Role Of Toll Like Receptors In Various Diseases

Year 2012, Volume: 2 Issue: 1, 1 - 10, 01.03.2012

Berrak Güven Murat Can

https://doi.org/10.5505/sakaryamj.2012.47550

Cited By: 2

Abstract

Toll like receptors are the innate immune receptors, responsible for the identification of pathogens. Ten different toll like receptors have been described in humans. Toll-like receptors are being activated by both exogenous ligands (bacterial, viral ve fungal pathogens) and endogenous ligands released from damaged cells. The several of studies show that toll like receptors signaling is important in the pathogenesis of disease as cancer, diabetes mellitus, atherosclerosis, renal disease, gastrointestinal disease, lung disease, central nervous system disease, autoimmune disease. The aim of this review is to define the role of toll like receptors in the pathogenesis of various diseases.

Keywords

TLR, TLR ligands, diseases

Çeşitli Hastalıklarda Toll Benzeri Reseptörlerin Rolü

Abstract

Toll benzeri reseptörler, patojenlerin tanınmasından sorumlu doğal immün reseptörlerdir. İnsanlarda on farklı toll benzeri reseptör tanımlanmıştır. Toll benzeri reseptörler çeşitli hastalıklarda ekzojen ligandlar (bakteriyel, viral ve fungal patojenler) ve hücre hasarı sonucu salınan endojen ligandlar ile aktive olur. Birçok çalışma toll benzeri reseptör sinyalizasyonunun kanser, diyabet, ateroskleroz, böbrek hastalıkları, gastrointestinal hastalıklar, akciğer hastalıkları, santral sinir sistemi hastalıkları, otoimmün hastalıklar gibi hastalıkların patogenezinde önemli olduğunu göstermektedir. Bu derlemenin amacı çeşitli hastalıkların patogenezinde toll benzeri reseptörlerin oynadığı rolü tanımlamaktır.

Keywords

TLR, TLR ligandları, hastalıklar

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