Erratum: Düzeltilmiş: Benzaldehit türevlerinin sığır böbrek aldoz redüktaz inhibitörleri olarak değerlendirilmesi

Year 2023, Volume: 12 Issue: 4, 184 - 190, 28.12.2023

Bülent Şengül

The original article was published on June 22, 2023. https://dergipark.org.tr/en/pub/tdfd/issue/78175/1204055

Erratum Note

Sayın Editör, Derginizde yayınlanan ve aşağıda bilgilerini sunmuş olduğum yayınım ile ilgili bir ricam olacaktı. Söz konusu yayında fon kaynağı olarak belirttiğim proje Üniversitem tarafından iptal edilmiştir. Proje iptaline yönelik itiraz dilekçem (Ek-1) ve ilgili birimin karar yazısı mail ekinde mevcuttur (Ek-2). Bu kapsamda doçentlik müracaatı sürecinde herhangi bir etik ihlal kaygısı oluşturmaması için yayın içerisinde yer alan fon bilgilerinin çıkarılmasını istiyorum. İlginiz için şimdiden teşekkür eder iyi çalışmalar dilerim. Saygılarımla, Dr. Bülent ŞENGÜL

Abstract

Keywords

Inhibition, molecular docking, polyol pathway, benzaldehydes

Erratum: Erratum: Evaluation of benzaldehyde derivatives as being bovine kidney aldose reductase inhibitors

The original article was published on June 22, 2023. https://dergipark.org.tr/en/pub/tdfd/issue/78175/1204055

Erratum Note

Sayın Editör, Derginizde yayınlanan ve aşağıda bilgilerini sunmuş olduğum yayınım ile ilgili bir ricam olacaktı. Söz konusu yayında fon kaynağı olarak belirttiğim proje Üniversitem tarafından iptal edilmiştir. Proje iptaline yönelik itiraz dilekçem (Ek-1) ve ilgili birimin karar yazısı mail ekinde mevcuttur (Ek-2). Bu kapsamda doçentlik müracaatı sürecinde herhangi bir etik ihlal kaygısı oluşturmaması için yayın içerisinde yer alan fon bilgilerinin çıkarılmasını istiyorum. İlginiz için şimdiden teşekkür eder iyi çalışmalar dilerim. Saygılarımla, Dr. Bülent ŞENGÜL

Abstract

Aldoz redüktaz (AR), poliol yolunda glikozdan sorbitol üretimini katalize eder ve insülinden bağımsız dokularda anormal sorbitol agregasyonuna neden olan, retinopati, nöropati ve nefropati gibi bazı problemler yaratan kritik bir enzimdir. AR inhibisyonunun bu yan etkileri azaltmak için uygun bir yaklaşım olduğu gösterilmiştir. Mevcut çalışma, literatüre yeni AR inhibitörlerini tanıtmayı amaçlamıştır. Bu amaçla AR inhibitörleri olarak benzaldehitler incelenmiştir. İlk olarak sığır böbreğinden homojenat hazırlanmış, ardından inhibisyon çalışmaları yapılmıştır. Çalışılan bütün benzaldehit türevlerinin AR'yi inhibe ettiği bulundu. 0.23 ve 1.37 µM IC50 değerlerine sahip olan türev 3 ve 6'nın inhibitör aktivitesi, standart inhibitör sorbinilden daha yüksek olduğu tespit edildi. In vitro inhibisyon çalışmalarından sonra, tahmini bağlanma enerjileri ve türevlerin enzime bağlanma modları moleküler docking ile tahmin edildi. Bileşik 3, -8,61 kcal/mol'lük bir maksimum yerleştirme puanı sergiledi. Sonuç olarak, bu bileşikler, özellikle bileşik 3, diyabetik komplikasyonların tedavisinde veya önlenmesinde yeni ilaç aday moleküllerinin sentezi için yol gösterici moleküller olabilir.

Keywords

Inhibition, molecular docking, polyol pathway, benzaldehydes

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