<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.4 20241031//EN"
        "https://jats.nlm.nih.gov/publishing/1.4/JATS-journalpublishing1-4.dtd">
<article  article-type="reviewer-report"        dtd-version="1.4">
            <front>

                <journal-meta>
                                                                <journal-id>selcuk dent j</journal-id>
            <journal-title-group>
                                                                                    <journal-title>Selcuk Dental Journal</journal-title>
            </journal-title-group>
                                        <issn pub-type="epub">2148-7529</issn>
                                                                                            <publisher>
                    <publisher-name>Selcuk University</publisher-name>
                </publisher>
                    </journal-meta>
                <article-meta>
                                        <article-id pub-id-type="doi">10.15311/selcukdentj.1658059</article-id>
                                                                <article-categories>
                                            <subj-group  xml:lang="en">
                                                            <subject>Paedodontics</subject>
                                                    </subj-group>
                                            <subj-group  xml:lang="tr">
                                                            <subject>Çocuk Diş Hekimliği</subject>
                                                    </subj-group>
                                    </article-categories>
                                                                                                                                                        <title-group>
                                                                                                                        <trans-title-group xml:lang="en">
                                    <trans-title>Sensitivity and Treatment in Molar Incisor Hypomineralization (MIH) Teeth</trans-title>
                                </trans-title-group>
                                                                                                                                                                                                <article-title>Büyük Azı Keser Hipomineralizasyonlu Dişlerde Hassasiyet ve Tedavisi</article-title>
                                                                                                    </title-group>
            
                                                    <contrib-group content-type="authors">
                                                                        <contrib contrib-type="author">
                                                                    <contrib-id contrib-id-type="orcid">
                                        https://orcid.org/0009-0005-0263-698X</contrib-id>
                                                                <name>
                                    <surname>Özdemir</surname>
                                    <given-names>Tuğba</given-names>
                                </name>
                                                                    <aff>İZMİR KATİP ÇELEBİ ÜNİVERSİTESİ</aff>
                                                            </contrib>
                                                    <contrib contrib-type="author">
                                                                    <contrib-id contrib-id-type="orcid">
                                        https://orcid.org/0000-0003-2705-2401</contrib-id>
                                                                <name>
                                    <surname>Savaş</surname>
                                    <given-names>Selçuk</given-names>
                                </name>
                                                                    <aff>İZMİR KATİP ÇELEBİ ÜNİVERSİTESİ</aff>
                                                            </contrib>
                                                    <contrib contrib-type="author">
                                                                    <contrib-id contrib-id-type="orcid">
                                        https://orcid.org/0000-0002-6086-7410</contrib-id>
                                                                <name>
                                    <surname>Küçükyılmaz İzgi</surname>
                                    <given-names>Ebru</given-names>
                                </name>
                                                                    <aff>İZMİR KATİP ÇELEBİ ÜNİVERSİTESİ</aff>
                                                            </contrib>
                                                                                </contrib-group>
                        
                                        <pub-date pub-type="pub" iso-8601-date="20251229">
                    <day>12</day>
                    <month>29</month>
                    <year>2025</year>
                </pub-date>
                                        <volume>12</volume>
                                        <issue>3</issue>
                                        <fpage>512</fpage>
                                        <lpage>521</lpage>
                        
                        <history>
                                    <date date-type="received" iso-8601-date="20250314">
                        <day>03</day>
                        <month>14</month>
                        <year>2025</year>
                    </date>
                                                    <date date-type="accepted" iso-8601-date="20250509">
                        <day>05</day>
                        <month>09</month>
                        <year>2025</year>
                    </date>
                            </history>
                                        <permissions>
                    <copyright-statement>Copyright © 2014, Selcuk Dental Journal</copyright-statement>
                    <copyright-year>2014</copyright-year>
                    <copyright-holder>Selcuk Dental Journal</copyright-holder>
                </permissions>
            
                                                                                                <trans-abstract xml:lang="en">
