Research Article
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The Diagnostic Significance of Serum Troponin Levels Lambs with White Muscle Disease

Year 2018, Volume: 2 Issue: 2, 5 - 11, 24.12.2018

Abstract

Objective:This study was carried
out to determine the prognostic importance of troponin enzyme levels in lambs
with White Muscle Disease (WMD).

Materials and Methods:This study consisted of
50 male and female lambs aged 0-3 months old, 30 of which had clinical white
muscle disease (Group I) and 20 of which were healthy (Group II – Control
Group). Group I was composed of lambs that showed clinical symptoms of the
disease. The disease was also identified by laboratory analysis. The lambs in
this group were treated and the course of the disease was followed for 15 days.

Results:Compared with the
control group, the Group I before treatment results were as follows: AST, LDH,
CK, CK-MB, Troponin I and T (P<0.001) were high, while GSH-Px (P<0.001),
SOD (P<0.01), Se (P<0.01), Retinol and Tocopherol were low. Compared with
the control group, the Group I After Treatment results were as follows: AST,
CK, Troponin T (P<0.001) were high, LDH (P<0.01) was high and GSH-Px
(P<0.01) was low. Comparing Group I Before Treatment and After Treatment
results, AST, CK, CK-MB and Troponin I (P<0.001), as well as GSH-Px, SOD and
Se (P<0.01) were high. It was determined that LDH decreased and Tocopherol
increased. Whereas Vitamin D3 was determined to be insignificant in all three
groups, the levels of CK-MB, Troponin I, Retinol, SOD and Se were insignificant
in the After Treatment and control groups, and the Troponin T and retinol
values were measured to be insignificant in the Before Treatment and After
Treatment groups.

Conclusion:To conclude, measuring
the AST, CK, CK-MB, LDH values as well as Troponin can be an important
parameter for the identification and prognosis of WMD


