Farklı Yönleriyle Netosis

Year 2017, Volume: 74 Issue: 4, 351 - 360, 01.12.2017

Neslihan Sürsal Kader Yıldız

Abstract

Gelişmiş ve gelişmekte olan ülkelerde otoimmün ve otoinflamatuar hastalıkların görülme sıklığında ciddi bir artış vardır. Bu hastalıkların etiyolojisi karmaşık ve multifaktöriyel nedenlere bağlı gelişmektedir. Sistemik otoimmün hastalıkların temelinde otoantijenler olduğu düşünülmektedir. Son yıllarda yapılan çalışmalar NETosisin bazı otoimmün ve otoinflamasyon hastalıkları tetikleyebileceği ortaya konulmuş ve bu savunma mekanizması büyük ilgi görmeye başlamıştır. Bu karmaşık mekanizmanın daha iyi anlaşılması otoimmün hastalıkların teşhisinde önemli araçların geliştirilmesi ile beraberinde bu hastalıklara yeni tedavi yöntemlerinin belirlenmesinde oldukça umut verici ve kritik bir öneme sahip olduğu düşünülmektedir. Bu derlemede organizmada bazı patolojilere karışan netosis hakkında bilgi verilmiştir

Keywords

NETosis, otoimmün hastalıklar, otoinflamasyon hastalıklar

Different Aspects of Netosis

Abstract

Autoimmune and autoinflammatory diseases have dramatically increased in both developed and developing countries. The etiology of these diseases is complex and developed due to multifactorial causes. It is tought that autoantigens are the basis of systemic autoimmune diseases in organism. Recent studies have revealed that NETosis can triggered some autoimmune and autoinflammatory diseases, so this defence mechanism has begun to attract great interest. A better understanding of this complex mechanism is believed to have a promising and critical prescription for the identification of new treatment modalities for these diseases with the development of important tools in the diagnosis of autoimmune diseases. In this review, information has been given on NETosis which is participate in some pathologies in the organism

Keywords

NETosis, autoimmun diseases, autoinflamatory diseases

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