                            <p>Molar Incisor Hypomineralization (MIH) is a developmental enamel defect characterized by hypomineralization and discoloration of one or more permanent first molars and incisors, often leading to sensitivity, enamel breakdown, and an increased risk of cavities. In MIH-affected teeth, the enamel tissue has reduced mineral content, increased protein and water content, and higher porosity. As a result of these physicochemical changes, negative clinical outcomes such as hypersensitivity, difficulty in achieving adequate anesthesia, atypical carious lesions, aesthetic concerns, and reduced quality of life arise. One of the most common and challenging complaints encountered by patients with MIH, which significantly impacts the treatment process, is hypersensitivity. This condition greatly reduces the quality of life, negatively affecting behaviors related to eating, drinking, and oral hygiene. Managing hypersensitivity in MIH-affected teeth can range from preventive and non-invasive approaches to invasive procedures and extractions due to the wide variety of treatment methods and the significant differences in the severity of the affected teeth. The aim of this review is to provide clinicians with a different perspective by comparing the current literature on the treatment of hypersensitivity in MIH-affected teeth.</p></trans-abstract>
                                                                                                                                    <abstract><p>Büyük Azı Keser Hipomineralizasyonu (BAKH), en az bir veya daha fazla birinci daimî molar diş ile keser dişleri etkileyen, minede hipomineralizasyon ve renk değişikliği ile karakterize, sıklıkla hassasiyet, mine yıkımı ve artan çürük riski ile sonuçlanan gelişimsel bir mine defektidir. BAKH&#039;lı dişlerde mine dokusu, azalmış mineral, artmış protein ve su içeriği ile artmış poroziteye sahiptir. Bu fizikokimyasal değişikliklerin sonucu olarak aşırı hassasiyet, yeterli anestezi sağlamakta zorluk, atipik çürük lezyonları, estetik kaygılar ve yaşam kalitesinde azalma gibi olumsuz klinik sonuçlar ortaya çıkmaktadır. BAKH&#039;lı dişlerde hastaların en sık karşılaştığı ve tedavi sürecini en fazla zorlayan şikayetlerden biri aşırı hassasiyettir. Bu durum, hastaların yaşam kalitesini önemli ölçüde düşürerek, özellikle yemek yeme, içecek tüketimi ve ağız hijyenine yönelik davranışları üzerinde olumsuz etkiler yaratır. BAKH&#039;lı dişlerde aşırı hassasiyetin yönetimi, tedavi yöntemlerinin geniş bir yelpazeye yayılması ve etkilenen dişlerin şiddetinin büyük ölçüde farklılık göstermesi nedeniyle, koruyucu ve invaziv olmayan yaklaşımlardan, invaziv işlemler ve diş çekimlerine kadar uzanabilmektedir. Bu derlemenin amacı, MIH&#039;lı dişlerde görülen aşırı hassasiyetin tedavisine yönelik güncel literatürde yer alan bilgileri karşılaştırarak tartışmak ve klinisyenlere bakış açısı kazandırmaktır.</p></abstract>
                                                            
            
                                                                                        <kwd-group>
                                                    <kwd>aşırı hassasiyet</kwd>
                                                    <kwd>  remineralizasyon</kwd>
                                                    <kwd>  büyük azı keser hipomineralizasyonu</kwd>
                                            </kwd-group>
                            
                                                <kwd-group xml:lang="en">
                                                    <kwd>molar incisor hypomineralization</kwd>
                                                    <kwd>  hypersensitivity</kwd>
                                                    <kwd>  remineralizasyon</kwd>
                                            </kwd-group>
                                                                                                                                        </article-meta>
    </front>
    <back>
                            <ref-list>
                                    <ref id="ref1">
                        <label>1</label>
                        <mixed-citation publication-type="journal">1. Weerheijm KL, Jälevik B, Alaluusua S. Molar-incisor hypomineralisation. Caries Res 2001;35(5):390-391.</mixed-citation>
                    </ref>
                                    <ref id="ref2">
                        <label>2</label>
                        <mixed-citation publication-type="journal">2. Zhao D, Dong B, Yu D, Ren Q, Sun Y. The prevalence of molar incisor hypomineralization: evidence from 70 studies. Int J Paediatr Dent. 2018;28(2):170-179.</mixed-citation>
                    </ref>
                                    <ref id="ref3">
                        <label>3</label>
                        <mixed-citation publication-type="journal">3. Bandeira Lopes L, Machado V, Botelho J, Haubek D. Molar-incisor hypomineralization: an umbrella review. Acta Odontol Scand. 2021;79(5):359-369.</mixed-citation>
                    </ref>
                                    <ref id="ref4">
                        <label>4</label>
                        <mixed-citation publication-type="journal">4. Schwendicke F, et al. Global burden of molar incisor hypomineralization. J Dent 2018;68:10-18.</mixed-citation>
                    </ref>
                                    <ref id="ref5">
                        <label>5</label>
                        <mixed-citation publication-type="journal">5. Garot E, et al. An update of the aetiological factors involved in molar incisor hypomineralisation (MIH): a systematic review and meta-analysis. Eur Arch Paediatr Dent. 2021;1-16.</mixed-citation>
                    </ref>
                                    <ref id="ref6">
                        <label>6</label>
                        <mixed-citation publication-type="journal">6. Silva MJ, Scurrah KJ, Craig JM, Manton DJ, Kilpatrick N. Etiology of molar incisor hypomineralization–A systematic review. Community Dent Oral Epidemiol 2016;44(4):342-353.</mixed-citation>
                    </ref>
                                    <ref id="ref7">
                        <label>7</label>
                        <mixed-citation publication-type="journal">7. Nanci A. Ten Cate&#039;s Oral Histology: Development, Structure, and Function. Elsevier Health Sciences; 2017.</mixed-citation>
                    </ref>
                                    <ref id="ref8">
                        <label>8</label>
                        <mixed-citation publication-type="journal">8. Alaluusua S. Aetiology of molar-incisor hypomineralisation: a systematic review. Eur Arch Paediatr Dent. 2010;11(2):53-58.</mixed-citation>
