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Türk Süt Çocuklarında Fonksiyonel Gastrointestinal Hastalıkların Sıklığının ve İlişkili Faktörlerin İncelenmesi

Year 2020, Volume: 14 Issue: 5, 428 - 434, 29.09.2020
https://doi.org/10.12956/tchd.753315

Abstract

Amaç: Bu çalışmada süt çocuklarında fonksiyonel gastrointestinal hastalıklardan (FGİH) fonksiyonel kabızlık, fonksiyonel ishal ve infantil kolik sıklığı ve bu hastalıkların beslenme alışkanlıkları ile ilişkisinin değerlendirilmesi amaçlandı.
Gereç ve Yöntemler: Çalışmaya, çocuk sağlığı ve hastalıkları polikliniğine ve acil polikliniğine 15 Şubat 2019 ile 31 Mayıs 2019 tarihleri arasında başvuran 4–24 aylık 400 hasta dahil edildi. Çalışmaya bilinen kronik hastalığı olmayan, D vitamini ve demir profilaksisi dışında vitamin veya iştah arttırıcı ilaç desteği almayan hastalar dahil edildi. Anket form aracılığıyla hastaların sosyo-demografik özellikleri ve beslenme özellikleri sorgulandı. İnfantil kolik, fonksiyonel ishal ve fonksiyonel kabızlık açısından şüpheli bulunan hastalar ROME-IV tanı ölçütlerine göre değerlendirildi.
Bulgular: Çalışmaya dahil edilen 400 hastanın %24.2 (n=97)’sinde infantil kolik, %5.8 (n=23)’inde fonksiyonel kabızlık, %2.5 (n=10)’inde fonksiyonel ishal olduğu belirlenmiştir. İnfantil koliği olan ve fonksiyonel kabızlığı olan grupta sezaryen ile doğum oranının fazla olduğu saptandı (sırasıyla, p=0.008, p=0.032). D vitamini profilaksisini düzenli kullanan hastalarda infantil kolik görülme sıklığının daha az olduğu saptanırken (p=0.032), fonksiyonel kabızlığı olanlarda D vitamini kullanımı daha düşük bulundu (p=0.001).
Sonuç: Çalışmamızda, infantil kolik süt çocuklarında görülen en sık FGİH olarak bulundu, ikinci sırada ise fonksiyonel kabızlık vardı. Fonksiyonel ishal ve fonksiyonel kabızlık olan hastalarda karbonhidrattan zengin beslenme oranının yüksek olduğu tespit edildi.

