Year 2009, Volume 33 , Issue 3, Pages 421 - 432 2009-03-01

Synthesis, reactions, and antiarrhythmic activities of some novel pyrimidines and pyridines fused with thiophene moiety
Synthesis, reactions, and antiarrhythmic activities of some novel pyrimidines and pyridines fused with thiophene moiety

Abdel-Galil El-Sayed AMR [1] , Naglaa Abdel-Samei ABDEL-HAFEZ [2] , Salwa Fahem MOHAMED [3] , Mohamed Mostafa ABDALLA [4]


We report herein the synthesis and antiarrhythmic activities of some newly synthesized heterocyclic theino[2,3-c]pyrimidine and theino[2,3-c]pyridine derivatives fused with thiophene moiety. Initially the acute toxicity of the compounds was assayed via the determination of their LD50. The antiarrhythmic activities for the compounds were determined and all the tested compounds were found more potent than Procaine amide\textregistered and Lidocaine\textregistered as positive antiarrhythmic controls.
We report herein the synthesis and antiarrhythmic activities of some newly synthesized heterocyclic theino[2,3-c]pyrimidine and theino[2,3-c]pyridine derivatives fused with thiophene moiety. Initially the acute toxicity of the compounds was assayed via the determination of their LD50. The antiarrhythmic activities for the compounds were determined and all the tested compounds were found more potent than Procaine amide\textregistered and Lidocaine\textregistered as positive antiarrhythmic controls.
  • Amr, A. E.; Sayed, H. H.; Abdulla, M. M. Arch. Pharm. Chem. Life Sci. 2005, 338, 433-440.
  • Abd El-Latif, N. A.; Amr, A. E.; Ibrahim, A. A. Monatsh. Chem. 2007, 138, 559-567.
  • Shalaby, A. F. A.; Abdulla, M. M.; Amr, A. E.; Hussain, A. A. Monatsh. Chem. 2007, 138, 1019-1027.
  • Amr, A. E.; Abdulla, M. M. Ind. J. Heterocycl. 2002, 12, 129-134.
  • Ouf, N. H.; Amr, A. E. Monatsh. Chem. 2008, 139, 579-585.
  • Amr, A. E.; Mohamed, A. M.; Mohamed, S. F.; Abdel-Hafez, N. A.; Hammam, A. G. Bioorg. Med. Chem. 2006, , 5481-5488.
  • Hammam, A. G.; Fahmy, A. F. M.; Amr, A. E.; Mohamed, A. M. Ind. J. Chem. 2003, 42B, 1985-1993.
  • Hammam, A. G.; Sharaf, M. A.; Abdel-Hafez, N. A. Ind. J. Chem. 2001, 40B, 213-221.
  • Hammam, A. G.; Abdel-Hafez, N. A.; Midura, W. H.; Mikolajczyk, M. Z. Naturforsch. 2000, 55b, 417-424.
  • Amr, A. E.; Hegab, M. I.; Ibrahim, A. A.; Abdalah, M. M. Monatsch Chem. 2003, 134, 1395-1409.
  • Abo-Ghalia, M. H.; Amr, A. E. Amino Acids 2004, 26, 283-289.
  • Attia, A.; Abdel-Salam, O. I.; Amr, A. E.; Stibor, I.; Budesinsky, M. Egypt. J. Chem. 2000, 43, 187-201.
  • Amr, A. E.; Abdulla, M. M. Ind. J. Heterocycl. Chem. 2002, 12, 129-134.
  • Edward, C. T.; Bin, L. J. Org. Chem. 2003, 68, 9938-9947.
  • Broom, A. B.; Shim, J. L.; Anderson, G. L. J. Org. Chem. 1976, 41, 1095-1099.
  • Bonde, C. G.; Gaikwad, N. J. Bioorg. Med. Chem. 2004, 12, 2151-2161.
  • Kucukguzel, G.; Kocatepe, A.; DeClercq, E.; Sahin, F.; Gulluce, M. Eur. J. Med. Chem. 2006, 41, 353-359.
  • Vicini, P.; Geroniki, A.; Anastasia, K.; Incerti, M.; Zani, F. Bioorg. Med. Chem. 2006, 14, 3859-3864.
  • Zhou, X.; Shao. L.; Jin, Z.; Liu, J. B.; Dai, H.; Fang, J.X. Heteroatom. Chem. 2007, 18, 55-59.
  • Leonid, G. V.; Anna, V. L.; Tatiana, N. B.; Svetlana, A. K.; Roman, S. B.; Alexey, V. V. Tetrahedron, 2008, 64, 10452.
  • Austen, K. F.; Brocklehurst, W. E. J. Exp. Med. 1961, 113, 521-539.
  • Walker, M. J. A.; Curtius, M. J.; Hearse, D. J.; Campbell, R. W. F.; Jams, M. J.; Yellon, D. M.; Coker, S. M.; Harness, J. B.; Harron, D. W. J.; Miggins, A. J.; Julian, D. G.; Lab, M. J.; Manning, A. S.; Northover, B. J.; Parratt, J. R.; Riemrsma, R. A.; Riva, A.; Russell, D. C.; Sheridan, D. J.; Winslow, E.; Woodward, B. Cardiovasc. Res. 1992, 22, 447-455.
  • Vaille, A.; Scottodi, T. A. M.; Maldonado, J.; Vanelle, P. Meth. Find. Exp. Clin. Pharmacol. 1992, 14, 183-187.
  • Bazzani, C.; Genedani, S.; Tugliavini, S.; Bertolini, A. J. Pharm. Pharmacol. 1989, 41, 651-653.
  • Huarong, L. U.; Declerck, F.; J. Cardiovasc Pharmacol. 1993, 22, 120-125.
  • Winslow, E. Br. J. Pharmac. 1980, 71, 615-622.
  • Winslow, E. J. Cardiovasc Pharmac. 1981, k, 87-100.
  • Fujita, M.; Seki, T.; Inada, H.; Ikeda, N. Bioorg. Med. Chem. Lett. 2002, 12, 1607-1613.
Primary Language tr
Journal Section Articles
Authors

