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MANDİBULADA MULTİLOKULER GÖRÜNÜMLÜ MULTİPLE MYELOM: RADYOGRAFİK BULGULARLA OLGU SUNUMU

Year 2024, Volume: 11 Issue: 3, 346 - 350, 23.12.2024
https://doi.org/10.15311/selcukdentj.1291565

Abstract

Amaç: Multiple myelom (MM), plazma hücrelerinin kemik iliğinde anormal immunoglobulin üretmeleri ile karakterize malign bir hastalıktır. Genellikle mandibulada kortikal yapı içermeyen, iyi sınırlı zımba deliği şeklinde radyolusent görüntü verir. Bu olgu sunumunun amacı, MM tanılı hastada farklı radyografik bulgular gösteren mandibular lezyonun sunulmasıdır.
Olgu sunumu: 49 yaşında MM tanılı erkek hasta bifosfonat kullanımı öncesi kliniğimize başvurdu. Panoramik radyografda sol mandibula angulus bölgesinde 2. ve 3. molar dişlerin apekslerini ve inferior alveolar kanalı içine alan, 3. molar dişte kök rezorpsiyonuna sebep olmuş, lobüle iyi sınırlı multiloküler görünümlü radyolüsent alan ve ramus orta kısmında iyi sınırlı zımba deliği görünümlü radyolüsent lezyon izlendi. Mevcut bilgisayarlı tomografi görüntülerinde aksiyel kesitlerde mandibula ramus bölgesinde hafif ekspansiyon gösteren, bukkal ve lingual kortikal kemiği inceltip yer yer destrükte eden, lobüle zayıf sınırlı homojen, hipodens kemik lezyonu görüldü.
Sonuç: Klinisyenlerin mandibulada görülen kistik veya multiloküler görünümlü lezyonların ayırıcı tanısında MM lezyonlarını da göz önünde bulundurmaları gerekmektedir.

