Case Report
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Cutaneous Ulceration Associated with Subcutaneous Interferon Beta 1a Injection

Year 2018, Volume: 12 Issue: 4, 280 - 282, 30.12.2018
https://doi.org/10.12956/tjpd.2018.336

Abstract

Subcutaneous interferon beta 1a (IFN β 1a) has been shown to reduce relapse rates in patients with relapsing-remitting


multiple sclerosis. We report the occurrence of severe necrotizing cutaneous reactions in a 19-year-old girl. She self


injected IFN β 1a three times a week on the abdomen and both thighs. Treatment was initially well tolerated, but she


described erythematous patches and local pain at the injection sites recently. The areas on the abdomen became


violaceous with necrotic ulcers. Her therapy was changed to 0.5 mg fingolimod. The lesions began to improve and


cicatrize after several weeks with postinflammatory hyperpigmentation. Early recognition of severe local adverse


reactions and correction of the injection technique is important.

References

  • 1. PRISMS (Prevention of Relapses and Disability by Interferon betala Subcutaneously in Multiple sclerosis) Study Group. Randomized double-blind placebo-controlled study of interferon beta-la in relapsing-remitting multiple sclerosis. Lancet 1998;352:1498-504.
  • 2. Elgart GW, Sheremata W, Ahn YS. Cutaneous reactions to recombinant human interferon beta 1b: The clinical and histologic spectrum. J Am Acad Dermatol 1997;37:5538.
  • 3. Lebrun C, Bertagna M, Cohen M. Cutanous side effects of immunomodulators in MS. Int MS J 2011;17:88-94.
  • 4. Beer K, Müller M, Hew-Winzeler AM, Bont A, Maire P, You X, et al. The prevalence of injection-site reactions with disease-modifying therapies and their effect on adherence in patients with multiple sclerosis: An observational study. BMC Neurol 2011;11:144.
  • 5. Sheremata WA, Taylor JR, Elgart GW. Severe necrotizing cutaneous lesions complicating treatment with interferon beta-1b. N Engl J Med 1995;332:1584.
Year 2018, Volume: 12 Issue: 4, 280 - 282, 30.12.2018
https://doi.org/10.12956/tjpd.2018.336

Abstract

References

  • 1. PRISMS (Prevention of Relapses and Disability by Interferon betala Subcutaneously in Multiple sclerosis) Study Group. Randomized double-blind placebo-controlled study of interferon beta-la in relapsing-remitting multiple sclerosis. Lancet 1998;352:1498-504.
  • 2. Elgart GW, Sheremata W, Ahn YS. Cutaneous reactions to recombinant human interferon beta 1b: The clinical and histologic spectrum. J Am Acad Dermatol 1997;37:5538.
  • 3. Lebrun C, Bertagna M, Cohen M. Cutanous side effects of immunomodulators in MS. Int MS J 2011;17:88-94.
  • 4. Beer K, Müller M, Hew-Winzeler AM, Bont A, Maire P, You X, et al. The prevalence of injection-site reactions with disease-modifying therapies and their effect on adherence in patients with multiple sclerosis: An observational study. BMC Neurol 2011;11:144.
  • 5. Sheremata WA, Taylor JR, Elgart GW. Severe necrotizing cutaneous lesions complicating treatment with interferon beta-1b. N Engl J Med 1995;332:1584.
There are 5 citations in total.

Details

Primary Language English
Subjects ​Internal Diseases
Journal Section Case Report
Authors

Gökçen Öz Tunçer

Publication Date December 30, 2018
Submission Date October 6, 2017
Published in Issue Year 2018 Volume: 12 Issue: 4

Cite

Vancouver Öz Tunçer G. Cutaneous Ulceration Associated with Subcutaneous Interferon Beta 1a Injection. Türkiye Çocuk Hast Derg. 2018;12(4):280-2.


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