Abstract
Hemanjiyomlar çocukluk çağında sık görülen benign tümörlerdir. Hemanjiyomlar vasküler endotel hücrelerin çoğalması ile ortaya çıkan vasküler tümörlerin tipik bir örneğidir. İnfantil tipleri doğumda mevcut olabildiği gibi, bazen doğumdan birkaç hafta sonra ortaya çıkar ve ilk 4-6 ayda hızlı büyürler. Kanama, enfeksiyon, kozmetik problemler oluşturmayan infantil hemanjiyomlarda herhangi bir tedavi önerilmez. Literatürde henüz standart bir tedavi seçeneği yoktur. Propranolol kapiller damarlarda vazokonstriksiyon, endotel hücrelerinde apopitozis artışı ve vasküler endotelyal büyüme faktörlerinde azalma mekanizmaları ile hemanjiyomda küçülmeye neden olur ve kullanım kolaylığı, yan etkilerinin azlığı, ekonomik oluşu ve tedaviye hızlı yanıt alınması gibi nedenlerle hemanjiyom tedavisinde tercih edilebilir ve güvenle kullanılabilir. Burada propranolol uygulanan bir hemanjiyom olgusu sunulmaktadır.
Keywords
References
- Chang LC, Haggstrom AN, Drolet BA, Baselga E, Chamlin SL, Garzon MC, et al. Growth characteristics of infantile hemangiomas: Implications for management. Pediatrics 2008;122:360-7.
- Zimmermann AP, Wiegand S, Werner JA, Eivazi. Propranolol therapy for infantile haemangiomas: Review of the literature. Int J Pediatr Otorhinolaryngol 2010; 74:338-42.
- Leaute-Labreze C, Dumas de la Roque E, Hubiche T, Boralevi F, Thambo JB, Taieb A. Propranolol for severe hemangiomas of infancy. N Engl J Med 2008;358:2649-51.
- Price CJ, Lattouf C, Baum B, McLeod M, Schachner LA, Duarte AM, et al. Propranolol vs corticosteroids for infantile hemangiomas: A multicenter retrospective analysis. Arch Dermatol 2011;147:1371– 6.
- Denoyelle F, Leboulanger N, Enjolras O, Harris R, Roger G, Garabedian EN. Role of Propranolol in the therapeutic strategy of infantile laryngotracheal hemangioma. Int J Pediatr Otorhinolaryngol 2009;73:1168-72.
- Drolet BA, Frommelt PC, Chamlin SL, Haggstrom A, Bauman NM, Chiu YE, et al. Initiation and use of propranolol for infantile hemangioma: Report of a consensus conference. Pediatrics 2013;131:128-40.
- Siegfried EC, Keenan WJ, Al-Jureidini S. More on propranolol for hemangiomas of infancy. N Engl J Med 2008;359:2846-7.
Abstract
Hemangiomas are the most common benign tumors in childhood. Hemangiomas are a typical example of a vascular tumor associated with the proliferation of vascular endothelial cells. The infantile type may be present at birth but sometimes develops a few weeks after birth and grows faster in the first 4-6 months. Treatment is not recommended for infantile hemanjiomas that do not cause problems such as bleeding, infections and cosmetic problems. There is no standard treatment protocol for hemangiomas in the literature. Propranolol causes contraction at the hemangioma with capillary vasoconstriction, increased apoptosis in endothelial cells, and decreased vascular endothelial growth factor mechanisms. It may be preferred because of ease of use, lack of side effects, economic reasons and early response to treatment and used safely in the treatment of hemangiomas. Here, we present a case of hemangioma treated by propranolol
Keywords
References
- Chang LC, Haggstrom AN, Drolet BA, Baselga E, Chamlin SL, Garzon MC, et al. Growth characteristics of infantile hemangiomas: Implications for management. Pediatrics 2008;122:360-7.
- Zimmermann AP, Wiegand S, Werner JA, Eivazi. Propranolol therapy for infantile haemangiomas: Review of the literature. Int J Pediatr Otorhinolaryngol 2010; 74:338-42.
- Leaute-Labreze C, Dumas de la Roque E, Hubiche T, Boralevi F, Thambo JB, Taieb A. Propranolol for severe hemangiomas of infancy. N Engl J Med 2008;358:2649-51.
- Price CJ, Lattouf C, Baum B, McLeod M, Schachner LA, Duarte AM, et al. Propranolol vs corticosteroids for infantile hemangiomas: A multicenter retrospective analysis. Arch Dermatol 2011;147:1371– 6.
- Denoyelle F, Leboulanger N, Enjolras O, Harris R, Roger G, Garabedian EN. Role of Propranolol in the therapeutic strategy of infantile laryngotracheal hemangioma. Int J Pediatr Otorhinolaryngol 2009;73:1168-72.
- Drolet BA, Frommelt PC, Chamlin SL, Haggstrom A, Bauman NM, Chiu YE, et al. Initiation and use of propranolol for infantile hemangioma: Report of a consensus conference. Pediatrics 2013;131:128-40.
- Siegfried EC, Keenan WJ, Al-Jureidini S. More on propranolol for hemangiomas of infancy. N Engl J Med 2008;359:2846-7.
Details
| Other ID | JA64DK52YJ |
|---|---|
| Journal Section | Case Report |
| Authors | |
| Publication Date | December 1, 2015 |
| Submission Date | December 1, 2015 |
| Published in Issue | Year 2015 Volume: 9 Issue: 4 |
The publication language of Turkish Journal of Pediatric Disease is English.
Manuscripts submitted to the Turkish Journal of Pediatric Disease will go through a double-blind peer-review process. Each submission will be reviewed by at least two external, independent peer reviewers who are experts in the field, in order to ensure an unbiased evaluation process. The editorial board will invite an external and independent editor to manage the evaluation processes of manuscripts submitted by editors or by the editorial board members of the journal. The Editor in Chief is the final authority in the decision-making process for all submissions. Articles accepted for publication in the Turkish Journal of Pediatrics are put in the order of publication, with at least 10 original articles in each issue, taking into account the acceptance dates. If the articles sent to the reviewers for evaluation are assessed as a senior for publication by the reviewers, the section editor and the editor considering all aspects (originality, high scientific quality and citation potential), it receives publication priority in addition to the articles assigned for the next issue.
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