Abstract
Objective: Iron containing drugs are one of the most commonly prescribed drugs in our country and accidental or
suicidal poisoning continues to be an important pediatric emergency. Our aim was to evaluate the clinical, laboratory,
radiologic findings, and treatment approaches of children hospitalized with acute iron poisoning.
Material and Methods: The clinical, laboratory, and radiologic findings of and treatment approaches for 17 patients
aged 14 months-15 years hospitalized with acute iron poisoning were reviewed.
Results: The mean age was 37±35.2 months. Iron poisoning was accidental in 16 patients. The mean duration
between drug intake and hospital admission was 177±149 minutes. The mean ingested amount of iron was 35.4±19
mg/kg. The mean blood iron level was 232±136 mcg/dl. There was no significant relationship between the reported
dose of ingested iron and the blood iron level (p>0.05). There was no significant relationship between blood iron level
and ingestion time (p>0.05). Laboratory results revealed metabolic acidosis in 3 patients, respiratory acidosis in one
patient, leucocytosis in one patient, and prolonged activated partial thromboplastin time in one patient. The patients’
findings were not consistent with blood iron levels. Whole bowel irrigation and IV deferoxamine were used in 3 patients.
There was no death. The mean hospitalization duration was 2.8±1.1 days.
Conclusion: Accidental iron poisoning continues to be an important pediatric emergency. There are no correlations
between blood iron levels and the amount of ingested iron or the ingestion time. There was also no correlation between
the blood iron levels and the clinical, laboratory and radiographic findings in our study.
References
- 1. Jayashree M, Singhi S. Changing trends and predictors of outcome in patients with acute poisoning admitted to the intensive care. J Trop Pediatr 2011;57:340-6.
- 2. Smolinske SC, Kaufman MM. Consumer perception of household hazardous materials. Clin Toxicol 2007;45:522-5.
- 3. Chang TP, Rangan C. Iron poisoning: A literature-based review of epidemiology, diagnosis, and management. Pediatr Emerg Care 2011;27:978-85.
- 4. Baranwal AK, Singhi SC. Acute iron poisoning: Management guidelines. Indian Pediatr. 2003;40:534-40.
- 5. Madiwale T, Liebelt E. Iron: Not a benign therapeutic drug. Curr Opin Pediatr 2006;18:174-9.
- 6. Skoczynska A, Kwiecinska D, Kielbinski M, Lukaszewski M. Acute iron poisoning in adult female. Hum Exp Toxicol 2007;26:663-6.
- 7. Porter JB. Concepts and goals in the management of transfusional iron overload. Am J Hematol 2007;82:1136-9.
- 8. Sipahi T, Karakurt C, Bakirtas A, Tavil B. Acute iron ingestion. Indian J Pediatr 2002;69:947-9.
- 9. Phillips S, Gomez H, Brent J. Pediatric gastrointestinal decontamination in acute toxin ingestion. J Clin Pharmacol 1993;33:497-507.
- 10. Carlsson M, Cortes D, Jepsen S, Kanstrup T. Severe iron intoxication treated with exchange transfusion. Arch Dis Child 2008;93:321-2.
- 11. Sankar J, Shukla A, Khurana R, Dubey N. Near fatal iron intoxication managed conservatively. BMJ Case Rep 2013; doi:10.1136/bcr- 2012-007670.
- 12. Gumber MR, Kute VB, Shah PR, Vanikar AV, Patel HV, Balwani MR, et al. Successful treatment of severe iron intoxication with gastrointestinal decontamination, deferoxamine, and hemodialysis. Renal failure 2013;35:729-31.
Abstract
References
- 1. Jayashree M, Singhi S. Changing trends and predictors of outcome in patients with acute poisoning admitted to the intensive care. J Trop Pediatr 2011;57:340-6.
- 2. Smolinske SC, Kaufman MM. Consumer perception of household hazardous materials. Clin Toxicol 2007;45:522-5.
- 3. Chang TP, Rangan C. Iron poisoning: A literature-based review of epidemiology, diagnosis, and management. Pediatr Emerg Care 2011;27:978-85.
- 4. Baranwal AK, Singhi SC. Acute iron poisoning: Management guidelines. Indian Pediatr. 2003;40:534-40.
- 5. Madiwale T, Liebelt E. Iron: Not a benign therapeutic drug. Curr Opin Pediatr 2006;18:174-9.
- 6. Skoczynska A, Kwiecinska D, Kielbinski M, Lukaszewski M. Acute iron poisoning in adult female. Hum Exp Toxicol 2007;26:663-6.
- 7. Porter JB. Concepts and goals in the management of transfusional iron overload. Am J Hematol 2007;82:1136-9.
- 8. Sipahi T, Karakurt C, Bakirtas A, Tavil B. Acute iron ingestion. Indian J Pediatr 2002;69:947-9.
- 9. Phillips S, Gomez H, Brent J. Pediatric gastrointestinal decontamination in acute toxin ingestion. J Clin Pharmacol 1993;33:497-507.
- 10. Carlsson M, Cortes D, Jepsen S, Kanstrup T. Severe iron intoxication treated with exchange transfusion. Arch Dis Child 2008;93:321-2.
- 11. Sankar J, Shukla A, Khurana R, Dubey N. Near fatal iron intoxication managed conservatively. BMJ Case Rep 2013; doi:10.1136/bcr- 2012-007670.
- 12. Gumber MR, Kute VB, Shah PR, Vanikar AV, Patel HV, Balwani MR, et al. Successful treatment of severe iron intoxication with gastrointestinal decontamination, deferoxamine, and hemodialysis. Renal failure 2013;35:729-31.
Details
| Primary Language | English |
|---|---|
| Subjects | Internal Diseases |
| Journal Section | ORIGINAL ARTICLES |
| Authors | |
| Publication Date | December 30, 2018 |
| Submission Date | September 18, 2017 |
| Published in Issue | Year 2018 Volume: 12 Issue: 4 |
The publication language of Turkish Journal of Pediatric Disease is English.
Manuscripts submitted to the Turkish Journal of Pediatric Disease will go through a double-blind peer-review process. Each submission will be reviewed by at least two external, independent peer reviewers who are experts in the field, in order to ensure an unbiased evaluation process. The editorial board will invite an external and independent editor to manage the evaluation processes of manuscripts submitted by editors or by the editorial board members of the journal. The Editor in Chief is the final authority in the decision-making process for all submissions. Articles accepted for publication in the Turkish Journal of Pediatrics are put in the order of publication, with at least 10 original articles in each issue, taking into account the acceptance dates. If the articles sent to the reviewers for evaluation are assessed as a senior for publication by the reviewers, the section editor and the editor considering all aspects (originality, high scientific quality and citation potential), it receives publication priority in addition to the articles assigned for the next issue.
The aim of the Turkish Journal of Pediatrics is to publish high-quality original research articles that will contribute to the international literature in the field of general pediatric health and diseases and its sub-branches. It also publishes editorial opinions, letters to the editor, reviews, case reports, book reviews, comments on previously published articles, meeting and conference proceedings, announcements, and biography. In addition to the field of child health and diseases, the journal also includes articles prepared in fields such as surgery, dentistry, public health, nutrition and dietetics, social services, human genetics, basic sciences, psychology, psychiatry, educational sciences, sociology and nursing, provided that they are related to this field. can be published.