                    </ref>
                                    <ref id="ref9">
                        <label>9</label>
                        <mixed-citation publication-type="journal">9. Smith C. Cellular and chemical events during enamel maturation. Crit Rev Oral Biol Med. 1998;9(2):128-161.</mixed-citation>
                    </ref>
                                    <ref id="ref10">
                        <label>10</label>
                        <mixed-citation publication-type="journal">10. Hernández M, Boj JR, Espasa E, Peretz B. First permanent molars and permanent incisors teeth by tooth prevalence of molar–incisor–hypomineralisation in a group of Spanish schoolchildren. Acta Stomatol Croat. 2018;52(4).</mixed-citation>
                    </ref>
                                    <ref id="ref11">
                        <label>11</label>
                        <mixed-citation publication-type="journal">11. Bekes K. Molar Incisor Hypomineralization: A Clinical Guide to Diagnosis and Treatment. Oralprophylaxe &amp; Kinderzahnheilkunde. 2021;43:10-11.</mixed-citation>
                    </ref>
                                    <ref id="ref12">
                        <label>12</label>
                        <mixed-citation publication-type="journal">12. Hubbard MJ, Mangum JE, Perez VA, Williams RA. A breakthrough in understanding the pathogenesis of molar hypomineralisation: the mineralisation-poisoning model. Front Physiol. 2021;12:2316.</mixed-citation>
                    </ref>
                                    <ref id="ref13">
                        <label>13</label>
                        <mixed-citation publication-type="journal">13. Weerheijm K. Molar incisor hypomineralization (MIH). Eur J Paediatr Dent. 2003;4.</mixed-citation>
                    </ref>
                                    <ref id="ref14">
                        <label>14</label>
                        <mixed-citation publication-type="journal">14. Farah R, Drummond B, Swain M, Williams S. Linking the clinical presentation of molar-incisor hypomineralisation to its mineral density. Int J Paediatr Dent. 2010;20(5):353-360.</mixed-citation>
                    </ref>
                                    <ref id="ref15">
                        <label>15</label>
                        <mixed-citation publication-type="journal">15. Carvalho MR, Regalo SCH. Electromyographic analysis of the stomatognathic system of children with molar-incisor hypomineralization. PLoS One. 2023;18:e0277030.</mixed-citation>
                    </ref>
                                    <ref id="ref16">
                        <label>16</label>
                        <mixed-citation publication-type="journal">16. Jälevik B, Klingberg G. Dental treatment, dental fear and behaviour management problems in children with severe enamel hypomineralization of their permanent first molars. Int J Paediatr Dent. 2002;12(1):24-32.</mixed-citation>
                    </ref>
                                    <ref id="ref17">
                        <label>17</label>
                        <mixed-citation publication-type="journal">17. Raposo F, de Carvalho Rodrigues AC, Lia ÉN, Leal SC. Prevalence of hypersensitivity in teeth affected by molar-incisor hypomineralization (MIH). Caries Res. 2019;53(4):424-430.</mixed-citation>
                    </ref>
                                    <ref id="ref18">
                        <label>18</label>
                        <mixed-citation publication-type="journal">18. Santos PS, et al. Dentin hypersensitivity and toothache among patients diagnosed with molar-molar-incisor hypomineralization: a systematic review and meta-analysis. J Dent. 2024;104981.</mixed-citation>
                    </ref>
                                    <ref id="ref19">
                        <label>19</label>
                        <mixed-citation publication-type="journal">19. Somani C, Taylor G. An update of treatment modalities in children and adolescents with teeth affected by molar incisor hypomineralisation (MIH): a systematic review. Eur Arch Paediatr Dent. 2022;23(1):39-64.</mixed-citation>
                    </ref>
                                    <ref id="ref20">
                        <label>20</label>
                        <mixed-citation publication-type="journal">20. Lygidakis N, et al. Best clinical practice guidance for clinicians dealing with children presenting with molar-incisor-hypomineralisation (MIH): an updated European Academy of Paediatric Dentistry policy document. Eur Arch Paediatr Dent. 2022;1-19.</mixed-citation>
                    </ref>
                                    <ref id="ref21">
                        <label>21</label>
                        <mixed-citation publication-type="journal">21. Jälevik B, Norén JG. Enamel hypomineralization of permanent first molars: a morphological study and survey of possible aetiological factors. Int J Paediatr Dent. 2000;10(4):278-289.</mixed-citation>
                    </ref>
                                    <ref id="ref22">
                        <label>22</label>
                        <mixed-citation publication-type="journal">22. Crombie F, Cochrane N, Manton D, Palamara J, Reynolds E. Mineralisation of developmentally hypomineralised human enamel in vitro. Caries Res. 2013;47(3):259-263.</mixed-citation>
                    </ref>
                                    <ref id="ref23">
                        <label>23</label>
                        <mixed-citation publication-type="journal">23. Fagrell TG, Salmon P, Melin L, Norén JG. Onset of molar incisor hypomineralization (MIH). Swed Dent J.2013;37(1):61-70.</mixed-citation>
                    </ref>
                                    <ref id="ref24">
                        <label>24</label>
                        <mixed-citation publication-type="journal">24. Clarkson J. FDI commission on oral health, research &amp; epidemiology. A review of the developmental defects of enamel index (DDE Index). Int Dent J. 1992;42(6):411-426.</mixed-citation>
                    </ref>
                                    <ref id="ref25">
                        <label>25</label>
                        <mixed-citation publication-type="journal">25. Gambetta‐Tessini K, Mariño R, Ghanim A, Adams GG, Manton DJ. Validation of quantitative light‐induced fluorescence‐digital in the quantification of demarcated hypomineralized lesions of enamel. J Investig Clin Dent.2017;8:e12259.</mixed-citation>
                    </ref>
                                    <ref id="ref26">
