Evaluation of Gastrin, Amylase, Homocysteine, and Cystatin C as Indicators of Renal Failure Severity in Dogs

Year 2025, Volume: 4 Issue: 1, 8 - 12, 25.12.2025

Zeki Yılmaz , Didem Algan , Tuğba Varlik , Yağmur Tunbul

https://izlik.org/JA77SE99MW

Abstract

Objective: The potential diagnostic value of gastrin, amylase, homocysteine (Hcy), and cystatin C (Cys-C) in differentiating acute (ARF) from chronic renal failure (CRF) remains largely unclear in veterinary medicine. This study aimed to assess the diagnostic potential of these four biomarkers in dogs with renal failure. Material and Methods: A total of 45 dogs were divided equally into three groups: dogs with ARF, dogs with CRF, and healthy controls. Results: Serum blood urea nitrogen (BUN), creatinine, and Cys-C levels were found to have elevated in dogs with renal failure compared to controls (p<0.001). Mean serum gastrin, Hcy, and amylase concentrations did not differ significantly between ARF dogs and controls, but were markedly higher in dogs with CRF than in the other two groups (p<0.01–0.001). The findings indicate that although serum gastrin, amylase, and Hcy tend to increase primarily in CRF, serum cystatin C is the only parameter that consistently differentiates between ARF and CRF. Conclusion: This comprehensive analysis provides new insights into the diagnostic utility of less commonly used renal biomarkers in dogs and supports cystatin C as a valuable marker for distinguishing the chronicity of renal injury.

Keywords

Amylase , cystatin , gastrin , homocysteine , renal failure , dog

Ethical Statement

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Köpeklerde Böbrek Yetmezliği Şiddetinin Belirteçleri Olarak Gastrin, Amilaz, Homosistein ve Cystatin C’nin Değerlendirilmesi

https://izlik.org/JA77SE99MW

Abstract

Gastrin, amilaz, homosistein (Hcy) ve cystatin C (Cys-C) gibi belirteçlerin akut (ARF) ve kronik böbrek yetmezliğini (CRF) ayırt etmedeki potansiyel tanısal değeri, veteriner hekimlikte büyük ölçüde belirsizliğini korumaktadır. Bu çalışma, renal yetmezlikli köpeklerde bu dört biyobelirtecin tanısal potansiyelinin değerlendirilmesini amaçlamıştır. Toplam 45 köpek ARF’li, CRF’li ve sağlıklı kontrollere olmak üzere üç gruba eşit şekilde ayrılmıştır. Serum kan üre nitrojeni (BUN), kreatinin ve Cys-C düzeylerinin, kontrol köpeklere kıyasla renal yetmezlikli köpeklerde arttığı saptanmıştır (P<0.001). Ortalama serum gastrin, Hcy ve amilaz konsantrasyonları ARF’li köpekler ile kontroller arasında anlamlı fark göstermemiş, ancak CRF’li köpeklerde her iki gruba göre belirgin şekilde daha yüksek bulunmuştur (P<0.01–0.001). Elde edilen bulgular, serum gastrin, amilaz ve Hcy’nin özellikle CRF’de artış eğiliminde olduğunu, ancak ARF ile CRF’yi tutarlı biçimde ayırt edebilen tek parametrenin serum cystatin C olduğunu göstermektedir. Bu kapsamlı değerlendirme, köpeklerde daha az kullanılan renal biyobelirteçlerin tanısal önemine ilişkin yeni bilgiler sunmakta ve cystatin C’nin böbrek hasarının kronikliğini ayırt etmede değerli bir belirteç olduğunu desteklemektedir.

Keywords

Amilaz , gastrin , homosistein , sistatin , böbrek yetmezliği , köpek

Project Number

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