References

  • Aksoy G. İz Element ve Vitamin Teminindeki Bozukluklar. In: Gül Y., Geviş getiren Hayvanların İç Hastalıkları. Medipress matbaacılık yayıncılık Ltd.Şti. Malatya 2012; pp: 511-533.
  • Altuğ N, Ağaoğlu ZT, Yüksek N, Kaya A, Keleş İ. Adenosine deaminase in the diagnosis of white muscle diseases in lambs. Medycyna Wet 2006; 62: 1007-1010.Ataollahi F, Mohri M, Seifi HA, Pingguan-Murphy B, Wan Abas WAB, Abu Osman NA. Evaluation of copper concentration in subclinical cases of white muscle disease and its relationship whit cardiac troponin I. Plos One 2013; 8: 1-5.
  • Aytuğ CN, Alaçam E, Özkoç Ü, Yalçın B, Gökçen H, Türker H, 1990. Koyun-Keçi hastalıkları ve yetiştiriciliği, Tüm. Vet. Hayvancılık Hizmetleri Yayını. No:2, Teknoğrafik Matbaası, Istanbul 1990; 289-293.
  • Azzazy HME, Christenson RH. Cardiac markers of acute coronary syndromes: Is there a case for point of caretesting. Clinical Chemistry 2002; 35: 13–27.Babuin L, Jaffe AL. Troponin: the biomarker of choice for the detection of cardiac injury. CMAJ 2005; 173,10, 1191- 1202.
  • Başbuğan Y, Ağaoğlu ZT, Yüksek N. An investigation on serum troponin concentration in healthy ruminants. Kafkas Univ. Vet Fak Derg 2010; 16: 641-645.
  • Bertsch T, H Bleuel H, Aufenanger J. Comparison of cardiac troponin-T and cardiac troponin-I concentration in blood during orciprenaline induced tachycardia in rats. Experimental toxicology and pathology 1997; 49: 467–468.
  • Boccara G, Pouzeratte Y, Troncin R, Bonardet A, Boularan AM, Colson P, Mann C. Cardiac troponin I and ECG study. Acta Anaesthesiol Scand 2000; 44: 398–402.
  • Christenson RH, Apple FS, Morgan DL, Alonsozona GL, Mascotti K, Olson M, RT McCormack RT, Wians FH, Keffer JH, Duh SH. Cardiac troponin-I measurement with the Access immunoassay system: analytical and clinical performance characteristics. Clinical Chemistry 1998; 44: 52–60.
  • Cooper BJ, Valentine BA. Muscle and tendon in: Maxie MG (editors), Jubb, Kennedy and Palmer’s Pathology of Domestic Animals Volume 1. Elesvier Printing, China. 2016; 214-218.
  • Fredricks S, Metron GK, Lerena MJ, Heining P, Carter ND, Holt DW. Cardiac troponins and ceratine kinase content of striated muscle in common laboratory animals. Clinica Chimica Acta 2001; 304: 65–74.
  • Gunes V, Erdogan HM, M. Citil M, Ozcan K. Assay of cardiac troponins in the diagnosis of myocardial degeneration due to foot and mouth disease in a calf. The Veterinary Record 2005; 156: 714–715.
  • Gunes V, Ozcan K, Citil M, Onmaz AC, Erdogan HM. Detection of myocardial degeneration with point-of-care cardiac troponin assays and histopathology in lambs with white muscle disease. Vet J 2010; 184, 3, 376-8
  • Gunsolus, I., Sandoval, Y., Smith, S. W., Sexter, A., Schulz, K., Herzog, C. A., & Apple, F. S. Renal dysfunction influences the diagnostic and prognostic performance of high-sensitivity cardiac troponin I. Journal of the American Society of Nephrology, 2018; 29.2: 636-643.Kaneko JK. Clinical Biochemistry of Domestic Animals, 5th Edn., Academic Pres, San Diego, 1997; 413 - 414.
  • Kozat S, Altuğ N, Yüksek N, Özkan C. Evaluation of the levels of homocysteine, troponin ı, and nitric oxide in lambs with subclinical white muscle disease Kafkas Univ Vet Fak Derg 2011; 17: 441-444.