References

  • 1. Rasquin-Weber A, Hyman P, Cucchiara S, Fleisher D, Hyams J, Milla P, et al. Childhood functional gastrointestinal disorders. Gut 1999;45:II60-II8.
  • 2. Koppen I, Nurko S, Saps M, Di Lorenzo C, Benninga M. The pediatric Rome IV criteria: what’s new? Expert Rev Gastroenterol Hepatol 2017; 11: 193-201.
  • 3. Benninga MA, Nurko S, Faure C, Hyman PE, Roberts ISJ, Schechter NL. Childhood functional gastrointestinal disorders: neonate/toddler. Gastroenterology 2016;150:1443-55. e2.
  • 4. McOmber ME, Shulman RJ. Recurrent abdominal pain and irritable bowel syndrome in children. Curr. Opin. Pediatr 2007;19:581.
  • 5. Carlson MJ, Moore CE, Tsai CM, Shulman RJ, Chumpitazi BP. Child and parent perceived food-induced gastrointestinal symptoms and quality of life in children with functional gastrointestinal disorders. J Acad Nutr Diet 2014;114:403-13.
  • 6. Bellaiche M, Oozeer R, Gerardi‐Temporel G, Faure C, Vandenplas Y. Multiple functional gastrointestinal disorders are frequent in formula‐fed infants and decrease their quality of life. Acta Paediatr 2018;107:1276-82.
  • 7. Pensabene L, Salvatore S, D'Auria E, Parisi F, Concolino D, Borrelli O, et al. Cow’s Milk Protein Allergy in Infancy: A Risk Factor for Functional Gastrointestinal Disorders in Children? Nutrients 2018;10:1716.
  • 8. Zeevenhooven J, Koppen IJ, Benninga MA. The new Rome IV criteria for functional gastrointestinal disorders in infants and toddlers. Pediatr Gastroenterol Hepatol Nutr 2017;20:1-13.
  • 9. Soylu ÖB, Bayir Ö. Karın Ağrısı İle Başvuran Çocukların Roma Iıı Ölçütlerine Göre Değerlendirilmesi. Türkiye Çocuk Hastalıkları Dergisi;3:15-20.
  • 10. Uysal G, Düzkaya DS, Bozkurt G. Factors Affecting Infantile Colic with Babies. Journal of health science and profession 2017;4:221-7.
  • 11. Kirsaçlioğlu CT, Kuloğlu Z, Üstündağ G, Ensarİ A, Kansu A. Çocuklarda Tekrarlayan Karın Ağrısı: Organik mi? Fonksiyonel mi? Turkiye Klinikleri Journal of Pediatrics 2016;25:74-81.
  • 12. Liu W, Xiao L, Li Y, Wang X, Xu C. Epidemiology of mild gastrointestinal disorders among infants and young children in Shanghai area. Zhonghua er ke za zhi= Chinese journal of pediatrics 2009;47:917-21.
  • 13. Van Tilburg MA, Hyman PE, Walker L, Rouster A, Palsson OS, Kim SM, et al. Prevalence of functional gastrointestinal disorders in infants and toddlers. The Journal of pediatrics 2015;166:684-9.
  • 14. Robin SG, Keller C, Zwiener R, Hyman PE, Nurko S, Saps M, et al. Prevalence of pediatric functional gastrointestinal disorders utilizing the Rome IV criteria. The Journal of pediatrics 2018;195:134-9.
  • 15. Chang L, Toner BB, Fukudo S, Guthrie E, Locke GR, Norton NJ, et al. Gender, age, society, culture, and the patient’s perspective in the functional gastrointestinal disorders. Gastroenterology 2006;130:1435-46.
  • 16. Fazil M. Prevalence and risk factors for infantile colic in District Mansehra. J Ayub Med Coll Abbottabad 2011;23:115-7.
  • 17. Kaymaz N, Yıldırım Ş, Topaloğlu N, Gencer M, Binnetoğlu FK, Tekin M, et al. Prenatal maternal risk factors for infantile colic. Nurs Child Young People 2015;27.
  • 18. Loening-Baucke V. Prevalence, symptoms and outcome of constipation in infants and toddlers. J Pediatr 2005;146:359-63.
  • 19. Krause L, Einsle F, Petzoldt J, Wittchen H-U, Martini J. The role of maternal anxiety and depressive disorders prior to and during pregnancy and perinatal psychopathological symptoms for early infant diseases and drug administration. Early Hum Dev 2017;109:7-14.
  • 20. Chalabi DA, Omer K. Risk Factors For Infantile Colic: A Case Control Study Journal of the Arab Board of Health Specializations Vol 2016;17.
  • 21. Alagöz H, Ertekin V. Türkiye’nin Doğusunda İnfantil Kolik İnsdansı, Etyolojisindeki Risk Faktörleri Ve Farklı Tedavi Seçeneklerinin Tespiti. Çağdaş Tıp Dergisi 2013;3:1-6.
  • 22. Camilleri M, Park SY, Scarpato E, Staiano A. Exploring hypotheses and rationale for causes of infantile colic. Neurogastroent Motil 2017;29:e12943.
  • 23. Panarese A, Pesce F, Porcelli P, Riezzo G, Iacovazzi PA, Leone CM, et al. Chronic functional constipation is strongly linked to vitamin D deficiency. World J Gastroentero 2019;25:1729.
  • 24. Kasırga E, Akil İ, Yılmaz D, Karakaş F, Polat M, Aslantaş H. Çocukluk Dönemi Fonksiyonel Kronik Kabızlığında Beslenmenin Önemi. Turkiye Klinikleri Journal of Pediatrics 2004;13:227-31.
  • 25. Khalil AF, Alkot M. Study of functional constipation among children attending the Gastroenterology Clinic at Alexandria University Children’s Hospital. Alexandria Journal of Pediatrics 2018;31:120.

