<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.4 20241031//EN"
        "https://jats.nlm.nih.gov/publishing/1.4/JATS-journalpublishing1-4.dtd">
<article  article-type="research-article"        dtd-version="1.4">
            <front>

                <journal-meta>
                                                                <journal-id>turk j food agric sci</journal-id>
            <journal-title-group>
                                                                                    <journal-title>Turkish Journal of Food and Agriculture Sciences</journal-title>
            </journal-title-group>
                                        <issn pub-type="epub">2687-3818</issn>
                                                                                            <publisher>
                    <publisher-name>Burhan ÖZTÜRK</publisher-name>
                </publisher>
                    </journal-meta>
                <article-meta>
                                        <article-id pub-id-type="doi">10.53663/turjfas.996406</article-id>
                                                                <article-categories>
                                            <subj-group  xml:lang="en">
                                                            <subject>Food Engineering</subject>
                                                    </subj-group>
                                            <subj-group  xml:lang="tr">
                                                            <subject>Gıda Mühendisliği</subject>
                                                    </subj-group>
                                    </article-categories>
                                                                                                                                                        <title-group>
                                                                                                                                                            <article-title>Efficacy of a pilot-scale ultrasonication system for pasteurization of milk</article-title>
                                                                                                    </title-group>
            
                                                    <contrib-group content-type="authors">
                                                                        <contrib contrib-type="author">
                                                                    <contrib-id contrib-id-type="orcid">
                                        https://orcid.org/0000-0001-5064-4195</contrib-id>
                                                                <name>
                                    <surname>Akdemir Evrendilek</surname>
                                    <given-names>Gülsün</given-names>
                                </name>
                                                                    <aff>BOLU ABANT İZZET BAYSAL ÜNİVERSİTESİ</aff>
                                                            </contrib>
                                                    <contrib contrib-type="author">
                                                                    <contrib-id contrib-id-type="orcid">
                                        https://orcid.org/0000-0002-2663-5800</contrib-id>
                                                                <name>
                                    <surname>Bodruk</surname>
                                    <given-names>Anıl</given-names>
                                </name>
                                                                    <aff>Pinar Dairy Products Inc., Research and Development, Center</aff>
                                                            </contrib>
                                                    <contrib contrib-type="author">
                                                                    <contrib-id contrib-id-type="orcid">
                                        https://orcid.org/0000-0002-9855-3409</contrib-id>
                                                                <name>
                                    <surname>Acar</surname>
                                    <given-names>Furkan</given-names>
                                </name>
                                                                    <aff>Pinar Dairy Products Inc., Research and Development, Center</aff>
                                                            </contrib>
                                                                                </contrib-group>
                        
                                        <pub-date pub-type="pub" iso-8601-date="20211230">
                    <day>12</day>
                    <month>30</month>
                    <year>2021</year>
                </pub-date>
                                        <volume>3</volume>
                                        <issue>2</issue>
                                        <fpage>50</fpage>
                                        <lpage>55</lpage>
                        
                        <history>
                                    <date date-type="received" iso-8601-date="20211002">
                        <day>10</day>
                        <month>02</month>
                        <year>2021</year>
                    </date>
                                                    <date date-type="accepted" iso-8601-date="20211027">
                        <day>10</day>
                        <month>27</month>
                        <year>2021</year>
                    </date>
                            </history>
                                        <permissions>
                    <copyright-statement>Copyright © 2019, Turkish Journal of Food and Agriculture Sciences</copyright-statement>
                    <copyright-year>2019</copyright-year>
                    <copyright-holder>Turkish Journal of Food and Agriculture Sciences</copyright-holder>
                </permissions>
            
