<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.4 20241031//EN"
        "https://jats.nlm.nih.gov/publishing/1.4/JATS-journalpublishing1-4.dtd">
<article  article-type="reviewer-report"        dtd-version="1.4">
            <front>

                <journal-meta>
                                                                <journal-id>turk j diab obes</journal-id>
            <journal-title-group>
                                                                                    <journal-title>Turkish Journal of Diabetes and Obesity</journal-title>
            </journal-title-group>
                            <issn pub-type="ppub">2587-0335</issn>
                                        <issn pub-type="epub">2587-0572</issn>
                                                                                            <publisher>
                    <publisher-name>Zonguldak Bulent Ecevit University</publisher-name>
                </publisher>
                    </journal-meta>
                <article-meta>
                                        <article-id pub-id-type="doi">10.25048/tudod.767999</article-id>
                                                                <article-categories>
                                            <subj-group  xml:lang="en">
                                                            <subject>Health Care Administration</subject>
                                                    </subj-group>
                                            <subj-group  xml:lang="tr">
                                                            <subject>Sağlık Kurumları Yönetimi</subject>
                                                    </subj-group>
                                    </article-categories>
                                                                                                                                                        <title-group>
                                                                                                                        <trans-title-group xml:lang="en">
                                    <trans-title>Intensive Care Approach In COVID-19 Patients</trans-title>
                                </trans-title-group>
                                                                                                                                                                                                <article-title>COVID-19 Hastalarında Yoğun Bakım Yaklaşımı</article-title>
                                                                                                    </title-group>
            
                                                    <contrib-group content-type="authors">
                                                                        <contrib contrib-type="author">
                                                                    <contrib-id contrib-id-type="orcid">
                                        https://orcid.org/0000-0002-6869-5932</contrib-id>
                                                                <name>
                                    <surname>Ayoğlu</surname>
                                    <given-names>Hilal</given-names>
                                </name>
                                                                    <aff>ZONGULDAK BÜLENT ECEVİT ÜNİVERSİTESİ, TIP FAKÜLTESİ</aff>
                                                            </contrib>
                                                                                </contrib-group>
                        
                                        <pub-date pub-type="pub" iso-8601-date="20200830">
                    <day>08</day>
                    <month>30</month>
                    <year>2020</year>
                </pub-date>
                                        <volume>4</volume>
                                        <issue>2</issue>
                                        <fpage>183</fpage>
                                        <lpage>193</lpage>
                        
                        <history>
                                    <date date-type="received" iso-8601-date="20200711">
                        <day>07</day>
                        <month>11</month>
                        <year>2020</year>
                    </date>
                                                    <date date-type="accepted" iso-8601-date="20200808">
                        <day>08</day>
                        <month>08</month>
                        <year>2020</year>
                    </date>
                            </history>
                                        <permissions>
                    <copyright-statement>Copyright © 2017, Turkish Journal of Diabetes and Obesity</copyright-statement>
                    <copyright-year>2017</copyright-year>
                    <copyright-holder>Turkish Journal of Diabetes and Obesity</copyright-holder>
                </permissions>
            
                                                                                                <trans-abstract xml:lang="en">
