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Zirai ilaç zehirlenmesi ile başvuran stent trombozu

Year 2021, Volume: 2 Issue: 2, 71 - 72, 30.06.2021

Abstract

İnsanların kimyasal maddelere maruz kalması büyüyen bir endişe kaynağıdır. Glifosat bazlı herbisit (GBH) kullanımı da akut zehirlenme sonucu çeşitli hastalıklara neden olur. GBH bazlı ilaçlar sinüs bradikardisi, QT uzaması, torsade de pointes, AV blok gibi elektrokardiyografi değişikliklerine ve nadiren koroner arter trombozu neden olabilir. 2 yıl önce ilaç kaplı stent uygulanmış olan 68 yaşında erkek hasta göğüs ağrısı şikayeti ile acil servise başvurdu. Hastadan alınan anamnezde GBH içeren zirai ilaç kullanarak 2 gündür tarlada maskesiz ilaçlama yaptığı, göğüs ağrısının başladığı ve acil servise başvurduğu anlaşıldı. Akut GBH entoksikasyonu hipotansiyon, solunum sıkıntısı, gastrointestinal semptomlar, bilinç kaybı, oligüri ve nadiren ölüme neden olabilir. GBH'ye kronik maruziyetin koroner arter hastalığına neden olduğu gösterilmiştir.

References

  • 1. Gress S, Lemoine S, Puddu PE, Séralini GE, Rouet R. Cardiotoxic electrophysiological effects of the herbicide Roundup® in rat and rabbit ventricular myocardium in vitro. Cardiovasc Toxicol 2015;15(4):324-35.
  • 2. Gress S, Lemoine S, Séralini GE, Puddu PE. Glyphosate-based herbicides potently affect cardiovascular system in mammals: Review of the literature. Cardiovasc Toxicol 2015;15(2):117-26.
  • 3. Roy NM, Ochs J, Zambrzycka E, Anderson A. Glyphosate induces cardiovascular toxicity in Danio rerio. Environ Toxicol Pharmacol 2016;46:292-300.
  • 4. Kimmel GL, Kimmel CA, Williams AL, DeSesso JM. Evaluation of developmental toxicity studies of glyphosate with attention to cardiovascular development. Crit Rev Toxicol 2013;43(2):79-95.
  • 5. Pan L, Xu M, Yang D, Wang B, Zhao Q, Ding E, Zhu B. The association between coronary artery disease and glyphosate exposure found in pesticide factory workers. J Public Health Emerg 2017;1:4.
  • 6. Paumgartten FJR. Glyphosate exposure, cardiovascular diseases and cancer risks. J Public Health Emerg 2017;1:15.
  • 7. Roberts DM, Buckley NA, Mohamed F, et al. A prospective observational study of the clinical toxicology of glyphosate-containing herbicides in adults with acute self-poisoning. Clin Toxicol (Phila) 2010;48(2):129-36.

Stent thrombosis presenting with herbicide poisoning

Year 2021, Volume: 2 Issue: 2, 71 - 72, 30.06.2021

Abstract

Human exposure to chemical pollutants is a growing concern. The use of glyphosate-based herbicide (GBH) also causes various diseases because of acute poisoning. GBH-based drugs may cause electrocardiography changes such as sinus bradycardia, QT prolongation, torsade de pointes, AV block, and rarely coronary artery thrombosis. A 68-year-old male patient, who had undergone a drug eluted stent 2 years ago, was admitted to the emergency department with chest pain. In his anamnesis, it was noted that he had been spraying weed in the field without a mask for 2 days using an agricultural drug containing GBH, and he admitted to the emergency service with chest pain. Acute GBH intoxication may cause hypotension, respiratory distress, gastrointestinal symptoms, unconsciousness, oliguria, and rarely death. It was shown that chronic exposure to GBH causes coronary artery disease.