                                                                                                                        <abstract><p>This study aimed to test a pilot-scale continuous ultrasonication (US) system to pasteurize whole milk in terms of physical properties, energy consumption, and inactivation of alkaline phosphatase (ALP), total mesophilic aerobic bacteria (TMAB), total coliform (TC), total enterobactericeae (TE), and Escherichia coli.  Except for those treated by 90% amplitude for 20 and 30 min, the samples were found negative for ALP activity. Inactivation of TC, TMAB, TE, and E. coli rose with an increased amplitude and temperature. The maximum cost was estimated at 2.778,00 € for the system and at 3.624,00 € for plate heat exchanger to pasteurize 20.000 L of milk. 96.52% amplitude, 40 min, and 53.50 °C were determined jointly as the optimal operational settings.</p></abstract>
                                                            
            
                                                                                        <kwd-group>
                                                    <kwd>Ultrasonication</kwd>
                                                    <kwd>  Milk processing</kwd>
                                                    <kwd>  Optimization</kwd>
                                                    <kwd>  Alkaline phosphatase</kwd>
                                                    <kwd>  Cost analyses</kwd>
                                            </kwd-group>
                            
                                                                                                                                                <funding-group specific-use="FundRef">
                    <award-group>
                                                    <funding-source>
                                <named-content content-type="funder_name">Bolu Abant Izzet Baysal University Research Fund and Republic of Turkey Ministry of Development Government Planning Agency</named-content>
                            </funding-source>
                                                                            <award-id>BAP- 2018.09.04.1304 and 2009 DPT K 120140</award-id>
                                            </award-group>
                </funding-group>
                                </article-meta>
    </front>
    <back>
                            <ref-list>
                                    <ref id="ref1">
                        <label>1</label>
                        <mixed-citation publication-type="journal">Asaithambi, N., Singha, P., Dwivedi, M., &amp; Singh, S. K. (2019). Hydrodynamic cavitation and its application in food and beverage industry: A review. Journal of Food Process Engineering, 42(5), e13144. https://doi.org/10.1111/jfpe.13144</mixed-citation>
                    </ref>
                                    <ref id="ref2">
                        <label>2</label>
                        <mixed-citation publication-type="journal">Ashokkumar, M., Bhaskaracharya, R., Kentish, S., Lee, J., Palmer, M., &amp; Zisu, B. (2010). The ultrasonic processing of dairy products—An overview. Dairy Science &amp; Technology, 90(2), 147–168. https://doi.org/10.1051/dst/2009044</mixed-citation>
                    </ref>
                                    <ref id="ref3">
                        <label>3</label>
                        <mixed-citation publication-type="journal">Bermúdez-Aguirre, D., Mobbs, T., &amp; Barbosa-Cánovas, G. V. (2011). Ultrasound Applications in Food Processing. In H. Feng, G. Barbosa-Canovas, &amp; J. Weiss (Eds.), Ultrasound Technologies for Food and Bioprocessing (pp. 65–105). Springer. https://doi.org/10.1007/978-1-4419-7472-3_3</mixed-citation>
                    </ref>
                                    <ref id="ref4">
                        <label>4</label>
                        <mixed-citation publication-type="journal">Cameron, M., McMaster, L. D., &amp; Britz, T. J. (2010). Impact of ultrasound on dairy spoilage microbes and milk components. Dairy Science &amp; Technology, 90(1), 119–119. https://doi.org/10.1051/dst/2010003</mixed-citation>
                    </ref>
                                    <ref id="ref5">
                        <label>5</label>