                        <label>26</label>
                        <mixed-citation publication-type="journal">26. Farah RA, Monk BC, Swain MV, Drummond BK. Protein content of molar–incisor hypomineralisation enamel. J Dent. 2010;38(7):591-596.</mixed-citation>
                    </ref>
                                    <ref id="ref27">
                        <label>27</label>
                        <mixed-citation publication-type="journal">27. Jälevik B, Dietz W, Norén J. Scanning electron micrograph analysis of hypomineralized enamel in permanent first molars. Int J Paediatr Dent. 2005;15(4):233-240.</mixed-citation>
                    </ref>
                                    <ref id="ref28">
                        <label>28</label>
                        <mixed-citation publication-type="journal">28. Jälevik B, Odelius H, Dietz W, Norén J. Secondary ion mass spectrometry and X-ray microanalysis of hypomineralized enamel in human permanent first molars. Arch Oral Biol. 2001;46(3):239-247.</mixed-citation>
                    </ref>
                                    <ref id="ref29">
                        <label>29</label>
                        <mixed-citation publication-type="journal">29. Elhennawy K, Schwendicke F. Managing molar-incisor hypomineralization: A systematic review. J Dent.2016;55:16-24.</mixed-citation>
                    </ref>
                                    <ref id="ref30">
                        <label>30</label>
                        <mixed-citation publication-type="journal">30. Elhennawy K, et al. Structural, mechanical, and chemical evaluation of molar incisor hypomineralization-affected enamel. Molar Incisor Hypomineralization: A Clinical Guide to Diagnosis and Treatment. 2020;11-20.</mixed-citation>
                    </ref>
                                    <ref id="ref31">
                        <label>31</label>
                        <mixed-citation publication-type="journal">31. Fagrell TG, Dietz W, Jälevik B, Norén JG. Chemical, mechanical and morphological properties of hypomineralized enamel of permanent first molars. Acta Odontol Scand. 2010;68(4):215-222.</mixed-citation>
                    </ref>
                                    <ref id="ref32">
                        <label>32</label>
                        <mixed-citation publication-type="journal">32. Heijs SC, Dietz W, Norén JG, Blanksma NG, Jälevik B. Morphology and chemical composition of dentin in permanent first molars with the diagnose MIH. Swed Dent J. 2007;31(4):155-164.</mixed-citation>
                    </ref>
                                    <ref id="ref33">
                        <label>33</label>
                        <mixed-citation publication-type="journal">33. Rodd H, Morgan C, Day P, Boissonade F. Pulpal expression of TRPV1 in molar incisor hypomineralisation. Eur Arch Paediatr Dent. 2007;8(4):184-188.</mixed-citation>
                    </ref>
                                    <ref id="ref34">
                        <label>34</label>
                        <mixed-citation publication-type="journal">34. Rodd HD, Boissonade FM, Day PF. Pulpal status of hypomineralized permanent molars. Pediatr Dent. 2007;29(6):514-520.</mixed-citation>
                    </ref>
                                    <ref id="ref35">
                        <label>35</label>
                        <mixed-citation publication-type="journal">35. Hernández M, Planells P, Martínez E, Mira A, Carda-Diéguez M. Microbiology of molar–incisor hypomineralization lesions. A pilot study. J Oral Microbiol. 2020;12(1):1766166.</mixed-citation>
                    </ref>
                                    <ref id="ref36">
                        <label>36</label>
                        <mixed-citation publication-type="journal">36. Fagrell TG, Lingström P, Olsson S, Steiniger F, Norén JG. Bacterial invasion of dentinal tubules beneath apparently intact but hypomineralized enamel in molar teeth with molar incisor hypomineralization. Int J Paediatr Dent. 2008;18(5):333-340.</mixed-citation>
                    </ref>
                                    <ref id="ref37">
                        <label>37</label>
                        <mixed-citation publication-type="journal">37. Saitoh M, Shintani S. Molar incisor hypomineralization: A review and prevalence in Japan. Jpn Dent Sci Rev.2021;57(1):71-77.</mixed-citation>
                    </ref>
                                    <ref id="ref38">
                        <label>38</label>
                        <mixed-citation publication-type="journal">38. Lygidakis N, et al. Best clinical practice guidance for clinicians dealing with children presenting with molar-incisor-hypomineralisation (MIH). Eur Arch Paediatr Dent 2010;11(2):75-81.</mixed-citation>
                    </ref>
                                    <ref id="ref39">
                        <label>39</label>
                        <mixed-citation publication-type="journal">39. Jairam LS, Dhananjaya G. Molar incisor hypomineralisation: An overview. J Dent Orofac Res. 2019;15(2):89-94.</mixed-citation>
                    </ref>
                                    <ref id="ref40">
                        <label>40</label>
                        <mixed-citation publication-type="journal">40. Garg N, Jain AK, Saha S, Singh J. Essentiality of early diagnosis of molar incisor hypomineralization in children and review of its clinical presentation, etiology and management. Int J Clin Pediatr Dent. 2012;5(3):190.</mixed-citation>
                    </ref>
                                    <ref id="ref41">
                        <label>41</label>
                        <mixed-citation publication-type="journal">41. Bakkal M, Abbasoglu Z, Kargul B. The effect of casein phosphopeptide-amorphous calcium phosphate on molar-incisor hypomineralisation: A pilot study. Oral Health Prev Dent. 2017;15.</mixed-citation>
                    </ref>
                                    <ref id="ref42">
                        <label>42</label>
                        <mixed-citation publication-type="journal">42. Bekes K, Heinzelmann K, Lettner S, Schaller HG. Efficacy of desensitizing products containing 8% arginine and calcium carbonate for hypersensitivity relief in MIH-affected molars: an 8-week clinical study. Clin Oral Investig. 2017;21(7):2311-2317.</mixed-citation>
                    </ref>
                                    <ref id="ref43">
                        <label>43</label>