                            <p>In the intensive care management of critical patients with severe hemodynamic disorders, severe pneumonia, respiratory failure, acute respiratory distress syndrome (ARDS), organ damage, sepsis and septic shock during the COVID-19 pandemic process; clinical researches, reviews, guides have been published which include many different topics such as the identification, treatment of patients who need intensive care and the design of intensive care in this process. The knowledge and experience of intensivists are increasing day by day in the pandemic process. This article was compiled in the light of the recommended information about intensive care management of adult COVID-19 patients from March to June 2020 both in our country and abroad.</p></trans-abstract>
                                                                                                                                    <abstract><p>COVID-19 pandemisi sürecinde ağır hemodinamik bozukluklar, ağır pnömoni, solunum yetmezliği, akut solunum sıkıntısı sendromu (ARDS), organ hasarı, sepsis, septik şok gibi sorunları olan kritik hastaların yoğun bakım yönetiminde; yoğun bakıma ihtiyacı olan hastaların belirlenmesi, tedavisi, bu süreçte yoğun bakımların dizaynı gibi pek çok farklı konuyu içeren klinik araştırmalar, derlemeler, kılavuzlar yayınlanmıştır. Pandemi sürecinde her geçen gün yoğun bakımcıların bilgi ve tecrübeleri giderek artmaktadır. Bu makaleMart-Haziran 2020 ayları arasında gerek ülkemiz gerekse de yurt dışı uygulamalarda erişkin COVID-19 hastalarının yoğun bakım yönetimi hakkında önerilen bilgiler ışığında derlenmiştir.</p></abstract>
                                                            
            
                                                                                        <kwd-group>
                                                    <kwd>COVID-19</kwd>
                                                    <kwd>  Yoğun Bakım</kwd>
                                                    <kwd>  Pandemi</kwd>
                                            </kwd-group>
                            
                                                <kwd-group xml:lang="en">
                                                    <kwd>COVID-19</kwd>
                                                    <kwd>  Intensive care management</kwd>
                                            </kwd-group>
                                                                                                                                        </article-meta>
    </front>
    <back>
                            <ref-list>
                                    <ref id="ref1">
                        <label>1</label>
                        <mixed-citation publication-type="journal">1. WHO Director-General’s opening remarks at the media
briefing on COVID-19 - 11 March 2020. (Available: https://
www.who.int/dg/speeches/detail/who-director-generals-
opening-remarks-at-the-media-briefing-on-covid-
19%2D%2D-11-march-2020.) [cited 12 Mar 2020].</mixed-citation>
                    </ref>
                                    <ref id="ref2">
                        <label>2</label>
                        <mixed-citation publication-type="journal">2. Team NCPERE. Vital surveillances: The epidemiological
characteristics of an outbreak of 2019 novel coronavirus
diseases (COVID-19) - China. China CDC Weekly.
2020;2(8):113-122.</mixed-citation>
                    </ref>
                                    <ref id="ref3">
                        <label>3</label>
                        <mixed-citation publication-type="journal">3. Auld SC, Caridi-Scheible M, Blum JM, Robichaux C et al.
ICU and ventilator mortality among critically Ill adults with
Coronavirus disease 2019. Crit Care Med. 2020;26:10.1097</mixed-citation>
                    </ref>
                                    <ref id="ref4">
                        <label>4</label>
                        <mixed-citation publication-type="journal">4. World Health Organization. Coronavirus disease
(COVID-2019) situation reports. 2020. (https://www.who.
int/emergencies/diseases/novel-coronavirus-2019/situationreports).</mixed-citation>
                    </ref>
                                    <ref id="ref5">
                        <label>5</label>
                        <mixed-citation publication-type="journal">5. Shang Y, Pan C, Yang X, Zhong M, et al. Management of
critically ill patients with COVID-19 in ICU: Statement
from front-line intensive care experts in Wuhan, China. Ann
Intensive Care. 2020;10(1):73.</mixed-citation>
                    </ref>
                                    <ref id="ref6">
                        <label>6</label>
                        <mixed-citation publication-type="journal">6. Varatharaj A, Thomas N, Ellul MA, et al. CoroNerve Study
Group. Neurological and neuropsychiatric complications of
COVID-19 in 153 patients: A UK-wide surveillance study.
Lancet Psychiatry. 2020;S2215-0366(20)30287-X. d</mixed-citation>
                    </ref>
                                    <ref id="ref7">
                        <label>7</label>
                        <mixed-citation publication-type="journal">7. Siddiqi HK, Mehra MR. COVID-19 Iillness in native and
immunosuppressed states: A clinical-therapeutic staging
proposal. J Heart Lung Transplant. 2020;39(5):405-407.</mixed-citation>
                    </ref>
                                    <ref id="ref8">
                        <label>8</label>
                        <mixed-citation publication-type="journal">8. Wu Z, McGoogan JM. Characteristics of and important lessons
from the coronavirus disease 2019 (COVID-19) outbreak in
China: Summary of a report of 72314 cases from the Chinese
center for disease control and prevention. Jama. 2020 Feb 24.
