Research Article
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Year 2022, Volume: 32 Issue: 2, 37 - 42, 11.05.2022
https://doi.org/10.26650/Tr-ENT.2022.1039303

Abstract

References

  • 1. Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. Cancer statistics, 2007. CA Cancer J Clin 2007;57(1):43-66. google scholar
  • 2. Kerr JF, Winterford CM, Harmon BV. Apoptosis. Its significance in cancer and cancer therapy. Cancer 1994;73(8):2013-26. google scholar
  • 3. Gastman BR, Atarshi Y, Reichert TE, Saito T, Balkir L, Rabinowich H, et al. Fas ligand is expressed on human squamous cell carcinomas of the head and neck and it promotes apoptosis of T lymphocytes. Cancer Res 1999;59(20):5356-64. google scholar
  • 4. Chinnaiyan AM, Tepper CG, Seldin MF, O’Rourke K, Kischkel FC, Hellbardt S, et al. FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced google scholar
  • 5. Hug H. Fas-mediated apoptosis in tumor formation and defense. Biol Chem 1997;378(12):1405-12. google scholar
  • 6. Sundelin K, Jadner M, Norberg-Spaak L, Davidsson A, Hellquist HB. Metallothionein and Fas (CD95) are expressed in squamous cell carcinoma of the tongue. Eur J Cancer 1997;33(11):1860-4. google scholar
  • 7. Loro LL, Vintermyr OK, Johannessen AC, Liavaag PG, Jonsson R. Suppression of Fas receptor and negative correlation of Fas ligand with differentiation and apoptosis in oral squamous cell carcinoma. J Oral Pathol Med 1999;28(2):82-7. google scholar
  • 8. Wang J, Gao J, Li Y, Zhao X, Gao W, Peng L, Yan D, et al. Functional polymorphisms in FAS and FASL contribute to risk of squamous cell carcinoma of the larynx and hypopharynx in a Chinese population. Gene 2013;524(2):193-6. google scholar
  • 9. Muraki Y, Yoshioka C, Tateishi A, Fukuda J, Haneji T, Kobayashi N. Localization of Fas antigen in oral squamous cell carcinoma. Br J Oral Maxillofac Surg 1999;37(1):37-40. google scholar
  • 10. Leithauser F, Dhein J, Mechtersheimer G, Koretz K, Brüderlein S, Henne C, et al. Constitutive and induced expression of APO-1, a new member of the nerve growth factor/tumor necrosis factor receptor superfamily, in normal and neoplastic cells. Lab Invest 1993;69(4):415-29. google scholar
  • 11. Gratas C, Tohma Y, Barnas C, Taniere P, Hainaut P, Ohgaki H. Up-regulation of Fas (APO-1/CD95) ligand and down-regulation of Fas expression in human esophageal cancer. Cancer Res 1998;58(10):2057-62. google scholar
  • 12. Jackel MC, Mitteldorf C, Schweyer S, Füzesi L. Clinical relevance of Fas (APO-1/CD95) expression in laryngeal squamous cell carcinoma. Head Neck 2001;23(8):646-52. google scholar
  • 13. Lee JK, Sayers TJ, Brooks AD, Back TC, Young HA, Komschlies KL, et al. IFN-gamma-dependent delay of in vivo tumor progression by Fas overexpression on murine renal cancer cells. J Immunol 2000;164(1):231-9. google scholar
  • 14. Shibakita M, Tachibana M, Dhar DK, Kotoh T, Kinugasa S, Kubota H, et al. Prognostic significance of Fas and Fas ligand expressions in human esophageal cancer. Clin Cancer Res 1999;5(9):2464-9. google scholar
  • 15. Kase S, Osaki M, Adachi H, Kaibara N, Ito H. Expression of Fas and Fas ligand in esophageal tissue mucosa and carcinomas. Int J Oncol 2002;20(2):291-7. google scholar
  • 16. Müllauer L, Mosberger I, Chott A. Fas ligand expression in nodal non-Hodgkin’s lymphoma. Mod Pathol 1998;11(4):369-75. google scholar
  • 17. Das SN, Khare P, Singh MK, Sharma SC. Fas receptor (CD95) & Fas ligand (CD178) expression in patients with tobacco-related intraoral squamous cell carcinoma. Indian J Med Res 2011;134(1):54-60. google scholar
  • 18. Mitsiades N, Poulaki V, Mastorakos G, Tseleni-Balafouta ST, Kotoula V, Koutras DA, et al. Fas ligand expression in thyroid carcinomas: a potential mechanism of immune evasion. J Clin Endocrinol Metab 1999;84(8):2924-32. google scholar
  • 19. Ji X, Jiang C, Liu Y, Bu D, Xiao S. Fas ligand gene transfer effectively induces apoptosis in head and neck cancer cells. Acta Otolaryngol 2011;131(8):876-81. google scholar
  • 20. Costa EFD, Lima TRP, Lopes-Aguiar L, Nogueira GAS, Visacri MB, Quintanilha JCF, Pincinato EC, Calonga L, Mariano FV, Altemani AMAM, Altemani JMC, Moriel P, Chone CT, Ramos CD, Lima CSP. FAS and FASL variations in outcomes of tobacco- and alcohol-related head and neck squamous cell carcinoma patients. Tumour Biol 2020;42(7). google scholar

