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Metastatic Adrenocortical Carcinoma of the Lung In A Four Years Old Child

Year 2018, , 38 - 43, 01.01.2018
https://doi.org/10.5455/umj.20180123053002

Abstract

Background: Studies of adrenocortical carcinoma is an aggressive rare type of endocrine tumors. It possesses a high mortality rate. This type of carcinomas occurs sporadically, while it could be part of hereditary syndromes. Only limited data is found about the recurrence of these tumors after resection and their prognosis is unclear. Case Presentation: We present a case of a four-year-old boy who presented with virilization symptoms and was referred for further investigation of left abdominal mass. He was cushingoid upon examination. The patient was managed by left nephrectomy and chemotherapy. Upon follow up, the residual mass lesion was seen on CT. Re-resection of the residual tumor was done. Adjuvant mitotane therapy and radiotherapy were started, 7 months later the patient was discovered to have left lung metastasis in which he underwent left lung wedge resection.

References

  • Breidbart E, Cameo T, Garvin JH, Hibshoosh H, Oberfield SE. Pubertal outcome in a female with virilizing adrenocortical carcinoma. J Pediatr Endocrinol Metab. 1 styczeń 2016;29(4): 503–9.
  • Fassnacht M, Kroiss M, Allolio B. Update in Adrenocortical Carcinoma. J Clin Endocrinol Metab. grudzień 2013;98(12): 4551–64.
  • Stewart DR, Morris Jones PH, Jolleys A. Carcinoma of the adrenal gland in children. J Pediatr Surg. luty 1974 [cytowane 30 wrzesień 2016];9(1):59–67.
  • Zaitoon MM, Gary Mackie G. Adrenal cortical tumors in children. Urology. grudzień 1978 [cytowane 30 wrzesień 2016]; 12(6):645–9.
  • Hisada M, Garber JE, Li FP, Fung CY, Fraumeni JF. Multiple Primary Cancers in Families With Li-Fraumeni Syndrome. JNCI J Natl Cancer Inst. 15 kwiecień 1998;90(8):606–11.
  • Stiller CA. International variations in the incidence of childhood carcinomas. Cancer Epidemiol Biomarkers; 1994; 3(4):305 LP-310.
  • Ribeiro RC, Figueiredo B. Childhood adrenocortical tumours. Eur J Cancer. maj 2004 [cytowane 30 wrzesień 2016]; 40(8):1117–26.
  • Wasserman JD, Zambetti GP, Malkin D. Towards an understanding of the role of p53 in adrenocortical carcino genesis. Mol Cell Endocrinol [Internet]. marzec 2012 [cytowane 1 październik 2016];351(1):101–10.
  • Patil KK, Ransley PG, McCullagh M, Malone M, Spitz L. Functioning adrenocortical neoplasms in children. BJU Int. 9 kwiecień 2002 [cytowane 1 październik 2016];89(6):562–5.
  • Ciftci BAO, Tanyel FC, Bu N. Adrenocortical Tumors in Children. 2001;36(4):549–54.
  • Wooten MD, King DK. Adrenal cortical carcinoma. Epidemiology and treatment with mitotane and a review of the literature. Cancer. 1 grudzień 1993;72(11):3145–55.
  • Srinivas K. Adrenocortical Tumors in Children. J Evol Med Dent Sci. 29 sierpień 2015;4(70):12184–6.
  • Wolthers OD, Cameron FJ, Scheimberg I, Honour JW, Hindmarsh PC, Savage MO. Androgen secreting adreno cortical tumours. Arch Dis Child. styczeń 1999;80(1):46–50.
  • Lau SK, Weiss LM. The Weiss system for evaluating adrenocortical neoplasms: 25 years later. Hum Pathol. czerwiec 2009;40(6):757–68.
  • Klein JD, Turner CG, Gray FL, Yu DC, Kozakewich HP, Perez-Atayde AR. Adrenal cortical tumors in children: factors associated with poor outcome. J Pediatr Surg. czerwiec 2011;46(6):1201–7.
  • Gulack BC, Rialon KL, Englum BR, Kim J, Talbot LJ, Adibe OO. Factors associated with survival in pediatric adrenocortical carcinoma: An analysis of the National Cancer Data Base (NCDB). J Pediatr Surg. styczeń 2016;51(1):172–7.
  • McAteer JP,Huaco JA,Gow KW.Predictorsof survival in pediatric adrenocortical carcinoma: A Surveillance, Epide- miology, and End Results (SEER) program study. J Pediatr Surg. 30 maj 2013;48(5):1025–31.
  • Union for International Cancer Control. The TNM Classification of Malignant Tumours. 7th Editio. Gospodaro wicz M, Wittekind Christian, Leslie S, redaktorzy. 2009.
  • Terzolo M, Angeli A, Fassnacht M, Daffara F, Tauchmanova L, Conton PA. Adjuvant mitotane treatment for adrenocortical carcinoma. N Engl J Med. 2007;356.
  • Postlewait LM, Ethun CG, Tran TB, Prescott JD, Pawlik TM, Wang TS, i in. Outcomes of Adjuvant Mitotane after Resection of Adrenocortical Carcinoma: A 13-Institution Study by the US Adrenocortical Carcinoma Group. J Am Coll Surg. 2016 [cytowane 19 listopad 2016];222(4):480–90.
Year 2018, , 38 - 43, 01.01.2018
https://doi.org/10.5455/umj.20180123053002

