Year 2020, Volume 5 , Issue 2, Pages 138 - 146 2020-12-18

A Study About the Synergy of Polar Fractions of Pomegranate Peel and Amoxicillin Trihydrate Against Enterococcus faecalis
Nar Kabuğu Polar Fraksiyonlarının ve Amoksisilin Trihidratın Enterococcus faecalis Üzerindeki Sinerjistik Etkisi Hakkında bir Çalışma

Ayşegül HOŞ [1] , Hilal KUDAY [2] , Kenan TUNÇ [3] , Alican Bahadir SEMERCİ [4]


The increase in the occurrence of the multidrug-resistant bacteria is the cause of need in the discovering new antimicrobial substances and antimicrobial combination drugs. The aim of this study was to investigate the synergistic interaction between polar fractions of pomegranate (Punica granatum L.) peel and Amoxicillin trihydrate against Enterococcus faecalis. In the first step of the study, polar fractions of pomegranate peel (ethyl acetate, butanol, distilled water) were prepared. Next, disc diffusion method was used for determination of the synergic effect. Here, the results indicated that the mixture of prepared polar fractions of pomegranate peel and Amoxicillin trihydrate showed synergistic interaction against E. faecalis. This study determined that polar fractions of pomegranate peel (ethyl acetate, butanol, distilled water) improved the effectiveness of Amoxicillin trihydrate against E. faecalis. Pomegranate peel may have potential applications in the new antibacterial therapy combinations due to its easy accessibility, therapeutic properties and being low cost. Results of the present study may be beneficial for further studies about the characterization of phytochemical compounds that are responsible for the improvement of the antibiotic effectiveness.
Çoklu antibiyotik direncine sahip bakterilerin ortaya çıkışındaki artış nedeniyle yeni antimikrobiyal maddelerin ve antimikrobiyal ilaç kombinasyonlarının keşfedilmesine ihtiyaç duyulmaktadır. Bu çalışmanın amacı, nar (Punica granatum L.) kabuğu polar fraksiyonları ile Amoksisilin trihidrat arasındaki sinerjistik etkileşimin Enterococcus faecalis üzerinde araştırılmasıdır. Çalışmanın ilk adımında, nar kabuğunun polar fraksiyonları (etil asetat, butanol, distile su) hazırlanmıştır. Sonraki aşamada sinerjik etkinin belirlenmesi için disk difüzyon yöntemi kullanılmıştır. Hazırlanan nar kabuğu polar fraksiyonları ile Amoksisilin trihidrat karışımının, E. faecalis üzerinde sinerjistik etkisinin olduğu gözlemlenmiştir. Bu çalışma, Amoksisilin trihidratın E. faecalis üzerindeki etkinliğini nar kabuğunun polar fraksiyonlarının (etil asetat, butanol, distile su) arttırdığını belirlemiştir. Nar kabuğu, kolay erişilebilirliği, terapötik özellikleri ve düşük maliyeti nedeniyle yeni antibakteriyal tedavi kombinasyonlarında potansiyel uygulamalara sahip olabilir. Bu çalışmanın sonuçları, antibiyotik etkinliğini arttıran fitokimyasal bileşiklerin karakterizasyonu ile ilgili daha ileri çalışmalar için yararlı olabilir.
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Primary Language en
Subjects Basic Sciences
Journal Section Research Articles
Authors

Orcid: 0000-0001-5605-6159
Author: Ayşegül HOŞ (Primary Author)
Institution: İSTANBUL MEDİPOL ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ
Country: Turkey


Orcid: 0000-0001-9279-1505
Author: Hilal KUDAY
Institution: İSTANBUL YENİ YÜZYIL ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ
Country: Turkey


Orcid: 0000-0002-9888-1453
Author: Kenan TUNÇ
Institution: SAKARYA ÜNİVERSİTESİ, FEN-EDEBİYAT FAKÜLTESİ
Country: Turkey


Orcid: 0000-0001-9502-9321
Author: Alican Bahadir SEMERCİ
Institution: SAKARYA ÜNİVERSİTESİ, FEN-EDEBİYAT FAKÜLTESİ
Country: Turkey


Dates

Application Date : October 23, 2019
Acceptance Date : May 22, 2020
Publication Date : December 18, 2020