Investigation of the Frequency of Functional Gastrointestinal Diseases and Related Factors in Turkish Infants

Year 2020, Volume: 14 Issue: 5, 428 - 434, 29.09.2020
https://doi.org/10.12956/tchd.753315

Abstract

Objective: In this study was to evaluate the frequency of functional gastrointestinal disorders (FGIDs) including functional constipation, functional diarrhea and infantile colic, and the relationship between these diseases and nutritional practices.
Material and Methods: The study included 400 patients (4–24 months old) that applied to the pediatric health and diseases outpatient clinic or emergency clinic between 15 February 2019 and 31 May 2019. Patients without chronic diseases and who did not receive vitamin or appetite-enhancing medications other than vitamin D and iron were included in the study. The socio-demographic and nutritional characteristics of the patients were evaluated through a questionnaire. Patients suspected of having infantile colic, functional diarrhea and functional constipation were evaluated with the ROME-IV diagnostic criteria.
Results: Among 400 patients, 24.2% (n = 97) had infantile colic, 5.8% (n = 23) had functional constipation, and 2.5% (n = 10) had functional diarrhea. In those with infantile colic or functional constipation, cesarean delivery rate was found to be higher than those without (p = 0.008 and p = 0.032, respectively). The frequency of infantile colic was found to be lower in recipients of vitamin D prophylaxis (p = 0.032), and vitamin D use frequency was lower in those with functional constipation (p = 0.001).
Conclusion: In our study, infantile colic was the most common FGID seen in infants, while functional constipation was the second. A higher rate of carbohydrate-rich nutrition was identified in patients with functional diarrhea.

