Research Article
BibTex RIS Cite

Çok Düşük Doğum Ağırlıklı Prematüre İnfantlarda Tiroid Fonksiyonlarının Değerlendirilmesi

Year 2019, Volume: 13 Issue: 3, 165 - 170, 24.05.2019
https://doi.org/10.12956/tjpd.2018.360

Abstract

Amaç: Konjenital hipotiroidizm (KH) dünya çapında zihinsel engelliğin önlenebilir ve önde gelen nedenidir. Konjenital
hipotiroidi prevalansı yaklaşık 1/3000’dir. Hipotiroidi, özellikle hasta olanlarda olmak üzere prematürelerde term bebeklere
göre daha sıktır. Çalışmamızda çok düşük doğum ağırlıklı (ÇDDA; <1500g) olan hastalarda KH sıklığını saptamayı
amaçladık.
Gereç ve Yöntemler: Çalışma 52 aylık dönem boyunca yatan ÇDDA bebeklerin tıbbi kayıtlarının retrospektif olarak
değerlendirilmesi neticesinde gerçekleştirildi. İlk yatıştan sonra 5 günden uzun yaşayan hastaların tiroid fonksiyon testleri
(TFT), [serbest tiroksin (sT4), tiroid stimülan hormon (TSH)] kayıt edildi. Anormal sonucu olan hastaların kontrol TFT sonuçlarına
göre hastalar alt gruplara ayrıldı. KH grubuna tiroid hormon takviyesi yapıldı.
Bulgular: Çalışmaya 5. günde alınan TFT sonucu elde edilebilen 581 hasta dahil edildi. Yetmişdokuz hastadan alınan
ilk TFT anormal, ikinci kontrolde 26 hastanın TFT değerleri anormal olması nedeniyle KH tanısı konularak tiroid hormon
takviyesi verildi. Çok düşük doğum ağırlıklı yenidoğanlarda KH oranı %4.4 (1/23) olarak tespit edildi. Ayrıca KH olan
hastaların gebelik haftaları, doğum ağırlığı anlamlı olarak daha düşük (sırasıyla p<0,00, p=0,037), kız cinsiyet oranı daha
yüksek (p=0.017) bulunmuştur.
Sonuç: Konjenital hipotiroidi oranı ÇDDA prematürelerde daha düşük gebelik haftası ve doğum ağırlığı ile kız cinsiyette
yüksek bulunmuştur. Prematürelerde tiroid fonksiyon bozukluğu yaygın olarak izlenmektedir. Özellikle prematürelerde
nörogelişimsel sonuçlar düşünüldüğünde tiroid fonksiyon testlerinin tekrarı KH’yi tespit etme açısından önemlidir.