                        <mixed-citation publication-type="journal">Carpenter, J., Badve, M., Rajoriya, S., George, S., Saharan, V., &amp; Pandit, A. (2016). Hydrodynamic cavitation: An emerging technology for the intensification of various chemical and physical processes in a chemical process industry. Reviews in Chemical Engineering, 33. https://doi.org/10.1515/revce-2016-0032</mixed-citation>
                    </ref>
                                    <ref id="ref6">
                        <label>6</label>
                        <mixed-citation publication-type="journal">Chandrapala, J., Martin, G. J. O., Zisu, B., Kentish, S. E., &amp; Ashokkumar, M. (2012). The effect of ultrasound on casein micelle integrity. Journal of Dairy Science, 95(12), 6882–6890. https://doi.org/10.3168/jds.2012-5318</mixed-citation>
                    </ref>
                                    <ref id="ref7">
                        <label>7</label>
                        <mixed-citation publication-type="journal">Chemat, F., Zill-e-Huma, &amp; Khan, M. K. (2011). Applications of ultrasound in food technology: Processing, preservation and extraction. Ultrasonics Sonochemistry, 18(4), 813–835. https://doi.org/10.1016/j.ultsonch.2010.11.023</mixed-citation>
                    </ref>
                                    <ref id="ref8">
                        <label>8</label>
                        <mixed-citation publication-type="journal">Chouliara, E., Georgogianni, K. G., Kanellopoulou, N., &amp; Kontominas, M. G. (2010). Effect of ultrasonication on microbiological, chemical and sensory properties of raw, thermized and pasteurized milk. International Dairy Journal, 20(5), 307–313. https://doi.org/10.1016/j.idairyj.2009.12.006</mixed-citation>
                    </ref>
                                    <ref id="ref9">
                        <label>9</label>
                        <mixed-citation publication-type="journal">De Jong, P., &amp; Villamiel, M. (2000). Inactivation of Pseudomonas flourescens and Streptococcus thermophilus in trypticase soy broth and total bacteria count in milk by continuous-flow ultrasonic treatment and conventional heating. Journal of Food Engineering, 45, 171–179. https://doi.org/10.1016/S0260-8774(00)00059-5</mixed-citation>
                    </ref>
                                    <ref id="ref10">
                        <label>10</label>
                        <mixed-citation publication-type="journal">Ganesan, B., Martini, S., Solorio, J., &amp; Walsh, M. K. (2015). Determining the effects of high intensity ultrasound on the reduction of microbes in milk and orange juice using response surface methodology. International Journal of Food Science, 2015, 1–7. https://doi.org/10.1155/2015/350719</mixed-citation>
                    </ref>
                                    <ref id="ref11">
                        <label>11</label>
                        <mixed-citation publication-type="journal">Gogate, P., &amp; Pandit, A. (2001). Hydrodynamic cavitation reactors: A state of the art review. Reviews in Chemical Engineering, 17, 1–85. https://doi.org/10.1515/REVCE.2001.17.1.1</mixed-citation>
                    </ref>
                                    <ref id="ref12">
                        <label>12</label>
                        <mixed-citation publication-type="journal">Griffiths, M. W. (1986). Use of milk enzymes as indices of heat treatment. Journal of Food Protection, 49(9), 696–705. https://doi.org/10.4315/0362-028X-49.9.696</mixed-citation>
                    </ref>
                                    <ref id="ref13">
                        <label>13</label>
                        <mixed-citation publication-type="journal">Martini, S. (2013). Common Uses of Power Ultrasound in the Food Industry. In S. Martini (Ed.), Sonocrystallization of Fats (pp. 27–33). Springer. https://doi.org/10.1007/978-1-4614-7693-1_4</mixed-citation>
                    </ref>
                                    <ref id="ref14">
                        <label>14</label>
                        <mixed-citation publication-type="journal">McSweeney, P. L. H., &amp; Fox, P. F. (2009). Significance of Lactose in Dairy Products. In P. McSweeney &amp; P. F. Fox (Eds.), Advanced Dairy Chemistry: Volume 3: Lactose, Water, Salts and Minor Constituents (pp. 35–104). Springer. https://doi.org/10.1007/978-0-387-84865-5_3</mixed-citation>
                    </ref>
