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Cetuximab-Induced Acneiform Eruption: A Case Report

Year 2022, Volume: 4 - Supplement 1, 117 - 119, 01.04.2022
https://doi.org/10.46310/tjim.1071185

Abstract

Epidermal growth factor receptor (EGFR) monoclonal antibody inhibitors are used to treat metastatic colorectal cancers. Cetuximab, an EGFR inhibitor drug, targets specific molecular pathways and does not cause the severe systemic side effects seen in cytotoxic chemotherapy. Herein, we presented a case who developed acneiform eruptions during cetuximab treatment.

References

  • Broadbridge VT, Karapetis CS, Price TJ. Cetuximab in metastatic colorectal cancer. Expert Rev Anticancer Ther. 2012 May;12(5):555-65. doi: 10.1586/era.12.25.
  • Beech J, Germetaki T, Judge M, Paton N, Collins J, Garbutt A, Braun M, Fenwick J, Saunders MP. Management and grading of EGFR inhibitor-induced cutaneous toxicity. Future Oncol. 2018 Oct;14(24):2531-41. doi: 10.2217/fon-2018-0187.
  • Messersmith WA, Ahnen DJ. Targeting EGFR in colorectal cancer. N Engl J Med. 2008 Oct 23;359(17):1834-6. doi: 10.1056/ NEJMe0806778.
  • Lacouture ME, Anadkat M, Jatoi A, Garawin T, Bohac C, Mitchell E. Dermatologic toxicity occurring during anti- EGFR monoclonal inhibitor therapy in patients with metastatic colorectal cancer: A systematic review. Clin Colorectal Cancer. 2018 Jun;17(2):85-96. doi: 10.1016/j.clcc.2017.12.004.
  • Nguyen A, Hoang V, Laquer V, Kelly KM. Angiogenesis in cutaneous disease: part I. J Am Acad Dermatol. 2009 Dec;61(6):921-42; quiz 943-4. doi: 10.1016/j.jaad.2009.05.052.
  • Hu JC, Sadeghi P, Pinter-Brown LC, Yashar S, Chiu MW. Cutaneous side effects of epidermal growth factor receptor inhibitors: Clinical presentation, pathogenesis, and management. J Am Acad Dermatol. 2007 Feb;56(2):317-26. doi: 10.1016/j. jaad.2006.09.005.
  • Sipples R. Common side effects of anti-EGFR therapy: Acneform rash. Semin Oncol Nurs. 2006 Feb;22(1 Suppl 1):28-34. doi: 10.1016/j.soncn.2006.01.013.
Year 2022, Volume: 4 - Supplement 1, 117 - 119, 01.04.2022
https://doi.org/10.46310/tjim.1071185

Abstract

References

  • Broadbridge VT, Karapetis CS, Price TJ. Cetuximab in metastatic colorectal cancer. Expert Rev Anticancer Ther. 2012 May;12(5):555-65. doi: 10.1586/era.12.25.
  • Beech J, Germetaki T, Judge M, Paton N, Collins J, Garbutt A, Braun M, Fenwick J, Saunders MP. Management and grading of EGFR inhibitor-induced cutaneous toxicity. Future Oncol. 2018 Oct;14(24):2531-41. doi: 10.2217/fon-2018-0187.
  • Messersmith WA, Ahnen DJ. Targeting EGFR in colorectal cancer. N Engl J Med. 2008 Oct 23;359(17):1834-6. doi: 10.1056/ NEJMe0806778.
  • Lacouture ME, Anadkat M, Jatoi A, Garawin T, Bohac C, Mitchell E. Dermatologic toxicity occurring during anti- EGFR monoclonal inhibitor therapy in patients with metastatic colorectal cancer: A systematic review. Clin Colorectal Cancer. 2018 Jun;17(2):85-96. doi: 10.1016/j.clcc.2017.12.004.
  • Nguyen A, Hoang V, Laquer V, Kelly KM. Angiogenesis in cutaneous disease: part I. J Am Acad Dermatol. 2009 Dec;61(6):921-42; quiz 943-4. doi: 10.1016/j.jaad.2009.05.052.
  • Hu JC, Sadeghi P, Pinter-Brown LC, Yashar S, Chiu MW. Cutaneous side effects of epidermal growth factor receptor inhibitors: Clinical presentation, pathogenesis, and management. J Am Acad Dermatol. 2007 Feb;56(2):317-26. doi: 10.1016/j. jaad.2006.09.005.
  • Sipples R. Common side effects of anti-EGFR therapy: Acneform rash. Semin Oncol Nurs. 2006 Feb;22(1 Suppl 1):28-34. doi: 10.1016/j.soncn.2006.01.013.
There are 7 citations in total.

Details

Primary Language English
Subjects ​Internal Diseases
Journal Section Case Reports
Authors

Büşra Güner 0000-0001-6320-9512

Türkkan Evrensel 0000-0002-9732-5340

Sibel Oyucu Orhan 0000-0001-8217-3471

Publication Date April 1, 2022
Submission Date February 10, 2022
Acceptance Date March 9, 2022
Published in Issue Year 2022 Volume: 4 - Supplement 1

Cite

EndNote Güner B, Evrensel T, Oyucu Orhan S (April 1, 2022) Cetuximab-Induced Acneiform Eruption: A Case Report. Turkish Journal of Internal Medicine 4 117–119.

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