Epilepsy is an important neurological disorder which affects more than 10.000.000 children around the world, characterized by epileptic seizures that occur due to abnormal, excessive and simultaneous stimulation of neurons in brain. Different classification schemes have been suggested in order to ensure correct diagnosis and treatment, predict prognosis and implement a standardized nomenclature among all clinicians. The International League Against Epilepsy (ILAE) has proposed several classifications, the most current ones are ILAE 2010 classification of epilepsy syndromes, ILAE 2017 classification of seizures and epilepsy, and ILAE 2021 classification of neonatal seizures. In the ILAE 2010 classification of epilepsy syndromes, different types of epilepsies were grouped according to the age of onset and other common characteristics. In the ILAE 2017 classification, seizures were grouped into three categories; focal, generalized and unknown, according to the onset of the semiology; furthermore, focal seizures were divided into two groups according to the level of awareness. Evaluation of the underlying etiology was recommended at every step. Etiologies were subclassified into structural, genetic, infectious, metabolic, immune and unknown causes. In the ILAE 2021 classification of neonatal seizures, seizures are divided into two groups, the first group includes electrographic seizures without clinical manifestations, and the second group covers motor, non-motor, sequential and unclassified seizures with clinical manifestations convergent with electroencephalography findings. Seizure and epilepsy classifications, and common pediatric epilepsy syndromes are revised in the light of current studies in this review.
Epilepsi beyindeki nöronların anormal, aşırı ve eş zamanlı olarak uyarılmasına bağlı olarak ortaya çıkan epileptik nöbetlerle karakterize, tüm dünyada 10.000.000’dan fazla çocuğu etkileyen önemli bir nörolojik hastalıktır. Doğru tanı ve tedavinin yapılabilmesi, prognozun öngörülmesi ve tüm klinisyenlerin aynı dili kullanması amacı ile çeşitli sınıflama önerilerinde bulunulmuştur. Bu sınıflamalardan en güncel olanları Uluslararası Epilepsi ile Savaş Derneği (International League Against Epilepsy-ILAE) tarafından önerilen 2010 epilepsi sendromları 2017 nöbet ve epilepsi, 2021 yenidoğan nöbetleri sınıflamalarıdır. ILAE 2010 epilepsi sendromları sınıflamasında epilepsiler başlangıç yaşına ve diğer bazı ortak özelliklerine göre gruplandırılmıştır. ILAE 2017 nöbet ve epilepsi sınıflamasında nöbetler başlangıçlarına göre fokal, jeneralize ve bilinmeyen olarak üçe ayrılmış, ayrıca fokal nöbet sırasında farkındalığın korunup/korunmaması ayrı olarak değerlendirilmiştir. Sınıflamanın her basamağında etiyolojinin de değerlendirmesi önerilmiştir. Etiyolojik açıdan yapısal, genetik, enfeksiyöz, metabolik, immun ve bilinmeyen alt sınıflaması yapılmıştır. ILAE 2021 yenidoğan nöbetleri sınıflamasında nöbetler ikiye ayrılmış, ilk grupta klinik bir bulgunun eşlik etmediği elektrografik nöbetler, ikinci grupta elektroensefalografi bulguları ile birlikte klinik bulguların görüldüğü motor, non-motor, ardışık ve sınıflandırılamayan nöbetler yer almıştır. Bu derlemede nöbet ve epilepsi sınıflamaları gözden geçirilmiş ve sık görülen pediatrik epilepsi sendromları güncel yayınlar ışığında incelenmiştir.
Primary Language | Turkish |
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Subjects | Internal Diseases |
Journal Section | REVIEW |
Authors | |
Publication Date | May 30, 2022 |
Submission Date | March 1, 2021 |
Published in Issue | Year 2022 Volume: 16 Issue: 3 |
The publication language of Turkish Journal of Pediatric Disease is English.
Manuscripts submitted to the Turkish Journal of Pediatric Disease will go through a double-blind peer-review process. Each submission will be reviewed by at least two external, independent peer reviewers who are experts in the field, in order to ensure an unbiased evaluation process. The editorial board will invite an external and independent editor to manage the evaluation processes of manuscripts submitted by editors or by the editorial board members of the journal. The Editor in Chief is the final authority in the decision-making process for all submissions. Articles accepted for publication in the Turkish Journal of Pediatrics are put in the order of publication, with at least 10 original articles in each issue, taking into account the acceptance dates. If the articles sent to the reviewers for evaluation are assessed as a senior for publication by the reviewers, the section editor and the editor considering all aspects (originality, high scientific quality and citation potential), it receives publication priority in addition to the articles assigned for the next issue.
The aim of the Turkish Journal of Pediatrics is to publish high-quality original research articles that will contribute to the international literature in the field of general pediatric health and diseases and its sub-branches. It also publishes editorial opinions, letters to the editor, reviews, case reports, book reviews, comments on previously published articles, meeting and conference proceedings, announcements, and biography. In addition to the field of child health and diseases, the journal also includes articles prepared in fields such as surgery, dentistry, public health, nutrition and dietetics, social services, human genetics, basic sciences, psychology, psychiatry, educational sciences, sociology and nursing, provided that they are related to this field. can be published.