The study aimed at investigates the science students’ satisfaction level of using e-learning and virtual classesin exceptional condition COVID-19 Crisis, in light of three demographic variables: students’ specialization,educational level, and GPA. The population consisted of all science students (Physics, Chemistry, Biology,and Mathematics) in the college of science at a university from Eastern Province, Saudi Arabia. The samplecomprised of 116 science students. The researcher developed a questionnaire and verified its validity andreliability for collecting data. Some statistical analyses such as mean, standard deviations, and ANOVAtests were conducted to analyze the questionnaire. The results indicated that the satisfaction level of usinge-learning and virtual classes by science students is medium in general but with varying degrees from oneitem to another. The results did not show significant statistical differences at the level (α = 0.05) of the useof e-learning and virtual classes for all independent variables: students’ specialization, educational level,and GPA. The study included several recommendations; the most important of which is the necessity ofproviding infrastructure in the university (all colleges) concerning e-learning and educational technology,providing training programs for all university professors and students on how to use e-learning efficiently toboost their competences and skills in utilizing these innovative models.