Abstract
Over kanseri hastalar›nda ikincil primer kanser izlenebilmektedir.
Bununla birlikte, ikincil primer kanser olarak vajinal yassı hücreli
kanser literatürde bildirilmemiştir.
Postmenapozal, 51 yaşındaki on yıllık diabetik ve hipertansif,
hasta bilateral adneksiyal kitle ile başvurdu. Serum CA-125 değeri
74,6 U/mL bulundu. Laparatomi sırasında yollanan frozen sonucu,
bilateral over kapsülleri intakt ancak overler içinde bazı odaklarda
malignite varlığı bildirildi. Batın sitoloji negatif değerlendirildi. Altı
kür adjuvan karboplatin/paklitaksel tedavisi verildi. Beş yıl sonra
rekürrens gelişti ve aynı ajanlar tekrar verildi. İkincil bakış laparotomisi
negatif bulundu. Daha sonra hastada kronik böbrek yetmezliği
geliflti ve dialize başlandı. Bir yıl sonra da vajen ön duvarda, vajinal
kaf yakınında yassı hücreli kanser saptandı. Cerrahi tedaviyi kabul
etmeyen hastaya radyoterapi/karboplatin verildi. Primer kanser
tanısının dokuzuncu yılında hastanın metastatik akciğer lezyonu
tespit edildi. Karboplatin/paklitaksel tekrar başlandı. Jinekolojik
kanserli hastalarda ikincil primer kanser riskinin artması alınan
kemoterapiler, uzayan sağ kalım, herediter ve sistemik hastalıklar gibi
genel etiyolojik nedenlere bağlı olabilir. Dikkatli izlem önerilir.
Keywords
References
- 1. Curtis RE, Hoover RN, Kleinerman RA, Harvey EB. Second cancer following cancer of the female genital system in Connecticut, 1935-82. Natl Cancer Inst Monogr. 1985;68:113-137.
- 2. Reimer RR, Hoover R, Fraumeni JF Jr, Young RC. Second primary neoplasms following ovarian cancer. J Natl Cancer Inst. 1978;61:1195-1197.
- 3. Bergfeldt K, Einhorn S, Rosendahl I, Hall P. Increased risk of second primary malignancies in patients with gynecological cancer. A Swedish record-linkage study. Acta Oncol. 1995;34:771-777.
- 4. Dorr FA, Coltman CA Jr. Second cancers following antineoplastic therapy. Curr Probl Cancer. 1985;9:1-43
Abstract
Second primary cancers in patients with ovarian cancer can be
observed. However, vaginal squamous cell cancer as a second primary
cancer has not been reported in the literature.
A postmenopausal, 51-year-old woman hypertensive and diabetic
for ten years, admitted with bilateral adnexal masses. Serum CA-
125 value was found as 74.6 U/ml. Intra-operative frozen section
reported that bilateral ovarian capsules were intact, but there were
ovarian malignancies in some foci. Abdomen cytology was evaluated
as negative. Six cycles of adjuvant carboplatin/paclitaxel treatment
was given. Recurrence developed five years later and the same agents
were again given. Second-look laparotomy was negative. Later,
patient developed chronic renal failure, and dialysis was started. One
year later, squamous cell carcinoma was detected at the anterior wall
of the vagina, next to the vaginal cuff. Radiotherapy/carboplatin was
given to the patient who declined surgical treatment. Patient’s
metastatic lung lesion was detected in the ninth year of primary cancer
diagnosis. Carboplatin/paclitaxel was restarted. In patients with
gynecological cancer, increased risk of second primary cancers may be
due to the common etiologic causes such as chemotherapies, prolonged
survival, hereditary and systemic diseases. Careful follow-up
is advised.
Keywords
References
- 1. Curtis RE, Hoover RN, Kleinerman RA, Harvey EB. Second cancer following cancer of the female genital system in Connecticut, 1935-82. Natl Cancer Inst Monogr. 1985;68:113-137.
- 2. Reimer RR, Hoover R, Fraumeni JF Jr, Young RC. Second primary neoplasms following ovarian cancer. J Natl Cancer Inst. 1978;61:1195-1197.
- 3. Bergfeldt K, Einhorn S, Rosendahl I, Hall P. Increased risk of second primary malignancies in patients with gynecological cancer. A Swedish record-linkage study. Acta Oncol. 1995;34:771-777.
- 4. Dorr FA, Coltman CA Jr. Second cancers following antineoplastic therapy. Curr Probl Cancer. 1985;9:1-43
Details
| Other ID | JA63PU39HE |
|---|---|
| Journal Section | Research Article |
| Authors | |
| Publication Date | October 1, 2011 |
| Submission Date | October 1, 2011 |
| Published in Issue | Year 2011 Volume: 14 Issue: 4 |