. J Pain Res 2017;10:1179–87.
42. Avşar MT, Okudan RN, Gümüş ZZ, Samancı R. Efficacy of Prolotherapy With Periarticular 5% Dextrose In The Treatment of Knee Joint Osteoarthritis. Int J Tradit Complement Med Res 2021;2(3):162–6.
43. Scarpone M, Rabago DP, Zgierska A, Arbogast G, Snell E. The Efficacy of Prolotherapy for Lateral Epicondylosis: A Pilot Study. Clin J Sport Med 2008;18(3):248–54.
44. Akcay S, Gurel Kandemir N, Kaya T, Dogan N, Eren M. Dextrose Prolotherapy Versus Normal Saline Injection for the Treatment of Lateral Epicondylopathy: A Randomized Controlled Trial. J Altern Complement Med 2020;26(12):1159–68.
45. Yelland M, Rabago D, Ryan M, Ng S-K, Vithanachchi D, Manickaraj N, et al. Prolotherapy injections and physiotherapy used singly and in combination for lateral epicondylalgia: a single- blinded randomised clinical trial. BMC Musculoskelet Disord 2019;20(1):509.
46. Bertrand H, Reeves KD, Bennett CJ, Bicknell S, Cheng A-L. Dextrose Prolotherapy Versus Control Injections in Painful Rotator Cuff Tendinopathy. Arch Phys Med Rehabil 2016;97(1):17–25.
47. Sari A, Eroglu A. Comparison of ultrasound-guided platelet-rich plasma, prolotherapy, and corticosteroid injections in rotator cuff lesions. J Back Musculoskelet Rehabil 2020;33(3):387–96.
48. Lin C-L, Huang C-C, Huang S-W. Effects of hypertonic dextrose injection in chronic supraspinatus tendinopathy of the shoulder: a randomized placebo-controlled trial. Eur J Phys Rehabil Med 2019; 55(4):480-7.
49. Chang Y-J, Chang F-H, Hou P-H, Tseng K-H, Lin Y-N. Effects of Hyperosmolar Dextrose Injection in Patients With Rotator Cuff Disease and Bursitis: A Randomized Controlled Trial. Arch Phys Med Rehabil 2021;102(2):245–50.
50. Akpancar S, Orscelik A, Murat SM, Kenan K. The effectiveness of prolotherapy on failed rotator cuff repair surgery. Turkish J Phys Med Rehabil 2019;65(4):394–401.
51. Rabago D, Nourani B. Prolotherapy for Osteoarthritis and Tendinopathy: a Descriptive Review. Curr Rheumatol Rep 2017;19(6):34.
52. Apaydin AH, Orscelik A, Yildiz Y. The Effects of Prolotherapy in Recreational Athletes with Plantar Fasciitis. Turkish J Sport Med 2018;53(1):37–46.
53. Solmaz İ, Orscelik A, Akpancar S, Seven MM. The Effectivity Of Prolotherapy Treatment In Shin Splint: A Randomized Controlled Study. Int J Tradit Complement Med Res 2022;3(1):1–7.