Abstract
Giriş ve Amaç: Antikardiyolipin antikorları erişkin hastalarda migren dahil olmak üzere birçok nörolojik hastalık ile ilişkilendirilmektedir. Ancak migren başağrısı olan çocuk hastalarda bu antikorların varlığı ile ilgili yeterli bilgi bulunmamaktadır. Bu çalışmanın amacı migren başağrısı tanısı almış çocuklarda antikardiyolipin antikorlarının varlığının araştırılmasıdır.Olgular ve Metod: Çalışmaya migren tanısı ile izlenen yirmi olgu dahil edilmişdi (14’ü kız; yaş ortalaması 13.55±2.60). Yirmi sağlıklı olgu kontrol grubunu oluşturdu (12’si kız; yaş ortalaması 13.65±2.23). Antikardiyolipin antikorları enzim bağlı immunosorbent (ELISA) yöntemi ile araştırıldı. Çalışma ve kontrol gruplarının sonuçları birbiri ile karşılaştırıldı.Bulgular: Çalışma grubundaki yirmi olgudan bir tanesinde yüksek serum antikardiyolipin antikor seviyesi saptandı. On dört yaşındaki bu kız olgu, iki yıldan bu yana adi migren tanısı ile izlenmekte olup kraniyal manyetik rezonans görüntülemesinde subkortikal infarktlarla uyumlu beyaz cevherde hiperintens lezyonlar saptandı. Kontrol grubundaki olguların serum antikardiyolipin antikor düzeyleri normal bulundu. İki grup arasında istatistiksel olarak anlamlı fark saptanmadı.Sonuç: Bu çalışmada elde edilen bulgular migren hastalarında antikardiyolipin antikorlarının artmadığını bildiren önceki çalışmalarla uyumlu bulundu. Ancak infarkt ile uyumlu kraniyal görüntüleme bulguları olan seçilmiş migrenli olgularda serum antikardiyolipin antikorlarının incelenmesi değerli olabilir. Çocukluk çağı migren olgularında antikardiyolipin antikorlarının özgün bir rolünün olup olmadığını belirlemek için daha geniş sayıda hastayı içeren çalışmalar gerekmektedir.
References
- Swaiman KF, Ashwal S. Eds. Headaches in infants and child- ren. Pediatric Neurology, 4th ed. St Louis, Missouri. Mosby Pres ;1183-1202.
- Straube A, Padovan CS, Förderreuther S, Wick M. Antinuclear and anticardiolipin antibodies in primary headache syndromes. Schmerz 1998;12:342-346.
- Pilarska E, Lemka M, Bakowska A. Prothrombotic risk factors in ischemic stroke and migraine in children. Acta Neurol Scand ;114:13-16. Harris EN, Baguley E. Clinical and serological features of the an- tiphospholipid syndrome. Br J Rheumatol 1987;26:19-25.
- Verro P, Levine SR, Tietjen E. Cerebrovascular ischemic events with high positive anticardiolipin antibodies. Stroke 1998;29:2245
- Asherson RA, Haris EN. Anticardiolipin antibodies: clinical asso- ciations. Postgrad Med J 1986;62:1081-1087.
- Levine SR, Deegan MJ, Futrell N, Welch KMA. Cerebrovascular and neurologic disease associated with antiphospholipid antibodi- es: 48 cases. Neurology 1990;40:1181-1189.
- Tanne D, Hassin-Baer S. Neurologic manifestations of the antip- hospholipid syndrome. Curr Rheumatol Rep 2001;3:286-292.
- Headache Classification Committee of the International Headac- he Society. The international classification of headache disorders, nd ed. Cephalalgia 2004;24:1-160.
- Loizou S, McCrea JD, Rudge AC, Reynolds R, Boyle CC, Haris EN. Measurement of anti-cardiolipin antibodies by an enzyme- linked immunosorbent assay (ELISA): standardization and quan- titation of results. Clin Exp Immunol 1985; 62: 738-745.
- Angelini L, Zibordi F, Zorzi G, Nardocci N, Caporali R, Ravelli A, Martini A. Neurological disorders, other than stroke, associated with antiphospholipid antibodies in childhood. Neuropediatrics ;27:149-153. Asherson RA, Cervera R. Antiphospholipid syndrome. J Invest Dermatol 1993;100:21-27.
