Abstract
Kaposi's sarcoma, the most frequently affecting immunosuppressed patients, is the tumoral structure that is mixed with infectious, immunologic, and neoplastic processes. The tumor was first described as “Idiopathic Multiple Pigmented Sarcoma” by Moritz Kaposi. According to the biological behavior, Kaposi Sarcoma is located in the vascular tumors group with low malignant potential. The disease occurs more often in the transplant and immunosuppressed patients such as Acquired Immune Deficiency Syndrome, affects mainly men in their fifth or sixth decades, and involves the low extremites. The tumor, that can present cutaneous lesions with or without internal involvement, has different clinical forms. In recent years, the pathological diagnosis of the tumor, which has several sub-types, is becoming increasingly important. We presented a sixty three years old male's case, diagnosed with seldom seen pyogenic granuloma-like Kaposi's sarcoma. Key words: Kaposi Sarcoma; Sub-Types; Pyogenic Granuloma-Like.
References
- Weedon D. Vascular tumors. In: Weedon D, eds. Weedon’s Skin Pathology. 3rd editon, Philadelphia: Churchill Livingstone Elsevier; 2010. p. 913-8.
- Iscovich J, Boffetta P, Franceschi S, Azizi E, Sarid R. Classic kaposi sarcoma: epidemiology and risk factors. Cancer 2000;88:500-17.
- Guttman-Yassky E, Kra-Oz Z, Dubnov J, Friedman- Birnbaum R, Segal I, Zaltzman N, et. al. Infection with Kaposi's sarcoma-associated herpesvirus among families of patients with classic Kaposi's sarcoma. Arch Dermatol 2005;141:1429-34.
- Hbid O, Belloul L, Fajali N, Ismaili N, Duprez R, Tanguy M, et. al. Kaposi's sarcoma in Morocco: a pathological study with immunostaining for human herpesvirus-8 LNA-1. Pathology 2005;37:288-95.
- Schwartz EJ, Dorfman RF, Kohler S. Human herpesvirus-8 latent nuclear antigen-1 expression in endemic Kaposi sarcoma: an immunohistochemical study of 16 cases. Am J Surg Pathol 2003;27:1546-50.
- Chang Y, Cesarman E, Pessin MS, Lee F, Culpepper J, Knowles DM,et. al. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 1994;16:1865-9.
- Prince HE, Schroff RW, Ayoub G, Han S, Gottlieb MS, Fahey JL. HLA studies in acquired immune deficiency syndrome patients with Kaposi's sarcoma. J Clin Immunol 1984;4:242-5.
- Hengge UR, Ruzicka T, Tyring SK, Stuschke M, Roggendorf M, Schwartz RA, et. al. Update on Kaposi's sarcoma and other HHV8 associated diseases. Part 2: pathogenesis, Castleman's disease, and pleural effusion lymphoma. Lancet Infect Dis 2002;2:344-52.
- Grayson W, Pantanowitz L. Histological variants of cutaneous Kaposi sarcoma. Diagn Pathol 2008;25:31.
- Kandemir NO, Gün BD, Barut F, Yurdakan G, Bahadır
- B, Bektaş S, ve ark. Klasik Kaposi sarkomu olgularında histolojik alt gruplar: Ön çalışma. Türkderm 2010;44: 73-8.
Abstract
Kaposi sarkomu, ön planda ve daha sık olarak immunsuprese hastalarda izlenen, infeksiyöz, immunolojik ve neoplastik süreçlerin iç içe girdiği tümöral bir yapılanmadır. İlk kez Moritz Kaposi tarafından "idiopatik multiple pigmentli sarkoma" olarak tanımlanmıştır. Biyolojik davranış açısından düşük malignite potansiyeli taşıyan vasküler tümörler gurubunda yer alır. Sıklıkla organ nakli alıcısı ve kazanılmış immün yetmezlik sendromu gibi immünsüprese hastalarda daha çok gelişen, lokalizasyon olarak alt ekstremite derisini tercih eden bu tümör başlıca 5-6. dekatlardaki erkeklerde görülür. Tümörün deri lezyonları ile birlikte organ tutulumu yapabilen farklı klinik formları vardır. Son yıllarda birçok alt tipi tanımlanan bu tümörde patolojik tanı giderek önem kazanmaktadır. Burada nadir görülen püyojenik granüloma benzeri tip tanısı konan altmış üç yaşındaki bir erkek hasta olgusu sunulmuştur. Anahtar kelimeler: Kaposi Sarkomu; Alt Tip; Püyojenik Granülom Benzeri.
References
- Weedon D. Vascular tumors. In: Weedon D, eds. Weedon’s Skin Pathology. 3rd editon, Philadelphia: Churchill Livingstone Elsevier; 2010. p. 913-8.
- Iscovich J, Boffetta P, Franceschi S, Azizi E, Sarid R. Classic kaposi sarcoma: epidemiology and risk factors. Cancer 2000;88:500-17.
- Guttman-Yassky E, Kra-Oz Z, Dubnov J, Friedman- Birnbaum R, Segal I, Zaltzman N, et. al. Infection with Kaposi's sarcoma-associated herpesvirus among families of patients with classic Kaposi's sarcoma. Arch Dermatol 2005;141:1429-34.
- Hbid O, Belloul L, Fajali N, Ismaili N, Duprez R, Tanguy M, et. al. Kaposi's sarcoma in Morocco: a pathological study with immunostaining for human herpesvirus-8 LNA-1. Pathology 2005;37:288-95.
- Schwartz EJ, Dorfman RF, Kohler S. Human herpesvirus-8 latent nuclear antigen-1 expression in endemic Kaposi sarcoma: an immunohistochemical study of 16 cases. Am J Surg Pathol 2003;27:1546-50.
- Chang Y, Cesarman E, Pessin MS, Lee F, Culpepper J, Knowles DM,et. al. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 1994;16:1865-9.
- Prince HE, Schroff RW, Ayoub G, Han S, Gottlieb MS, Fahey JL. HLA studies in acquired immune deficiency syndrome patients with Kaposi's sarcoma. J Clin Immunol 1984;4:242-5.
- Hengge UR, Ruzicka T, Tyring SK, Stuschke M, Roggendorf M, Schwartz RA, et. al. Update on Kaposi's sarcoma and other HHV8 associated diseases. Part 2: pathogenesis, Castleman's disease, and pleural effusion lymphoma. Lancet Infect Dis 2002;2:344-52.
- Grayson W, Pantanowitz L. Histological variants of cutaneous Kaposi sarcoma. Diagn Pathol 2008;25:31.
- Kandemir NO, Gün BD, Barut F, Yurdakan G, Bahadır
- B, Bektaş S, ve ark. Klasik Kaposi sarkomu olgularında histolojik alt gruplar: Ön çalışma. Türkderm 2010;44: 73-8.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Articles |
| Authors | |
| Publication Date | February 1, 2013 |
| Published in Issue | Year 2013 Volume: 20 Issue: 1 |