References

  • 1. Gress S, Lemoine S, Puddu PE, Séralini GE, Rouet R. Cardiotoxic electrophysiological effects of the herbicide Roundup® in rat and rabbit ventricular myocardium in vitro. Cardiovasc Toxicol 2015;15(4):324-35.
  • 2. Gress S, Lemoine S, Séralini GE, Puddu PE. Glyphosate-based herbicides potently affect cardiovascular system in mammals: Review of the literature. Cardiovasc Toxicol 2015;15(2):117-26.
  • 3. Roy NM, Ochs J, Zambrzycka E, Anderson A. Glyphosate induces cardiovascular toxicity in Danio rerio. Environ Toxicol Pharmacol 2016;46:292-300.
  • 4. Kimmel GL, Kimmel CA, Williams AL, DeSesso JM. Evaluation of developmental toxicity studies of glyphosate with attention to cardiovascular development. Crit Rev Toxicol 2013;43(2):79-95.
  • 5. Pan L, Xu M, Yang D, Wang B, Zhao Q, Ding E, Zhu B. The association between coronary artery disease and glyphosate exposure found in pesticide factory workers. J Public Health Emerg 2017;1:4.
  • 6. Paumgartten FJR. Glyphosate exposure, cardiovascular diseases and cancer risks. J Public Health Emerg 2017;1:15.
  • 7. Roberts DM, Buckley NA, Mohamed F, et al. A prospective observational study of the clinical toxicology of glyphosate-containing herbicides in adults with acute self-poisoning. Clin Toxicol (Phila) 2010;48(2):129-36.
There are 7 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Articles
Authors

Ali Duygu 0000-0001-6849-8894

Bahadır Kırılmaz 0000-0002-5929-1426

Mehmet Arslan 0000-0001-8785-7944

Uğur Küçük 0000-0003-4669-7387

Publication Date June 30, 2021
Submission Date May 23, 2021
Published in Issue Year 2021 Volume: 2 Issue: 2

Cite

APA Duygu, A., Kırılmaz, B., Arslan, M., Küçük, U. (2021). Zirai ilaç zehirlenmesi ile başvuran stent trombozu. Troia Medical Journal, 2(2), 71-72.
AMA Duygu A, Kırılmaz B, Arslan M, Küçük U. Zirai ilaç zehirlenmesi ile başvuran stent trombozu. Troia Med J. June 2021;2(2):71-72.
Chicago Duygu, Ali, Bahadır Kırılmaz, Mehmet Arslan, and Uğur Küçük. “Zirai Ilaç Zehirlenmesi Ile başvuran Stent Trombozu”. Troia Medical Journal 2, no. 2 (June 2021): 71-72.
EndNote Duygu A, Kırılmaz B, Arslan M, Küçük U (June 1, 2021) Zirai ilaç zehirlenmesi ile başvuran stent trombozu. Troia Medical Journal 2 2 71–72.
IEEE A. Duygu, B. Kırılmaz, M. Arslan, and U. Küçük, “Zirai ilaç zehirlenmesi ile başvuran stent trombozu”, Troia Med J, vol. 2, no. 2, pp. 71–72, 2021.
ISNAD Duygu, Ali et al. “Zirai Ilaç Zehirlenmesi Ile başvuran Stent Trombozu”. Troia Medical Journal 2/2 (June 2021), 71-72.
JAMA Duygu A, Kırılmaz B, Arslan M, Küçük U. Zirai ilaç zehirlenmesi ile başvuran stent trombozu. Troia Med J. 2021;2:71–72.
MLA Duygu, Ali et al. “Zirai Ilaç Zehirlenmesi Ile başvuran Stent Trombozu”. Troia Medical Journal, vol. 2, no. 2, 2021, pp. 71-72.
Vancouver Duygu A, Kırılmaz B, Arslan M, Küçük U. Zirai ilaç zehirlenmesi ile başvuran stent trombozu. Troia Med J. 2021;2(2):71-2.