BİR ÜNİVERSİTE HASTANESİNDE GESTASYONEL TROFOBLASTİK HASTALIK OLGULARININ DEĞERLENDİRİLMESİ

Year 2014, Volume: 17 Issue: 4, 0 - 0, 01.10.2014

Pınar Solmaz Hasdemir Tevfik Güvenal

Abstract

Amaç: Gestasyonel trofoblastik hastalık (GTH) tanısı almış olguların klinikopatolojik özelliklerinin ve tedavilerinin değerlendirilmesi.

Yöntemler: 2003- 2013 yılları arasında kliniğimize GTH tanısı ile yatırılmış olan ve bilgilerine ulaşılan 34 hasta bu çalışmaya alınmıştır.
Hastaların demografik, kliniko-patolojik özellikleri ile uygulanan tedavi yöntemleri ve izlem sonuçları retrospektif olarak
değerlendirilmiştir.
Bulgular: Çalışmamızda 27 adet hidatiform mol (HM) (15 komplet, 12 parsiyel), 7 adet non-metastatik gestasyonel trofoblastik
neoplazi (NM-GTN) olgusu değerlendirilmiştir. Olguların yaş ortalaması 31,3± 9,2 yıl, ortalama gebelik sayısı 2,7± 1,5, ortalama
doğum sayısı 1,13± 1,03, düşük ve geçirilmiş mol gebelik oranları sırasıyla ortalama 0,3± 0,5 ve 0,1± 0,4 şeklinde idi. HM tanısı
almış olguların 3 tanesinde (%8,8) tedavi sonrası mol gebelik tekrarlamış, bunlardan birinde histerektomi, diğer ikisinde tekrar revüzyone
küretaj (R/C) ile remisyon sağlanmıştır. NM-GTN tanılı hastaların tümünde tek ajan kemoterapi ile remisyon sağlanmıştır.
Sonuç: Gestasyonel trofoblastik hastalık, erken tanı, uygun tedavi ve izlem yapıldığında remisyon oranları yüksektir. Ancak tedaviye
bağlı ciddi komplikasyonlar ile karşılaşılabilir.

Keywords

Gestasyonel trofoblastik hastalık, mol hidatiform, gestasyonel trofoblastik neoplazi

OUTCOMES OF PATIENTS WITH GESTATIONAL TROPHOBLASTIC DISEASE IN AN UNIVERSITY HOSPITAL

Abstract

Aim: To investigate the clinicopathologic features and treatment procedures of the patients who diagnosed as Gestational Trophoblastic
Disease (GTD).
Methods: Thirty-four patients who pre-diagnosed as GTD between the years 2003- 2013 included to this investigation. Descriptive
and clinicopathologic features, treatment and follow-up results of the patients investigated retrospectively.
Results: Totally 27 hydatiform mole (HM) (15 of them complete and 12 of them partial) and 7 non-metastatic gestational trophoblastic
neoplasia (NM-GTN) case was found in 10 years period of time. The mean age of the patients was 331,37± 9,27 (16-52),
the pregnancy rate was 2,7± 1,5 (0-7), parity rate was 1,13± 1,03 (0-4), the abortus and history of molar pregnancy rates were
0,35± 0,58 (0-2) ve 0,15± 0,44 (0-2), respectively. Three recurrences (8,8%) was seen in HM cases and two of them needed repeat
curettage (R/C) and the other one needed hystetectomy and all the three cases survived. Single agent chemotheraphy was been
successful in all the GTN cases.
Conclusion: GTD is a curable condition with early diagnosis, adequate management and follow-up. Complications due to treatment
should be kept in mind.

Keywords

hydatidiform mole, gestational trophoblastic disease, gestational trophoblastic neoplasia.

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