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Kikuchi-Fujimoto disease

Year 2014, Volume: 24 Issue: 3, 164 - 167, 19.06.2014

Abstract

Kikuchi-Fujimoto disease is a form of necrotizing lymphadenitis. Although the disease usually affects young women aged less than 30 years, it may also affect men with a wide range of age. Clinically generalized lymphadenopathy in the head and neck region may present. Lymph node specimens show areas of necrosis without neutrophilic infiltration. Necrotic areas result from lymphocyte-mediated apoptotic mechanisms. Clinically, it should be differentiated from many infectious diseases including cat scratch disease and rheumatological diseases such as systemic lupus erythematosus. Pathologically, it should be differentiated from lymphomas. Our patient was 30-year-old young and healthy female except cervical lymphadenopathy, and fever symptoms. Lymph node biopsy was performed for the diagnosis. Pathological examination of a lymph node specimen was reported as established Kikuchi-Fujimoto disease histiocytic necrotizing lymphadenitis . After the treatment the patient's symptoms have completely disappeared.

References

  • Kikuchi M, Yoshizumi T, Nakamura H. Necrotizing lymphadenitis: possible acute toxoplasmic infection. Virchows Arch A Pathol Anat Histol 1977;376:247-53.
  • Nikanne E, Ruoppi P, Vornanen M. Kikuchi’s disease: report of three cases and an overview. Laryngoscope 1997;107:273-6.
  • Taguri AH, McIlwaine GG. Bilateral panuveitis: a possible association with Kikuchi-Fujimoto disease. Am J Ophthalmol 2001;132:419-21.
  • Tsang WY, Chan JK, Ng CS. Kikuchi's lymphadenitis. A morphologic analysis of 75 cases with special reference to unusual features. Am J Surg Pathol 1994;18:219-31.
  • Hsueh EJ, Ko WS, Hwang WS, Yam LT. Fine-needle aspiration of histiocytic necrotizing lymphadenitis (Kikuchi's disease). Diagn Cytopathol 1993;9:448-52.
  • Tong TR, Chan OW, Lee KC. Diagnosing Kikuchi disease on fine needle aspiration biopsy: a retrospective study of 44 cases diagnosed by cytology and 8 by histopathology. Acta Cytol 2001;45:953-7.
  • García CE, Girdhar-Gopal HV, Dorfman DM. Kikuchi- Fujimoto disease of the neck. Update. Ann Otol Rhinol Laryngol 1993;102:11-5.
  • Chan JK, Wong KC, Ng CS. A fatal case of multicentric Kikuchi's histiocytic necrotizing lymphadenitis. Cancer 1989;63:1856-62.
  • Krueger GR, Huetter ML, Rojo J, Romero M, Cruz- Ortiz H. Human herpesviruses HHV-4 (EBV) and HHV-6 in Hodgkin’s and Kikuchi’s diseases and their relation to proliferation and apoptosis. Anticancer Res 2001;21:2155-61.
  • Takada K, Suzuki K, Hidaka T, Konishi T, Shinohara T, Kataharada K, et al. Immediate remission obtained by minocycline in a patient with histiocytic necrotizing lymphadenitis. Intern Med 2001;40:1055-8.
  • Rich SA. De novo synthesis and secretion of a 36-kD protein by cells that form lupus inclusions in response to alpha-interferon. J Clin Invest 1995;95:219-26.
  • Kubota M, Tsukamoto R, Kurokawa K, Imai T, Furusho K. Elevated serum interferon gamma and interleukin-6 in patients with necrotizing lymphadenitis (Kikuchi’s disease). Br J Haematol 1996;95:613-5.
  • Yabe H, Sinzato I, Hashimoto K. Necrotizing lymphadenitis presenting as mesenteric lymphadenopathy. Rinsho Ketsueki 1999;40:658-62. [Abstract]
  • Litwin MD, Kirkham B, Henderson DR, Milazzo SC. Histiocytic necrotising lymphadenitis in systemic lupus erythematosus. Ann Rheum Dis 1992;51:805-7.
  • Chen YH, Lan JL. Kikuchi disease in systemic lupus erythematosus: clinical features and literature review. J Microbiol Immunol Infect 1998;31:187-92.
  • Jang YJ, Park KH, Seok HJ. Management of Kikuchi's disease using glucocorticoid. J Laryngol Otol 2000;114:709-11.

Kikuchi-Fujimoto disease

Year 2014, Volume: 24 Issue: 3, 164 - 167, 19.06.2014

Abstract

Kikuchi-Fujimoto hastalığı bir nekrotizan lenfadenit formudur. Hastalık genellikle 30 yaş altında genç kadınlarda görülse de, erkekleri de etkileyebilir ve yaş sınırları geniştir. Klinik olarak baş boyun bölgesinde ortaya çıkan yaygın lenfadenopati ile seyredebilir. Lenf nodu örneklerinde nötrofilik infitrasyonun olmadığı nekroz alanları görülür. Nekrotik alanlar, lenfosit aracılı apoptotik mekanizmalar sonucunda oluşur. Klinik olarak kedi tırmığı hastalığı gibi enfeksiyon hastalıklarından ve sistemik lupus eritematöz gibi romatolojik hastalıklardan ayırıcı tanısı yapılmalıdır. Patolojik olarak lenfomalardan ayrılmalıdır. Hastamız servikal lenfadenopati ve ateş semptomları dışında 30 yaşında genç ve sağlıklı bir kadındı. Tanı için lenf nodu biyopsisi yapıldı. Lenf nodu örneğinin patolojik incelemesi, yerleşik Kikuchi-Fujimoto hastalığı histiositik nekrotizan lenfadenit olarak bildirildi. Hastanın semptomlarının tamamen ortadan kalktığı izlendi

