The Prognostic Value of The Platelet/Lymphocyte Ratio in Predicting Short-Term Mortality in Patients with Acute Pulmonary Embolism

Year 2015, Volume: 5 Issue: 4, 204 - 208, 17.12.2015

Alp Şener Hatice Çiftçi Sivri , Serkan Sivri Ahmet Ertem Gülhan Kurtoğlu Çelik Cemal Köseoğlu Ferhat İçme Şervan Gökhan Engin Bozkurt

Abstract

Objectıves: Pulmonary embolism (PE), which has an inflammatory component, has high mortality and morbidity rates. The platelet/lymphocyte
ratio is a novel marker of inflammation that is an independent predictor of mortality in cardiac and various oncological diseases. The
aim of the present study was to determine the prognostic value of the platelet/lymphocyte ratio for short-term mortality for patients
with acute pulmonary embolism.
Materials
and Methods:
A total of 290 patients who were admitted to the emergency department and diagnosed with acute PE were enrolled retrospectively.
Acute pulmonary embolism was confirmed via multislice computerized tomography.
Results: Of the 290 patients, 53 (18.2%) died within 1 month after the diagnosis was made. Age, malignancy, coronary artery disease, right
ventricular dilatation, hemoglobin, white blood cell, neutrophil, and platelet counts, systolic pulmonary artery pressure, neutrophil/
lymphocyte ratio, platelet/lymphocyte ratio, and pulmonary embolism severity index were significantly higher in group 1 than in group
2. The platelet/lymphocyte ratio, hemoglobin, and simplified pulmonary embolism severity index were independent predictors of mortality in patients with acute pulmonary embolism. A platelet/lymphocyte ratio of more than 176.31 predicted the presence of mortality
within 30 days after acute pulmonary embolism with a sensitivity of 79% and a specificity of 70%.
Conclusion: Platelet/lymphocyte ratios were higher in patients who died within 30 days of PE than those who did not. An inexpensive and practical
parameter such as the platelet/lymphocyte ratio might be useful in mortality risk prediction in acute pulmonary embolism.

Keywords

Platelet/lymphocyte ratio, pulmonary embolism, mortality

Akut Pulmoner Emboli Tanısı Almış Hastalarda Platelet/Lenfosit Oranının Kısa Dönem Mortaliteyi Ön Gördürmedeki Prognostik Değeri

Abstract

Amaç Pulmoner emboli yüksek mortalite ve morbidite oranları ile inflamatuvar bileşeni iyi bilinen bir hastalıktır. Platelet / lenfosit oranı, kalp
ve çeşitli onkolojik hastalıklarda mortalitenin bağımsız belirleyicisi olan inflamasyonun yeni bir belirtecidir. Bu çalışmanın amacı, akut
pulmoner emboli hastalarında kısa süreli mortalite için platelet / lenfosit oranının prognostik değerini belirlemektir.
Materyal ve Metot: Acil servise başvuran ve akut PE tanısı toplam 290 hasta çalışmaya retrospektif olarak alındı . Akut pulmoner emboli çok kesitli bilgisayarlı
tomografi ile teyit edildi.
Bulgular: Pulmoner emboli tanısı alan 290 hastanın, tanı aldıktan sonra 53’ü (%18,2) 1 ay içinde öldü. Yaş, malignite, koroner arter hastalığı, sağ
ventrikül dilatasyonu, hemoglobin beyaz kan hücresi nötrofil ve trombosit sayımları sistolik pulmoner arter basıncı nötrofil / lenfosit
oranı platelet / lenfosit oranı ve pulmoner emboli ciddiyet indeksi grup 1'de grup 2’ye göre anlamlı derecede yüksek bulundu. Platelet
/ lenfosit oranının 176.31 ve üzerinde olması akut pulmoner emboli sonrası 30 günlük mortaliteyi predikte ettirmedeki duyarlılığı %79
ve özgüllüğü %70’ti. Platelet / lenfosit oranı, hemoglobin ve basitleştirilmiş pulmoner emboli ciddiyet indeksi, akut pulmoner emboli
tanısı almış hastalarda mortalitenin bağımsız bir belirleyicisiydi.
Sonuç: Platelet / lenfosit oranı, pulmoner emboli sonrası erken dönemde mortalite gelişen hastalarda, mortalite gelişmeyenlere göre daha
yüksekti. Bu sebeple, platelet / lenfosit oranı gibi ucuz ve pratik bir parametre akut pulmoner embolide mortalite risk tahmininde
kullanılabilir

Keywords

Platelet / lenfosit oranı, pulmoner emboli, mortalite

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