Bölgesel nöral tüp defektli gebelerin sağlıklı gebelerle karşılaştırılması

Year 2018, Volume: 9 Issue: 1, 50 - 54, 20.03.2018

Cemile Dayangan Sayan , Nevin Sağsöz , Zehra Sema Özkan , Mahmut İlkin Yeral , Serkan Tursun

https://doi.org/10.18663/tjcl.391392

Abstract

Amaç:
Nöral
tüp defektleri  nöral tüpün bir bölümünün
kapanmasında meydana gelen kusur sonucu ortaya çıkan ve sık görülen
konjenital  anomalilerdir. Dünya çapında her yıl yaklaşık 300.000 bebek NTD ile
doğmaktadır ve NTD konjenital anomalilerle ilişkili neonatal ölümlerin yaklaşık
olarak %29’undan sorumlu tutulmaktadır. Bu çalışmada Kırıkkale ilinde 2014-2017
yılları arasında saptanan NTD’li gebeler ile sağlıklı gebelerin demografik
özellikleri ve laboratuar bulgularını karşılaştırmayı amaçladık.

Gereç ve Yöntem: Bu
retrospektif çalışmaya NTD’i tanısı almış 27 olgu ve  30 sağlıklı gebe dahil edildi. Olguların
demografik verileri ve laboratuvar değerleri kayıtlardan tarandı ve kaydedildi.
Bulgular NTD’li ve sağlıklı gebelik grupları arasında karşılaştırıldı.

Bulgular: NTD’li hastaların 15
tanesi meningomyelosel, 4 tanesi anensefali, 2 tanesi ensefalosel, 2 tanesi
eksensefali, 2 tanesi anensefali+ensefalosel, 1 tanesi
meningomyelosel+ensefalosel ve 1 tanesi de myeloşizis
tanılı idi. NTD grubunun ortalama vücut kitle indeksi kontrol grubuna göre
anlamlı olarak yüksekti. Gruplar arasında laboratuvar parametreleri açısından
istatistiksel olarak anlamlı bir fark yoktu.

Sonuçlar: Kırıkkale ilinde NTD’li ve
sağlıklı gebeleri karşılaştırdığımız çalışmamızda NTD grubunda VKİ’nin kontrol
grubuna göre anlamlı daha yüksek olduğunu tespit ettik. Çok merkezli ve artmış
popülasyonla yapılacak yeni çalışmalar, Türk toplumunda NTD risklerini
ayrıntılı olarak belirlemek açısından faydalı olacaktır.

Keywords

Nöral tüp defekti, gebelik

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