Risk Factors For Seizure Recurrence After Antiepileptic Drug Withdrawal in Children with Idiopathic Epilepy

Abstract

Objective: The purpose of this study is to evaluate the risk factors on seizure recurrence after antiepileptic drug withdrawal in children with idiopathic epilepsy.

Material and Methods: The treatment is withdrawn within 4-6 months in all patients who had normal magnetic resonance imaging and electroencephalogram results on at least 24 months of antiepileptic drug treatment. After drug withdrawal 72 patients had seizure recurrence in whom labeled as relapse group. Eighty-two patients had no seizure recurrence are labeled as remission group.

Results: The age of diagnosis with epilepsy and remission time were observed as risk factors on seizure recurrence. It is determined that after drug withdrawal seizure recurrence is occurred within the first 2 years of follow-up in 95,9 % of the relapse group’s patients.

Conclusion: In patients, who had more than 3 months of seizure remission time have more seizure recurrence risk after drug withdrawal. Furthermore, it is observed that in patients older than 12 years old the risk of recurrence

Keywords

• Epilepsy
• Seizure
• Drug withdrawal

İdiyopatik Epilepsi Tanılı Çocuk Hastalarda Antiepileptik Tedavi Kesimi Sonrası Nöbet Tekrarı ile İlişkili Risk Faktörleri

Abstract

Amaç: Bu çalışmanın amacı idiyopatik epilepsi tanılı çocuklarda anti epileptik tedavi kesimi sonrası nöbet tekrarına etki eden risk faktörlerini değerlendirmektir.

Gereç ve Yöntem: En az 24 ay anti epileptik tedavi alan, kraniyal manyetik rezonans görüntüleme ve elektroensefalografi sonuçları normal olan hastaların ilaç tedavisi 4-6 aylık süreçte azaltılarak kesilmiştir. Tedavi kesimi sonrası nöbeti tekrarlayan 72 hasta relaps grubunu, nöbeti tekrar etmeyen 82 hasta ise remisyon grubunu oluşturmuştur.

Sonuç: Hastaların tanı yaşı ve tedavi başlanması sonrasında nöbet kontrol sürelerinin relaps üzerine etki eden risk faktörleri olduğu görülmüştür. Relaps grubundaki hastaların %95,9’unda nöbet tekrarının ilk 2 yıl içerisinde geliştiği belirlenmiştir.

Tartışma: Tedavi başlanmasından sonra nöbet kontrol süresi 3 ay ve üzerinde olan hastalarda ilaç kesim sonrası tekrarlama riski daha yüksektir. Ayrıca epilepsi tanı yaşı 12 ve üzerinde olan hastalarda da tekrarlama riskinin yüksek olduğu görülmüştür. Bununla birlikte anti epileptik tedavisi kesilen tüm hastalarda 2 yıl yakın takip önermekteyiz.

Keywords

• Epilepsi
• Nöbet tekrarı
• Tedavi kesimi

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