  • Mair J, Morandell D, Genser N. Equivalant early sensitivities of myoglobin, creatine kinase MB mass, creatine kinase isoform ratios and cardiac traponins I and T for acute myocardial infarction. Clin Chem 1995; 41:1266-72.
  • M-Bardorff M, Hallermayer K, Schro A, Ebert C. Improved troponin T Elisa specific for cardiac troponin T isoform: assay devlopment and analytical and clinical validation. Clinical Biochemistry 1999; 26: 7035–7042.
  • Murphy AN. Another new targets troponin I. Circulation Research 2004; 95: 1043.
  • Nizamlıoğlu M, Tiftik AM, Turgut K, Traş B. Kuzuların beyaz kas hastalığında vitamin E, Glutamik Okzalasetik Transaminaz (GOT), Kreatin Kinaz (CK) ve Laktat Dehidrogenaz (LDH) Aktivitelerinin Araştırılması. Doğa Türk Vet ve Hay Derg 1991; 15: 59-64.
  • O’Brien PJ, Dameron GW, Berk ML. Differantial reactivity of cardiac and skeletal muscle from various species in two generations of cardiac troponin-T immunoassays. Research in Veterinary Science 1998; 65: 135–137.
  • O’Brien PJ, Lant Y, Landenson JH. Differantial reactivity of cardiac and skeletal muscle from various species in a cardiac troponin-I immunoassay. Clinical Chemistry 1997; 43: 2333–2338.
  • Or ME, Dodurka HT Kayar A. A diagnostic importance of erythrocyte glutathioneperoxidase (GSH-Px) activity and some serum parameters in lambs with white muscle disease. Turk J Vet Anim Sci 2003; 27: 1-6.Panteghini M. Presenttissues in the determination of troponin sandothermarkers of cardiac damage. Clinical Biochemitry 2000; 33: 161–166.
  • Radostits OM, Gay CC, Hinchcliff KW, Constable PD. Veterinary Medicine ”A Texbook of The Diseases of Cattle, Horses, Sheep, Pigs and Goats”. 10th Ed. Bailliere Tindall, London 2006; 1716-1748.
  • Schober KE, Kirbach B. Noninvasive assessment of myocardial cell injury in dogs with suspected cardiac contusioan. Journal of Veterinary Cardiology 1999; 1: 17-25.
  • Scott PR. Sheep Medicine. CRC Press, Second Edition, 2015; 334-336.
  • Sugen B. Gunes V. Beyaz kas hastalıklı kuzularda kalp kası hasarının teşhisinde kardiyak troponin kit analizleri ve serum enzim aktivitelerinin önemi. Sağlık Bilimleri Dergisi (Journal of Health Sciences) 2008; 17: 144-149.
  • Tharwat M, Al-Sobayit F, El-Sayed M. Cardiac troponin I in healthy newborn goat kids and in goat kids with cardiac nutritional muscular dystrophy. Acta Veterinaria Hungarica 2013; 61(4): 442-453.
  • Tunca R, Erdoğan HM, Sözmen M, Çitil M, Devrim AK, Erginsoy S, Uzlu E. Evaluation of cardiac troponin I and inducible nitric oxide synthase expression in lambs with white muscle disease. Türk Journal of Vetetinary Animal Science 2009; 33: 53-59.
  • Turgut K. Veteriner Klinik Laboratuvar Teşhis. Bahçıvanlar Basım Sanayi Konya, 2000; 179-257.Yavuz O. The Pathological Investigations on Nutritional Myopaty Causeing Lamb Deaths in Neonatal Period. Journal of Bahri Dagdas Animal Research 2017; 6(2): 1-8.
  • Yüksek N, Başbuğan Y, Altug, N. İz Element-Vitamin Yetmezlikleri ve Metabolik Bozukluklar. In: Yaran E. Koyun ve Keçi Hekimliği. Güneş Tıp Kitap Evleri Ostim Ankara. 2017; 511-531.
Year 2018, Volume: 2 Issue: 2, 5 - 11, 24.12.2018