                        <mixed-citation publication-type="journal">43. Byers MR, Suzuki H, Maeda T. Dental neuroplasticity, neuro‐pulpal interactions, and nerve regeneration. Microsc Res Tech. 2003;60(5):503-515.</mixed-citation>
                    </ref>
                                    <ref id="ref44">
                        <label>44</label>
                        <mixed-citation publication-type="journal">44. de Castro CRN, et al. Hypomineralized teeth have a higher frequency of dental hypersensitivity. Pediatr Dent. 2021;43(4):218-222.</mixed-citation>
                    </ref>
                                    <ref id="ref45">
                        <label>45</label>
                        <mixed-citation publication-type="journal">45. Miglani S, Aggarwal V, Ahuja B. Dentin hypersensitivity: Recent trends in management. J Conserv Dent.2010;13(4):218-224.</mixed-citation>
                    </ref>
                                    <ref id="ref46">
                        <label>46</label>
                        <mixed-citation publication-type="journal">46. Addy M. Dentine hypersensitivity: definition, prevalence, distribution and aetiology. Tooth Wear and Sensitivity: Clinical Advances in Restorative Dentistry. 2000;239-248.</mixed-citation>
                    </ref>
                                    <ref id="ref47">
                        <label>47</label>
                        <mixed-citation publication-type="journal">47. Elhennawy K, et al. Structural, mechanical and chemical evaluation of molar-incisor hypomineralization-affected enamel: A systematic review. Arch Oral Biol 2017;83:272-281.</mixed-citation>
                    </ref>
                                    <ref id="ref48">
                        <label>48</label>
                        <mixed-citation publication-type="journal">48. Steffen R, Krämer N, Bekes K. The Würzburg MIH concept: the MIH treatment need index (MIH TNI) A new index to assess and plan treatment in patients with molar incisior hypomineralisation (MIH). Eur Arch Paediatr Dent. 2017;18(5):355-361.</mixed-citation>
                    </ref>
                                    <ref id="ref49">
                        <label>49</label>
                        <mixed-citation publication-type="journal">49. Kumar A, Goyal A. An evaluation of remineralised MIH using CPP-ACP and fluoride varnish: An in-situ and in-vitro study. Eur Arch Paediatr Dent. 2022;23(1):79-87.</mixed-citation>
                    </ref>
                                    <ref id="ref50">
                        <label>50</label>
                        <mixed-citation publication-type="journal">50. Dababneh R, Khouri A, Addy M. Dentine hypersensitivity—An enigma? A review of terminology, mechanisms, aetiology and management. Br Dent J. 1999;187(11):606-611.</mixed-citation>
                    </ref>
                                    <ref id="ref51">
                        <label>51</label>
                        <mixed-citation publication-type="journal">51. Brodowski D, Imfeld T. Dentin hypersensitivity—A review. Schweiz Monatsschr Zahnmed. 2003;113(1):49-58.</mixed-citation>
                    </ref>
                                    <ref id="ref52">
                        <label>52</label>
                        <mixed-citation publication-type="journal">52. Lygidakis N, et al. Best clinical practice guidance for clinicians dealing with children presenting with molar-incisor-hypomineralisation (MIH): an updated European Academy of Paediatric Dentistry policy document. Eur Arch Paediatr Dent. 2021;1-19.</mixed-citation>
                    </ref>
                                    <ref id="ref53">
                        <label>53</label>
                        <mixed-citation publication-type="journal">53. Tenuta LMA, Cury JA. Fluoride: its role in dentistry.Braz Oral Res. 2010;24(1):9-17.</mixed-citation>
                    </ref>
                                    <ref id="ref54">
                        <label>54</label>
                        <mixed-citation publication-type="journal">54. Muniz RSC, Carvalho CN. Efficacy of low-level laser therapy associated with fluoride therapy for the desensitisation of molar-incisor hypomineralisation: Randomised clinical trial. Int J Paediatr Dent. 2020;30(3):323-333.</mixed-citation>
                    </ref>
                                    <ref id="ref55">
                        <label>55</label>
                        <mixed-citation publication-type="journal">55. Biondi AM, Cortese SG, Babino L, Fridman DE. Comparison of mineral density in molar incisor hypomineralization applying fluoride varnishes and casein phosphopeptide-amorphous calcium phosphate. Acta Odontol Latinoam. 2017;30(2):118-123.</mixed-citation>
                    </ref>
                                    <ref id="ref56">
                        <label>56</label>
                        <mixed-citation publication-type="journal">56. Restrepo M, Jeremias F, Santos-Pinto L, Cordeiro RC, Zuanon AC. Effect of fluoride varnish on enamel remineralization in anterior teeth with molar incisor hypomineralization. J Clin Pediatr Dent. 2016;40(3):207-210.</mixed-citation>
                    </ref>
                                    <ref id="ref57">
                        <label>57</label>
                        <mixed-citation publication-type="journal">57. Robinson C, et al. The chemistry of enamel caries. Crit Rev Oral Biol Med. 2000;11(4):481-495.</mixed-citation>
                    </ref>
                                    <ref id="ref58">
                        <label>58</label>
                        <mixed-citation publication-type="journal">58. Morris M, Davis R, Richardson B. Clinical efficacy of two dentin desensitizing agents. Am J Dent. 1999;12(2):72-76.</mixed-citation>
                    </ref>
                                    <ref id="ref59">
                        <label>59</label>
                        <mixed-citation publication-type="journal">59. Cochrane N, Shen P, Yuan Y, Reynolds E. Ion release from calcium and fluoride containing dental varnishes. Aust Dent J. 2014;59(1):100-105.</mixed-citation>
                    </ref>
                                    <ref id="ref60">
                        <label>60</label>
                        <mixed-citation publication-type="journal">60. Mei ML, et al. Formation of fluorohydroxyapatite with silver diamine fluoride. J Dent Res. 2017;96(10):1122-1128.</mixed-citation>
                    </ref>
                                    <ref id="ref61">
                        <label>61</label>