(Online ahead of print).</mixed-citation>
                    </ref>
                                    <ref id="ref9">
                        <label>9</label>
                        <mixed-citation publication-type="journal">9. T.C. Sağlık Bakanlığı Halk Sağlığı Genel Müdürlüğü,
COVID-19 (SARS-CoV-2 Enfeksiyonu) Ağır Pnömoni,
ARDS, Sepsis ve Septik Şok Yönetimi 1 Haziran 2020. (https://
covid19bilgi.saglik.gov.tr).</mixed-citation>
                    </ref>
                                    <ref id="ref10">
                        <label>10</label>
                        <mixed-citation publication-type="journal">10. Phua J, Weng L, Ling L, et al. Asian Critical Care Clinical
Trials Group Intensive care management of coronavirus
disease 2019 (COVID-19): challenges and recommendations.
Lancet Respir Med. 2020;8(5):506-517.</mixed-citation>
                    </ref>
                                    <ref id="ref11">
                        <label>11</label>
                        <mixed-citation publication-type="journal">11. Karabıyık L. COVID-19 hastaların yoğun bakım süreci. Gazi
Medical Journal 2020;31:331-336</mixed-citation>
                    </ref>
                                    <ref id="ref12">
                        <label>12</label>
                        <mixed-citation publication-type="journal">12. Centers for Disease Control and Prevention. Interim infection
prevention and control recommendations for patients
with suspected or confirmed coronavirus disease 2019
(COVID-19) in healthcare settings. (June 19, 2020. https://
www.cdc.gov/coronavirus/2019-ncov/hcp/infection-controlrecommendations.
html).</mixed-citation>
                    </ref>
                                    <ref id="ref13">
                        <label>13</label>
                        <mixed-citation publication-type="journal">13. T.C. Sağlık Bakanlığı Halk Sağlığı Genel Müdürlüğü,
COVID-19 (SARS-CoV-2 Enfeksiyonu) Erişkin Hasta
Tedavisi. (19 Haziran 2020. https://covid19bilgi.saglik.gov.
tr/depo/rehberler/covid-19-rehberi/COVID-19_REHBERI_
ERISKIN_HASTA_TEDAVISI.pdf).</mixed-citation>
                    </ref>
                                    <ref id="ref14">
                        <label>14</label>
                        <mixed-citation publication-type="journal">14. Guan W, Liang W, Zhao Y, et al. China Medical Treatment
Expert Group for COVID-19. Comorbidity and its impact
on 1590 patients with COVID-19 in China: A nationwide
analysis. Eur Respir J. 2020;55(5):2000547.</mixed-citation>
                    </ref>
                                    <ref id="ref15">
                        <label>15</label>
                        <mixed-citation publication-type="journal">15. Alhazzani W, Moller MH, Arabi YM, et al. Surviving Sepsis
Campaign: Guidelines on the management of critically Ill
adults with coronavirus disease 2019 (COVID-19). Intensive
Care Med. 2020;46:854-887.</mixed-citation>
                    </ref>
                                    <ref id="ref16">
                        <label>16</label>
                        <mixed-citation publication-type="journal">16. Lamontagne F, Rochwerg B, Lytvyn L, Guyatt HG, Moller
MH, Annane D. Corticosteroid therapy for sepsis: A clinical
practice guideline. BMJ. 2018;362:k3284.</mixed-citation>
                    </ref>
                                    <ref id="ref17">
                        <label>17</label>
                        <mixed-citation publication-type="journal">17. Tran K, Cimon K, Severn M, Pessoa-Silva CL, Conly J.
Aerosol-Generating procedures and risk of transmission of
acute respiratory infections: A systematic review. PLoS One.
