Does Oxidative Stress Promote The Effect of The Paraoxonase Enzyme Family (PON) On Cancer? A Review Study to Clarify This Relationship by PONs

Year 2022, Volume: 12 Issue: 4, 756 - 765, 28.12.2022

Tugba Kevser Uysal Muhammet Örnek Özen Özensoy Güler

https://doi.org/10.31832/smj.1199508

Abstract

Cancer development and progression are associated with oxidative stress. Oxidative stress can favor high concentrations of reactive oxygen species (ROS), and free radicals are associated with antioxidant metabolism. The human enzyme paraoxonase (PON) contributes to antioxidant metabolism and decreased antioxidant levels. This leads to a high-risk factor for coronary heart disease. This review focuses on specific changes that affect the DNA molecule, and signaling pathways, and regulate the various cancers through the attraction of PON, an enzyme for degrading lipid peroxides within the cell as well as lipoproteins in the bloodstream.

Keywords

PON, cancer, antioxidant, oxidative stress, hypoxia

Oksidatif Stres Paraoksonaz Enzim Ailesinin (PON) Kanser Üzerindeki Etkisini Arttırır mı? PON Ailesinin Oksidatif Stres ve Kanser İlişkisinin İncelenmesini Amaçlayan Bir Derleme

Abstract

Kanser gelişimi ve ilerlemesi oksidatif stres ile ilişkilidir. Yüksek seviyelerde reaktif oksijen türleri (ROS) ve serbest radikaller, fizyolojik bir durum olan oksidatif strese neden olmaktadır. Oksidatif strese karşı geliştirilen antioksidan metabolizması çok önemlidir. Antioksidan seviyelerindeki azalma, koroner kalp hastalıklarının risk faktörleri arasında sayılabilir. Paraoksonaz enzimi (PON), kan dolaşımındaki lipoproteinlerin yanı sıra hücre içindeki lipid peroksitlerini de parçalayarak antioksidan metabolizmanın devreye girmesine sebep olmakta ve düşük seviylerdeki antioksidanlar koroner kalp hastalığinda etkili bir risk faktörü haline gelebilmektedir. Bu derleme, önemli bir antioksidan enzim olan PON’un; DNA hasarı, çeşitli kanser türlerinin progresyonu ve sinyal yolaklarındaki değişiklikler ve lipoproteinler ile ilişkisi üzerindeki rollerine odaklanmaktadır.

Keywords

PON, kanser, antioksidan, oksidatif stres, hipoksi

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