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Toplum Kökenli Çocukluk Çağı Pnömoni Olgularımızda Mycoplasma pneumoniae ve Chlamydia pneumoniae’nın Seropozitiflik Oranları

Year 2019, Volume: 13 Issue: 6, 406 - 412, 23.12.2019

Eda Mengen

https://doi.org/10.12956/tjpd.2018.377

Abstract



Amaç: Çalışma ile toplum kökenli çocukluk çağı pnömoni olgularımızda Mycoplasma pneumoniae ve Chlamydia pneumoniae’nın seropozitiflik oranlarını saptamayı amaçladık. 


Gereç ve Yöntemler: Çalışmamıza, Adana Numune Eğitim ve Araştırma Hastanesi Çocuk Polikliniğine; önceden sağlıklı, başvurudan 48 saat öncesine kadar antibiyotik kullanmayan ve solunum sistemi enfeksiyonları şikayetleri ile başvuran, Toplum Kökenli Pnömoni tanısı alarak kliniğimize yatırılan, yaşları 3 ay-15 yaş arasında değişen 150 çocuk alındı. Başvuru anında vital bulguları, boy ve kilo persentil değerleri alındı ve ayrıntılı fizik muayene bulguları kaydedildi. Yatan tüm hastalardan başvuru anında rutin testler için alınan kanlardan arta kalan yaklaşık 3μl’lik kısımda; Mycoplasma pneumoniae ve Chlamydia pneumoniae serolojileri mikro Enzyme Linked İmmünosorbent Assay yöntemi ile çalışıldı. Tüm hastalara yatış anında posterior-anterior akciğer grafisi çekildi. 


Bulgular: Çalışmamızdaki çocukluk çağı Toplum Kökenli Pnömoni olgularımızda Mycoplasma pneumoniae IgM pozitifliğini; %9.3, yaş ortalamasını; 78.71 ay, Chlamydia pneumoniae IgM pozitifliğini; % 2, yaş ortalamasını ise 21.66 ay olarak saptadık. Mycoplasma pneumoniae IgM pozitifliği yaş artışı ile pozitif korelasyon gösteriyordu. 


Sonuç: Pnömoniler hastaneye yatış nedenleri içerisinde yüksek bir orana sahiptir. Toplum Kökenli Pnömoni olgularımız içerisinde Mycoplasma pneumoniae ve Chlamydia pneumoniae seropozitif olgu oranı literatür verileri ile uyumlu olduğu saptanmıştır. Toplum Kökenli Pnömoni’li hastalarda atipik etkenlerin önemli oranda sorumlu olabileceği düşünüldü. Atipik pnömoniden şüphelenilen durumlarda uygun tetkikler alınıp makrolid başlanmalıdır. İleri tanı yöntemlerinin günlük kullanıma geçmesi hastalığın tanınması ve tedavisi konusunda önemli bir yer tutmaktadır. 