2012;7(4):e35797.</mixed-citation>
                    </ref>
                                    <ref id="ref18">
                        <label>18</label>
                        <mixed-citation publication-type="journal">18. Clinical management of COVID-19. Interim guidance 27
May 2010. World Health Organization. WHO72019-nCoV/
clinical/2020.5. (https://apps.who.int/iris/handle/10665/332196).</mixed-citation>
                    </ref>
                                    <ref id="ref19">
                        <label>19</label>
                        <mixed-citation publication-type="journal">19. Coppo A, Bellani G, Winterton D, et al. Feasibility and
physiological effects of prone positioning in non-intubated
patients with acute respiratory failure due to COVID-19
(PRON-COVID): A prospective cohort study. Lancet Respir
Med. 2020;8(8):765-774.</mixed-citation>
                    </ref>
                                    <ref id="ref20">
                        <label>20</label>
                        <mixed-citation publication-type="journal">20. Agarwal A, Basmaji J, Muttalib F, et al. High-Flow nasal
cannula for acute hypoxemic respiratory failure in patientswith
COVID-19: Systematic reviews of effectiveness and its risks of
aerosolization, dispersion, and infection transmission. Can J
Anaesth. 2020;67(9):1217-1248.</mixed-citation>
                    </ref>
                                    <ref id="ref21">
                        <label>21</label>
                        <mixed-citation publication-type="journal">21. Talan L, Altıntaș ND. Yoğun Bakımda Hasta Yönetimi/
COVID-19. Ankara Üniversitesi Tıp Fakültesi. Ankara
Üniversitesi Basımevi 2020. (E-kitap).</mixed-citation>
                    </ref>
                                    <ref id="ref22">
                        <label>22</label>
                        <mixed-citation publication-type="journal">22. Turner JS, Bucca AW, Propst SL, Ellender TJ, Sarmiento
EJ, Menard LM, Hunter BR. Association of checklist Use in
endotracheal intubation with clinically important outcomes
a systematic review and meta-analysis. JAMA Netw Open.
2020;3(7):e209278.</mixed-citation>
                    </ref>
                                    <ref id="ref23">
                        <label>23</label>
                        <mixed-citation publication-type="journal">23. Goh KJ, Wong J, Tien JC, Ng SY, Duu Wen S, Phua GC, Leong
CK. Preparing your intensive care unit for the COVID-19
pandemic: Practical considerations and strategies. Crit Care.
2020;24(1):215.</mixed-citation>
                    </ref>
                                    <ref id="ref24">
                        <label>24</label>
                        <mixed-citation publication-type="journal">24. Fan E, Brodie D, Slutsky AS. Acute respiratory distress
syndrome: Advances in diagnosis and treatment. JAMA.
2018;319(7):698-710.</mixed-citation>
                    </ref>
                                    <ref id="ref25">
                        <label>25</label>
                        <mixed-citation publication-type="journal">25. Gattinoni L, Chiumello D, Rossi S. COVID-19 pneumonia:
ARDS or not? Crit Care. 2020;24(1):154.</mixed-citation>
                    </ref>
                                    <ref id="ref26">
                        <label>26</label>
                        <mixed-citation publication-type="journal">26. Gattinoni L, Chiumello D, Caironi P, Busana M, Romitti F,
Brazzi L, Camporota L. COVID-19 pneumonia: Different
respiratory treatments for different phenotypes? Intensive
Care Med. 2020;46(6):1099-1102.</mixed-citation>
                    </ref>
                                    <ref id="ref27">
                        <label>27</label>
                        <mixed-citation publication-type="journal">27. Tobaiqy M, Qashqary M, Al-Dahery S, Mujallad A, Hershan
AA, Kamal MA, Helmi N. Therapeutic management of patients
with COVID-19: A systematic review. Infection Prevention in
Practice. 2020;2(3):100061.</mixed-citation>
                    </ref>
                                    <ref id="ref28">
                        <label>28</label>
                        <mixed-citation publication-type="journal">28. Srinivas P, Sacha G, Koval C. Antivirals for COVID-19. Cleve
Clin J Med. 2020 May 14. (Online ahead of print).</mixed-citation>
                    </ref>
                                    <ref id="ref29">
                        <label>29</label>
                        <mixed-citation publication-type="journal">29. Yang X, Yu Y, Xu J, et al. Clinical course and outcomes of
critically ill patients with SARS-CoV-2 pneumonia in Wuhan,
China: A single-centered, retrospective, observational study.
