Efficacy of Intravenous Iron Therapy in Female Patients with Iron Deficiency Anemia

Year 2023, Volume: 12 Issue: 4, 134 - 138, 28.12.2023

Sevgi Güneş , Naci Ömer Alayunt , Osman Özüdoğru

https://doi.org/10.46810/tdfd.1342791

Abstract

Abstract: In this study, it was aimed to show the efficacy of intravenous (IV) ferric carboxymaltose treatment for iron deficiency anemia (IDA), which is a public health problem due to its high prevalence in the world and in Turkey. Since it is the first study in the region, its importance is increasing even more. Eighty female diagnosed with IDA and treated with IV iron carboxymaltose, who applied to Siirt Training and Research Hospital Internal Diseases Polyclinics between June 2018 and September 2019, were included in the study. After obtaining voluntary consent of female patients, biochemical data of pre- and post-treatment were included in the study retrospectively. After treatment, hemoglobin (HGB), hematocrit (HTC), mean cell volume (MCV), ferritin, iron and B12 values increased statistically (p<0.05). In addition, platelet (PLT), total iron binding capacity (TIBC) and folate values were statistically significantly lower (p<0.05). The study is important in terms of revealing the female IDA profile in the region and showing the positive results of IV iron therapy data. It is thought that the study can be a guide in finding solutions to irrational drug use, prolongation of the treatment period and high expenditures while creating IDA treatment protocols.

Keywords

Iron deficiency anemia, Iron replacement, Intravenous carboxymaltose, Serum TIBC, Serum folate

Supporting Institution

Yok

Project Number

Yok

Thanks

We thank the Siirt University Training and Research Hospital and patients participating in the study.

Demir Eksikliği Anemili Kadın Hastalarda İntravenöz Demir Tedavisinin Etkinliği

Abstract

Bu çalışmada, dünyada ve Türkiye'de prevalansının yüksek olması nedeniyle bir halk sağlığı sorunu olan demir eksikliği anemisinde (DEA) intravenöz (İV) ferrik karboksimaltoz tedavisinin etkinliğinin gösterilmesi amaçlandı. Bölgedeki ilk çalışma olması nedeniyle önemi daha da artmaktadır. Haziran 2018-Eylül 2019 tarihleri arasında Siirt Eğitim ve Araştırma Hastanesi İç Hastalıkları Polikliniği'ne başvuran, DEA tanılı ve İV demir karboksimaltoz tedavisi uygulanan 80 kadın çalışmaya dahil edildi. Kadın hastalardan gönüllü onam alındıktan sonra tedavi öncesi ve sonrası biyokimyasal veriler retrospektif olarak çalışmaya dahil edildi. Tedavi sonrası hemoglobin (HGB), hematokrit (HTC), ortalama hücre hacmi (MCV), ferritin, demir ve B12 değerleri istatistiksel olarak arttı (p<0.05). (p<0.05). Ayrıca trombosit (PLT), toplam demir bağlama kapasitesi (TIBC) ve folat değerleri istatistiksel olarak anlamlı derecede düşüktü (p<0.05). Çalışma bölgedeki kadın DEA profilini ortaya koyması ve İV demir tedavisi verilerinin olumlu sonuçlarını göstermesi açısından önemlidir. Çalışmanın DEA tedavi protokolleri oluşturulurken akılcı olmayan ilaç kullanımına, tedavi süresinin uzamasına ve yüksek tedavi harcamalarına çözüm bulunmasında yol gösterici olabileceği düşünülmektedir.

Keywords

Demir eksikliği anemisi, Demir replasmanı, İntravenoz karboksimaltoz, Serum TIBC, Serum folat

Project Number

Yok

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