                                    <ref id="ref15">
                        <label>15</label>
                        <mixed-citation publication-type="journal">Milly, P. J., Toledo, R. T., Kerr, W., &amp; Armstead, D. (2008). Hydrodynamic cavitation: characterization of a novel design with energy considerations for the ınactivation of Saccharomyces cerevisiae in apple juice. Journal of Food Science, 73, M298-303. https://doi.org/10.1111/j.1750-3841.2008.00827.x</mixed-citation>
                    </ref>
                                    <ref id="ref16">
                        <label>16</label>
                        <mixed-citation publication-type="journal">Milly, P., Toledo, R., Harrison, M., &amp; Armstead, D. (2007). Inactivation of food spoilage microorganisms by hydrodynamic cavitation to achieve pasteurization and sterilization of fluid foods. Journal of Food Science, 72, M414-22. https://doi.org/10.1111/j.1750-3841.2007.00543.x</mixed-citation>
                    </ref>
                                    <ref id="ref17">
                        <label>17</label>
                        <mixed-citation publication-type="journal">Munir, M., Nadeem, M., Qureshi, T. M., Leong, T. S. H., Gamlath, C. J., Martin, G. J. O., &amp; Ashokkumar, M. (2019). Effects of high pressure, microwave and ultrasound processing on proteins and enzyme activity in dairy systems—A review. Innovative Food Science and Emerging Technologies, 57.</mixed-citation>
                    </ref>
                                    <ref id="ref18">
                        <label>18</label>
                        <mixed-citation publication-type="journal">Nguyen, N. H. A., &amp; Anema, S. G. (2017). Ultrasonication of reconstituted whole milk and its effect on acid gelation. Food Chemistry, 217, 593–601. https://doi.org/10.1016/j.foodchem.2016.08.117</mixed-citation>
                    </ref>
                                    <ref id="ref19">
                        <label>19</label>
                        <mixed-citation publication-type="journal">Pegu, K., &amp; Arya, S. S. (2021). Comparative assessment of HTST, hydrodynamic cavitation and ultrasonication on physico-chemical properties, microstructure, microbial and enzyme inactivation of raw milk. Innovative Food Science &amp; Emerging Technologies, 69, 102640. https://doi.org/10.1016/j.ifset.2021.102640</mixed-citation>
                    </ref>
                                    <ref id="ref20">
                        <label>20</label>
                        <mixed-citation publication-type="journal">Prasantha, B. D. R., &amp; Wimalasiri, K. M. S. (2019). Effect of HTST thermal treatments on end-use quality characteristics of goat milk. International Journal of Food Science, 2019, 1801724. https://doi.org/10.1155/2019/1801724</mixed-citation>
                    </ref>
                                    <ref id="ref21">
                        <label>21</label>
                        <mixed-citation publication-type="journal">Salve, A. R., Pegu, K., &amp; Arya, S. S. (2019). Comparative assessment of high-intensity ultrasound and hydrodynamic cavitation processing on physico-chemical properties and microbial inactivation of peanut milk. Ultrasonics Sonochemistry, 59, 104728. https://doi.org/10.1016/j.ultsonch.2019.104728</mixed-citation>
                    </ref>
                                    <ref id="ref22">
                        <label>22</label>
                        <mixed-citation publication-type="journal">Shamsi, K., Versteeg, C., Sherkat, F., &amp; Wan, J. (2008). Alkaline phosphatase and microbial inactivation by pulsed electric field in bovine milk. Innovative Food Science &amp; Emerging Technologies, 9, 217–223. https://doi.org/10.1016/j.ifset.2007.06.012</mixed-citation>
                    </ref>
                                    <ref id="ref23">
                        <label>23</label>
                        <mixed-citation publication-type="journal">Tao, N., Liu, Y., &amp; Zhang, M. (2009). Chemical composition and antimicrobial activities of essential oil from the peel of bingtang sweet orange (Citrus sinensis Osbeck). International Journal of Food Science &amp; Technology, 44, 1281–1285. https://doi.org/10.1111/j.1365-2621.2009.01947.x</mixed-citation>
                    </ref>
                            </ref-list>
                    </back>
    </article>