Bibtex @research article { sinopfbd634931, journal = {Sinop Üniversitesi Fen Bilimleri Dergisi}, issn = {2536-4383}, eissn = {2564-7873}, address = {Sinop Üniversitesi Fen Bilimleri Enstitüsü Osmaniye Köyü Nasuhbeyoğlu Mah. Fen-Edebiyat Fakültesi Yerleşkesi – Sinop}, publisher = {Sinop University}, year = {2020}, volume = {5}, pages = {138 - 146}, doi = {10.33484/sinopfbd.634931}, title = {A Study About the Synergy of Polar Fractions of Pomegranate Peel and Amoxicillin Trihydrate Against Enterococcus faecalis}, key = {cite}, author = {Hoş, Ayşegül and Kuday, Hilal and Tunç, Kenan and Semerci, Alican Bahadir} }
APA Hoş, A , Kuday, H , Tunç, K , Semerci, A . (2020). A Study About the Synergy of Polar Fractions of Pomegranate Peel and Amoxicillin Trihydrate Against Enterococcus faecalis . Sinop Üniversitesi Fen Bilimleri Dergisi , 5 (2) , 138-146 . DOI: 10.33484/sinopfbd.634931
MLA Hoş, A , Kuday, H , Tunç, K , Semerci, A . "A Study About the Synergy of Polar Fractions of Pomegranate Peel and Amoxicillin Trihydrate Against Enterococcus faecalis" . Sinop Üniversitesi Fen Bilimleri Dergisi 5 (2020 ): 138-146 <https://dergipark.org.tr/en/pub/sinopfbd/issue/58391/634931>
Chicago Hoş, A , Kuday, H , Tunç, K , Semerci, A . "A Study About the Synergy of Polar Fractions of Pomegranate Peel and Amoxicillin Trihydrate Against Enterococcus faecalis". Sinop Üniversitesi Fen Bilimleri Dergisi 5 (2020 ): 138-146
RIS TY - JOUR T1 - A Study About the Synergy of Polar Fractions of Pomegranate Peel and Amoxicillin Trihydrate Against Enterococcus faecalis AU - Ayşegül Hoş , Hilal Kuday , Kenan Tunç , Alican Bahadir Semerci Y1 - 2020 PY - 2020 N1 - doi: 10.33484/sinopfbd.634931 DO - 10.33484/sinopfbd.634931 T2 - Sinop Üniversitesi Fen Bilimleri Dergisi JF - Journal JO - JOR SP - 138 EP - 146 VL - 5 IS - 2 SN - 2536-4383-2564-7873 M3 - doi: 10.33484/sinopfbd.634931 UR - https://doi.org/10.33484/sinopfbd.634931 Y2 - 2020 ER -
EndNote %0 Sinop Üniversitesi Fen Bilimleri Dergisi A Study About the Synergy of Polar Fractions of Pomegranate Peel and Amoxicillin Trihydrate Against Enterococcus faecalis %A Ayşegül Hoş , Hilal Kuday , Kenan Tunç , Alican Bahadir Semerci %T A Study About the Synergy of Polar Fractions of Pomegranate Peel and Amoxicillin Trihydrate Against Enterococcus faecalis %D 2020 %J Sinop Üniversitesi Fen Bilimleri Dergisi %P 2536-4383-2564-7873 %V 5 %N 2 %R doi: 10.33484/sinopfbd.634931 %U 10.33484/sinopfbd.634931
ISNAD Hoş, Ayşegül , Kuday, Hilal , Tunç, Kenan , Semerci, Alican Bahadir . "A Study About the Synergy of Polar Fractions of Pomegranate Peel and Amoxicillin Trihydrate Against Enterococcus faecalis". Sinop Üniversitesi Fen Bilimleri Dergisi 5 / 2 (December 2020): 138-146 . https://doi.org/10.33484/sinopfbd.634931
AMA Hoş A , Kuday H , Tunç K , Semerci A . A Study About the Synergy of Polar Fractions of Pomegranate Peel and Amoxicillin Trihydrate Against Enterococcus faecalis. Sinopjns. 2020; 5(2): 138-146.
Vancouver Hoş A , Kuday H , Tunç K , Semerci A . A Study About the Synergy of Polar Fractions of Pomegranate Peel and Amoxicillin Trihydrate Against Enterococcus faecalis. Sinop Üniversitesi Fen Bilimleri Dergisi. 2020; 5(2): 138-146.
IEEE A. Hoş , H. Kuday , K. Tunç and A. Semerci , "A Study About the Synergy of Polar Fractions of Pomegranate Peel and Amoxicillin Trihydrate Against Enterococcus faecalis", Sinop Üniversitesi Fen Bilimleri Dergisi, vol. 5, no. 2, pp. 138-146, Dec. 2020, doi:10.33484/sinopfbd.634931