Clinical Research
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Year 2022, Volume 4, Issue 2, 9 - 16, 31.08.2022
https://doi.org/10.55895/sshs.1145995

Abstract

References

  • Referans1 Ardeljan D, Wang Y, Park S, Shen D, Chu XK, Yu CR, et al. Interleukin-17 Retinotoxicity Is Prevented by Gene Transfer of a Soluble Interleukin-17 Receptor Acting as a Cytokine Blocker: Implications for Age-Related Macular Degeneration. Plos One. 2014;9(4), e95900.
  • Referans2 Batman C, ve Çalış F. Yaş Tip (Neovasküler) Yaşa Bağlı Makula Dejenerasyonunda Cerrahi Tedavi. Guncel Retina. 2017;1(3), 229-234.
  • Referans3 Bojanowski CM, Tuo J, Chew EY, Csaky KG, and Chan CC. Analysıs Of Hemıcentın-1, Hogg1, And E-Selectın Sıngle Nucleotıde Polymorphısms In Age-Related Macular Degeneratıon. Trans Am Ophthalmol Soc. 2005;103, 37-45. Referans4 Buschini E, Fea AM, Lavia CA, Nassisi M, Pignata G, Zola M, et al. Recent developments in the management of dry age-related macular degeneration. Clinical Ophthalmology. 2015; 9, 563–574.
  • Referans5 Canter JA, Olson LM, Spencer K, Boutaud Schnetz N, Anderson B, Hauser MA, et al. Mitochondrial DNA Polymorphism A4917G Is Independently Associated with Age-Related Macular Degeneration. Plos One. 2008; 3(5), e2091.
  • Referans6 Ferrara D, Silver RE, Louzada RN, Novais EA, Collins GK, and Seddon JM. Optical coherence tomography features preceding the onset of advanced age-related macular degeneration. Invest Ophthalmol Vis Sci. 2017;58(9), 3519-3529.
  • Referans7 Hallak JA, Sisternes L, Osborne A, Yaspan B, Rubin DL, and Leng T. Imaging, Genetic, and Demographic Factors Associated With Conversion to Neovascular Age-Related Macular Degeneration: Secondary Analysis of a Randomized Clinical Trial. JAMA Ophthalmol. 2019; 137(7):738-744.
  • Referans8 Komiyama Y, Nakae S, Matsuki T, Nambu A, Ishigame H, Kakuta S, et al. IL-17 Plays an Important Role in the Development of Experimental Autoimmune Encephalomyelitis. The Journal of Immunology. 2006;177, 566-573.
  • Referans9 Liu B, Wei L, Meyerle C, Tuo J, Sen HN, Li Z, Chakrabarty S, et al. Complement component C5a Promotes Expression of IL-22 and IL-17 from Human T cells and its Implication in Age-related Macular Degeneration. Journal of Translational Medicine. 2011;9(111), 1-12.
  • Referans10 Mahr MA, Hodge DO, and Erie JC. Racial Differences in Age-Related Macular Degeneration and Associated Anti-Vascular Endothelial Growth Factor Intravitreal Injections among Medicare Beneficiaries. Ophthalmol Retina. 2018;2(12), 1188-1195.
  • Referans11 Park H, Li Z, Yang XO, Chang SH, Nurieva R, Wang Yh, Wang Y, et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol. 2005;6(11), 1133-1141.
  • Referans12 Patel M, ve Chan CC. Immunopathological aspects of age-related macular degeneration. Semin Immunopathol. 2008;30(2), 97-110.
  • Referans13 Pauer GJT, Sturgill GM, Peachey NS, Hagstrom SA, and The Clinical Genomic and Proteomic AMD Study Group. Protective Effect of Paraoxonase 1 Gene Variant Gln192Arg in Age-Related Macular Degeneration. Am J Ophthalmol. 2010;149(3), 513–522.
  • Referans14 Qu CH, Hou Y, Bi YF, Han QR, Jiao CH, Zou QF. Diagnostic values of serum IL-10 and IL-17 in rheumatoid arthritis and their correlation with serum 14-3-3η protein. Eur Rev Med Pharmacol Sci. 2019;23(5), 1899-1906.
  • Referans15 Shen H, and Shi LZ. Metabolic regulation of TH17 cells. Mol Immunol. 2019;109(5), 81-87.
  • Referans16 Spooner KL, Mhlanga CT, Hong TH, Broadhead GK, and Chang AA. The Burden Of Neovascular Age-Related Macular Degeneration: A Patient’s Perspective. Clinical Ophthalmology. 2018;12, 2483–2491.
  • Referans17 Stone EM, Sheffield VC, and Hageman GS. Molecular Genetics Of Age-Related Macular Degeneration. Human Molecular Genetics.2001;10(20), 2285-2292.
  • Referans18 Taipale C, Laine I, ve Tuuminen R. Anatomical And Functional Response After Conversion To Aflibercept Using The Treat-And-Extend Regimen Protocol İn Bevacizumab Treatment-Resistant Wet Age-Related Macular Degeneration. Clinical Ophthalmology. 2018;13, 17–23.
  • Referans19 Thapa R, Bajimaya S, Paudyal G, Khanal S, Tan S, Thapa SS, et al. Prevalence of and risk factors for age-related macular degeneration in Nepal: the Bhaktapur Retina Study. Clinical Ophthalmology. 2017; 11, 963–972.
  • Referans20 Yılmaz T. Yaşa Bağlı Makula Dejenerasyonunda Epidemiyoloji Prevalans Ve İnsidans. Güncel Retina. 2017;1(2), 97-99.

