Endometrial karsinomda serum adropin düzeyleri, vücut kitle indeksi ve kan basıncı değerleri arasındaki ilişki

Year 2024, Volume: 24 Issue: 2, 44 - 53, 30.08.2024

Cihat Murat Alınca , Esra Keles , Uğur Kemal Öztürk , Ayşe Ender Yumru

Abstract

Amaç: Adropin, enerji homeostazı açısından beyin, karaciğer ve periferik dokularda bulunan bir proteindir. Serum adropin düzeyleri hipertansiyon, diabetes mellitus ve metabolik sendromda daha düşük bulunmuştur. Bu çalışmanın amacı endometriyal karsinomlu (EC) hastalarda adropin düzeyleri, vücut kitle indeksi (VKİ) ve kan basıncı değerleri arasındaki ilişkiyi araştırmaktır.

Gereç ve Yöntemler: Toplam 40 sağlıklı ve 50 EC hastanın obstetrik öykü, diabetes mellitus (DM), hipertansiyon (HT) ve aile öyküsü özelliklerini içeren demografik bilgileri kaydedildi. Venöz kan örneklerinden açlık insülini, insülin direnci için homeostaz modeli değerlendirmesi (HOMA-IR), yüksek yoğunluklu lipoprotein (HDL), düşük yoğunluklu lipoprotein (LDL), total kolesterol (TK), trigliserit (TG) ve adropin düzeyleri elde edildi.

Bulgular: Kontrol ve EC grupları arasında serum adropin düzeyi açısından istatistiksel olarak anlamlı bir fark bulunmamıştır. Ancak tip 2 EC’de adropin anlamlı derecede düşük bulunmuştur (OR=0,350; %95CI 0,156-0,783; p=0,011). ROC eğrisi analizinde adropin için optimum cut-off değeri 0,4 ng/mL olarak hesaplanmıştır (%63,6 duyarlılık, %64,7 özgüllük). Pozitif Olabilirlik oranı (LR+) 1,8 ve negatif Olabilirlik oranı (LR-) 0,56 olarak hesaplanmıştır.

Sonuç: Adropin, cerrahi öncesi tip 1 ve tip 2 endometriyal karsinomun ayırıcı tanısı için umut verici bir belirteç olabilir ve daha ileri çalışmalarla doğrulanması gerekmektedir.

Keywords

Adropin, Vücut Kitle İndeksi, Kan Basıncı, Endometriyal Karsinom

The relationship between serum adropin levels, body mass index and blood pressure values in endometrial carcinoma

Abstract

Aim: Adropin is a protein that has been found in the brain, liver, and peripheral tissues in terms of energy homeostasis. Serum adropin levels were lower in hypertension, diabetes mellitus, and metabolic syndrome. This study aimed to investigate the relationship between adropin levels, body mass index (BMI), and blood pressure values in endometrial carcinoma (EC).

Material and Methods: Fourty healthy and 50 EC patients’ demographic information, including characteristics of obstetric history, diabetes mellitus (DM), hypertension (HT), and family history were recorded. Fasting insulin, homeostasis model assessment for insulin resistance (HOMA-IR), high-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterol (TC), triglyceride (TG), and adropin levels were obtained from venous blood samples.

Results: We found no statistically significant difference between the control and EC groups at the serum adropin level. However, adropin was found to be significantly lower in type 2 EC (OR=0.350; 95%CI 0.156-0.783; p=0.011). Optimal cut-off value was calculated in ROC curve analysis as 0.4 ng/mL for adropin (63.6% sensitivity, 64.7% specificity). Positive Likelihood ratio (LR+) was 1.8 and the negative Likelihood ratio (LR-) was 0.56.

Conclusion: Adropin may be a promising marker for the differential diagnosis of type 1 and type 2 endometrial carcinoma before surgery and needs to be confirmed by further studies.

Keywords

Adropin, Body Mass Index, Blood Pressure, Endometrial Carcinoma

Ethical Statement

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by the Ethics Committee of University of Health Sciences Turkey, Sisli Hamidiye Etfal Education and Research Hospital (Date: 03/10/2017 No: 1704/866).

Supporting Institution

None.

Thanks

The authors would like to thank the study participants for their contribution.

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