Laryngeal adenoid cystic carcinoma in an adolescent

Year 2008, Volume: 18 Issue: 5, 319 - 322, 10.10.2008

Ömer Aydın Emre Üstündağ Mete İşeri Cengiz Erçin

Abstract

Malignant tumors of the larynx are extremely rare in children and adolescents. Adenoid cystic carcinoma accounts for less than 1% of all malignant tumors in the larynx. We presented a 16-year-old girl with subglottic adenoid cystic carcinoma, whose symptoms of prolonged and exacerbating dyspnea had been attributed to asthma at another medical center. Indirect flexible and rigid laryngoscopy revealed a smooth mass in the subglottic region occupying 80% of the airway passage. The lesion was also confirmed by both CT and MRI. There was no lymphadenopathy in the neck. The patient was successfully treated by surgery and postoperative radiotherapy. Pathological staging was T4N0M0 according to the AJCC, 2003. During six years of follow-up, there was no evidence for local recurrence or regional and distant metastasis.

Keywords

Adolescent, carcinoma, adenoid cystic/surgery, child, laryngeal neoplasms/surgery

Ergen bir hastada larengeal adenoid kistik karsinom

Abstract

Larenksin malign tümörleri çocukluk ve ergenlik döneminde çok nadir görülür. Adenoid kistik karsi- nom bu bölgenin malign tümörlerinin %1’den azını oluşturmaktadır. Bu yazıda, subglottik adenoid kistik karsinom saptanan 16 yaşında bir kız hasta sunuldu. Hastanın uzamış ve şiddetlenen dispne semptomları başka bir merkezde astım lehine yorumlanmıştı. İndirekt fleksibl ve rijid larengoskopide, subglottik bölgede, havayolu pasajını %80 dolduran düz bir kitle görüldü. Lezyon bilgisayarlı tomografi ve manyetik rezonans ile de doğrulandı. Boyunda lenfadenopati yoktu. Hasta başarılı bir şekilde cerrahi ve ameliyat sonrası radyoterapi ile tedavi edildi. Tümörün pato- lojik evrelemesi AJCC 2003’e göre T4N0M0 bulundu. Hastanın altı yıllık takibi sırasında lokal nüks veya rejyonel ya da uzak metastaz bulgusu saptanmadı

Keywords

Ergen, karsinom, adenoid kistik/cerrahi, çocuk, larenks neoplazileri/cerrahi

References

• McGuirt WF Jr, Little JP. Laryngeal cancer in children and adolescents. Otolaryngol Clin North Am 1997; 30:207-14.
• Mitchell DB, Humphreys S, Kearns DB. Mucoepidermoid carcinoma of the larynx in a child. Int J Pediatr Otorhinolaryngol 1988;15:211-5.
• Javadi M, Bafrouee FM, Mohseni M, Asghari A. Laryngeal adenoid cystic carcinoma in a child: a case report. Ear Nose Throat J 2002;81:34-5.
• Tewfik TL, Novick WH, Schipper HM. Adenoid cystic carcinoma of the larynx. J Otolaryngol 1983;12:151-4.
• Cappellari JO. Histopathology and pathologic prognostic indicators. Otolaryngol Clin North Am 1997;30:251-68.
• Ferlito A, Rinaldo A. The pathology and manage- ment of subglottic cancer. Eur Arch Otorhinolaryngol 2000;257:168-73.
• Alavi S, Namazie A, Calcaterra TC, Blackwell KE. Glandular carcinoma of the larynx: the UCLA experi- ence. Ann Otol Rhinol Laryngol 1999;108:485-9.
• Barnes C, Sexton M, Sizeland A, Tiedemann K, Berkowitz RG, Waters K. Laryngo-pharyngeal carcinoma in child- hood. Int J Pediatr Otorhinolaryngol 2001;61:83-6.
• Dahm JD, Sessions DG, Paniello RC, Harvey J. Primary subglottic cancer. Laryngoscope 1998;108:741-6.
• Shin YJ, Percodani J, Coste EU, Delisle MB, Serrano E, Pessey JJ. Adenoid cystic carcinoma of the larynx. A case report and review of the literature. Rev Laryngol Otol Rhinol 1998;119:105-8. [Abstract]
• Batsakis JG, Luna MA, el-Naggar AK. Nonsquamous carcinomas of the larynx. Ann Otol Rhinol Laryngol 1992;101:1024-6.
• Jones AS, Hamilton JW, Rowley H, Husband D, Helliwell TR. Adenoid cystic carcinoma of the head and neck. Clin Otolaryngol Allied Sci 1997;22:434-43.
• Kaya S. Larenksin seyrek görülen benign ve malign tümörleri. In: Kaya S. Larenks hastalıkları. Ankara: Bilimsel Tıp Yayınevi; 2002. p. 492-539.
• Hogg RP, Kuo MJ, Olliff J, Das Gupta AR. Invasion of the recurrent laryngeal nerve by adenoid cystic carci- noma. An unusual cause of true vocal fold paralysis. J Laryngol Otol 1999;113:260-2.