INVESTIGATION OF LEVEL OF SERUM INTERLEUKİN 17 IN AGE-RELATED MACULAR DEGENERATİON

Year 2022, Volume 4, Issue 2, 9 - 16, 31.08.2022
https://doi.org/10.55895/sshs.1145995

Abstract

Age-related macular degeneration (AMD) is a non-recyclable visual disorder among elderly people worldwide and AMD is one of the leading causes of blindness. Former studies, interleukins were found to be effective in patients with AMD. This study’s object, the relationship of serum interleukin 17 with age-related macular degeneration was evaluated. Interleukin 17 levels were measured by ELISA method using the blood sera of 100 patients diagnosed with age-related macular degeneration and 100 healthy individuals in the control group. Acording to the results of the study, the differences between the patient and control groups of interleukin 17 levels was found statistically significant (p:0,001; p > 0,05). It was found that gender difference in patients did not affect interleukin 17 levels (p=0,649; p > 0,05). In the study, there was a significant relationship between age-related macular degeneration and serum interleukin 17.

References

  • Referans1 Ardeljan D, Wang Y, Park S, Shen D, Chu XK, Yu CR, et al. Interleukin-17 Retinotoxicity Is Prevented by Gene Transfer of a Soluble Interleukin-17 Receptor Acting as a Cytokine Blocker: Implications for Age-Related Macular Degeneration. Plos One. 2014;9(4), e95900.
  • Referans2 Batman C, ve Çalış F. Yaş Tip (Neovasküler) Yaşa Bağlı Makula Dejenerasyonunda Cerrahi Tedavi. Guncel Retina. 2017;1(3), 229-234.
  • Referans3 Bojanowski CM, Tuo J, Chew EY, Csaky KG, and Chan CC. Analysıs Of Hemıcentın-1, Hogg1, And E-Selectın Sıngle Nucleotıde Polymorphısms In Age-Related Macular Degeneratıon. Trans Am Ophthalmol Soc. 2005;103, 37-45. Referans4 Buschini E, Fea AM, Lavia CA, Nassisi M, Pignata G, Zola M, et al. Recent developments in the management of dry age-related macular degeneration. Clinical Ophthalmology. 2015; 9, 563–574.
  • Referans5 Canter JA, Olson LM, Spencer K, Boutaud Schnetz N, Anderson B, Hauser MA, et al. Mitochondrial DNA Polymorphism A4917G Is Independently Associated with Age-Related Macular Degeneration. Plos One. 2008; 3(5), e2091.
  • Referans6 Ferrara D, Silver RE, Louzada RN, Novais EA, Collins GK, and Seddon JM. Optical coherence tomography features preceding the onset of advanced age-related macular degeneration. Invest Ophthalmol Vis Sci. 2017;58(9), 3519-3529.
  • Referans7 Hallak JA, Sisternes L, Osborne A, Yaspan B, Rubin DL, and Leng T. Imaging, Genetic, and Demographic Factors Associated With Conversion to Neovascular Age-Related Macular Degeneration: Secondary Analysis of a Randomized Clinical Trial. JAMA Ophthalmol. 2019; 137(7):738-744.
  • Referans8 Komiyama Y, Nakae S, Matsuki T, Nambu A, Ishigame H, Kakuta S, et al. IL-17 Plays an Important Role in the Development of Experimental Autoimmune Encephalomyelitis. The Journal of Immunology. 2006;177, 566-573.