References

  • 1. Rasquin-Weber A, Hyman P, Cucchiara S, Fleisher D, Hyams J, Milla P, et al. Childhood functional gastrointestinal disorders. Gut 1999;45:II60-II8.
  • 2. Koppen I, Nurko S, Saps M, Di Lorenzo C, Benninga M. The pediatric Rome IV criteria: what’s new? Expert Rev Gastroenterol Hepatol 2017; 11: 193-201.
  • 3. Benninga MA, Nurko S, Faure C, Hyman PE, Roberts ISJ, Schechter NL. Childhood functional gastrointestinal disorders: neonate/toddler. Gastroenterology 2016;150:1443-55. e2.
  • 4. McOmber ME, Shulman RJ. Recurrent abdominal pain and irritable bowel syndrome in children. Curr. Opin. Pediatr 2007;19:581.
  • 5. Carlson MJ, Moore CE, Tsai CM, Shulman RJ, Chumpitazi BP. Child and parent perceived food-induced gastrointestinal symptoms and quality of life in children with functional gastrointestinal disorders. J Acad Nutr Diet 2014;114:403-13.
  • 6. Bellaiche M, Oozeer R, Gerardi‐Temporel G, Faure C, Vandenplas Y. Multiple functional gastrointestinal disorders are frequent in formula‐fed infants and decrease their quality of life. Acta Paediatr 2018;107:1276-82.
  • 7. Pensabene L, Salvatore S, D'Auria E, Parisi F, Concolino D, Borrelli O, et al. Cow’s Milk Protein Allergy in Infancy: A Risk Factor for Functional Gastrointestinal Disorders in Children? Nutrients 2018;10:1716.
  • 8. Zeevenhooven J, Koppen IJ, Benninga MA. The new Rome IV criteria for functional gastrointestinal disorders in infants and toddlers. Pediatr Gastroenterol Hepatol Nutr 2017;20:1-13.
  • 9. Soylu ÖB, Bayir Ö. Karın Ağrısı İle Başvuran Çocukların Roma Iıı Ölçütlerine Göre Değerlendirilmesi. Türkiye Çocuk Hastalıkları Dergisi;3:15-20.
  • 10. Uysal G, Düzkaya DS, Bozkurt G. Factors Affecting Infantile Colic with Babies. Journal of health science and profession 2017;4:221-7.
  • 11. Kirsaçlioğlu CT, Kuloğlu Z, Üstündağ G, Ensarİ A, Kansu A. Çocuklarda Tekrarlayan Karın Ağrısı: Organik mi? Fonksiyonel mi? Turkiye Klinikleri Journal of Pediatrics 2016;25:74-81.
  • 12. Liu W, Xiao L, Li Y, Wang X, Xu C. Epidemiology of mild gastrointestinal disorders among infants and young children in Shanghai area. Zhonghua er ke za zhi= Chinese journal of pediatrics 2009;47:917-21.
  • 13. Van Tilburg MA, Hyman PE, Walker L, Rouster A, Palsson OS, Kim SM, et al. Prevalence of functional gastrointestinal disorders in infants and toddlers. The Journal of pediatrics 2015;166:684-9.
  • 14. Robin SG, Keller C, Zwiener R, Hyman PE, Nurko S, Saps M, et al. Prevalence of pediatric functional gastrointestinal disorders utilizing the Rome IV criteria. The Journal of pediatrics 2018;195:134-9.
  • 15. Chang L, Toner BB, Fukudo S, Guthrie E, Locke GR, Norton NJ, et al. Gender, age, society, culture, and the patient’s perspective in the functional gastrointestinal disorders. Gastroenterology 2006;130:1435-46.
  • 16. Fazil M. Prevalence and risk factors for infantile colic in District Mansehra. J Ayub Med Coll Abbottabad 2011;23:115-7.
  • 17. Kaymaz N, Yıldırım Ş, Topaloğlu N, Gencer M, Binnetoğlu FK, Tekin M, et al. Prenatal maternal risk factors for infantile colic. Nurs Child Young People 2015;27.
  • 18. Loening-Baucke V. Prevalence, symptoms and outcome of constipation in infants and toddlers. J Pediatr 2005;146:359-63.
  • 19. Krause L, Einsle F, Petzoldt J, Wittchen H-U, Martini J. The role of maternal anxiety and depressive disorders prior to and during pregnancy and perinatal psychopathological symptoms for early infant diseases and drug administration. Early Hum Dev 2017;109:7-14.
  • 20. Chalabi DA, Omer K. Risk Factors For Infantile Colic: A Case Control Study Journal of the Arab Board of Health Specializations Vol 2016;17.
  • 21. Alagöz H, Ertekin V. Türkiye’nin Doğusunda İnfantil Kolik İnsdansı, Etyolojisindeki Risk Faktörleri Ve Farklı Tedavi Seçeneklerinin Tespiti. Çağdaş Tıp Dergisi 2013;3:1-6.
  • 22. Camilleri M, Park SY, Scarpato E, Staiano A. Exploring hypotheses and rationale for causes of infantile colic. Neurogastroent Motil 2017;29:e12943.
  • 23. Panarese A, Pesce F, Porcelli P, Riezzo G, Iacovazzi PA, Leone CM, et al. Chronic functional constipation is strongly linked to vitamin D deficiency. World J Gastroentero 2019;25:1729.
  • 24. Kasırga E, Akil İ, Yılmaz D, Karakaş F, Polat M, Aslantaş H. Çocukluk Dönemi Fonksiyonel Kronik Kabızlığında Beslenmenin Önemi. Turkiye Klinikleri Journal of Pediatrics 2004;13:227-31.
  • 25. Khalil AF, Alkot M. Study of functional constipation among children attending the Gastroenterology Clinic at Alexandria University Children’s Hospital. Alexandria Journal of Pediatrics 2018;31:120.
There are 25 citations in total.

Details

Primary Language English
Subjects ​Internal Diseases
Journal Section ORIGINAL ARTICLES
Authors

Neslihan Gulsen This is me 0000-0002-0474-3720

Eda Sünnetçi Silistre 0000-0003-0450-0152

Publication Date September 29, 2020
Submission Date June 15, 2020
Published in Issue Year 2020 Volume: 14 Issue: 5

Cite

Vancouver Gulsen N, Sünnetçi Silistre E. Investigation of the Frequency of Functional Gastrointestinal Diseases and Related Factors in Turkish Infants. Türkiye Çocuk Hast Derg. 2020;14(5):428-34.


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