Lancet Respir Med; 2020;8(5):475-481.</mixed-citation>
                    </ref>
                                    <ref id="ref30">
                        <label>30</label>
                        <mixed-citation publication-type="journal">30. Wang D, Hu B, Hu C, et al. Clinical Characteristics of 138
Hospitalized Patients with 2019 Novel Coronavirus-Infected
Pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-
1069.</mixed-citation>
                    </ref>
                                    <ref id="ref31">
                        <label>31</label>
                        <mixed-citation publication-type="journal">31. Ruan Q, Yang K, Wang W, Jiang L, Song J. Clinical predictors
of mortality due to COVID-19 based on an analysis of data of
150 patients from Wuhan, China. Intensive Care Med. 2020;
46:846-8.</mixed-citation>
                    </ref>
                                    <ref id="ref32">
                        <label>32</label>
                        <mixed-citation publication-type="journal">32. Zitek T. The Appropriate Use of Testing for COVID-19. West
J Emerg Med. 2020;21(3):470-472.</mixed-citation>
                    </ref>
                                    <ref id="ref33">
                        <label>33</label>
                        <mixed-citation publication-type="journal">33. Zhang L, Wang M, Wang Y, Zhu J, Zhang N. Focus on a
2019-novel coronavirus (SARS-CoV-2). Future Microbiol.
2020;10.2217/fmb-2020-0063.</mixed-citation>
                    </ref>
                                    <ref id="ref34">
                        <label>34</label>
                        <mixed-citation publication-type="journal">34. Russell CD, Millar JE, Baillie JK. Clinical evidence does not
support corticosteroid treatment for 2019-CoV lung injury.
Lancet. 2020;395:473-475.</mixed-citation>
                    </ref>
                                    <ref id="ref35">
                        <label>35</label>
                        <mixed-citation publication-type="journal">35. T.C. Sağlık Bakanlığı Halk Sağlığı Genel Müdürlüğü,
COVID-19 Rehberi Antisitokin antiinflamatuar tedaviler
koagulopati yönetimi. (https://covid19bilgi.saglik.gov.tr/
depo/rehberler/covid-19-rehberi/COVID-19_REHBERI_
ANTISITOKIN-ANTI_INFLAMATUAR_TEDAVILER_
KOAGULOPATI_YONETIMI.pdf).</mixed-citation>
                    </ref>
                                    <ref id="ref36">
                        <label>36</label>
                        <mixed-citation publication-type="journal">36. Chen X, Zhao B, Qu Y, et al. Detectable serum SARSCoV-2
viral load (RNAaemia) is closely associated with drastically
elevated interleukin 6 (IL-6) level in critically ill COVID-19
patients. Clin Infect Dis. 2020;ciaa449.</mixed-citation>
                    </ref>
                                    <ref id="ref37">
                        <label>37</label>
                        <mixed-citation publication-type="journal">37. Shen, C, Wang, Z, Zhao F, et al. Treatment of 5 critically Ill
patients with COVID-19 with convalescent plasma. JAMA.
2020;323(16):1582-1589.</mixed-citation>
                    </ref>
                                    <ref id="ref38">
                        <label>38</label>
                        <mixed-citation publication-type="journal">38. Casadevall A, Pirofski L, The convalescent sera option for
containing COVID-19. J Clin Invest. 2020;130:1545-1548.</mixed-citation>
                    </ref>
                                    <ref id="ref39">
                        <label>39</label>
                        <mixed-citation publication-type="journal">39. T.C. Sağlık Bakanlığı Sağlık Hizmtleri Genel Müdürlüğü,
Kan ve Kan Ürünleri Dairesi Başkanlığı. Covid-19-immunkonvalesan-
plazma-tedarik-ve-klinik-kullanim-rehberi
(https://dosyamerkez.saglik.gov.tr/Eklenti/37341,covid-19-
immun-konvalesan-plazma-tedarik-ve-klinik-kullanimrehberi-
guncel--r1-v1pdf.pdf?0).</mixed-citation>
                    </ref>
                                    <ref id="ref40">
                        <label>40</label>
                        <mixed-citation publication-type="journal">40. Zhu Z, Lu Z, Xu T, Chen C, Yang G, Zha T, Lu J, Xue Y.