Keywords

Mycoplasma pneumoniae Chlamydia pneumoniae Öksürük Pnömoni

References

  • 1. Güler N, Kılıç G. Alt solunum yolları ve hastalıkları. Neyzi O, Ertuğrul T (ed). Pediyatri. 4. baskı, İstanbul: Nobel Tıp Kitapevleri Ltd Şti, 2010:1087-97.
  • 2. Henrickson KJ. Viral pneumonia in children. Sem Pediatr Infect Dis J 1998;9:217-33.
  • 3. World Health Organization 2016. Pneumonia. http://www.who.int/ news-room/fact-sheets/detail/pneumonia.
  • 4. Kocabaş E, Doğru ED, Karakoç F ve ark. Türk Toraks Derneği çocuklarda toplumda gelişen pnömoni tanı ve tedavi uzlaşı raporu 2009. Türk Toraks Dergisi 2009;10:3-24.
  • 5. Powell DA. Mycoplasma infections. In: Behrman RE, Kliegman RM, Jenson HB (eds). Nelson Textbook of Pediatrics. 18 th ed. Philadelphia: WB Saunders Company, 2007:1278-81.
  • 6. Tezer H, Kara A, Çiftçi E. Mycoplasma pneumoniae ve diğer mikoplazma enfeksiyonları. Red Book. 29. baskı, Ankara: Pelikan Kitap Evi Ltd Şti, 2015:518-20.
  • 7. File TM. Community-acquired pneumonia. Lancet 2003;362:1991- 2001.
  • 8. Boyer KM. Nonbacteria pneumonia. In: Feigin RD, James D (eds). Textbook of Pediatric Infectious Diseases. 4th ed., Philadelphia:WB Saunders, 1998:260-64.
  • 9. Selwyn BJ. The epidemiology of acute respiratory tract infection in young children: Comparison of findings from several developing countries. Coordinated Data Group of BOSTID Researchers. Rev Infect Dis 1990;12 Suppl 8:S870-88.
  • 10. Numazaki K, Chiba S, Umetsu M, Tanaka T, Yoshimura H, Kuniya Y, et al. Etiological agents of lower respiratory tract infections in Japanese children. In Vivo 2004;18:67-71.
  • 11. Virkki R, Juven T, Rikalainen H, Svedström E, Mertsola J, Ruuskanen O. Differentiation of bacterial and viral pneumonia in children. Thorax 2002;57:438-41.
  • 12. Somer A, Salman N, Yalçın I, Ağaçfidan A. Role of Mycoplasma pneumonia and Chlamydia pneumoniae in children with community-acquired pneumonia in Istanbul, Turkey. J Trop Pediatr 2006;52:173-8.
  • 13. Lochindarat S, Suwanjutha S, Prapphal N, Chantarojanasiri T, Bunnag T, Deerojanawong J et al. Mycoplasma pneumonia and Chlamydia pneumoniae in children with community-acquired pneumonia in Thailand. Int J Tuberc Lung Dis 2007;11:814-19.
  • 14. Sidal M, Kilic A, Unuvar E, Oguz F, Onel M, Agacfidan A et al. Frequency of chlamydia pneumoniae and mycoplasma pneumonia Infections in children. J Trop Pediatr 2007;53:225-31.
  • 15. Grayston JT, Campbell LA, Kuo CC, Mordhorst CH, Saikku P, Thom DH et al. A nev respiratory tract pathogen: Chlamydia pneumoniae strain TWAR. J Infect Dis 1990;161:618-25.1
  • 6. Esposito S, Balsi F, Bellini F, Allegra L, Principi N; Mowgli Study Group. Mycoplasma pneumonia and Chlamydia pneumoniae infections in children with pneumonia. Eur Respir J 2001;17:241-5.
  • 17. Somer A. Mikoplazma enfeksiyonları. İçinde: Neyzi O, Ertuğrul T (ed). Pediyatri. 4. Baskı. İstanbul: Nobel Tıp Kitapevleri Ltd Şti, 2010:669-71.
  • 18. Courtoy I, Lande AE, Turner RB. Accuracy of radigraphic differentiation of bacterial from nonbacterial pneumonia. Clin Pediatr 1989; 28:261-4.
  • 19. McCarthy PL, Spiesel SZ, Stashwick CA, Ablow RC, Masters SJ, Dolan TF Jr. Radiographic findings and etiologic diagnosis in ambulatory childhood pneumonias. Clin Pediatr 1981;20:686-91.
  • 20. British Thoracic Society Standards of Care Committee. British Thoracic Society guidelines for the management of community acquired pneumonia in childhood. Thorax 2002; 57(suppl 1):1-24.
  • 21. Hazir T, Nisar YB, Qazi SA, Khan SF, Raza M, Zameer S et al. Chest radiography in children aged 2-59 months diagnosed with non-severe pneumonia as defined by World Health Organizations: Descriptive multicenter study in Pakistan. BMJ 2006;10:1136-7.
  • 22. Korppi M. Community-Acquired Pneumonia in Children. Pediatr Drugs 2003;5:821-32.
  • 23. Shenoy VD, Upadhyaya SA, Rao SP, Shobha KL. Mycoplasma pneumonia infections in children with acute respiratory infections. J Trop Pediatr 2005; 38:157-60.
  • 24. Defilippi A, Silvestri M, Tacchella A, Giacchino R, Melioli G, Di Marco E, et al. Epidemiology and clinical features of Mycoplasma pneumonia infections in children. Respir Med 2008;102:1762-68.
  • 25. Drummond P, Clark J, Wheeler J, Galloway A, Freeman R, Cant A. Community acquired pneumonia-a prospective UK study. Arch Dis Child 2000; 83:408-12.
  • 26. Youn YS, Lee KY, Hwang JY, Rhim JW, Kang JH, Lee JS, et al. Difference of clinical features in childhood Mycoplasma pneumonia. BMC Pediatrics, 2010;10:48.
  • 27. Bulaşıcı Hastalıkların Laboratuvar Tanısı için Saha Rehberi. Mycoplasma pneumoniae Pnömonisi. ICD-10 J15.7.
  • 28. Waris M, Toikka P, Saarinen T, Nikkari S, Meurman O, Vainionpää R,et al. Diagnosis of Mycoplasma pneumoniae in children. J Clin Microbiol 1998; 36:3155-9.
  • 29. Uldum SA, Jensen JS, Sondergard-Andersen J, Lind K. Enzyme immunoassay for detection of immunoglobulin M (IgM) and IgG antibodies to Mycoplasma pneumoniae. J Clin Microbiol 1992;30:1198-204.
  • 30. Saggev JS, Lis I, Siman-Tov R, Gutman R, Abu-Samara H, Schey G, et al. Mycoplasma pneumoniae is a frequent cause of exacerbation of bronchial asthma in adults. Ann Allergy 1986; 57:263-5.
  • 31. Bloc S, Hedrick J, Hammerschlag MR, Cassell GH, Craft JC. Mycoplasma pneumonia and Chlamydia pneumoniae in pediatric community-acquired pneumonia: Comparative efficacy and safety of clarithromycin vs. erytromycin ethylsuccinate. Pediatr Infect Dis J 1995;14:471-7.
  • 32. Numazaki K, Sakamato Y, Umetsu M, Agatsuma Y, Yamanaka T, Kogasaka R et al. Therapeutic effect of clarithromycin for respiratory tract infections in children caused by Chlamydia pneumonia. Int J Antimicrob Agents 2000;13:219-22.