  • Referans9 Liu B, Wei L, Meyerle C, Tuo J, Sen HN, Li Z, Chakrabarty S, et al. Complement component C5a Promotes Expression of IL-22 and IL-17 from Human T cells and its Implication in Age-related Macular Degeneration. Journal of Translational Medicine. 2011;9(111), 1-12.
  • Referans10 Mahr MA, Hodge DO, and Erie JC. Racial Differences in Age-Related Macular Degeneration and Associated Anti-Vascular Endothelial Growth Factor Intravitreal Injections among Medicare Beneficiaries. Ophthalmol Retina. 2018;2(12), 1188-1195.
  • Referans11 Park H, Li Z, Yang XO, Chang SH, Nurieva R, Wang Yh, Wang Y, et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol. 2005;6(11), 1133-1141.
  • Referans12 Patel M, ve Chan CC. Immunopathological aspects of age-related macular degeneration. Semin Immunopathol. 2008;30(2), 97-110.
  • Referans13 Pauer GJT, Sturgill GM, Peachey NS, Hagstrom SA, and The Clinical Genomic and Proteomic AMD Study Group. Protective Effect of Paraoxonase 1 Gene Variant Gln192Arg in Age-Related Macular Degeneration. Am J Ophthalmol. 2010;149(3), 513–522.
  • Referans14 Qu CH, Hou Y, Bi YF, Han QR, Jiao CH, Zou QF. Diagnostic values of serum IL-10 and IL-17 in rheumatoid arthritis and their correlation with serum 14-3-3η protein. Eur Rev Med Pharmacol Sci. 2019;23(5), 1899-1906.
  • Referans15 Shen H, and Shi LZ. Metabolic regulation of TH17 cells. Mol Immunol. 2019;109(5), 81-87.
  • Referans16 Spooner KL, Mhlanga CT, Hong TH, Broadhead GK, and Chang AA. The Burden Of Neovascular Age-Related Macular Degeneration: A Patient’s Perspective. Clinical Ophthalmology. 2018;12, 2483–2491.
  • Referans17 Stone EM, Sheffield VC, and Hageman GS. Molecular Genetics Of Age-Related Macular Degeneration. Human Molecular Genetics.2001;10(20), 2285-2292.
  • Referans18 Taipale C, Laine I, ve Tuuminen R. Anatomical And Functional Response After Conversion To Aflibercept Using The Treat-And-Extend Regimen Protocol İn Bevacizumab Treatment-Resistant Wet Age-Related Macular Degeneration. Clinical Ophthalmology. 2018;13, 17–23.
  • Referans19 Thapa R, Bajimaya S, Paudyal G, Khanal S, Tan S, Thapa SS, et al. Prevalence of and risk factors for age-related macular degeneration in Nepal: the Bhaktapur Retina Study. Clinical Ophthalmology. 2017; 11, 963–972.
  • Referans20 Yılmaz T. Yaşa Bağlı Makula Dejenerasyonunda Epidemiyoloji Prevalans Ve İnsidans. Güncel Retina. 2017;1(2), 97-99.

Details

Primary Language English
Subjects Medicine
Journal Section Research Articles
Authors

Hatice TÜRKER ASLAN> (Primary Author)
TOKAT GAZİOSMANPAŞA ÜNİVERSİTESİ, TIP FAKÜLTESİ
0000-0003-4634-1508
Türkiye


Ömer ATEŞ>
TOKAT GAZIOSMANPASA UNIVERSITY
0000-0003-4266-393X
Türkiye

Publication Date August 31, 2022
Submission Date July 20, 2022
Acceptance Date August 16, 2022
Published in Issue Year 2022, Volume 4, Issue 2

Cite

APA Türker Aslan, H. & Ateş, Ö. (2022). INVESTIGATION OF LEVEL OF SERUM INTERLEUKİN 17 IN AGE-RELATED MACULAR DEGENERATİON . Sabuncuoglu Serefeddin Health Sciences , 4 (2) , 9-16 . DOI: 10.55895/sshs.1145995