The process of digitalisation has been found to exert a considerable influence on the mental wellbeing of those engaged in maritime activities, as well as on the prevalence of digital fatigue. The aim of this study is to analyse the effects of digital fatigue on seafarers' mental health. In the study, the data collected through questionnaires were subjected to analysis using regression analysis and the Delphi method. The findings indicate that prolonged screen use, an intensive digital workload, irregular sleep patterns and social isolation are the primary factors contributing to an increased prevalence of mental health issues among seafarers. In particular, digital communication and screen exposure have been identified as having a detrimental impact on mental health. Furthermore, it was determined that the implementation of stress management and psychological support mechanisms can effectively mitigate the adverse effects observed. The participants were predominantly young and had extensive experience with digital technology. Of the 150 seafarers who took part in the study, 70% were male and aged between 26 and 35 years. The findings indicate the necessity for strategic approaches to the management of the psycho-social risks associated with digitalisation. From the findings, only stress management indicates a negative correlation. These include the limitation of digital device usage, the implementation of social support programmes and the introduction of measures for stress management. These results are of significant value to ship-owning companies and maritime authorities, providing guidance on the protection of seafarers' mental health and the reduction of digital fatigue.