                        <mixed-citation publication-type="journal">61. Rösing CK, Fiorini T, Liberman DN, Cavagni J. Dentine hypersensitivity: analysis of self-care products. Braz Oral Res. 2009;23(1):56-63.</mixed-citation>
                    </ref>
                                    <ref id="ref62">
                        <label>62</label>
                        <mixed-citation publication-type="journal">62. Ballikaya E, Ünverdi GE, Cehreli ZC. Management of initial carious lesions of hypomineralized molars (MIH) with silver diamine fluoride or silver-modified atraumatic restorative treatment (SMART): 1-year results of a prospective, randomized clinical trial. Clin Oral Investig. 2022;26(4):2197-2205.</mixed-citation>
                    </ref>
                                    <ref id="ref63">
                        <label>63</label>
                        <mixed-citation publication-type="journal">63. Saad AE, Alhosainy AY, Abdellatif AM. Evaluation of silver diamine fluoride modified atraumatic restorative treatment (SMART) on hypomineralized first permanent molar—a randomized controlled clinical study. BMC Oral Health. 2024;24:1182.</mixed-citation>
                    </ref>
                                    <ref id="ref64">
                        <label>64</label>
                        <mixed-citation publication-type="journal">64. Lall M. Is SDF better than the SMART (silver modified atraumatic restorative technique) in the management of molar incisor hypomineralisation molars with initial caries? Evid Based Dent. 024;25(4):162-163.</mixed-citation>
                    </ref>
                                    <ref id="ref65">
                        <label>65</label>
                        <mixed-citation publication-type="journal">65. Lakhani S, Noble F, Rodd H, Cobourne MT. Management of children with poor prognosis first permanent molars: an interdisciplinary approach is the key. Br Dent J. 023;234(10):731-736.</mixed-citation>
                    </ref>
                                    <ref id="ref66">
                        <label>66</label>
                        <mixed-citation publication-type="journal">66. Almuallem Z, Busuttil-Naudi A. Molar incisor hypomineralisation (MIH)–an overview. Br Dent J. 2018;225(7):601-609.</mixed-citation>
                    </ref>
                                    <ref id="ref67">
                        <label>67</label>
                        <mixed-citation publication-type="journal">67. Reynolds EC. Casein phosphopeptide-amorphous calcium phosphate: the scientific evidence. Adv Dent Res. 2009;21(1):25-29.</mixed-citation>
                    </ref>
                                    <ref id="ref68">
                        <label>68</label>
                        <mixed-citation publication-type="journal">68. Baroni C, Marchionni S. MIH supplementation strategies: prospective clinical and laboratory trial. J Dent Res. 2011;90(3):371-376.</mixed-citation>
                    </ref>
                                    <ref id="ref69">
                        <label>69</label>
                        <mixed-citation publication-type="journal">69. Ehlers V, et al. Efficacy of a toothpaste based on microcrystalline hydroxyapatite on children with hypersensitivity caused by MIH: a randomised controlled trial. Oral Health Prev Dent. 2021;19(5):647-658.</mixed-citation>
                    </ref>
                                    <ref id="ref70">
                        <label>70</label>
                        <mixed-citation publication-type="journal">70. Srinivasan N, Kavitha M, Loganathan S. Comparison of the remineralization potential of CPP–ACP and CPP–ACP with 900 ppm fluoride on eroded human enamel: an in situ study. Arch Oral Biol. 2010;55(6):541-544.</mixed-citation>
                    </ref>
                                    <ref id="ref71">
                        <label>71</label>
                        <mixed-citation publication-type="journal">71. Shetty S, Hegde MN, Bopanna TP. Enamel remineralization assessment after treatment with three different remineralizing agents using surface microhardness: an in vitro study. J Conserv Dent. 2014;17(1):49-52.</mixed-citation>
                    </ref>
                                    <ref id="ref72">
                        <label>72</label>
                        <mixed-citation publication-type="journal">72. Guanipa Ortiz MI, et al. Effect of the casein phosphopeptide-amorphous calcium phosphate fluoride (CPP-ACPF) and photobiomodulation (PBM) on dental hypersensitivity: a randomized controlled clinical trial. PLoS One. 2019;14(11):e0225501.</mixed-citation>
                    </ref>
                                    <ref id="ref73">
                        <label>73</label>
                        <mixed-citation publication-type="journal">73. Afreen A, et al. Comparison of the effect of GC tooth mousse and fluoride varnish on dentin hypersensitivity reduction. Prof Med J. 2021;28(4):598-604.</mixed-citation>
                    </ref>
                                    <ref id="ref74">
                        <label>74</label>
                        <mixed-citation publication-type="journal">74. Pasini M, Giuca MR, Scatena M, Gatto R, Caruso S. Molar incisor hypomineralization treatment with casein phosphopeptide and amorphous calcium phosphate in children. Minerva Stomatol. 2018;67(1):20-25.</mixed-citation>
                    </ref>
                                    <ref id="ref75">
                        <label>75</label>
                        <mixed-citation publication-type="journal">75. Bardellini E, et al. Molar incisor hypomineralization: optimizing treatment protocols for hypersensitivity: A randomized clinical trial. Dent J. 2024;12(2):186.</mixed-citation>
                    </ref>
                                    <ref id="ref76">
                        <label>76</label>
                        <mixed-citation publication-type="journal">76. Al-Nerabieah Z, AlKhouli M, Dashash M. Preventive efficacy of 38% silver diamine fluoride and CPP-ACP fluoride varnish on molars affected by molar incisor hypomineralization in children: A randomized controlled trial. F1000Research. 2023;12.</mixed-citation>
                    </ref>
                                    <ref id="ref77">
                        <label>77</label>
                        <mixed-citation publication-type="journal">77. Singh SK, Goyal A, Gauba K, Rathore M. A comparative evaluation of CPP-ACP cream and fluoride varnish in remineralization of MIH-affected teeth using laser fluorescence. Pediatr Dent. 2021;4:117-121.</mixed-citation>
                    </ref>