Year 2019, Volume: 13 Issue: 6, 406 - 412, 23.12.2019

Eda Mengen

https://doi.org/10.12956/tjpd.2018.377

Abstract

References

  • 1. Güler N, Kılıç G. Alt solunum yolları ve hastalıkları. Neyzi O, Ertuğrul T (ed). Pediyatri. 4. baskı, İstanbul: Nobel Tıp Kitapevleri Ltd Şti, 2010:1087-97.
  • 2. Henrickson KJ. Viral pneumonia in children. Sem Pediatr Infect Dis J 1998;9:217-33.
  • 3. World Health Organization 2016. Pneumonia. http://www.who.int/ news-room/fact-sheets/detail/pneumonia.
  • 4. Kocabaş E, Doğru ED, Karakoç F ve ark. Türk Toraks Derneği çocuklarda toplumda gelişen pnömoni tanı ve tedavi uzlaşı raporu 2009. Türk Toraks Dergisi 2009;10:3-24.
  • 5. Powell DA. Mycoplasma infections. In: Behrman RE, Kliegman RM, Jenson HB (eds). Nelson Textbook of Pediatrics. 18 th ed. Philadelphia: WB Saunders Company, 2007:1278-81.
  • 6. Tezer H, Kara A, Çiftçi E. Mycoplasma pneumoniae ve diğer mikoplazma enfeksiyonları. Red Book. 29. baskı, Ankara: Pelikan Kitap Evi Ltd Şti, 2015:518-20.
  • 7. File TM. Community-acquired pneumonia. Lancet 2003;362:1991- 2001.
  • 8. Boyer KM. Nonbacteria pneumonia. In: Feigin RD, James D (eds). Textbook of Pediatric Infectious Diseases. 4th ed., Philadelphia:WB Saunders, 1998:260-64.
  • 9. Selwyn BJ. The epidemiology of acute respiratory tract infection in young children: Comparison of findings from several developing countries. Coordinated Data Group of BOSTID Researchers. Rev Infect Dis 1990;12 Suppl 8:S870-88.
  • 10. Numazaki K, Chiba S, Umetsu M, Tanaka T, Yoshimura H, Kuniya Y, et al. Etiological agents of lower respiratory tract infections in Japanese children. In Vivo 2004;18:67-71.
  • 11. Virkki R, Juven T, Rikalainen H, Svedström E, Mertsola J, Ruuskanen O. Differentiation of bacterial and viral pneumonia in children. Thorax 2002;57:438-41.
  • 12. Somer A, Salman N, Yalçın I, Ağaçfidan A. Role of Mycoplasma pneumonia and Chlamydia pneumoniae in children with community-acquired pneumonia in Istanbul, Turkey. J Trop Pediatr 2006;52:173-8.
  • 13. Lochindarat S, Suwanjutha S, Prapphal N, Chantarojanasiri T, Bunnag T, Deerojanawong J et al. Mycoplasma pneumonia and Chlamydia pneumoniae in children with community-acquired pneumonia in Thailand. Int J Tuberc Lung Dis 2007;11:814-19.
  • 14. Sidal M, Kilic A, Unuvar E, Oguz F, Onel M, Agacfidan A et al. Frequency of chlamydia pneumoniae and mycoplasma pneumonia Infections in children. J Trop Pediatr 2007;53:225-31.
  • 15. Grayston JT, Campbell LA, Kuo CC, Mordhorst CH, Saikku P, Thom DH et al. A nev respiratory tract pathogen: Chlamydia pneumoniae strain TWAR. J Infect Dis 1990;161:618-25.1
  • 6. Esposito S, Balsi F, Bellini F, Allegra L, Principi N; Mowgli Study Group. Mycoplasma pneumonia and Chlamydia pneumoniae infections in children with pneumonia. Eur Respir J 2001;17:241-5.
  • 17. Somer A. Mikoplazma enfeksiyonları. İçinde: Neyzi O, Ertuğrul T (ed). Pediyatri. 4. Baskı. İstanbul: Nobel Tıp Kitapevleri Ltd Şti, 2010:669-71.
  • 18. Courtoy I, Lande AE, Turner RB. Accuracy of radigraphic differentiation of bacterial from nonbacterial pneumonia. Clin Pediatr 1989; 28:261-4.