References

  • 1. Malard F, Neri P, Bahlis NJ, Terpos E, Moukalled N, Hungria VTM, Manier S, Mohty M. Multiple myeloma, Nature Reviews Disease Primers, 2024; 10:45.
  • 2. Brad W. Neville, Douglas D. Damn, Carl M. Allen, Angela C. Chi. Oral and Maxillofacial Pathology. Fourth Edition 2016.
  • 3. White SC, Pharoah MJ. Oral Radyoloji İlkeler ve Yorumlama. 7. Baskı. Ankara: Palme Yayınevi 2018: s.233-446.
  • 4. Lae ME, Vencio EF, Inwards CY, Unni KK, Nascimento AG. Myeloma of the jaw bones: a clinicopathologic study of 33 cases. Head Neck. 2003 May;25(5):373-81.
  • 5. Narquina S, Ingrand P, Azais I, Delwail V, Viallea R, Boucecbi S, Tasu JP. Comparison of whole-body diffusion MRI and conventional radiological assessment in the staging of myeloma. Diagnostic and Interventional Imaging 2013; 94: 629-636.
  • 6. Koenig LJ, Tamimi D, Petrikowski CG, Perschbacher SE. Diagnostic Imaging: Oral and Maxillofacial. 2nd ed. Canada: Elsevier; 2017
  • 7. Mary C. Multiple Myelom, Home Healthcare Now. 2024;42:3.
  • 8. Cowan AJ, Green DJ, Kwok M, Lee s, Coffey DG et all. Diagnosis and Management of Multiple Myeloma: A Review, JAMA. 2022;327(5):464-477.
  • 9. Jiang A, Zhang Z, Qiu X, Guo Q. Medication-related osteonecrosis of the jaw (MRONJ): a review of pathogenesis hypothesis and therapy strategies. Arch Toxicol. 2024;98(3):689-708.
  • 10. Ruggiero SL, Dodson TB, Fantasia J, Goodday R, Aghaloo T, Mehrotra B, O’Ryan F. American Association of Oral and Maxillofacial Surgeons Position Paper on Medication-Related Osteonecrosis of the Jaw—2014 Update, American Association of Oral and Maxillofacial Surgeons J Oral Maxillofac Surg 2014;72:1938-1956.
  • 11. DeRossi SS, Garfunkel A, Greenberg MS. Hematologic Diseases. In: Greenberg MS. Glik M. Burket’s oral medicine diagnosis treatment. 10th ed. Spain: BC Decker; 2003:429-474
  • 12. Shibata M, Kodani I, Doi R, Takubo K, Kidani K, Sakai H, Sonoda M, Ryoke K. Multiple Myeloma Presenting Symptoms in the Oral and Maxillofacial Region. Yonago Acta medica 2003; 46:77–81
  • 13. Pisano J, Coupland R, Chen SY, Miller AS. Plasmacytoma of the oral cavity and jaws. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997; 83:265-71
  • 14. Kulkarni S, Shroff JA, Meghana SM, Godge P, Yadav M, Naik CS. Solitary plasmacytoma of mandible: an unusual bilateral presentation. Autops Case Rep. 2020;11:e2021298.
  • 15. Suryavanshi H, Patankar S, Dhumal S, Choudhari S. Solitary plasmacytoma of jaw bone: A case report and systematic review of fifty cases from literature. J Oral Maxillofac Pathol 2021;25:205-6.
  • 16. Regezi JA, Sciuba J, Jordan JRK. Oral Pathology Clinical- Pathologic Correlations. 4th.ed.USA: Elsevier Science 2003;411:3.
  • 17. Lambertenghi DG, Bruno E, Cortelezzi A, Fumagalli L, Morosini A. Incidence of jaw lesions in 193 patients with multiple myeloma. Oral Surg Oral Med Oral Pathol. 1988; 65: 533–537.
  • 18. Vieira-Leite-Segundo A, Lima-Falcão MF, Correia-Lins-Filho R, Marques-Soares
  • 19. MS, López-López J, Chimenos-Küstner E. Multiple Myeloma with primary manifestation in the mandible: A case report. Med Oral Patol Oral Cir Bucal. 2008; 13(4):E232-4.
  • 20. Hegde PJ, Ramesh M, Shetty VV, Kumar S. Multiple myeloma as a mandibular primary Dilemma in diagnosing rare tumours of the mandible. J Oral Maxillofac Pathol 2024;28:138-41.
  • 21. Mohan RS, Gill N, Verma S, Chawa VR, Tyagi K, Agarwal N. A multilocular radiolucency of mandible as the first evidence of multiple myeloma: A clinico-radiographic case report. Dent Res J 2014;11:272-5.
Year 2024, Volume: 11 Issue: 3, 346 - 350, 23.12.2024
https://doi.org/10.15311/selcukdentj.1291565

