ijerad International Journal of Engineering Research and Development 1308-5506 1308-5514 Kirikkale University 10.29137/umagd.1037361 Materials Engineering (Other) Malzeme Mühendisliği (Diğer) Autotransporter Proteins https://orcid.org/0000-0003-4463-0912 Göksel Şeyma GAZİ ÜNİVERSİTESİ, FEN BİLİMLERİ ENSTİTÜSÜ, İLERİ TEKNOLOJİLER ANABİLİM DALI (DİSİPLİNLERARASI), İLERİ TEKNOLOJİLER (DR) https://orcid.org/0000-0002-1227-2324 Akçelik Mustafa ANKARA ÜNİVERSİTESİ, FEN BİLİMLERİ ENSTİTÜSÜ 12 31 2021 13 3 49 57 10 07 2021 12 25 2021 Copyright © 2009, International Journal of Engineering Research and Development 2009 International Journal of Engineering Research and Development

Autotransporter proteins, which are examined under five groups on the basis of their secretory systems, constitute the largest protein family found in Gram-negative pathogenic bacteria. The determination that all autotransporter proteins are associated with pathogenicity and virulence in these bacteria has made them the focus of molecular pathogenicity studies. Although the structural organization of autotransporter proteins and the base sequences of the genes encoding them are highly similar, their functions in the strains they are found in show a high diversity. This indicates that pathogen-host adaptation may also result from differences in protein processing and secretion system, and that new and effective approaches can be developed in the fight against pathogens. In this review article, the contemporary literature of this important protein family has been examined, and it has been tried to be interpreted as a basis for new scientific studies.

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