tjcl Turkish Journal of Clinics and Laboratory 2149-8296 DNT Ortadoğu Yayıncılık A.Ş. 10.18663/tjcl.1893840 Cancer Therapy (Excl. Chemotherapy and Radiation Therapy) Major Global Burdens of Disease Kanser Tedavisi (Kemoterapi ve Radyoterapi hariç) Başlıca Küresel Hastalık Yükleri Amerika Birleşik Devletleri’nde gastrik kanserde venöz tromboembolizm ilişkili mortalitenin zaman içindeki değişimi, 1999–2020 Temporal trends in venous thromboembolism–related mortality among gastric cancer deaths in the United States, 1999–2020. https://orcid.org/0000-0002-6091-730X Başkurt Kadriye Etik Şehr Hastanesi https://orcid.org/0000-0002-0698-777X Uyar Galip Can etlik şehir hastanesi https://orcid.org/0000-0002-0947-702X Yeşilbaş Enes etlik şehir hastanesi https://orcid.org/0000-0002-1561-9346 Şahinli Hayriye etlik şehir hastanesi https://orcid.org/0000-0003-0356-0727 İmamoğlu Gökşen İnanç etlik şehir hastanesi 03 29 2026 1 02 20 2026 03 13 2026 Copyright © 2010, Turkish Journal of Clinics and Laboratory 2010 Turkish Journal of Clinics and Laboratory

Amaç: Venöz tromboembolizm (VTE), gastrik kanserde klinik açıdan önemli bir komplikasyon olmasına rağmen ülke düzeyindeki mortalite değişimleri yeterince tanımlanmamıştır. Bu çalışmada Amerika Birleşik Devletleri’nde gastrik kanser ölümleri arasında VTE ilişkili mortalitenin zaman içinde nasıl değiştiği değerlendirilmiştir.Gereç ve Yöntemler: Bu popülasyon temelli zaman eğilimi analizinde 1999–2020 yıllarını kapsayan CDC WONDER Çoklu Ölüm Nedeni veritabanı kullanıldı. Gastrik kanser ölümleri altta yatan ölüm nedeni olarak ICD-10 C16 kodu ile, VTE ise I26 ve I80–I82 kodları ile tanımlandı. Gastrik kanser ölümleri içinde eşlik eden VTE oranları hesaplandı. Zaman içindeki değişim doğrusal ve log-doğrusal regresyon modelleri ile değerlendirilerek yıllık yüzde değişim (APC) hesaplandı ve joinpoint analizi uygulandı.Bulgular: Toplam 254,449 gastrik kanser ölümü içinde 5,371 (%2,11) olguda eşlik eden VTE saptandı. Gastrik kanser ölümleri içinde VTE oranı 1999’da %1,52’den 2020’de %2,90’a yükseldi ve toplam APC %3,47 olarak bulundu (95% GA, %3,00–3,95; p

Aim: Venous thromboembolism (VTE) is a clinically important complication in gastric cancer, yet nationwide mortality trends remain poorly defined. We evaluated temporal trends in VTE-related mortality among gastric cancer deaths in the United States.Materials and Methods: This population-based time-trend study used the CDC WONDER Multiple Cause of Death database (1999–2020). Gastric cancer deaths were identified using ICD-10 code C16, and VTE using codes I26 and I80–I82. Annual proportions of gastric cancer deaths with concomitant VTE were calculated. Temporal trends and annual percent change (APC) were assessed using linear and log-linear regression models with joinpoint analysis.Results: Among 254,449 gastric cancer deaths, 5,371 (2.11%) had concomitant VTE. The proportion of gastric cancer deaths with VTE increased from 1.52% in 1999 to 2.90% in 2020, corresponding to an overall APC of 3.47% (95% CI, 3.00–3.95; p

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