ERİŞKİN YAŞTA GELEN ÇOCUKLUK ÇAĞI VE ADOLESAN KANSER HASTALARINDA DİĞER NONREPRODÜKTİF ENDOKRİN ANORMALLİKLER

Year 2011, Volume: 14 Issue: 4, 91 - 95, 01.10.2011

Özgür Öktem Bülent Urman

Abstract

Erişkin yaşa gelen çocukluk çağı kanser hastalarında tedaviye
bağlı olarak pekçok sitemik ve endokrin bozukluk izlenmektedir.
Malesef kız cinsiyet bu olumsuzluklardan daha fazla pay almaktadır.
Özellikle kraniospinal radyasyon sonrası, kognitif bozukluklar, obesite,
kardiovasküler hastalık, pubertenin zamanlamasına aksaklık,
tiroid fonskiyon bozuklukları, iskelet büyümesinde gerilik bunlardan
bir kaçıdır. Bu bülümde bu hastalarda uzun dönemde görülen üreme
dışı endokrin anormallikler işlenecektir.

OTHER LONG-TERM ENDOCRINE ABNORMALITIES IN THE CHILDHOOD CANCER SURVIVORS

Abstract

There are numerous treatment-related risks for long-term adverse
outcomes among survivors of childhood cancer after exposure to
chemotherapeutic drugs and radiotherapy. Sadly, It appears that female
sex is more commonly associated with treatment related risks such as
cognitive dysfunction after cranial irradiation, poor cardiovascular outcomes,
obesity, radiation-associated differences in pubertal timing,
development of primary hypothyroidism, impaired skeletal growth
breast cancer as a second malignant neoplasm, and osteonecrosis.

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