                                    <ref id="ref78">
                        <label>78</label>
                        <mixed-citation publication-type="journal">78. Olgen IC, Sonmez H, Bezgin T. Effects of different remineralization agents on MIH defects: A randomized clinical study. Clin Oral Investig. 2022;26(5):3227-3238.</mixed-citation>
                    </ref>
                                    <ref id="ref79">
                        <label>79</label>
                        <mixed-citation publication-type="journal">79. Cardoso-Martins I, Pessanha S, Coelho A, Arantes-Oliveira S, Marques PF. Evaluation of the efficacy of CPP-ACP remineralizing mousse in molar-incisor hypomineralized teeth using polarized Raman and scanning electron microscopy—An in vitro study. Biomedicines. 2022;10(12):3086.</mixed-citation>
                    </ref>
                                    <ref id="ref80">
                        <label>80</label>
                        <mixed-citation publication-type="journal">80. Cardoso-Martins I, Arantes-Oliveira S, Coelho A, Pessanha S, Marques PF. Evaluation of the efficacy of CPP-ACP remineralizing mousse in MIH white and yellow opacities—In vitro Vickers microhardness analysis. Dent J. 2022;10(3):186.</mixed-citation>
                    </ref>
                                    <ref id="ref81">
                        <label>81</label>
                        <mixed-citation publication-type="journal">81. Franco S, Cardoso-Martins I, Arantes-Oliveira S, Pessanha S, Marques PF. In vitro polarized Raman analysis for the evaluation of the efficacy of CPP-ACP remineralizing mousse in tooth hypomineralization. Results Chem.2021;3:100232.</mixed-citation>
                    </ref>
                                    <ref id="ref82">
                        <label>82</label>
                        <mixed-citation publication-type="journal">82. Ishihata H, Finger WJ, Kanehira M, Shimauchi H, Komatsu M. In vitro dentin permeability after application of Gluma® desensitizer as aqueous solution or aqueous fumed silica dispersion. J Appl Oral Sci. 2011;19(2):147-153.</mixed-citation>
                    </ref>
                                    <ref id="ref83">
                        <label>83</label>
                        <mixed-citation publication-type="journal">83. Machado AC, et al. Associative protocol for dentin hypersensitivity using Nd:YAG laser and desensitizing agent in teeth with molar-incisor hypomineralization. Photobiomodul Photomed Laser Surg. 2019;37(5):262-266.</mixed-citation>
                    </ref>
                                    <ref id="ref84">
                        <label>84</label>
                        <mixed-citation publication-type="journal">84. Lopes AO, de Paula Eduardo C, Aranha ACC. Evaluation of different treatment protocols for dentin hypersensitivity: an 18-month randomized clinical trial. Lasers Med Sci. 2017;32(5):1023-1030.</mixed-citation>
                    </ref>
                                    <ref id="ref85">
                        <label>85</label>
                        <mixed-citation publication-type="journal">85. Zhao S, Zhou L, Jiang Y, Xing X. Er:YAG laser therapy in combination with GLUMA desensitizer reduces dentin hypersensitivity in children with molar-incisor hypomineralization: A randomized clinical trial. Lasers Med Sci. 2023;38:280.</mixed-citation>
                    </ref>
                                    <ref id="ref86">
                        <label>86</label>
                        <mixed-citation publication-type="journal">86. Brunton P, et al. Treatment of early caries lesions using biomimetic self-assembling peptides–a clinical safety trial. Br Dent J. 2013;215(1):E6-E6.</mixed-citation>
                    </ref>
                                    <ref id="ref87">
                        <label>87</label>
                        <mixed-citation publication-type="journal">87. Amaechi BT. Remineralization therapies for initial caries lesions. Curr Oral Health Rep. 2015;2(2):95-101.</mixed-citation>
                    </ref>
                                    <ref id="ref88">
                        <label>88</label>
                        <mixed-citation publication-type="journal">88. Hill RG, Chen H, Lysek DA, Gillam D. An in vitro comparison of a novel self-assembling peptide matrix gel and selected desensitizing toothpastes in reducing fluid flow by dentine tubular occlusion. J Dent. 2019;83:100-106.</mixed-citation>
                    </ref>
                                    <ref id="ref89">
                        <label>89</label>
                        <mixed-citation publication-type="journal">89. Singh SK, Rathore M, Goyal A. Assessment of remineralization of hypomineralized enamel lesions using self-assembling peptide using laser fluorescence—a pilot study. Saudi J Oral Dent Res. 2021;6(5):498-501.</mixed-citation>
                    </ref>
                                    <ref id="ref90">
                        <label>90</label>
                        <mixed-citation publication-type="journal">90. Schlee M, Rathe F, Bommer C, Bröseler F, Kind L. Self‐assembling peptide matrix for treatment of dentin hypersensitivity: A randomized controlled clinical trial. J Periodontol. 2018;89(5):653-660.</mixed-citation>
                    </ref>
                                    <ref id="ref91">
                        <label>91</label>
                        <mixed-citation publication-type="journal">91. Lynch E. Ozone: The Revolution in Dentistry. Quintessence Publishing; 2004.</mixed-citation>
                    </ref>
                                    <ref id="ref92">
                        <label>92</label>
                        <mixed-citation publication-type="journal">92. Beretta M, Federici Canova F, Moscati M, Campanella V, Gallusi G. State-of-the-art on MIH. Part 2: MIH clinical management using ozone. Eur J Paediatr Dent. 2020;21(3):163-166.</mixed-citation>
                    </ref>
                                    <ref id="ref93">
                        <label>93</label>
                        <mixed-citation publication-type="journal">93. Naik SV, Rajeshwari K, Kohli S, Zohabhasan S, Bhatia S. Ozone—a biological therapy in dentistry: reality or myth? Open Dent J. 2016;10:196-201.</mixed-citation>
                    </ref>
                                    <ref id="ref94">
                        <label>94</label>
                        <mixed-citation publication-type="journal">94. Frencken JE. The state-of-the-art of ART restorations. Dent Update. 2014;41(3):218-224.</mixed-citation>