- Hering R, Couturier EG, Asherson RA, Steiner TJ. Anticardiolipin antibodies in cluster headache. Cephalalgia. 1991;11:101-102.
THE INVESTIGATION OF SERUM ANTICARDIOLIPIN ANTIBODIES IN CHILDREN WITH THE DIAGNOSIS OF MIGRAINE HEADACHE
Abstract
Intraduction: The occurrence of anticardiolipin antibodies has been related to a variety of neurologic disorders including migraine in adult patients. But, their presence in pediatric population with migraine headache is uncertain. The aim of this study was to investigate the presence of anticardiolipin antibodies in children with the diagnosis of migraine headache.Patents And Method: Twenty consecutive patients with the diagnosis of migraine were enrolled to the study (14 female; mean age 13.55±2.60). Twenty healthy subjects served as the control group (12 female; mean age 13.65±2.23). Anticardiolipin antibodies were assayed by enzymelinked immunosorbent assay (ELISA). The results were compared between the study and control groups. Results: One of the twenty study patients showed elevated serum anticardiolipin antibody titer. This 14 years old girl had common migraine since two years and her cranial magnetic resonance imaging showed white matter hyperintensities suggesting subcortical infarcts. Serum levels of anticardiolipin antibodies in the control subjects were normal. The difference between the two groups was not statistically significant. Conclusion: Our data overlap with the results of previous reports which did not find increased serum levels of anticardiolipin antibodies in migraine patients. On the other hand, in selected migraine patients with cranial imaging abnormalities suggesting infarcts, the evaluation of serum anticardiolipin antibodies could be of value. Studies with larger numbers of patients are warranted to determine if anticardiolipin antibodies have a specific role in pediatric migraine patients
Keywords
References
- Swaiman KF, Ashwal S. Eds. Headaches in infants and child- ren. Pediatric Neurology, 4th ed. St Louis, Missouri. Mosby Pres ;1183-1202.
- Straube A, Padovan CS, Förderreuther S, Wick M. Antinuclear and anticardiolipin antibodies in primary headache syndromes. Schmerz 1998;12:342-346.
- Pilarska E, Lemka M, Bakowska A. Prothrombotic risk factors in ischemic stroke and migraine in children. Acta Neurol Scand ;114:13-16. Harris EN, Baguley E. Clinical and serological features of the an- tiphospholipid syndrome. Br J Rheumatol 1987;26:19-25.
- Verro P, Levine SR, Tietjen E. Cerebrovascular ischemic events with high positive anticardiolipin antibodies. Stroke 1998;29:2245
- Asherson RA, Haris EN. Anticardiolipin antibodies: clinical asso- ciations. Postgrad Med J 1986;62:1081-1087.
- Levine SR, Deegan MJ, Futrell N, Welch KMA. Cerebrovascular and neurologic disease associated with antiphospholipid antibodi- es: 48 cases. Neurology 1990;40:1181-1189.
- Tanne D, Hassin-Baer S. Neurologic manifestations of the antip- hospholipid syndrome. Curr Rheumatol Rep 2001;3:286-292.
- Headache Classification Committee of the International Headac- he Society. The international classification of headache disorders, nd ed. Cephalalgia 2004;24:1-160.
- Loizou S, McCrea JD, Rudge AC, Reynolds R, Boyle CC, Haris EN. Measurement of anti-cardiolipin antibodies by an enzyme- linked immunosorbent assay (ELISA): standardization and quan- titation of results. Clin Exp Immunol 1985; 62: 738-745.
- Angelini L, Zibordi F, Zorzi G, Nardocci N, Caporali R, Ravelli A, Martini A. Neurological disorders, other than stroke, associated with antiphospholipid antibodies in childhood. Neuropediatrics ;27:149-153. Asherson RA, Cervera R. Antiphospholipid syndrome. J Invest Dermatol 1993;100:21-27.
- Hering R, Couturier EG, Asherson RA, Steiner TJ. Anticardiolipin antibodies in cluster headache. Cephalalgia. 1991;11:101-102.
Details
| Other ID | JA59CB95BY |
|---|---|
| Journal Section | Research Article |
| Authors | |
| Publication Date | June 1, 2009 |
| Submission Date | June 1, 2009 |
| Published in Issue | Year 2009 Volume: 3 Issue: 3 |
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