EVALUATION OF SERUM LEVELS OF NETRIN-1 AS A POTENTIAL BIOMARKER FOR EARLY PREDICTION OF PREDIABETES

Year 2021, Volume: 4 Issue: 2, 70 - 76, 31.08.2021

Çiğdem Aydın Acar , Suray Pehlivanoğlu , Mehmet Kök Gizem Yılmaz

Abstract

Objectives: Prediabetes is a candidate status for Type 2 diabetes, typically identified glycemic values range above normal but below diabetes thresholds. Early and accurate diagnosis of this period would be helpful to prevent the diabetes and its consequences. Netrin-1 is a potential metabolic biomarker that has been associated with diabetes. Previous studies are scarce and have yielded contrasting results on serum netrin-1 levels in diabetes. The aim of this study was to investigate the correlation between serum netrin-1 levels and prediabetes.
Methods: Sixty nine participants with prediabetes and 35 healthy controls were included in this study. Serum netrin-1 levels were determined using the Enzyme Linked Immunosorbent Assay (ELISA) method. Correlation analysis were done to assess the relationship between serum netrin-1 levels and biochemical parameters.
Results: Serum netrin-1 levels were significantly decreased in the prediabetes group compared to the healthy control group (P<0.0001). A significant negative correlation was observed between serum netrin-1 levels and age, hemoglobin A1c (HbA1c), sedimantation, fasting blood glucose (FBG) and C-reactive protein (CRP) (r = -0.2738, 0.2886, r = -0.3180; P<0.01, r = -0.3439 and r = -0.3987; P<0.01, respectively.
Conclusion: Serum netrin-1 significantly negative-correlated with prediabetes and also with FBG and HbA1c. These results suggested that netrin-1 could be used as a biomarker for the early detection or screening of prediabetes.

Keywords

Netrin-1, Prediabetes, Biomarker

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