Arbidol monotherapy is superior to lopinavir/ritonavir in
treating COVID-19. J Infect. 2020;81(1):e21-e23.</mixed-citation>
                    </ref>
                                    <ref id="ref41">
                        <label>41</label>
                        <mixed-citation publication-type="journal">41. Fowler AA, Truwit JD, Hite RD, Morris PE, et al. Effect
of vitamin C infusion on organ failure and biomarkers of
inflammation and vascular injury in patients with sepsis and
severe acute respiratory failure: The CITRIS-ALI randomized
clinical trial. JAMA. 2019;322:1261-1270.</mixed-citation>
                    </ref>
                                    <ref id="ref42">
                        <label>42</label>
                        <mixed-citation publication-type="journal">42. Ali N. Role of vitamin D in preventing of COVID-19 infection,
progression and severity. J Infect Public Health. 2020;S1876-
0341(20)30531-1.</mixed-citation>
                    </ref>
                                    <ref id="ref43">
                        <label>43</label>
                        <mixed-citation publication-type="journal">43. Blaser AR, Starkopf J, Alhazzani W, et al. Early enteral
nutrition in critically Ill patients: ESICM clinical practice
guidelines. Intensive Care Med. 2017;43:380-398.</mixed-citation>
                    </ref>
                                    <ref id="ref44">
                        <label>44</label>
                        <mixed-citation publication-type="journal">44. Cheng Y, Luo R, Wang K, et al. Kidney disease is associated
with in-hospital death of patients with COVID-19. Kidney Int.
2020 May;97(5):829-838.</mixed-citation>
                    </ref>
                                    <ref id="ref45">
                        <label>45</label>
                        <mixed-citation publication-type="journal">45. Adapa S, Aeddula NR, Konala VM , et al. COVID-19 and
renal failure: Challenges in the delivery of renal replacement
therapy. J Clin Med Res. 2020;12(5):276-285.</mixed-citation>
                    </ref>
                                    <ref id="ref46">
                        <label>46</label>
                        <mixed-citation publication-type="journal">46. Huang L, Zhang W, Yang Y, et al. Application of extracorporeal
membrane oxygenation in patients with severe acute
respiratory distress syndrome induced by avian influenza
a (H7N9) viral pneumonia: National data from the chinese
multicentre collaboration. BMC Infect Dis. 2018;18:23.</mixed-citation>
                    </ref>
                                    <ref id="ref47">
                        <label>47</label>
                        <mixed-citation publication-type="journal">47. Abrams D, Ferguson ND, Brochard L, et al. ECMO for
ARDS: From salvage to standard of care? Lancet Respir Med.
2019;7(2):108-110.</mixed-citation>
                    </ref>
                                    <ref id="ref48">
                        <label>48</label>
                        <mixed-citation publication-type="journal">48. Huang C, Wang Y, Li X, et al. Clinical features of patients
infected with 2019 novel coronavirus in Wuhan, China.
Lancet. 2020;395(10223):497-506.</mixed-citation>
                    </ref>
                                    <ref id="ref49">
                        <label>49</label>
                        <mixed-citation publication-type="journal">49. Klok FA, Kruip MJHA, Meer NJM, et al. Incidence of
thrombotic complications in critically Ill ICU patients with
COVID-19. Thromb Res. 2020;191:145-147.</mixed-citation>
                    </ref>
                                    <ref id="ref50">
                        <label>50</label>
                        <mixed-citation publication-type="journal">50. European resuscitation council COVID-19 guidelines-24.April.
2020 (https://erc.edu/sites/5714e77d5e615861f00f7d18/content_
entry5ea884fa4c84867335e4d1ff/5ea885f34c84867335e-
4d20e/files/ERC_covid19_pages.pdf?1588257310).</mixed-citation>
                    </ref>
                                    <ref id="ref51">
                        <label>51</label>
                        <mixed-citation publication-type="journal">51. Centers for disease control and prevention. Interim
infection prevention and control recommendations for
healthcare personnel during the coronavirus disease 2019
(COVID-19) pandemic June 19, 2020. (https://www.
cdc.gov/coronavirus/2019-ncov/hcp/infection-controlrecommendations.
html).</mixed-citation>
                    </ref>
                                    <ref id="ref52">
                        <label>52</label>
                        <mixed-citation publication-type="journal">52. The Australian and New Zealand Intensive Care Society
(ANZICS) COVID-19 Guidelines. Intensive care management
of coronavirus disease 2019 (COVID-19): Challenges and
recommendations. (https://www.anzics.com.au/wp-content/
uploads/2020/04/ANZI_3367_Guidelines_V2.pdf)</mixed-citation>
                    </ref>
                            </ref-list>
                    </back>
    </article>
