tjcl Turkish Journal of Clinics and Laboratory 2149-8296 DNT Ortadoğu Yayıncılık A.Ş. 10.18663/tjcl.1788113 Gynecologic Oncology Surgery Jinekolojik Onkoloji Cerrahisi SMILE, Servikal İntraepitelyal Neoplazi 3 ve Adenokarsinoma in situ Hastalarının Klinikopatolojik Değerlendirilmesi Clinicopathological Evaluation of Patients with SMILE, Cervical Intraepithelial Neoplasia 3, and Adenocarcinoma in Situ https://orcid.org/0000-0002-7733-9171 Sözen Işık Başakşehir Çam ve Sakura Şehir Hastanesi, Jinekolojik Onkoloji Cerrahisi https://orcid.org/0000-0002-4958-2393 Arslan Hilal Serap Basaksehir Cam and Sakura City Hospital https://orcid.org/0000-0003-3067-9125 Şahin Gözde Basaksehir Cam and Sakura City Hospital https://orcid.org/0000-0002-6231-9223 Aboalhasan Yasemin Basaksehir Cam and Sakura City Hospital https://orcid.org/0009-0004-9034-1454 Tasti Elif Dila Basaksehir Cam and Sakura City Hospital https://orcid.org/0000-0002-7337-9977 Temel İlkbal Basaksehir Cam and Sakura City Hospital 09 30 2025 16 3 625 633 09 21 2025 09 30 2025 Copyright © 2010, Turkish Journal of Clinics and Laboratory 2010 Turkish Journal of Clinics and Laboratory

Amaç: SMILE, CIN3 ve AIS tanılı hastalarda servikal biyopsi sonuçlarının konizasyon/histerektomi sonrası kesin patolojik tanılarla uyumunu ve klinik özelliklerdeki farklılıkları karşılaştırmak.Yöntemler: Tek merkezli retrospektif bir çalışma kapsamında SMILE (n=8), CIN3 (n=16) veya AIS (n=14) tanısı alarak cerrahi tedavi uygulanmış hastaların klinikopatolojik verileri incelenmiştir. Hastaların HPV genotip sonuçları, sitoloji (Pap smear) bulguları, uygulanan cerrahi işlemler ve cerrahi örneklerin patoloji sonuçları retrospektif olarak kayıt edildi.Bulgular: HPV yüksek riskli genotip dağılımı ve sitolojik tanılar gruplar arasında benzer bulundu (p>0.05). AIS tanılı hastalarda ilk tedavide veya yeniden cerrahi sonrası histerektomi uygulanma oranı diğer gruplara kıyasla daha yüksekti. Biyopsi ön tanısı ile cerrahi eksizyon sonrası patoloji tanısının uyumu lezyon tiplerine göre anlamlı farklılık gösterdi (p

Aim: To compare cervical biopsy diagnoses with final surgical pathology results among patients with SMILE, CIN3, and AIS, and to evaluate differences in clinical-pathological features between these lesions. Methods: We performed a retrospective single-center analysis of patients diagnosed with SMILE (n=8), CIN3 (n=16), or AIS (n=14) who underwent surgical treatment. Clinical variables, high-risk HPV genotypes, cervical cytology findings, treatment modality, and pathological outcomes of surgical specimens were reviewed.Results: The distribution of HPV high-risk genotypes and cytologic diagnoses were similar between the groups (p>0.05). The rate of hysterectomy performed during initial treatment or after reoperation was higher in patients with AIS compared to the other groups. The concordance between the preliminary biopsy diagnosis and the pathological diagnosis after surgical excision differed significantly across lesion types (p

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