THE EFFECTS OF FICUS CARICA SEED OIL ADMINISTRATION ON RENAL TAS, TOS, OSI, PON AND TOTAL THIOL VALUES IN RENAL ISCHEMIA REPERFUSION DAMAGE

Year 2023, Volume: 6 Issue: 3, 156 - 160, 31.12.2023

Ferhat Şirinyıldız , Serdal Öğüt

https://doi.org/10.56150/tjhsl.1293701

Cited By: 1

Abstract

Background and Objective: Renal ischemia-reperfusion is an important health condition that occurs for various reasons and causes kidney losses, and protective activities are especially important due to the short duration of the process. Studies with Ficus carica seed oil have shown that it has high antioxidant and anti-inflammatory effects. The aim of the study is to determine the protective effects of fig seed oil on renal ischemia-reperfusion injury.
Material and Method: The study was formed by dividing 30 Wistar Albino rats into 3 groups as control, ischemia reperfusion and ischemia reperfusion group performed after intragastric administration of 3 ml/kg Ficus carica seed oil for 14 days. At the end of the study, TOS, TAS, OSI, PON and total thiol levels were biochemically measured from the kidney tissues.
Results: Obtained results showed that 14-day fig seed oil application reduced oxidative damage (TOS, OSI) and increased antioxidant level (TAS, PON and total thiol) in kidneys exposed to ischemia-reperfusion injury statistically (p<0.05).
Conclusion: It has been determined that fig seed oil provides protective properties due to its ability to reduce oxidative damage, and has positive effects against ischemia-reperfusion injury that can occur randomly.

Keywords

Antioxidant, Ficus carica seed oil, Oxidative damage, Renal ischemia reperfusion damage