A Comparison of Fas-Fas Ligand Mediated Apoptosis with Clinical and Pathological Parameters in Larynx Cancers; Twenty Years After Laryngectomy

Year 2022, Volume: 32 Issue: 2, 37 - 42, 11.05.2022
https://doi.org/10.26650/Tr-ENT.2022.1039303

Abstract

Objective: Larynx cancer constitutes 2% of all cancers in adults with 96% of larynx malignancies being squamous cell carcinoma (SHC). Apoptosis is a cell death mechanism that is quite different from necrosis. It is also known as programmed cell death, physiological cell death, or cell suicide. Physiological mediators that activate programmed cell death (apoptosis) are Fas and Fas Ligand (FasL).Materials and Methods: In a thesis study conducted by our authors in 2004, we investigated the relationship of Fas-Fas ligand-mediated apoptosis with survival in laryngeal cancer, prognostic factors (age, localization, histological grade, tumor size, lymph, blood vessel invasion), stage, and inflammatory response of the tumor. In this study, we investigated the relationship between survival and death rates after 20 years and Fas-FasL.Results: When FAS was evaluated 20 years later, a statistically significant difference was found between mortality rates depending on stage (p=0.023; p<0.05). While the survival rate is higher in stage 1 cases, the rate of death is higher in stage 3 cases. No statistically significant difference was found between mortality rates according to stages for FAS Ligand 20 years later (p>0.05).Conclusion: In conclusion, we found that the Fas/Fas-L system was not associated with clinical parameters in laryngeal cancers in our short-term follow-up. However, when we repeated our follow-up 20 years later, we found that Fas system deficiency, although not in FAS Ligand, adversely affected survival in the long term in laryngeal cancer patients.