References

  • 1. LaFranchi S. Thyroid function in the preterm infant. Thyroid 1999;9:71-8.
  • 2. Lee JH, Kim SW, Jeon GW, Sin JB. Thyroid dysfunction in very low birth weight preterm infants. Korean J Pediatr 2015;58:224-9.
  • 3. Torkaman M, Ghasemi F, Amirsalari S, Abyazi M, Afsharpaiman S, Kavehmanesh Z, et al. Thyroid Function Test in pre-term neonates during the first five weeks of life. Int J Prev Med 2013;4:1271-6.
  • 4. Hashemipour M, Hovsepian S, Ansari A, Keikha M, Khalighinejad P, Niknam N. Screening of congenital hypothyroidism in preterm, low birth weight and very low birth weight neonates: A systematic review. Pediatr Neonatol 2018; 59:3-14.
  • 5. Wassner AJ, Brown RS. Congenital hypothyroidism: Recent advances. Curr Opin Endocrinol Diabetes Obes 2015;22:407-12.
  • 6. Vigone MC, Caiulo S, Di Frenna M, Ghirardello S, Corbetta C, Mosca F, et al. Evolution of thyroid function in preterm infants detected by screening for congenital hypothyroidism. J Pediatr 2014;164:1296-302.
  • 7. Chung ML, Yoo HW, Kim KS, Lee BS, Pi SY, Lim G, et al. Thyroid dysfunctions of prematurity and their impacts on neurodevelopmental outcome. J Pediatr Endocrinol Metab 2013;26:449-55.
  • 8. American Academy of Pediatrics; Rose SR; Section on Endocrinology and Committee on Genetics, American Thyroid Association; Brown RS; Public Health Committee, et al. Update of newborn screening and therapy for congenital hypothyroidism. Pediatrics 2006;117:2290-303.
  • 9. Guy VV, Johnny D. Disorders of the thyroid in the newborn and infant. In: Sperling MA (ed). Pediatric Endocrinology. 4th ed. Philadelphia (PA): Saunders, 2014:186-208.
  • 10. Chiesa A, Prieto L, Mendez V, Papendieck P, Calcagno Mde L, Gruñeiro-Papendieck L. Prevalence and etiology of congenital hypothyroidism detected through an argentine neonatal screening program (1997-2010). Horm Res Paediatr 2013;80:185-92.
  • 11. Olivieri A, Fazzini C, Medda E; Italian Study Group for Congenital Hypothyroidism. Multiple factors influencing the incidence of congenital hypothyroidism detected by neonatal screening. Horm Res Paediatr 2015; 83:86–93.
  • 12. Yordam N, Calikoglu AS, Hatun S, Kandemir N, Oguz H, Tezic T, et al. Screening for congenital hypothyroidism in Turkey. Eur J Pediatr 1995;154:614-6.
  • 13. Turkmen S, Vahapoglu A, Doğan N, Can UG. Congenital hypothyroidism. Turk J Biochem 2012; 37:366.
  • 14. Larson C, Hermos R, Delaney A, Daley D, Mitchell M. Risk factors associated with delayed thyrotropin elevations in congenital hypothyroidism. J Pediatr 2003;143:587-91.
  • 15. Mitchell ML, Hsu HW, Sahai I. The increased incidence of congenital hypothyroidism: fact or fancy? Clin Endocrinol (Oxf) 2011;75:806– 10.
  • 16. Deladoey J, Ruel J, Giguere Y, Van Vliet G. Is the incidence of congenital hypothyroidism really increasing? A 20-year retrospective population-based study in Quebec. J Clin Endocrinol Metab 2011; 96:2422–9.
  • 17. Phelps DL, ET-ROP Cooperative Group. The early treatment for retinopathy of prematurity study: Better outcomes, changing strategy. Pediatrics 2004;114:490-1.
  • 18. Kapelari K, Kirchlechner C, Hogler W, Schweitzer K, Virgolini I, Moncayo R. Pediatric reference intervals for thyroid hormone levels from birth to adulthood: A retrospective study. BMC Endocr Disord 2008;8:15.
  • 19. Hatipoglu N, Buyukkayhan D, Kurtoglu S. Yenidogan dönemi tiroid hastalıkları. Turkiye Klinikleri J Pediatr Sci 2006;2:63-82.
  • 20. Woo HC, Lizarda A, Tucker R, Mitchell ML, Vohr B, Oh W, et al. Congenital hypothyroidism with a delayed thyroid-stimulating hormone elevation in very premature infants: incidence and growth and developmental outcomes. J Pediatr 2011;158:538-42.

Evaluation of Thyroid Functions in Very Low Birth Weight Preterm Infants

Year 2019, Volume: 13 Issue: 3, 165 - 170, 24.05.2019
https://doi.org/10.12956/tjpd.2018.360

