Year 2012, Volume 42 , Issue 3, Pages 433 - 440 2012-03-01

Risk factors and prognosis in children hospitalized due to pandemic H1N1 influenza A virus infection in Ankara, Turkey*
Risk factors and prognosis in children hospitalized due to pandemic H1N1 influenza A virus infection in Ankara, Turkey*

Medine Ayşin TAŞAR [1] , Yıldız DALLAR [2] , Özge UYSAL SOYER [3] , Şükran YILDIRIM [4] , Mustafa TAŞAR [5] , Fatma İnci ARIKAN [6]


To describe the demographic characteristics and clinical features in children with influenza A (H1N1) virus infection and to identify risk factors for severe disease or poor prognosis. Following the first tourist-imported case in Turkey on 16 May 2009, the influenza A (H1N1) virus has spread throughout the country. Materials and methods: Children under 18 years of age who were hospitalized for at least 24 h with an influenza-like illness and who had confirmed influenza A (H1N1) virus infection were included in the study. Demographic factors, clinical signs and symptoms, laboratory results, radiographic findings, treatments, and follow-up periods were noted. Results: During the period of October to December 2009, 126 [63.5% males, median age: 3 years (range: 0.1-9 years)] children with cases of influenza A (H1N1) virus infection were hospitalized. Fever (95.2%), cough (84.1%), rhinorrhea (70%), and dyspnea (63.5%) were the most common presenting symptoms. A total of 46 patients (36.4%) had chronic underlying medical conditions, with asthma being the most common (21.4%). During hospitalization, durations of oxygen requirement and wheezing were longer in patients with chronic respiratory disease. Duration of oxygen requirement and tachypnea decreased if oseltamivir was initiated within 48 h (P = 0.006 and 0.033, respectively). No risk factor was defined for hospitalization longer than 4 days. Conclusion: In our cohort, influenza A (H1N1) virus infection did not appear to cause severe disease. Asthma was a significant risk factor for severe disease. Delayed (>48 h) initiation of antiviral therapy might have contributed to an increase in morbidity, which suggests the importance of timely administration of antiviral treatments.
To describe the demographic characteristics and clinical features in children with influenza A (H1N1) virus infection and to identify risk factors for severe disease or poor prognosis. Following the first tourist-imported case in Turkey on 16 May 2009, the influenza A (H1N1) virus has spread throughout the country. Materials and methods: Children under 18 years of age who were hospitalized for at least 24 h with an influenza-like illness and who had confirmed influenza A (H1N1) virus infection were included in the study. Demographic factors, clinical signs and symptoms, laboratory results, radiographic findings, treatments, and follow-up periods were noted. Results: During the period of October to December 2009, 126 [63.5% males, median age: 3 years (range: 0.1-9 years)] children with cases of influenza A (H1N1) virus infection were hospitalized. Fever (95.2%), cough (84.1%), rhinorrhea (70%), and dyspnea (63.5%) were the most common presenting symptoms. A total of 46 patients (36.4%) had chronic underlying medical conditions, with asthma being the most common (21.4%). During hospitalization, durations of oxygen requirement and wheezing were longer in patients with chronic respiratory disease. Duration of oxygen requirement and tachypnea decreased if oseltamivir was initiated within 48 h (P = 0.006 and 0.033, respectively). No risk factor was defined for hospitalization longer than 4 days. Conclusion: In our cohort, influenza A (H1N1) virus infection did not appear to cause severe disease. Asthma was a significant risk factor for severe disease. Delayed (>48 h) initiation of antiviral therapy might have contributed to an increase in morbidity, which suggests the importance of timely administration of antiviral treatments.
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Primary Language tr
Journal Section Articles
Authors