Author: Abdel-Galil El-Sayed AMR

Author: Naglaa Abdel-Samei ABDEL-HAFEZ

Author: Salwa Fahem MOHAMED

Author: Mohamed Mostafa ABDALLA

Dates

Publication Date : March 1, 2009

Bibtex @ { tbtkchem142321, journal = {Turkish Journal of Chemistry}, issn = {1300-0527}, eissn = {1303-6130}, address = {}, publisher = {TUBITAK}, year = {2009}, volume = {33}, pages = {421 - 432}, doi = {}, title = {Synthesis, reactions, and antiarrhythmic activities of some novel pyrimidines and pyridines fused with thiophene moiety}, key = {cite}, author = {AMR, Abdel-Galil El-Sayed and ABDEL-HAFEZ, Naglaa Abdel-Samei and MOHAMED, Salwa Fahem and ABDALLA, Mohamed Mostafa} }
APA AMR, A , ABDEL-HAFEZ, N , MOHAMED, S , ABDALLA, M . (2009). Synthesis, reactions, and antiarrhythmic activities of some novel pyrimidines and pyridines fused with thiophene moiety. Turkish Journal of Chemistry , 33 (3) , 421-432 . Retrieved from https://dergipark.org.tr/en/pub/tbtkchem/issue/11904/142321
MLA AMR, A , ABDEL-HAFEZ, N , MOHAMED, S , ABDALLA, M . "Synthesis, reactions, and antiarrhythmic activities of some novel pyrimidines and pyridines fused with thiophene moiety". Turkish Journal of Chemistry 33 (2009 ): 421-432 <https://dergipark.org.tr/en/pub/tbtkchem/issue/11904/142321>
Chicago AMR, A , ABDEL-HAFEZ, N , MOHAMED, S , ABDALLA, M . "Synthesis, reactions, and antiarrhythmic activities of some novel pyrimidines and pyridines fused with thiophene moiety". Turkish Journal of Chemistry 33 (2009 ): 421-432
RIS TY - JOUR T1 - Synthesis, reactions, and antiarrhythmic activities of some novel pyrimidines and pyridines fused with thiophene moiety AU - Abdel-Galil El-Sayed AMR , Naglaa Abdel-Samei ABDEL-HAFEZ , Salwa Fahem MOHAMED , Mohamed Mostafa ABDALLA Y1 - 2009 PY - 2009 N1 - DO - T2 - Turkish Journal of Chemistry JF - Journal JO - JOR SP - 421 EP - 432 VL - 33 IS - 3 SN - 1300-0527-1303-6130 M3 - UR - Y2 - 2019 ER -
EndNote %0 Turkish Journal of Chemistry Synthesis, reactions, and antiarrhythmic activities of some novel pyrimidines and pyridines fused with thiophene moiety %A Abdel-Galil El-Sayed AMR , Naglaa Abdel-Samei ABDEL-HAFEZ , Salwa Fahem MOHAMED , Mohamed Mostafa ABDALLA %T Synthesis, reactions, and antiarrhythmic activities of some novel pyrimidines and pyridines fused with thiophene moiety %D 2009 %J Turkish Journal of Chemistry %P 1300-0527-1303-6130 %V 33 %N 3 %R %U
ISNAD AMR, Abdel-Galil El-Sayed , ABDEL-HAFEZ, Naglaa Abdel-Samei , MOHAMED, Salwa Fahem , ABDALLA, Mohamed Mostafa . "Synthesis, reactions, and antiarrhythmic activities of some novel pyrimidines and pyridines fused with thiophene moiety". Turkish Journal of Chemistry 33 / 3 (March 2009): 421-432 .
AMA AMR A , ABDEL-HAFEZ N , MOHAMED S , ABDALLA M . Synthesis, reactions, and antiarrhythmic activities of some novel pyrimidines and pyridines fused with thiophene moiety. Turkish Journal of Chemistry. 2009; 33(3): 421-432.
Vancouver AMR A , ABDEL-HAFEZ N , MOHAMED S , ABDALLA M . Synthesis, reactions, and antiarrhythmic activities of some novel pyrimidines and pyridines fused with thiophene moiety. Turkish Journal of Chemistry. 2009; 33(3): 432-421.