  • 19. McCarthy PL, Spiesel SZ, Stashwick CA, Ablow RC, Masters SJ, Dolan TF Jr. Radiographic findings and etiologic diagnosis in ambulatory childhood pneumonias. Clin Pediatr 1981;20:686-91.
  • 20. British Thoracic Society Standards of Care Committee. British Thoracic Society guidelines for the management of community acquired pneumonia in childhood. Thorax 2002; 57(suppl 1):1-24.
  • 21. Hazir T, Nisar YB, Qazi SA, Khan SF, Raza M, Zameer S et al. Chest radiography in children aged 2-59 months diagnosed with non-severe pneumonia as defined by World Health Organizations: Descriptive multicenter study in Pakistan. BMJ 2006;10:1136-7.
  • 22. Korppi M. Community-Acquired Pneumonia in Children. Pediatr Drugs 2003;5:821-32.
  • 23. Shenoy VD, Upadhyaya SA, Rao SP, Shobha KL. Mycoplasma pneumonia infections in children with acute respiratory infections. J Trop Pediatr 2005; 38:157-60.
  • 24. Defilippi A, Silvestri M, Tacchella A, Giacchino R, Melioli G, Di Marco E, et al. Epidemiology and clinical features of Mycoplasma pneumonia infections in children. Respir Med 2008;102:1762-68.
  • 25. Drummond P, Clark J, Wheeler J, Galloway A, Freeman R, Cant A. Community acquired pneumonia-a prospective UK study. Arch Dis Child 2000; 83:408-12.
  • 26. Youn YS, Lee KY, Hwang JY, Rhim JW, Kang JH, Lee JS, et al. Difference of clinical features in childhood Mycoplasma pneumonia. BMC Pediatrics, 2010;10:48.
  • 27. Bulaşıcı Hastalıkların Laboratuvar Tanısı için Saha Rehberi. Mycoplasma pneumoniae Pnömonisi. ICD-10 J15.7.
  • 28. Waris M, Toikka P, Saarinen T, Nikkari S, Meurman O, Vainionpää R,et al. Diagnosis of Mycoplasma pneumoniae in children. J Clin Microbiol 1998; 36:3155-9.
  • 29. Uldum SA, Jensen JS, Sondergard-Andersen J, Lind K. Enzyme immunoassay for detection of immunoglobulin M (IgM) and IgG antibodies to Mycoplasma pneumoniae. J Clin Microbiol 1992;30:1198-204.
  • 30. Saggev JS, Lis I, Siman-Tov R, Gutman R, Abu-Samara H, Schey G, et al. Mycoplasma pneumoniae is a frequent cause of exacerbation of bronchial asthma in adults. Ann Allergy 1986; 57:263-5.
  • 31. Bloc S, Hedrick J, Hammerschlag MR, Cassell GH, Craft JC. Mycoplasma pneumonia and Chlamydia pneumoniae in pediatric community-acquired pneumonia: Comparative efficacy and safety of clarithromycin vs. erytromycin ethylsuccinate. Pediatr Infect Dis J 1995;14:471-7.
  • 32. Numazaki K, Sakamato Y, Umetsu M, Agatsuma Y, Yamanaka T, Kogasaka R et al. Therapeutic effect of clarithromycin for respiratory tract infections in children caused by Chlamydia pneumonia. Int J Antimicrob Agents 2000;13:219-22.
There are 32 citations in total.

Details

Primary Language Turkish
Subjects ​Internal Diseases
Journal Section ORIGINAL ARTICLES
Authors

Eda Mengen

Publication Date December 23, 2019
Submission Date March 25, 2018
Published in Issue Year 2019 Volume: 13 Issue: 6

Cite

Vancouver Mengen E. Toplum Kökenli Çocukluk Çağı Pnömoni Olgularımızda Mycoplasma pneumoniae ve Chlamydia pneumoniae’nın Seropozitiflik Oranları. Türkiye Çocuk Hast Derg. 2019;13(6):406-12.
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