References

  • 1. Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. Cancer statistics, 2007. CA Cancer J Clin 2007;57(1):43-66. google scholar
  • 2. Kerr JF, Winterford CM, Harmon BV. Apoptosis. Its significance in cancer and cancer therapy. Cancer 1994;73(8):2013-26. google scholar
  • 3. Gastman BR, Atarshi Y, Reichert TE, Saito T, Balkir L, Rabinowich H, et al. Fas ligand is expressed on human squamous cell carcinomas of the head and neck and it promotes apoptosis of T lymphocytes. Cancer Res 1999;59(20):5356-64. google scholar
  • 4. Chinnaiyan AM, Tepper CG, Seldin MF, O’Rourke K, Kischkel FC, Hellbardt S, et al. FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced google scholar
  • 5. Hug H. Fas-mediated apoptosis in tumor formation and defense. Biol Chem 1997;378(12):1405-12. google scholar
  • 6. Sundelin K, Jadner M, Norberg-Spaak L, Davidsson A, Hellquist HB. Metallothionein and Fas (CD95) are expressed in squamous cell carcinoma of the tongue. Eur J Cancer 1997;33(11):1860-4. google scholar
  • 7. Loro LL, Vintermyr OK, Johannessen AC, Liavaag PG, Jonsson R. Suppression of Fas receptor and negative correlation of Fas ligand with differentiation and apoptosis in oral squamous cell carcinoma. J Oral Pathol Med 1999;28(2):82-7. google scholar
  • 8. Wang J, Gao J, Li Y, Zhao X, Gao W, Peng L, Yan D, et al. Functional polymorphisms in FAS and FASL contribute to risk of squamous cell carcinoma of the larynx and hypopharynx in a Chinese population. Gene 2013;524(2):193-6. google scholar
  • 9. Muraki Y, Yoshioka C, Tateishi A, Fukuda J, Haneji T, Kobayashi N. Localization of Fas antigen in oral squamous cell carcinoma. Br J Oral Maxillofac Surg 1999;37(1):37-40. google scholar
  • 10. Leithauser F, Dhein J, Mechtersheimer G, Koretz K, Brüderlein S, Henne C, et al. Constitutive and induced expression of APO-1, a new member of the nerve growth factor/tumor necrosis factor receptor superfamily, in normal and neoplastic cells. Lab Invest 1993;69(4):415-29. google scholar
  • 11. Gratas C, Tohma Y, Barnas C, Taniere P, Hainaut P, Ohgaki H. Up-regulation of Fas (APO-1/CD95) ligand and down-regulation of Fas expression in human esophageal cancer. Cancer Res 1998;58(10):2057-62. google scholar
  • 12. Jackel MC, Mitteldorf C, Schweyer S, Füzesi L. Clinical relevance of Fas (APO-1/CD95) expression in laryngeal squamous cell carcinoma. Head Neck 2001;23(8):646-52. google scholar
  • 13. Lee JK, Sayers TJ, Brooks AD, Back TC, Young HA, Komschlies KL, et al. IFN-gamma-dependent delay of in vivo tumor progression by Fas overexpression on murine renal cancer cells. J Immunol 2000;164(1):231-9. google scholar
  • 14. Shibakita M, Tachibana M, Dhar DK, Kotoh T, Kinugasa S, Kubota H, et al. Prognostic significance of Fas and Fas ligand expressions in human esophageal cancer. Clin Cancer Res 1999;5(9):2464-9. google scholar
  • 15. Kase S, Osaki M, Adachi H, Kaibara N, Ito H. Expression of Fas and Fas ligand in esophageal tissue mucosa and carcinomas. Int J Oncol 2002;20(2):291-7. google scholar
  • 16. Müllauer L, Mosberger I, Chott A. Fas ligand expression in nodal non-Hodgkin’s lymphoma. Mod Pathol 1998;11(4):369-75. google scholar
  • 17. Das SN, Khare P, Singh MK, Sharma SC. Fas receptor (CD95) & Fas ligand (CD178) expression in patients with tobacco-related intraoral squamous cell carcinoma. Indian J Med Res 2011;134(1):54-60. google scholar
  • 18. Mitsiades N, Poulaki V, Mastorakos G, Tseleni-Balafouta ST, Kotoula V, Koutras DA, et al. Fas ligand expression in thyroid carcinomas: a potential mechanism of immune evasion. J Clin Endocrinol Metab 1999;84(8):2924-32. google scholar
  • 19. Ji X, Jiang C, Liu Y, Bu D, Xiao S. Fas ligand gene transfer effectively induces apoptosis in head and neck cancer cells. Acta Otolaryngol 2011;131(8):876-81. google scholar
  • 20. Costa EFD, Lima TRP, Lopes-Aguiar L, Nogueira GAS, Visacri MB, Quintanilha JCF, Pincinato EC, Calonga L, Mariano FV, Altemani AMAM, Altemani JMC, Moriel P, Chone CT, Ramos CD, Lima CSP. FAS and FASL variations in outcomes of tobacco- and alcohol-related head and neck squamous cell carcinoma patients. Tumour Biol 2020;42(7). google scholar
There are 20 citations in total.

