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The Prognostic Value of The Platelet/Lymphocyte Ratio in Predicting Short-Term Mortality in Patients with Acute Pulmonary Embolism

Year 2015, Volume: 5 Issue: 4, 204 - 208, 17.12.2015

Abstract

Objectıves: Pulmonary embolism (PE), which has an inflammatory component, has high mortality and morbidity rates. The platelet/lymphocyte
ratio is a novel marker of inflammation that is an independent predictor of mortality in cardiac and various oncological diseases. The
aim of the present study was to determine the prognostic value of the platelet/lymphocyte ratio for short-term mortality for patients
with acute pulmonary embolism.
Materials
and Methods:
A total of 290 patients who were admitted to the emergency department and diagnosed with acute PE were enrolled retrospectively.
Acute pulmonary embolism was confirmed via multislice computerized tomography.
Results: Of the 290 patients, 53 (18.2%) died within 1 month after the diagnosis was made. Age, malignancy, coronary artery disease, right
ventricular dilatation, hemoglobin, white blood cell, neutrophil, and platelet counts, systolic pulmonary artery pressure, neutrophil/
lymphocyte ratio, platelet/lymphocyte ratio, and pulmonary embolism severity index were significantly higher in group 1 than in group
2. The platelet/lymphocyte ratio, hemoglobin, and simplified pulmonary embolism severity index were independent predictors of mortality in patients with acute pulmonary embolism. A platelet/lymphocyte ratio of more than 176.31 predicted the presence of mortality
within 30 days after acute pulmonary embolism with a sensitivity of 79% and a specificity of 70%.
Conclusion: Platelet/lymphocyte ratios were higher in patients who died within 30 days of PE than those who did not. An inexpensive and practical
parameter such as the platelet/lymphocyte ratio might be useful in mortality risk prediction in acute pulmonary embolism.

References

  • Garvie NW. Imaging the parathyroids. In: Peters AM, editor. NuclearMedicine in Radiologic Diagnosis. London, Martin Dunitz; 2003. p. 681-94.
  • Abboud B, Sleilaty G, Ayoub S, q Intrathyroidparathyroid adenoma in primary hyperparathyroidism: can it be predicted preoperatively? World J Surg B 2007; 31:817823.
  • Bahar G, Feinmesser R, Joshua BZ, Hyperfunctioning intrathyroid parathyroid gland: a potentialcause of failure in parathyroidectomy. Surgery 2006;139:821-826.
  • Feliciano DV. Parathyroidpathology in an intrathyroidalposition. Am J Surg 1992; 164:496-500.
  • Zhu X, Zhai H, Tang SF, Intrathyroidal parathyroid adenoma presenting with neuromuscular manifestation.Neurol India 2009 May-Jun;57(3):340-3.
  • Arnault V, Beaulieu A, Lifante JC, et al. Multicenter study of 19 aortopulmonary window parathyroid tumors: the challenge of embryologic origin. World J Surg 2010; 34: 2211-2216.
  • Cupisti K, Dotzenrath C, Simon D,et al. Therapy of suspected intrathoracic parathyroid adenomas. Experiences using open transthoracic approach and video assisted thoracoscopic surgery. Langenbecks Arch Surg 2002;386: 488-93.
  • Ros S, Sitges-Serra A, Pereira JA, et al. Intrathyroid parathyroid adenomas: Right and lower. Cir Esp 2008;84(4):196-200.
  • Gogas J, Kouskos E, Mantas D, et al. Pre-operative Tc-99msestamibi scanning and intra-operative nuclear mapping: are they accurate in localizing parathyroid adenoma? Acta Chir Belg 2003;103:626-30.
  • Grisel JJ, Al-Ghawi H, Heubi CH,et al. Successful removal of an intrathyroidal parathyroid adenoma located by technetiumTc 99m sestamibiscan and ultrasound. Thyroid 2009;19:423–5.
  • Yabuta T, Tsushima Y, Masuoka H, et al. Ultrasonographic features of intrathyroidal parathyroid adenoma causing primary hyperparathyroidism. Endocr J. 2011;58(11):98994. Epub 2011 Sep 8. PubMed PMID: 21908928.
  • Mazeh H, Kouniavsky G, Schneider DF, et al. Intrathyroidal parathyroidglands: small, but mighty (a Napoleonphenomenon). Surgery 2012 Dec;152(6):1193200.
  • Abdo A, Kowdley GC. An intrathyroidal parathyroid: thyroid in sampling priortolobectomy. Am Surg 2012;78:818–9.
  • Ing SW, Pelliteri PK. Diagnostic fine-needle aspiration biopsy of an intrathyroidalparathyroid gland and subsequent eucalcemia in a patient with primary hyperparathyroidism. Endocr Pract 2008;14:80–6.
  • Absher KJ, Truong LD, Khurana KK, et al. Parathyroidcytolo¬gy: avoiding diagnostic pitfalls. HeadNeck 2002; 24: 157-64
  • Akram K, Parker JA, Donohoe K, et al. Role of single photon emission computed tomography/computed tomography in localization of ectopic parathyroid adenoma: a pictorial case series and review of the current literature. Clin Nucl Med 2009; 34: 500-502.