Abstract

References

  • Aksoy G. İz Element ve Vitamin Teminindeki Bozukluklar. In: Gül Y., Geviş getiren Hayvanların İç Hastalıkları. Medipress matbaacılık yayıncılık Ltd.Şti. Malatya 2012; pp: 511-533.
  • Altuğ N, Ağaoğlu ZT, Yüksek N, Kaya A, Keleş İ. Adenosine deaminase in the diagnosis of white muscle diseases in lambs. Medycyna Wet 2006; 62: 1007-1010.Ataollahi F, Mohri M, Seifi HA, Pingguan-Murphy B, Wan Abas WAB, Abu Osman NA. Evaluation of copper concentration in subclinical cases of white muscle disease and its relationship whit cardiac troponin I. Plos One 2013; 8: 1-5.
  • Aytuğ CN, Alaçam E, Özkoç Ü, Yalçın B, Gökçen H, Türker H, 1990. Koyun-Keçi hastalıkları ve yetiştiriciliği, Tüm. Vet. Hayvancılık Hizmetleri Yayını. No:2, Teknoğrafik Matbaası, Istanbul 1990; 289-293.
  • Azzazy HME, Christenson RH. Cardiac markers of acute coronary syndromes: Is there a case for point of caretesting. Clinical Chemistry 2002; 35: 13–27.Babuin L, Jaffe AL. Troponin: the biomarker of choice for the detection of cardiac injury. CMAJ 2005; 173,10, 1191- 1202.
  • Başbuğan Y, Ağaoğlu ZT, Yüksek N. An investigation on serum troponin concentration in healthy ruminants. Kafkas Univ. Vet Fak Derg 2010; 16: 641-645.
  • Bertsch T, H Bleuel H, Aufenanger J. Comparison of cardiac troponin-T and cardiac troponin-I concentration in blood during orciprenaline induced tachycardia in rats. Experimental toxicology and pathology 1997; 49: 467–468.
  • Boccara G, Pouzeratte Y, Troncin R, Bonardet A, Boularan AM, Colson P, Mann C. Cardiac troponin I and ECG study. Acta Anaesthesiol Scand 2000; 44: 398–402.
  • Christenson RH, Apple FS, Morgan DL, Alonsozona GL, Mascotti K, Olson M, RT McCormack RT, Wians FH, Keffer JH, Duh SH. Cardiac troponin-I measurement with the Access immunoassay system: analytical and clinical performance characteristics. Clinical Chemistry 1998; 44: 52–60.
  • Cooper BJ, Valentine BA. Muscle and tendon in: Maxie MG (editors), Jubb, Kennedy and Palmer’s Pathology of Domestic Animals Volume 1. Elesvier Printing, China. 2016; 214-218.
  • Fredricks S, Metron GK, Lerena MJ, Heining P, Carter ND, Holt DW. Cardiac troponins and ceratine kinase content of striated muscle in common laboratory animals. Clinica Chimica Acta 2001; 304: 65–74.
  • Gunes V, Erdogan HM, M. Citil M, Ozcan K. Assay of cardiac troponins in the diagnosis of myocardial degeneration due to foot and mouth disease in a calf. The Veterinary Record 2005; 156: 714–715.
  • Gunes V, Ozcan K, Citil M, Onmaz AC, Erdogan HM. Detection of myocardial degeneration with point-of-care cardiac troponin assays and histopathology in lambs with white muscle disease. Vet J 2010; 184, 3, 376-8
  • Gunsolus, I., Sandoval, Y., Smith, S. W., Sexter, A., Schulz, K., Herzog, C. A., & Apple, F. S. Renal dysfunction influences the diagnostic and prognostic performance of high-sensitivity cardiac troponin I. Journal of the American Society of Nephrology, 2018; 29.2: 636-643.Kaneko JK. Clinical Biochemistry of Domestic Animals, 5th Edn., Academic Pres, San Diego, 1997; 413 - 414.
  • Kozat S, Altuğ N, Yüksek N, Özkan C. Evaluation of the levels of homocysteine, troponin ı, and nitric oxide in lambs with subclinical white muscle disease Kafkas Univ Vet Fak Derg 2011; 17: 441-444.
  • Mair J, Morandell D, Genser N. Equivalant early sensitivities of myoglobin, creatine kinase MB mass, creatine kinase isoform ratios and cardiac traponins I and T for acute myocardial infarction. Clin Chem 1995; 41:1266-72.
  • M-Bardorff M, Hallermayer K, Schro A, Ebert C. Improved troponin T Elisa specific for cardiac troponin T isoform: assay devlopment and analytical and clinical validation. Clinical Biochemistry 1999; 26: 7035–7042.
  • Murphy AN. Another new targets troponin I. Circulation Research 2004; 95: 1043.
  • Nizamlıoğlu M, Tiftik AM, Turgut K, Traş B. Kuzuların beyaz kas hastalığında vitamin E, Glutamik Okzalasetik Transaminaz (GOT), Kreatin Kinaz (CK) ve Laktat Dehidrogenaz (LDH) Aktivitelerinin Araştırılması. Doğa Türk Vet ve Hay Derg 1991; 15: 59-64.
  • O’Brien PJ, Dameron GW, Berk ML. Differantial reactivity of cardiac and skeletal muscle from various species in two generations of cardiac troponin-T immunoassays. Research in Veterinary Science 1998; 65: 135–137.
  • O’Brien PJ, Lant Y, Landenson JH. Differantial reactivity of cardiac and skeletal muscle from various species in a cardiac troponin-I immunoassay. Clinical Chemistry 1997; 43: 2333–2338.
  • Or ME, Dodurka HT Kayar A. A diagnostic importance of erythrocyte glutathioneperoxidase (GSH-Px) activity and some serum parameters in lambs with white muscle disease. Turk J Vet Anim Sci 2003; 27: 1-6.Panteghini M. Presenttissues in the determination of troponin sandothermarkers of cardiac damage. Clinical Biochemitry 2000; 33: 161–166.
  • Radostits OM, Gay CC, Hinchcliff KW, Constable PD. Veterinary Medicine ”A Texbook of The Diseases of Cattle, Horses, Sheep, Pigs and Goats”. 10th Ed. Bailliere Tindall, London 2006; 1716-1748.
  • Schober KE, Kirbach B. Noninvasive assessment of myocardial cell injury in dogs with suspected cardiac contusioan. Journal of Veterinary Cardiology 1999; 1: 17-25.
  • Scott PR. Sheep Medicine. CRC Press, Second Edition, 2015; 334-336.
  • Sugen B. Gunes V. Beyaz kas hastalıklı kuzularda kalp kası hasarının teşhisinde kardiyak troponin kit analizleri ve serum enzim aktivitelerinin önemi. Sağlık Bilimleri Dergisi (Journal of Health Sciences) 2008; 17: 144-149.
  • Tharwat M, Al-Sobayit F, El-Sayed M. Cardiac troponin I in healthy newborn goat kids and in goat kids with cardiac nutritional muscular dystrophy. Acta Veterinaria Hungarica 2013; 61(4): 442-453.
  • Tunca R, Erdoğan HM, Sözmen M, Çitil M, Devrim AK, Erginsoy S, Uzlu E. Evaluation of cardiac troponin I and inducible nitric oxide synthase expression in lambs with white muscle disease. Türk Journal of Vetetinary Animal Science 2009; 33: 53-59.
  • Turgut K. Veteriner Klinik Laboratuvar Teşhis. Bahçıvanlar Basım Sanayi Konya, 2000; 179-257.Yavuz O. The Pathological Investigations on Nutritional Myopaty Causeing Lamb Deaths in Neonatal Period. Journal of Bahri Dagdas Animal Research 2017; 6(2): 1-8.
  • Yüksek N, Başbuğan Y, Altug, N. İz Element-Vitamin Yetmezlikleri ve Metabolik Bozukluklar. In: Yaran E. Koyun ve Keçi Hekimliği. Güneş Tıp Kitap Evleri Ostim Ankara. 2017; 511-531.
There are 29 citations in total.