Abstract

References

  • 1. LaFranchi S. Thyroid function in the preterm infant. Thyroid 1999;9:71-8.
  • 2. Lee JH, Kim SW, Jeon GW, Sin JB. Thyroid dysfunction in very low birth weight preterm infants. Korean J Pediatr 2015;58:224-9.
  • 3. Torkaman M, Ghasemi F, Amirsalari S, Abyazi M, Afsharpaiman S, Kavehmanesh Z, et al. Thyroid Function Test in pre-term neonates during the first five weeks of life. Int J Prev Med 2013;4:1271-6.
  • 4. Hashemipour M, Hovsepian S, Ansari A, Keikha M, Khalighinejad P, Niknam N. Screening of congenital hypothyroidism in preterm, low birth weight and very low birth weight neonates: A systematic review. Pediatr Neonatol 2018; 59:3-14.
  • 5. Wassner AJ, Brown RS. Congenital hypothyroidism: Recent advances. Curr Opin Endocrinol Diabetes Obes 2015;22:407-12.
  • 6. Vigone MC, Caiulo S, Di Frenna M, Ghirardello S, Corbetta C, Mosca F, et al. Evolution of thyroid function in preterm infants detected by screening for congenital hypothyroidism. J Pediatr 2014;164:1296-302.
  • 7. Chung ML, Yoo HW, Kim KS, Lee BS, Pi SY, Lim G, et al. Thyroid dysfunctions of prematurity and their impacts on neurodevelopmental outcome. J Pediatr Endocrinol Metab 2013;26:449-55.
  • 8. American Academy of Pediatrics; Rose SR; Section on Endocrinology and Committee on Genetics, American Thyroid Association; Brown RS; Public Health Committee, et al. Update of newborn screening and therapy for congenital hypothyroidism. Pediatrics 2006;117:2290-303.
  • 9. Guy VV, Johnny D. Disorders of the thyroid in the newborn and infant. In: Sperling MA (ed). Pediatric Endocrinology. 4th ed. Philadelphia (PA): Saunders, 2014:186-208.
  • 10. Chiesa A, Prieto L, Mendez V, Papendieck P, Calcagno Mde L, Gruñeiro-Papendieck L. Prevalence and etiology of congenital hypothyroidism detected through an argentine neonatal screening program (1997-2010). Horm Res Paediatr 2013;80:185-92.
  • 11. Olivieri A, Fazzini C, Medda E; Italian Study Group for Congenital Hypothyroidism. Multiple factors influencing the incidence of congenital hypothyroidism detected by neonatal screening. Horm Res Paediatr 2015; 83:86–93.
  • 12. Yordam N, Calikoglu AS, Hatun S, Kandemir N, Oguz H, Tezic T, et al. Screening for congenital hypothyroidism in Turkey. Eur J Pediatr 1995;154:614-6.
  • 13. Turkmen S, Vahapoglu A, Doğan N, Can UG. Congenital hypothyroidism. Turk J Biochem 2012; 37:366.
  • 14. Larson C, Hermos R, Delaney A, Daley D, Mitchell M. Risk factors associated with delayed thyrotropin elevations in congenital hypothyroidism. J Pediatr 2003;143:587-91.
  • 15. Mitchell ML, Hsu HW, Sahai I. The increased incidence of congenital hypothyroidism: fact or fancy? Clin Endocrinol (Oxf) 2011;75:806– 10.
  • 16. Deladoey J, Ruel J, Giguere Y, Van Vliet G. Is the incidence of congenital hypothyroidism really increasing? A 20-year retrospective population-based study in Quebec. J Clin Endocrinol Metab 2011; 96:2422–9.
  • 17. Phelps DL, ET-ROP Cooperative Group. The early treatment for retinopathy of prematurity study: Better outcomes, changing strategy. Pediatrics 2004;114:490-1.
  • 18. Kapelari K, Kirchlechner C, Hogler W, Schweitzer K, Virgolini I, Moncayo R. Pediatric reference intervals for thyroid hormone levels from birth to adulthood: A retrospective study. BMC Endocr Disord 2008;8:15.
  • 19. Hatipoglu N, Buyukkayhan D, Kurtoglu S. Yenidogan dönemi tiroid hastalıkları. Turkiye Klinikleri J Pediatr Sci 2006;2:63-82.
  • 20. Woo HC, Lizarda A, Tucker R, Mitchell ML, Vohr B, Oh W, et al. Congenital hypothyroidism with a delayed thyroid-stimulating hormone elevation in very premature infants: incidence and growth and developmental outcomes. J Pediatr 2011;158:538-42.
There are 20 citations in total.

Details

Primary Language Turkish
Subjects ​Internal Diseases
Journal Section ORIGINAL ARTICLES
Authors

Ufuk Çakır

Publication Date May 24, 2019
Submission Date January 5, 2018
Published in Issue Year 2019 Volume: 13 Issue: 3

Cite

Vancouver Çakır U. Çok Düşük Doğum Ağırlıklı Prematüre İnfantlarda Tiroid Fonksiyonlarının Değerlendirilmesi. Türkiye Çocuk Hast Derg. 2019;13(3):165-70.


The publication language of Turkish Journal of Pediatric Disease is English.


Manuscripts submitted to the Turkish Journal of Pediatric Disease will go through a double-blind peer-review process. Each submission will be reviewed by at least two external, independent peer reviewers who are experts in the field, in order to ensure an unbiased evaluation process. The editorial board will invite an external and independent editor to manage the evaluation processes of manuscripts submitted by editors or by the editorial board members of the journal. The Editor in Chief is the final authority in the decision-making process for all submissions. Articles accepted for publication in the Turkish Journal of Pediatrics are put in the order of publication, with at least 10 original articles in each issue, taking into account the acceptance dates. If the articles sent to the reviewers for evaluation are assessed as a senior for publication by the reviewers, the section editor and the editor considering all aspects (originality, high scientific quality and citation potential), it receives publication priority in addition to the articles assigned for the next issue.


The aim of the Turkish Journal of Pediatrics is to publish high-quality original research articles that will contribute to the international literature in the field of general pediatric health and diseases and its sub-branches. It also publishes editorial opinions, letters to the editor, reviews, case reports, book reviews, comments on previously published articles, meeting and conference proceedings, announcements, and biography. In addition to the field of child health and diseases, the journal also includes articles prepared in fields such as surgery, dentistry, public health, nutrition and dietetics, social services, human genetics, basic sciences, psychology, psychiatry, educational sciences, sociology and nursing, provided that they are related to this field. can be published.