Akut Pulmoner Emboli Tanısı Almış Hastalarda Platelet/Lenfosit Oranının Kısa Dönem Mortaliteyi Ön Gördürmedeki Prognostik Değeri

Year 2015, Volume: 5 Issue: 4, 204 - 208, 17.12.2015

Abstract

Amaç Pulmoner emboli yüksek mortalite ve morbidite oranları ile inflamatuvar bileşeni iyi bilinen bir hastalıktır. Platelet / lenfosit oranı, kalp
ve çeşitli onkolojik hastalıklarda mortalitenin bağımsız belirleyicisi olan inflamasyonun yeni bir belirtecidir. Bu çalışmanın amacı, akut
pulmoner emboli hastalarında kısa süreli mortalite için platelet / lenfosit oranının prognostik değerini belirlemektir.
Materyal ve Metot: Acil servise başvuran ve akut PE tanısı toplam 290 hasta çalışmaya retrospektif olarak alındı . Akut pulmoner emboli çok kesitli bilgisayarlı
tomografi ile teyit edildi.
Bulgular: Pulmoner emboli tanısı alan 290 hastanın, tanı aldıktan sonra 53’ü (%18,2) 1 ay içinde öldü. Yaş, malignite, koroner arter hastalığı, sağ
ventrikül dilatasyonu, hemoglobin beyaz kan hücresi nötrofil ve trombosit sayımları sistolik pulmoner arter basıncı nötrofil / lenfosit
oranı platelet / lenfosit oranı ve pulmoner emboli ciddiyet indeksi grup 1'de grup 2’ye göre anlamlı derecede yüksek bulundu. Platelet
/ lenfosit oranının 176.31 ve üzerinde olması akut pulmoner emboli sonrası 30 günlük mortaliteyi predikte ettirmedeki duyarlılığı %79
ve özgüllüğü %70’ti. Platelet / lenfosit oranı, hemoglobin ve basitleştirilmiş pulmoner emboli ciddiyet indeksi, akut pulmoner emboli
tanısı almış hastalarda mortalitenin bağımsız bir belirleyicisiydi.
Sonuç: Platelet / lenfosit oranı, pulmoner emboli sonrası erken dönemde mortalite gelişen hastalarda, mortalite gelişmeyenlere göre daha
yüksekti. Bu sebeple, platelet / lenfosit oranı gibi ucuz ve pratik bir parametre akut pulmoner embolide mortalite risk tahmininde
kullanılabilir