Details

Primary Language English
Journal Section 2018 Volume 2 Number 2
Authors

Yıldıray Basbugan

Nazmi Yüksek

Nuri Altuğ

Ebubekir Ceylan

İbrahim Hakkı Yörük

Zahit Tevfik Ağaoğlu

Publication Date December 24, 2018
Submission Date October 24, 2018
Published in Issue Year 2018 Volume: 2 Issue: 2

Cite

APA Basbugan, Y., Yüksek, N., Altuğ, N., Ceylan, E., et al. (2018). The Diagnostic Significance of Serum Troponin Levels Lambs with White Muscle Disease. Turkish Journal of Veterinary Research, 2(2), 5-11.
AMA Basbugan Y, Yüksek N, Altuğ N, Ceylan E, Yörük İH, Ağaoğlu ZT. The Diagnostic Significance of Serum Troponin Levels Lambs with White Muscle Disease. TJVR. December 2018;2(2):5-11.
Chicago Basbugan, Yıldıray, Nazmi Yüksek, Nuri Altuğ, Ebubekir Ceylan, İbrahim Hakkı Yörük, and Zahit Tevfik Ağaoğlu. “The Diagnostic Significance of Serum Troponin Levels Lambs With White Muscle Disease”. Turkish Journal of Veterinary Research 2, no. 2 (December 2018): 5-11.
EndNote Basbugan Y, Yüksek N, Altuğ N, Ceylan E, Yörük İH, Ağaoğlu ZT (December 1, 2018) The Diagnostic Significance of Serum Troponin Levels Lambs with White Muscle Disease. Turkish Journal of Veterinary Research 2 2 5–11.
IEEE Y. Basbugan, N. Yüksek, N. Altuğ, E. Ceylan, İ. H. Yörük, and Z. T. Ağaoğlu, “The Diagnostic Significance of Serum Troponin Levels Lambs with White Muscle Disease”, TJVR, vol. 2, no. 2, pp. 5–11, 2018.
ISNAD Basbugan, Yıldıray et al. “The Diagnostic Significance of Serum Troponin Levels Lambs With White Muscle Disease”. Turkish Journal of Veterinary Research 2/2 (December 2018), 5-11.
JAMA Basbugan Y, Yüksek N, Altuğ N, Ceylan E, Yörük İH, Ağaoğlu ZT. The Diagnostic Significance of Serum Troponin Levels Lambs with White Muscle Disease. TJVR. 2018;2:5–11.
MLA Basbugan, Yıldıray et al. “The Diagnostic Significance of Serum Troponin Levels Lambs With White Muscle Disease”. Turkish Journal of Veterinary Research, vol. 2, no. 2, 2018, pp. 5-11.
Vancouver Basbugan Y, Yüksek N, Altuğ N, Ceylan E, Yörük İH, Ağaoğlu ZT. The Diagnostic Significance of Serum Troponin Levels Lambs with White Muscle Disease. TJVR. 2018;2(2):5-11.