Details

Primary Language English
Subjects Otorhinolaryngology
Journal Section Research Articles
Authors

Ahmet Mert Bilgili 0000-0003-2326-4511

Tolga Ersözlü This is me 0000-0001-8629-6022

Publication Date May 11, 2022
Submission Date December 22, 2021
Published in Issue Year 2022 Volume: 32 Issue: 2

Cite

APA Bilgili, A. M., & Ersözlü, T. (2022). A Comparison of Fas-Fas Ligand Mediated Apoptosis with Clinical and Pathological Parameters in Larynx Cancers; Twenty Years After Laryngectomy. The Turkish Journal of Ear Nose and Throat, 32(2), 37-42. https://doi.org/10.26650/Tr-ENT.2022.1039303
AMA Bilgili AM, Ersözlü T. A Comparison of Fas-Fas Ligand Mediated Apoptosis with Clinical and Pathological Parameters in Larynx Cancers; Twenty Years After Laryngectomy. Tr-ENT. May 2022;32(2):37-42. doi:10.26650/Tr-ENT.2022.1039303
Chicago Bilgili, Ahmet Mert, and Tolga Ersözlü. “A Comparison of Fas-Fas Ligand Mediated Apoptosis With Clinical and Pathological Parameters in Larynx Cancers; Twenty Years After Laryngectomy”. The Turkish Journal of Ear Nose and Throat 32, no. 2 (May 2022): 37-42. https://doi.org/10.26650/Tr-ENT.2022.1039303.
EndNote Bilgili AM, Ersözlü T (May 1, 2022) A Comparison of Fas-Fas Ligand Mediated Apoptosis with Clinical and Pathological Parameters in Larynx Cancers; Twenty Years After Laryngectomy. The Turkish Journal of Ear Nose and Throat 32 2 37–42.
IEEE A. M. Bilgili and T. Ersözlü, “A Comparison of Fas-Fas Ligand Mediated Apoptosis with Clinical and Pathological Parameters in Larynx Cancers; Twenty Years After Laryngectomy”, Tr-ENT, vol. 32, no. 2, pp. 37–42, 2022, doi: 10.26650/Tr-ENT.2022.1039303.
ISNAD Bilgili, Ahmet Mert - Ersözlü, Tolga. “A Comparison of Fas-Fas Ligand Mediated Apoptosis With Clinical and Pathological Parameters in Larynx Cancers; Twenty Years After Laryngectomy”. The Turkish Journal of Ear Nose and Throat 32/2 (May 2022), 37-42. https://doi.org/10.26650/Tr-ENT.2022.1039303.
JAMA Bilgili AM, Ersözlü T. A Comparison of Fas-Fas Ligand Mediated Apoptosis with Clinical and Pathological Parameters in Larynx Cancers; Twenty Years After Laryngectomy. Tr-ENT. 2022;32:37–42.
MLA Bilgili, Ahmet Mert and Tolga Ersözlü. “A Comparison of Fas-Fas Ligand Mediated Apoptosis With Clinical and Pathological Parameters in Larynx Cancers; Twenty Years After Laryngectomy”. The Turkish Journal of Ear Nose and Throat, vol. 32, no. 2, 2022, pp. 37-42, doi:10.26650/Tr-ENT.2022.1039303.
Vancouver Bilgili AM, Ersözlü T. A Comparison of Fas-Fas Ligand Mediated Apoptosis with Clinical and Pathological Parameters in Larynx Cancers; Twenty Years After Laryngectomy. Tr-ENT. 2022;32(2):37-42.