Author: Medine Ayşin TAŞAR

Author: Yıldız DALLAR

Author: Özge UYSAL SOYER

Author: Şükran YILDIRIM

Author: Mustafa TAŞAR

Author: Fatma İnci ARIKAN

Dates

Publication Date : March 1, 2012

Bibtex @ { tbtkmedical147106, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {}, publisher = {TUBITAK}, year = {2012}, volume = {42}, pages = {433 - 440}, doi = {}, title = {Risk factors and prognosis in children hospitalized due to pandemic H1N1 influenza A virus infection in Ankara, Turkey*}, key = {cite}, author = {TAŞAR, Medine Ayşin and DALLAR, Yıldız and SOYER, Özge UYSAL and YILDIRIM, Şükran and TAŞAR, Mustafa and ARIKAN, Fatma İnci} }
APA TAŞAR, M , DALLAR, Y , SOYER, Ö , YILDIRIM, Ş , TAŞAR, M , ARIKAN, F . (2012). Risk factors and prognosis in children hospitalized due to pandemic H1N1 influenza A virus infection in Ankara, Turkey*. Turkish Journal of Medical Sciences , 42 (3) , 433-440 . Retrieved from https://dergipark.org.tr/en/pub/tbtkmedical/issue/12298/147106
MLA TAŞAR, M , DALLAR, Y , SOYER, Ö , YILDIRIM, Ş , TAŞAR, M , ARIKAN, F . "Risk factors and prognosis in children hospitalized due to pandemic H1N1 influenza A virus infection in Ankara, Turkey*". Turkish Journal of Medical Sciences 42 (2012 ): 433-440 <https://dergipark.org.tr/en/pub/tbtkmedical/issue/12298/147106>
Chicago TAŞAR, M , DALLAR, Y , SOYER, Ö , YILDIRIM, Ş , TAŞAR, M , ARIKAN, F . "Risk factors and prognosis in children hospitalized due to pandemic H1N1 influenza A virus infection in Ankara, Turkey*". Turkish Journal of Medical Sciences 42 (2012 ): 433-440
RIS TY - JOUR T1 - Risk factors and prognosis in children hospitalized due to pandemic H1N1 influenza A virus infection in Ankara, Turkey* AU - Medine Ayşin TAŞAR , Yıldız DALLAR , Özge UYSAL SOYER , Şükran YILDIRIM , Mustafa TAŞAR , Fatma İnci ARIKAN Y1 - 2012 PY - 2012 N1 - DO - T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 433 EP - 440 VL - 42 IS - 3 SN - 1300-0144-1303-6165 M3 - UR - Y2 - 2019 ER -
EndNote %0 Turkish Journal of Medical Sciences Risk factors and prognosis in children hospitalized due to pandemic H1N1 influenza A virus infection in Ankara, Turkey* %A Medine Ayşin TAŞAR , Yıldız DALLAR , Özge UYSAL SOYER , Şükran YILDIRIM , Mustafa TAŞAR , Fatma İnci ARIKAN %T Risk factors and prognosis in children hospitalized due to pandemic H1N1 influenza A virus infection in Ankara, Turkey* %D 2012 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 42 %N 3 %R %U
ISNAD TAŞAR, Medine Ayşin , DALLAR, Yıldız , SOYER, Özge UYSAL , YILDIRIM, Şükran , TAŞAR, Mustafa , ARIKAN, Fatma İnci . "Risk factors and prognosis in children hospitalized due to pandemic H1N1 influenza A virus infection in Ankara, Turkey*". Turkish Journal of Medical Sciences 42 / 3 (March 2012): 433-440 .
AMA TAŞAR M , DALLAR Y , SOYER Ö , YILDIRIM Ş , TAŞAR M , ARIKAN F . Risk factors and prognosis in children hospitalized due to pandemic H1N1 influenza A virus infection in Ankara, Turkey*. Turkish Journal of Medical Sciences. 2012; 42(3): 433-440.
Vancouver TAŞAR M , DALLAR Y , SOYER Ö , YILDIRIM Ş , TAŞAR M , ARIKAN F . Risk factors and prognosis in children hospitalized due to pandemic H1N1 influenza A virus infection in Ankara, Turkey*. Turkish Journal of Medical Sciences. 2012; 42(3): 440-433.