References

  • Kikuchi M, Yoshizumi T, Nakamura H. Necrotizing lymphadenitis: possible acute toxoplasmic infection. Virchows Arch A Pathol Anat Histol 1977;376:247-53.
  • Nikanne E, Ruoppi P, Vornanen M. Kikuchi’s disease: report of three cases and an overview. Laryngoscope 1997;107:273-6.
  • Taguri AH, McIlwaine GG. Bilateral panuveitis: a possible association with Kikuchi-Fujimoto disease. Am J Ophthalmol 2001;132:419-21.
  • Tsang WY, Chan JK, Ng CS. Kikuchi's lymphadenitis. A morphologic analysis of 75 cases with special reference to unusual features. Am J Surg Pathol 1994;18:219-31.
  • Hsueh EJ, Ko WS, Hwang WS, Yam LT. Fine-needle aspiration of histiocytic necrotizing lymphadenitis (Kikuchi's disease). Diagn Cytopathol 1993;9:448-52.
  • Tong TR, Chan OW, Lee KC. Diagnosing Kikuchi disease on fine needle aspiration biopsy: a retrospective study of 44 cases diagnosed by cytology and 8 by histopathology. Acta Cytol 2001;45:953-7.
  • García CE, Girdhar-Gopal HV, Dorfman DM. Kikuchi- Fujimoto disease of the neck. Update. Ann Otol Rhinol Laryngol 1993;102:11-5.
  • Chan JK, Wong KC, Ng CS. A fatal case of multicentric Kikuchi's histiocytic necrotizing lymphadenitis. Cancer 1989;63:1856-62.
  • Krueger GR, Huetter ML, Rojo J, Romero M, Cruz- Ortiz H. Human herpesviruses HHV-4 (EBV) and HHV-6 in Hodgkin’s and Kikuchi’s diseases and their relation to proliferation and apoptosis. Anticancer Res 2001;21:2155-61.
  • Takada K, Suzuki K, Hidaka T, Konishi T, Shinohara T, Kataharada K, et al. Immediate remission obtained by minocycline in a patient with histiocytic necrotizing lymphadenitis. Intern Med 2001;40:1055-8.
  • Rich SA. De novo synthesis and secretion of a 36-kD protein by cells that form lupus inclusions in response to alpha-interferon. J Clin Invest 1995;95:219-26.
  • Kubota M, Tsukamoto R, Kurokawa K, Imai T, Furusho K. Elevated serum interferon gamma and interleukin-6 in patients with necrotizing lymphadenitis (Kikuchi’s disease). Br J Haematol 1996;95:613-5.
  • Yabe H, Sinzato I, Hashimoto K. Necrotizing lymphadenitis presenting as mesenteric lymphadenopathy. Rinsho Ketsueki 1999;40:658-62. [Abstract]
  • Litwin MD, Kirkham B, Henderson DR, Milazzo SC. Histiocytic necrotising lymphadenitis in systemic lupus erythematosus. Ann Rheum Dis 1992;51:805-7.
  • Chen YH, Lan JL. Kikuchi disease in systemic lupus erythematosus: clinical features and literature review. J Microbiol Immunol Infect 1998;31:187-92.
  • Jang YJ, Park KH, Seok HJ. Management of Kikuchi's disease using glucocorticoid. J Laryngol Otol 2000;114:709-11.
There are 16 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Erkan Lebe This is me

Publication Date June 19, 2014
Published in Issue Year 2014 Volume: 24 Issue: 3

Cite

APA Lebe, E. (2014). Kikuchi-Fujimoto disease. The Turkish Journal of Ear Nose and Throat, 24(3), 164-167.
AMA Lebe E. Kikuchi-Fujimoto disease. Tr-ENT. June 2014;24(3):164-167.
Chicago Lebe, Erkan. “Kikuchi-Fujimoto Disease”. The Turkish Journal of Ear Nose and Throat 24, no. 3 (June 2014): 164-67.
EndNote Lebe E (June 1, 2014) Kikuchi-Fujimoto disease. The Turkish Journal of Ear Nose and Throat 24 3 164–167.
IEEE E. Lebe, “Kikuchi-Fujimoto disease”, Tr-ENT, vol. 24, no. 3, pp. 164–167, 2014.
ISNAD Lebe, Erkan. “Kikuchi-Fujimoto Disease”. The Turkish Journal of Ear Nose and Throat 24/3 (June 2014), 164-167.
JAMA Lebe E. Kikuchi-Fujimoto disease. Tr-ENT. 2014;24:164–167.
MLA Lebe, Erkan. “Kikuchi-Fujimoto Disease”. The Turkish Journal of Ear Nose and Throat, vol. 24, no. 3, 2014, pp. 164-7.
Vancouver Lebe E. Kikuchi-Fujimoto disease. Tr-ENT. 2014;24(3):164-7.