tr-ent The Turkish Journal of Ear Nose and Throat 2602-4837 Istanbul University Concurrent medullary and papillary carcinoma of thyroid Tiroidin eşzamanlı medüller ve papiller karsinomu Ateşpare Altay Department of Otolaryngology, Medical Faculty of Maltepe University, İstanbul, Turkey Batur Çalış Aslı Department of Otolaryngology, Şişli Etfal Training and Research Hospital, İstanbul, Turkey Çelik Öner Department of Otolaryngology, Medical Faculty of Maltepe University, İstanbul, Turkey Yener Neşe Department of Pathology, Medical Faculty of Maltepe University, İstanbul, Turkey Vural Çetin Department of Otolaryngology, Medical Faculty of Maltepe University, İstanbul, Turkey 07 19 2015 25 3 170 173 Copyright © 1990, The Turkish Journal of Ear Nose and Throat 1990 The Turkish Journal of Ear Nose and Throat

Simultaneous occurrence of papillary thyroid carcinoma PTC and medullary thyroid carcinoma MTC in the same thyroid gland is a rare condition. These tumors derive from different cells; PTC originates from follicular cells whereas MTC originates from parafollicular cells. Because of this, the treatment of these tumors also differs. This article describes two rare cases of the simultaneous occurrence of MTC and PTC in the thyroid gland.

Papiller tiroid karsinomu PTK ve medüller tiroid karsinomunun MTK aynı tiroid bezinde simültane oluşumu nadir bir durumdur. Bu tümörler farklı hücrelerden köken alır; PTC foliküler hücrelerden kaynaklanırken MTC parafoliküler hücrelerden kaynaklanır. Bu nedenle, bu tümörlerin tedavisi de farklıdır. Bu yazıda tiroid bezinde MTK ve PTK’nın simültane oluşumuna dair iki nadir olgu tanımlandı

 Cancer concurrent medullary papillary thyroid Kanser eşzamanlı medüller papiller tiroid Lamberg BA, Reissel P, Stenman S, Koivuniemi A, Ekbolm M, Mäkinen J, et al. Concurrent medullary and papillary thyroid carcinoma in the same thyroid lobe and in siblings. Acta Med Scand 1981;209:421-4. Biscolla RP, Ugolini C, Sculli M, Bottici V, Castagna MG, Romei C, et al. Medullary and papillary tumors are frequently associated in the same thyroid gland without evidence of reciprocal influence in their biologic behavior. Thyroid 2004;14:946-52. Vural Ç, Koç AÖ, Çelikoyar MM. Meduller tiroit kanseri. Türkiye Klinikleri Kulak Burun Boğaz Dergisi, Tiroit Özel Sayısı 2007;3:35-40. Machens A, Dralle H. Simultaneous medullary and papillary thyroid cancer: a novel entity? Ann Surg Oncol 2012;19:37-44. Romei C, Fugazzola L, Puxeddu E, Frasca F, Viola D, Muzza M, et al. Modifications in the papillary thyroid cancer gene profile over the last 15 years. J Clin Endocrinol Metab 2012;97:1758-65. Gul K, Ozdemir D, Ugras S, Inancli SS, Ersoy R, Cakir B. Coexistent familial nonmultiple endocrine neoplasia medullary thyroid carcinoma and papillary thyroid carcinoma associated with RET polymorphism. Am J Med Sci 2010;340:60-3. Kim WG, Gong G, Kim EY, Kim TY, Hong SJ, Kim WB, et al. Concurrent occurrence of medullary thyroid carcinoma and papillary thyroid carcinoma in the same thyroid should be considered as coincidental. Clin Endocrinol (Oxf) 2010;72:256-63.