References

  • Garvie NW. Imaging the parathyroids. In: Peters AM, editor. NuclearMedicine in Radiologic Diagnosis. London, Martin Dunitz; 2003. p. 681-94.
  • Abboud B, Sleilaty G, Ayoub S, q Intrathyroidparathyroid adenoma in primary hyperparathyroidism: can it be predicted preoperatively? World J Surg B 2007; 31:817823.
  • Bahar G, Feinmesser R, Joshua BZ, Hyperfunctioning intrathyroid parathyroid gland: a potentialcause of failure in parathyroidectomy. Surgery 2006;139:821-826.
  • Feliciano DV. Parathyroidpathology in an intrathyroidalposition. Am J Surg 1992; 164:496-500.
  • Zhu X, Zhai H, Tang SF, Intrathyroidal parathyroid adenoma presenting with neuromuscular manifestation.Neurol India 2009 May-Jun;57(3):340-3.
  • Arnault V, Beaulieu A, Lifante JC, et al. Multicenter study of 19 aortopulmonary window parathyroid tumors: the challenge of embryologic origin. World J Surg 2010; 34: 2211-2216.
  • Cupisti K, Dotzenrath C, Simon D,et al. Therapy of suspected intrathoracic parathyroid adenomas. Experiences using open transthoracic approach and video assisted thoracoscopic surgery. Langenbecks Arch Surg 2002;386: 488-93.
  • Ros S, Sitges-Serra A, Pereira JA, et al. Intrathyroid parathyroid adenomas: Right and lower. Cir Esp 2008;84(4):196-200.
  • Gogas J, Kouskos E, Mantas D, et al. Pre-operative Tc-99msestamibi scanning and intra-operative nuclear mapping: are they accurate in localizing parathyroid adenoma? Acta Chir Belg 2003;103:626-30.
  • Grisel JJ, Al-Ghawi H, Heubi CH,et al. Successful removal of an intrathyroidal parathyroid adenoma located by technetiumTc 99m sestamibiscan and ultrasound. Thyroid 2009;19:423–5.
  • Yabuta T, Tsushima Y, Masuoka H, et al. Ultrasonographic features of intrathyroidal parathyroid adenoma causing primary hyperparathyroidism. Endocr J. 2011;58(11):98994. Epub 2011 Sep 8. PubMed PMID: 21908928.
  • Mazeh H, Kouniavsky G, Schneider DF, et al. Intrathyroidal parathyroidglands: small, but mighty (a Napoleonphenomenon). Surgery 2012 Dec;152(6):1193200.
  • Abdo A, Kowdley GC. An intrathyroidal parathyroid: thyroid in sampling priortolobectomy. Am Surg 2012;78:818–9.
  • Ing SW, Pelliteri PK. Diagnostic fine-needle aspiration biopsy of an intrathyroidalparathyroid gland and subsequent eucalcemia in a patient with primary hyperparathyroidism. Endocr Pract 2008;14:80–6.
  • Absher KJ, Truong LD, Khurana KK, et al. Parathyroidcytolo¬gy: avoiding diagnostic pitfalls. HeadNeck 2002; 24: 157-64
  • Akram K, Parker JA, Donohoe K, et al. Role of single photon emission computed tomography/computed tomography in localization of ectopic parathyroid adenoma: a pictorial case series and review of the current literature. Clin Nucl Med 2009; 34: 500-502.
There are 16 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Articles
Authors

Alp Şener This is me

Hatice Çiftçi Sivri

Serkan Sivri This is me

Ahmet Ertem This is me

Gülhan Kurtoğlu Çelik This is me

Cemal Köseoğlu This is me

Ferhat İçme This is me

Şervan Gökhan This is me

Engin Bozkurt This is me

Publication Date December 17, 2015
Submission Date December 17, 2015
Published in Issue Year 2015 Volume: 5 Issue: 4

Cite

AMA Şener A, Çiftçi Sivri H, Sivri S, Ertem A, Kurtoğlu Çelik G, Köseoğlu C, İçme F, Gökhan Ş, Bozkurt E. The Prognostic Value of The Platelet/Lymphocyte Ratio in Predicting Short-Term Mortality in Patients with Acute Pulmonary Embolism. Sakarya Tıp Dergisi. December 2015;5(4):204-208.

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