Abstract

References

  • 1. Malard F, Neri P, Bahlis NJ, Terpos E, Moukalled N, Hungria VTM, Manier S, Mohty M. Multiple myeloma, Nature Reviews Disease Primers, 2024; 10:45.
  • 2. Brad W. Neville, Douglas D. Damn, Carl M. Allen, Angela C. Chi. Oral and Maxillofacial Pathology. Fourth Edition 2016.
  • 3. White SC, Pharoah MJ. Oral Radyoloji İlkeler ve Yorumlama. 7. Baskı. Ankara: Palme Yayınevi 2018: s.233-446.
  • 4. Lae ME, Vencio EF, Inwards CY, Unni KK, Nascimento AG. Myeloma of the jaw bones: a clinicopathologic study of 33 cases. Head Neck. 2003 May;25(5):373-81.
  • 5. Narquina S, Ingrand P, Azais I, Delwail V, Viallea R, Boucecbi S, Tasu JP. Comparison of whole-body diffusion MRI and conventional radiological assessment in the staging of myeloma. Diagnostic and Interventional Imaging 2013; 94: 629-636.
  • 6. Koenig LJ, Tamimi D, Petrikowski CG, Perschbacher SE. Diagnostic Imaging: Oral and Maxillofacial. 2nd ed. Canada: Elsevier; 2017
  • 7. Mary C. Multiple Myelom, Home Healthcare Now. 2024;42:3.
  • 8. Cowan AJ, Green DJ, Kwok M, Lee s, Coffey DG et all. Diagnosis and Management of Multiple Myeloma: A Review, JAMA. 2022;327(5):464-477.
  • 9. Jiang A, Zhang Z, Qiu X, Guo Q. Medication-related osteonecrosis of the jaw (MRONJ): a review of pathogenesis hypothesis and therapy strategies. Arch Toxicol. 2024;98(3):689-708.
  • 10. Ruggiero SL, Dodson TB, Fantasia J, Goodday R, Aghaloo T, Mehrotra B, O’Ryan F. American Association of Oral and Maxillofacial Surgeons Position Paper on Medication-Related Osteonecrosis of the Jaw—2014 Update, American Association of Oral and Maxillofacial Surgeons J Oral Maxillofac Surg 2014;72:1938-1956.
  • 11. DeRossi SS, Garfunkel A, Greenberg MS. Hematologic Diseases. In: Greenberg MS. Glik M. Burket’s oral medicine diagnosis treatment. 10th ed. Spain: BC Decker; 2003:429-474
  • 12. Shibata M, Kodani I, Doi R, Takubo K, Kidani K, Sakai H, Sonoda M, Ryoke K. Multiple Myeloma Presenting Symptoms in the Oral and Maxillofacial Region. Yonago Acta medica 2003; 46:77–81
  • 13. Pisano J, Coupland R, Chen SY, Miller AS. Plasmacytoma of the oral cavity and jaws. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997; 83:265-71
  • 14. Kulkarni S, Shroff JA, Meghana SM, Godge P, Yadav M, Naik CS. Solitary plasmacytoma of mandible: an unusual bilateral presentation. Autops Case Rep. 2020;11:e2021298.
  • 15. Suryavanshi H, Patankar S, Dhumal S, Choudhari S. Solitary plasmacytoma of jaw bone: A case report and systematic review of fifty cases from literature. J Oral Maxillofac Pathol 2021;25:205-6.
  • 16. Regezi JA, Sciuba J, Jordan JRK. Oral Pathology Clinical- Pathologic Correlations. 4th.ed.USA: Elsevier Science 2003;411:3.
  • 17. Lambertenghi DG, Bruno E, Cortelezzi A, Fumagalli L, Morosini A. Incidence of jaw lesions in 193 patients with multiple myeloma. Oral Surg Oral Med Oral Pathol. 1988; 65: 533–537.
  • 18. Vieira-Leite-Segundo A, Lima-Falcão MF, Correia-Lins-Filho R, Marques-Soares
  • 19. MS, López-López J, Chimenos-Küstner E. Multiple Myeloma with primary manifestation in the mandible: A case report. Med Oral Patol Oral Cir Bucal. 2008; 13(4):E232-4.
  • 20. Hegde PJ, Ramesh M, Shetty VV, Kumar S. Multiple myeloma as a mandibular primary Dilemma in diagnosing rare tumours of the mandible. J Oral Maxillofac Pathol 2024;28:138-41.
  • 21. Mohan RS, Gill N, Verma S, Chawa VR, Tyagi K, Agarwal N. A multilocular radiolucency of mandible as the first evidence of multiple myeloma: A clinico-radiographic case report. Dent Res J 2014;11:272-5.
There are 21 citations in total.

Details

Primary Language Turkish
Subjects Dentistry
Journal Section Case Report
Authors

Kübra Çam 0009-0000-6474-5894

Ayşe Zeynep Zengin 0000-0002-4388-7751

Publication Date December 23, 2024
Submission Date June 3, 2023
Published in Issue Year 2024 Volume: 11 Issue: 3

Cite

Vancouver Çam K, Zengin AZ. MANDİBULADA MULTİLOKULER GÖRÜNÜMLÜ MULTİPLE MYELOM: RADYOGRAFİK BULGULARLA OLGU SUNUMU. Selcuk Dent J. 2024;11(3):346-50.