Supporting Institution

-

Project Number

-

Thanks

-

References

• Hssaini L, Hanine H, Charafi J, Razouk R, Elantari A, Ennahli S, et al. First report on fatty acids composition, total phenolics and antioxidant activity in seeds oil of four fig cultivars (Ficus carica L.) grown in Morocco. OCL. 2020;27:8.
• Chougui N, Tamendjari A, Hamidj W, Hallal S, Barras A, Richard T, et al. Oil composition and characterisation of phenolic compounds of Opuntia ficus-indica seeds. Food Chem. 2013;139(1–4):796–803.
• Raihana AN, Marikkar JMN, Amin I, Shuhaimi M. A review on food values of selected tropical fruits’ seeds. Int J Food Prop. 2015;18(11):2380–92.
• Gaaliche B, Trad M, Mars M. Effect of pollination intensity, frequency and pollen source on fig (Ficus carica L.) productivity and fruit quality. Sci Hortic. 2011;130(4):737–42.
• Rajendran EGMG. Fig (Ficus carica) Seed Oil. In: Fig (Ficus carica): Production, Processing, and Properties. Springer; 2023. p. 357–68.
• Vardin AY, Şirinyıldız DD, Yorulmaz A. Impact of Roasting on Quality and Compositional Characteristics of Fig Seed Oil. J Agric Sci. 2023;29(2):404–12.
• Veberic R, Mikulic-Petkovsek M. Phytochemical composition of common fig (Ficus carica L.) cultivars. In: Nutritional composition of fruit cultivars. Elsevier; 2016. p. 235–55.
• Badgujar SB, Patel VV, Bandivdekar AH, Mahajan RT. Traditional uses, phytochemistry and pharmacology of Ficus carica: A review. Pharm Biol. 2014;52(11):1487–503.
• Mawa S, Husain K, Jantan I. Ficus carica L.(Moraceae): phytochemistry, traditional uses and biological activities. Evid Based Complement Alternat Med. 2013;2013.
• Orak C, Şirinyıldız F, Yılmaz EG, Cesur G, Ek RO. Protective effects of Ficus carica seed oil on ischemia and reperfusion injury in a rat model of acute mesenteric ischemia. Turk J Trauma Emerg Surg. 2021;27(4):402.
• Saoudi M, El Feki A. Protective role of Ficus carica stem extract against hepatic oxidative damage induced by methanol in male Wistar rats. Evid Based Complement Alternat Med. 2012;2012.
• Bird JE, Milhoan K, Wilson CB, Young SG, Mundy CA, Parthasarathy S, et al. Ischemic acute renal failure and antioxidant therapy in the rat. The relation between glomerular and tubular dysfunction. J Clin Invest. 1988;81(5):1630–8.
• Joosten SA, Sijpkens YW, Van Kooten C, Paul LC. Chronic renal allograft rejection: pathophysiologic considerations. Kidney Int. 2005;68(1):1–13.
• Weight SC, Bell PRF, Nicholson ML. Renal ischaemia-reperfusion injury. Br J Surg. 1996;83(2):162–70.
• Williams P, Lopez H, Britt D, Chan C, Ezrin A, Hottendorf R. Characterization of renal ischemia-reperfusion injury in rats. J Pharmacol Toxicol Methods. 1997;37(1):1–7.
• Tuğtepe H, Şener G, Bıyıklı NK, Yüksel M, Çetinel Ş, Gedik N, et al. The protective effect of oxytocin on renal ischemia/reperfusion injury in rats. Regul Pept. 2007;140(3):101–8.
• Erel O. A novel automated method to measure total antioxidant response against potent free radical reactions. Clin Biochem. 2004;37(2):112–9.
• Erel O, Neselioglu S. A novel and automated assay for thiol/disulphide homeostasis. Clin Biochem. 2014;47(18):326–32.
• Eckerson HW, Wyte CM, La Du BN. The human serum paraoxonase/arylesterase polymorphism. Am J Hum Genet. 1983;35(6):1126.
• İşler D, ŞİRİNYILDIZ F, Ek RO. Effect of Ficus carica (fig) seed oil administration on GSH levels, necrosis and cast formation in myoglobinuric acute kidney injury. Cukurova Med J. 2022;47(1):152–60.
• Serteser M, Koken T, Kahraman A, Yilmaz K, Akbulut G, Dilek ON. Changes in hepatic TNF-α levels, antioxidant status, and oxidation products after renal ischemia/reperfusion injury in mice. J Surg Res. 2002;107(2):234–40.
• Rovcanin B, Medic B, Kocic G, Cebovic T, Ristic M, Prostran M. Molecular dissection of renal ischemia-reperfusion: oxidative stress and cellular events. Curr Med Chem. 2016;23(19):1965–80.
• Walker LM, York JL, Imam SZ, Ali SF, Muldrew KL, Mayeux PR. Oxidative stress and reactive nitrogen species generation during renal ischemia. Toxicol Sci. 2001;63(1):143–8.
• Ates HA, Yücetaş U, Erkan E, Yucetas E, Ulusoy S, Kadihasanoglu M, et al. The predictive value of ischemia-modified albumin in renal ischemia-reperfusion injury. Urol Int. 2019;103(4):473–81.
• Sancaktutar AA, Bodakci MN, Hatipoglu NK, Soylemez H, Basarılı K, Turkcu G. The protective effects of pomegranate extracts against renal ischemia-reperfusion injury in male rats. Urol Ann. 2014;6(1):46.
• Bozkurt Y, Fırat U, Atar M, Sancaktutar AA, Pembegül N, Söylemez H, et al. The protective effect of ellagic acid against renal ischemia-reperfusion injury in male rats. 2012;18(5):823–8.
• Toprak T, Sekerci CA, Aydın HR, Ramazanoglu MA, Arslan FD, Basok BI, et al. Protective effect of chlorogenic acid on renal ischemia/reperfusion injury in rats. Arch Ital Urol E Androl. 2020;92(2).
• Tavafi M, Ahmadvand H, Tamjidipour A, Hasanvand A. Rosmarinic acid ameliorates renal ischemia reperfusion damage in rats. J Nephropharmacology. 2019;9(2):e15–e15.
• Kulah E, Tascilar O, Acikgoz S, Karadeniz G, Ozel Tekin I, Can M, et al. Oxidized LDL accumulation in experimental renal ischemia reperfusion injury model. Ren Fail. 2007;29(4):409–15.
• Hosseinzadeh H, Sadeghnia HR, Ziaee T, Danaee A. Protective effect of aqueous saffron extract (Crocus sativus L.) and crocin, its active constituent, on renal ischemia-reperfusion-induced oxidative damage in rats. J Pharm Pharm Sci. 2005;8(3):387–93.
• Volti GL, Sorrenti V, Murabito P, Galvano F, Veroux M, Gullo A, et al. Pharmacological induction of heme oxygenase-1 inhibits iNOS and oxidative stress in renal ischemia-reperfusion injury. In: Transplantation proceedings. Elsevier; 2007. p. 2986–91.