Abstract

References

  • Breidbart E, Cameo T, Garvin JH, Hibshoosh H, Oberfield SE. Pubertal outcome in a female with virilizing adrenocortical carcinoma. J Pediatr Endocrinol Metab. 1 styczeń 2016;29(4): 503–9.
  • Fassnacht M, Kroiss M, Allolio B. Update in Adrenocortical Carcinoma. J Clin Endocrinol Metab. grudzień 2013;98(12): 4551–64.
  • Stewart DR, Morris Jones PH, Jolleys A. Carcinoma of the adrenal gland in children. J Pediatr Surg. luty 1974 [cytowane 30 wrzesień 2016];9(1):59–67.
  • Zaitoon MM, Gary Mackie G. Adrenal cortical tumors in children. Urology. grudzień 1978 [cytowane 30 wrzesień 2016]; 12(6):645–9.
  • Hisada M, Garber JE, Li FP, Fung CY, Fraumeni JF. Multiple Primary Cancers in Families With Li-Fraumeni Syndrome. JNCI J Natl Cancer Inst. 15 kwiecień 1998;90(8):606–11.
  • Stiller CA. International variations in the incidence of childhood carcinomas. Cancer Epidemiol Biomarkers; 1994; 3(4):305 LP-310.
  • Ribeiro RC, Figueiredo B. Childhood adrenocortical tumours. Eur J Cancer. maj 2004 [cytowane 30 wrzesień 2016]; 40(8):1117–26.
  • Wasserman JD, Zambetti GP, Malkin D. Towards an understanding of the role of p53 in adrenocortical carcino genesis. Mol Cell Endocrinol [Internet]. marzec 2012 [cytowane 1 październik 2016];351(1):101–10.
  • Patil KK, Ransley PG, McCullagh M, Malone M, Spitz L. Functioning adrenocortical neoplasms in children. BJU Int. 9 kwiecień 2002 [cytowane 1 październik 2016];89(6):562–5.
  • Ciftci BAO, Tanyel FC, Bu N. Adrenocortical Tumors in Children. 2001;36(4):549–54.
  • Wooten MD, King DK. Adrenal cortical carcinoma. Epidemiology and treatment with mitotane and a review of the literature. Cancer. 1 grudzień 1993;72(11):3145–55.
  • Srinivas K. Adrenocortical Tumors in Children. J Evol Med Dent Sci. 29 sierpień 2015;4(70):12184–6.
  • Wolthers OD, Cameron FJ, Scheimberg I, Honour JW, Hindmarsh PC, Savage MO. Androgen secreting adreno cortical tumours. Arch Dis Child. styczeń 1999;80(1):46–50.
  • Lau SK, Weiss LM. The Weiss system for evaluating adrenocortical neoplasms: 25 years later. Hum Pathol. czerwiec 2009;40(6):757–68.
  • Klein JD, Turner CG, Gray FL, Yu DC, Kozakewich HP, Perez-Atayde AR. Adrenal cortical tumors in children: factors associated with poor outcome. J Pediatr Surg. czerwiec 2011;46(6):1201–7.
  • Gulack BC, Rialon KL, Englum BR, Kim J, Talbot LJ, Adibe OO. Factors associated with survival in pediatric adrenocortical carcinoma: An analysis of the National Cancer Data Base (NCDB). J Pediatr Surg. styczeń 2016;51(1):172–7.
  • McAteer JP,Huaco JA,Gow KW.Predictorsof survival in pediatric adrenocortical carcinoma: A Surveillance, Epide- miology, and End Results (SEER) program study. J Pediatr Surg. 30 maj 2013;48(5):1025–31.
  • Union for International Cancer Control. The TNM Classification of Malignant Tumours. 7th Editio. Gospodaro wicz M, Wittekind Christian, Leslie S, redaktorzy. 2009.
  • Terzolo M, Angeli A, Fassnacht M, Daffara F, Tauchmanova L, Conton PA. Adjuvant mitotane treatment for adrenocortical carcinoma. N Engl J Med. 2007;356.
  • Postlewait LM, Ethun CG, Tran TB, Prescott JD, Pawlik TM, Wang TS, i in. Outcomes of Adjuvant Mitotane after Resection of Adrenocortical Carcinoma: A 13-Institution Study by the US Adrenocortical Carcinoma Group. J Am Coll Surg. 2016 [cytowane 19 listopad 2016];222(4):480–90.
There are 20 citations in total.

Details

Primary Language English
Journal Section Case Report
Authors

Lulu Abdulaziz Alobaid This is me

İlhama Jafari This is me

Osama Almosallam This is me

Muhammed Amin Ur Rahman This is me

Abdulwahhab Aljubab This is me

Publication Date January 1, 2018
Published in Issue Year 2018

Cite

Vancouver Alobaid LA, Jafari İ, Almosallam O, Rahman MAU, Aljubab A. Metastatic Adrenocortical Carcinoma of the Lung In A Four Years Old Child. ULUTAS MED J. 2018;4(1):38-43.