                    </ref>
                                    <ref id="ref95">
                        <label>95</label>
                        <mixed-citation publication-type="journal">95. Ozgül BM, Saat S, Sönmez H, Oz FT. Clinical evaluation of desensitizing treatment for incisor teeth affected by molar-incisor hypomineralization. J Clin Pediatr Dent. 2013;38(2):101-105.</mixed-citation>
                    </ref>
                                    <ref id="ref96">
                        <label>96</label>
                        <mixed-citation publication-type="journal">96. Kimura Y, Wilder‐Smith P, Yonaga K, Matsumoto K. Treatment of dentine hypersensitivity by lasers: A review. J Clin Periodontol. 2000;27(9):715-721.</mixed-citation>
                    </ref>
                                    <ref id="ref97">
                        <label>97</label>
                        <mixed-citation publication-type="journal">97. Hagiwara S, Iwasaka H, Hasegawa A, Noguchi T. Pre-irradiation of blood by gallium aluminum arsenide (830 nm) low-level laser enhances peripheral endogenous opioid analgesia in rats. Anesth Analg. 2008;107(3):1058-1063.</mixed-citation>
                    </ref>
                                    <ref id="ref98">
                        <label>98</label>
                        <mixed-citation publication-type="journal">98. Orchardson R, Gillam DG. Managing dentin hypersensitivity. J Am Dent Assoc. 2006;137(7):990-998.</mixed-citation>
                    </ref>
                                    <ref id="ref99">
                        <label>99</label>
                        <mixed-citation publication-type="journal">99. Özgür B, Kargın ST, Ölmez MS. Clinical evaluation of giomer- and resin-based fissure sealants on permanent molars affected by molar-incisor hypomineralization: A randomized clinical trial. BMC Oral Health. 2022;22:275.</mixed-citation>
                    </ref>
                                    <ref id="ref100">
                        <label>100</label>
                        <mixed-citation publication-type="journal">100. Lygidakis N. Treatment modalities in children with teeth affected by molar-incisor enamel hypomineralisation (MIH): A systematic review. Eur Arch Paediatr Dent. 2010;11(2):65-74.</mixed-citation>
                    </ref>
                                    <ref id="ref101">
                        <label>101</label>
                        <mixed-citation publication-type="journal">101. Bekes K, et al. Hypersensitivity relief of MIH-affected molars using two sealing techniques: a 12-week follow-up. Clin Oral Investig. 2022;26(4):1879-1888.</mixed-citation>
                    </ref>
                                    <ref id="ref102">
                        <label>102</label>
                        <mixed-citation publication-type="journal">102. Fütterer J, Ebel M, Bekes K, Klode C, Hirsch C. Influence of customized therapy for molar incisor hypomineralization on children&#039;s oral hygiene and quality of life. Clin Exp Dent Res. 2020;6(1):33-43.</mixed-citation>
                    </ref>
                                    <ref id="ref103">
                        <label>103</label>
                        <mixed-citation publication-type="journal">103. Singh SK, Goyal A. Full coverage crowns for rehabilitation of MIH affected molars: 24-month randomized clinical trial. Eur Arch Paediatr Dent. 2022;23(2):147-158.</mixed-citation>
                    </ref>
                                    <ref id="ref104">
                        <label>104</label>
                        <mixed-citation publication-type="journal">104. Rolim TZC, et al. Adhesive restoration of molars affected by molar incisor hypomineralization: a randomized clinical trial. Clin Oral Investig. 2021;25(5):1513-1524.</mixed-citation>
                    </ref>
                                    <ref id="ref105">
                        <label>105</label>
                        <mixed-citation publication-type="journal">105. Lynch R. Calcium glycerophosphate and caries: a review of the literature. Int Dent J. 2004;54(6):310-314.</mixed-citation>
                    </ref>
                                    <ref id="ref106">
                        <label>106</label>
                        <mixed-citation publication-type="journal">106. Sezer B, Kargul B. Effect of remineralization agents on molar-incisor hypomineralization-affected incisors: a randomized controlled clinical trial. J Clin Pediatr Dent. 2022;46(3):192-198.</mixed-citation>
                    </ref>
                                    <ref id="ref107">
                        <label>107</label>
                        <mixed-citation publication-type="journal">107. Franca IL, et al. Efficacy of a combined in-office/home-use desensitizing system containing 8% arginine and calcium carbonate in reducing dentin hypersensitivity: an 8-week randomized clinical study. Am J Dent. 2015;28(1):45-50.</mixed-citation>
                    </ref>
                                    <ref id="ref108">
                        <label>108</label>
                        <mixed-citation publication-type="journal">108. Epple M. Review of potential health risks associated with nanoscopic calcium phosphate. Acta Biomater. 2018;77:1-14.</mixed-citation>
                    </ref>
                                    <ref id="ref109">
                        <label>109</label>
                        <mixed-citation publication-type="journal">109. Amaechi BT, et al. Remineralization of molar incisor hypomineralization (MIH) with a hydroxyapatite toothpaste: An in-situ study. BDJ Open. 2022;8:33.</mixed-citation>
                    </ref>
                                    <ref id="ref110">
                        <label>110</label>
                        <mixed-citation publication-type="journal">110. Solinas G, et al. Management of a hypomineralisation of the enamel by applying a remineraliser based on zinc hydroxyapatite (microRepair). Biomed Res Int. 2021;2021:5291858.</mixed-citation>
                    </ref>
                                    <ref id="ref111">
                        <label>111</label>
                        <mixed-citation publication-type="journal">111. Butera A, Pascadopoli M. Biomimetic hydroxyapatite paste for molar-incisor hypomineralization: A randomized clinical trial. Oral Dis. 2022;28(2):14388.</mixed-citation>
                    </ref>
                            </ref-list>
                    </back>
    </article>
